-
1دورية أكاديمية
المؤلفون: Mako Nagayoshi, Asahi Hishida, Tomonori Shimizu, Yasufumi Kato, Yoko Kubo, Rieko Okada, Takashi Tamura, Jun Otonari, Hiroaki Ikezaki, Megumi Hara, Yuichiro Nishida, Isao Oze, Yuriko N. Koyanagi, Yohko Nakamura, Miho Kusakabe, Rie Ibusuki, Keiichi Shibuya, Sadao Suzuki, Takeshi Nishiyama, Teruhide Koyama, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Yasuyuki Nakamura, Sakurako Katsuura-Kamano, Kokichi Arisawa, Masahiro Nakatochi, Yukihide Momozawa, Kenji Takeuchi, Kenji Wakai
المصدر: Journal of Epidemiology, Vol 34, Iss 2, Pp 51-62 (2024)
مصطلحات موضوعية: body mass index, diabetes mellitus, cardiometabolic risk factors, mendelian randomization analysis, east asian people, Medicine (General), R5-920
الوصف: Background: Although many observational studies have demonstrated significant relationships between obesity and cardiometabolic traits, the causality of these relationships in East Asians remains to be elucidated. Methods: We conducted individual-level Mendelian randomization (MR) analyses targeting 14,083 participants in the Japan Multi-Institutional Collaborative Cohort Study and two-sample MR analyses using summary statistics based on genome-wide association study data from 173,430 Japanese. Using 83 body mass index (BMI)-related loci, genetic risk scores (GRS) for BMI were calculated, and the effects of BMI on cardiometabolic traits were examined for individual-level MR analyses using the two-stage least squares estimator method. The β-coefficients and standard errors for the per-allele association of each single-nucleotide polymorphism as well as all outcomes, or odds ratios with 95% confidence intervals were calculated in the two-sample MR analyses. Results: In individual-level MR analyses, the GRS of BMI was not significantly associated with any cardiometabolic traits. In two-sample MR analyses, higher BMI was associated with increased risks of higher blood pressure, triglycerides, and uric acid, as well as lower high-density-lipoprotein cholesterol and eGFR. The associations of BMI with type 2 diabetes in two-sample MR analyses were inconsistent using different methods, including the directions. Conclusion: The results of this study suggest that, even among the Japanese, an East Asian population with low levels of obesity, higher BMI could be causally associated with the development of a variety of cardiometabolic traits. Causality in those associations should be clarified in future studies with larger populations, especially those of BMI with type 2 diabetes.
وصف الملف: electronic resource
-
2دورية أكاديمية
المؤلفون: Teruhide Koyama, Etsuko Ozaki, Nagato Kuriyama, Satomi Tomida, Tamami Yoshida, Ritei Uehara, Keitaro Tanaka, Megumi Hara, Asahi Hishida, Rieko Okada, Yoko Kubo, Isao Oze, Yuriko N. Koyanagi, Haruo Mikami, Yohko Nakamura, Ippei Shimoshikiryo, Toshiro Takezaki, Sadao Suzuki, Takahiro Otani, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Kokichi Arisawa, Sakurako Katsuura‐Kamano, Hiroaki Ikezaki, Masayuki Murata, Kenji Takeuchi, Kenji Wakai
المصدر: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 13 (2021)
مصطلحات موضوعية: all‐cause mortality, diabetes mellitus, dyslipidemia, hypertension, sedentary time, Diseases of the circulatory (Cardiovascular) system, RC666-701
الوصف: Background This study aimed to determine the association between sedentary time and mortality with regard to leisure‐time physical activity with or without cardiometabolic diseases such as hypertension, dyslipidemia, and diabetes mellitus. Methods and Results Using data from the J‐MICC (Japan Multi‐Institutional Collaborative Cohort) Study, 64 456 participants (29 022 men, 35 434 women) were analyzed. Hazard ratios (HRs) and 95% CIs were used to characterize the relative risk of all‐cause mortality to evaluate its association with sedentary time (categorical variables:
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2047-9980
-
3
المؤلفون: Takashi Matsunaga, Yuka Kadomatsu, Mineko Tsukamoto, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Takashi Tamura, Asahi Hishida, Toshiro Takezaki, Ippei Shimoshikiryo, Sadao Suzuki, Hiroko Nakagawa, Naoyuki Takashima, Yoshino Saito, Kiyonori Kuriki, Kokichi Arisawa, Sakurako Katsuura-Kamano, Nagato Kuriyama, Daisuke Matsui, Haruo Mikami, Yohko Nakamura, Isao Oze, Hidemi Ito, Masayuki Murata, Hiroaki Ikezaki, Yuichiro Nishida, Chisato Shimanoe, Kenji Takeuchi, Kenji Wakai
المصدر: PLoS ONE, Vol 17, Iss 1, p e0262252 (2022)
PLoS ONEمصطلحات موضوعية: Adult, Epidemiology, Endocrine Disorders, Maternal Health, Science, Cardiology, Blood Pressure, Cardiovascular Medicine, Pediatrics, Vascular Medicine, Medical Conditions, Endocrinology, Japan, Surveys and Questionnaires, Medicine and Health Sciences, Diabetes Mellitus, Prevalence, Humans, Public and Occupational Health, Aged, Metabolic Syndrome, Multidisciplinary, Cancer Risk Factors, Physical Activity, Cardiovascular Disease Risk, Middle Aged, Type 2 Diabetes, Breast Feeding, Cross-Sectional Studies, Oncology, Cardiovascular Diseases, Age Groups, Metabolic Disorders, Medical Risk Factors, People and Places, Women's Health, Medicine, Population Groupings, Female, Independent Living, Neonatology, Type 2 Diabetes Risk, Research Article
الوصف: Objective The aim of the present study was to investigate the associations between breastfeeding and the prevalence of metabolic syndrome in community-dwelling parous women and to clarify whether the associations depend on age. Methods The present cross-sectional study included 11,118 women, aged 35–69 years. Participants’ longest breastfeeding duration for one child and their number of breastfed children were assessed using a self-administered questionnaire, and their total breastfeeding duration was approximated as a product of the number of breastfed children and the longest breastfeeding duration. The longest and the total breastfeeding durations were categorized into none and tertiles above 0 months. Metabolic syndrome and cardiovascular risk factors (obesity, hypertension, dyslipidemia, and hyperglycemia) were defined as primary and secondary outcomes, respectively. Associations between breastfeeding history and metabolic syndrome or each cardiovascular risk factor were assessed using multivariable unconditional logistic regression analysis. Results Among a total of 11,118 women, 10,432 (93.8%) had ever breastfed, and 1,236 (11.1%) had metabolic syndrome. In participants aged Conclusions Breastfeeding history may be related to lower prevalence of metabolic syndrome in middle-aged parous women.
وصف الملف: application/pdf
-
4
المؤلفون: Kiyonori Kuriki, Miho Kusakabe, Keitaro Matsuo, Kenji Wakai, Keitaro Tanaka, Takuma Furukawa, Asahi Hishida, Daisuke Matsui, Sakurako Katsuura-Kamano, Yuichiro Nishida, Daisaku Nishimoto, Kenji Takeuchi, Miki Watanabe, Hiroaki Ikezaki, Takashi Tamura, Jun Otonari, Kayoko Koga, Chisato Shimanoe, Etsuko Ozaki, Yoko Kubo, Keiichi Shibuya, Chiharu Iwasaka, Sadao Suzuki, Kokichi Arisawa, Megumi Hara, Hidemi Ito, Naoyuki Takashima, Yohko Nakamura, Yasufumi Kato, Aya Kadota
المصدر: Scientific Reports
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)مصطلحات موضوعية: Adult, Male, Lifestyle modification, Science, Emotions, Renal function, Kidney, Psychological Distress, Risk Assessment, Article, Sex Factors, Japan, Risk Factors, Chronic kidney disease, Stress (linguistics), Adaptation, Psychological, Diabetes Mellitus, Medicine, Humans, Prospective Studies, Renal Insufficiency, Chronic, Association (psychology), Problem Solving, Aged, Multidisciplinary, business.industry, Age Factors, Social Support, Middle Aged, Cross-Sectional Studies, Hypertension, Female, business, Stress, Psychological, Clinical psychology, Glomerular Filtration Rate
الوصف: Elucidating risk factors for chronic kidney disease is important for preventing end-stage kidney disease and reducing mortality. However, little is known about the roles of psychosocial stress and stress coping behaviors in deterioration of the renal function, as measured by the estimated glomerular filtration rate (eGFR). This cross-sectional study of middle-aged and older Japanese men (n=31,703) and women (n=38,939) investigated whether perceived stress and coping strategies (emotional expression, emotional support seeking, positive reappraisal, problem solving, and disengagement) were related to the eGFR, with mutual interactions. In multiple linear regression analyses adjusted for age, area, lifestyle factors, and psychosocial variables, we found a significant inverse association between perceived stress and the eGFR in men (Ptrend=0.02), but not women. This male-specific inverse association was slightly attenuated after adjustment for the history of hypertension and diabetes and was more evident in lower levels of emotional expression (Pinteraction=0.003). Unexpectedly, problem solving in men (PtrendPtrend=0.002) also showed an inverse association with the eGFR. Perceived stress may affect eGFR, partly through the development of hypertension and diabetes. Based on the unexpected findings regarding coping strategies, further studies are required to clarify the underlying mechanisms, including the hormonal and immunological aspects.
وصف الملف: application/pdf
-
5
المؤلفون: Nagato Kuriyama, Teruhide Koyama, Satomi Tomida, Isao Oze, Naoyuki Takashima, Kenji Takeuchi, Sakurako Katsuura-Kamano, Yuichiro Nishida, Keitaro Matsuo, Asahi Hishida, Chisato Shimanoe, Kiyonori Kuriki, Kenji Wakai, Etsuko Ozaki, Masayuki Murata, Aya Kadota, Takeshi Nishiyama, Hirokazu Uemura, Hiroaki Ikezaki, Takashi Tamura, Rie Ibusuki, Toshiro Takezaki, Yohko Nakamura, Haruo Mikami, Sadao Suzuki, Ritei Uehara, Mineko Tsukamoto, Yuka Kadomatsu
المصدر: Journal of Atherosclerosis and Thrombosis
مصطلحات موضوعية: Adult, Male, Cross-sectional study, Blood Pressure, 030204 cardiovascular system & hematology, Metabolic equivalent, Population approach, Diabetes Complications, 03 medical and health sciences, 0302 clinical medicine, Leisure Activities, Sex Factors, Quality of life, Japan, Risk Factors, Diabetes mellitus, Surveys and Questionnaires, Internal Medicine, medicine, Humans, Life Style, Triglycerides, Aged, Dyslipidemias, business.industry, Biochemistry (medical), Cholesterol, HDL, Anthropometry, Middle Aged, medicine.disease, Cardiometabolic diseases, Sedentary time, Blood pressure, Cross-Sectional Studies, Cardiovascular Diseases, Hypertension, Quality of Life, Female, Original Article, Sedentary Behavior, Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery, Dyslipidemia, Demography, Cohort study
الوصف: Aim: Accumulating evidence reveals that sedentary behavior is associated with mortality and cardiometabolic disease; however, there are potential age and sex differences in sedentary behavior and health outcomes that have not been adequately addressed. This study aimed to determine the association of sedentary behavior with cardiometabolic diseases such as hypertension, dyslipidemia, diabetes mellitus, and its risk factors in a large Japanese population according to age and sex. Methods: Using data from the Japan Multi-Institutional Collaborative Cohort Study obtained from baseline surveys, data of 62,754 participants (27,930 males, 34,824 females) were analyzed. This study uses a cross-sectional design and self-administered questionnaires to evaluate sedentary time and anamnesis. For the logistic regression analysis, sedentary time < 5 h/day was used as the reference and then adjusted for age, research areas, leisure-time metabolic equivalents, and alcohol and smoking status. From the analysis of anthropometric and blood examinations, 35,973 participants (17,109 males, 18,864 females) were analyzed. Results: For hypertension and diabetes, sedentary time was associated with a significantly higher proportion of male participants. Both sexes were associated with a significantly higher proportion of participants with dyslipidemia. Participants who had longer sedentary time tended to have increased levels of blood pressure, triglycerides, and non-high-density lipoprotein cholesterol (HDL-C), and decreased levels of HDL-C, especially in the 60–69 years group. Conclusions: Independent of leisure-time physical activity, sedentary time was associated with cardiometabolic diseases in a large Japanese population classified by age and sex. Our findings indicate that regularly interrupting and replacing sedentary time may contribute to better physical health-related quality of life.
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b87a2bdfaea9b41dbff04c4f9e513c
https://pubmed.ncbi.nlm.nih.gov/32269208 -
6
المؤلفون: Keitaro Tanaka, Kiyonori Kuriki, Nagato Kuriyama, Hirokazu Uemura, Asahi Hishida, Aya Kadota, Yoshiyuki Watanabe, Yohko Nakamura, Hidemi Ito, Haruo Mikami, Sayo Kawai, Mariko Naito, Masahiro Nakatochi, Rieko Okada, Norihiro Furusyo, Michiaki Kubo, Teruhide Koyama, Chisato Shimanoe, Akihiro Hosono, Naoyuki Takashima, Kaori Endoh, Sakurako Katsuura-Kamano, Hiroaki Ikezaki, Etsuko Ozaki, Kenji Wakai, Isao Oze, Daisuke Matsui, Rie Ibusuki, Ippei Shimoshikiryo, Tae Sasakabe, Wakiko Takeshita, Sadao Suzuki, Komei Iwai, Isao Watanabe
المصدر: Journal of Atherosclerosis and Thrombosis. 24:1267-1281
مصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, business.industry, Biochemistry (medical), Single-nucleotide polymorphism, Odds ratio, Disease, 030204 cardiovascular system & hematology, medicine.disease, Logistic regression, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Endocrinology, Diabetes mellitus, Internal medicine, Internal Medicine, Medicine, SNP, Cardiology and Cardiovascular Medicine, business, Stroke, Dyslipidemia
الوصف: Aim: Stroke is associated closely with vascular homeostasis, and several complex processes and interacting pathways, which involve various genetic and environmental factors, contribute to the risk of stroke. Although adrenomedullin (ADM) has a number of physiological and vasoprotective functions, there are few studies of the ADM receptor system in humans. The ADM receptor comprises a calcitonin-receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs). We analyzed single nucleotide polymorphisms (SNPs) in the RAMP2 and CLR genes to determine their association with stroke in the light of gene-environment interactions. Methods: Using cross-sectional data from the Japan Multi-Institutional Collaborative Cohort Study in the baseline surveys, 14,087 participants from 12 research areas were genotyped. We conducted a hypothesis-based association between stroke prevalence and SNPs in the RAMP2 and CLR genes based on data abstracted from two SNPs in RAMP2 and 369 SNPs in CLR. We selected five SNPs from among the CLR variants (rs77035639, rs3815524, rs75380157, rs574603859, and rs147565266) and one RAMP2 SNP (rs753152), which were associated with stroke, for analysis. Results: Five of the SNPs (rs77035639, rs3815524, rs75380157, rs147565266, and rs753152) showed no significant association with obesity, ischemic heart disease, hypertension, dyslipidemia, and diabetes. In the logistic regression analysis, rs574603859 had a lower odds ratio (0.238; 95% confidence interval, 0.076–0.745, adjusted for age, sex, and research area) and the other SNPs had higher odds ratios for association with stroke. Conclusions: This was the first study to investigate the relationships between ADM receptor genes (RAMP2 and CLR) and stroke in the light of gene-environment interactions in human.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::45d6736a97beddad40a43fc2d2a39286
https://doi.org/10.5551/jat.41517 -
7
المؤلفون: Sayo Kawai, Nobuyuki Hamajima, Mariko Naito, Tae Sasakabe, Shino Suma, Asahi Hishida, Takashi Matsunaga, Masahiko Satoh, Sahoko Takagi, Masashi Kato, Masahiro Nakatochi, Kenji Wakai, Hisao Naito, Rieko Okada, Yuta Hattori, Toshio Seiki
المصدر: Toxicological Sciences
مصطلحات موضوعية: Male, 0301 basic medicine, Oncology, Longitudinal study, Cross-sectional study, Toxicology, Bioinformatics, 0302 clinical medicine, Gene Frequency, Risk Factors, Genotype, Odds Ratio, Longitudinal Studies, Metallothionein Polymorphisms in Diabetes and Renal Disease, education.field_of_study, Homozygote, risk assessment, Middle Aged, Zinc, Phenotype, 030220 oncology & carcinogenesis, Female, Cohort study, Adult, Heterozygote, medicine.medical_specialty, Population, SNP, Single-nucleotide polymorphism, 03 medical and health sciences, Internal medicine, Diabetes Mellitus, medicine, Humans, Genetic Predisposition to Disease, Renal Insufficiency, Chronic, education, Genetic Association Studies, Aged, Chi-Square Distribution, Polymorphism, Genetic, business.industry, Odds ratio, metallothionein, medicine.disease, Cross-Sectional Studies, Logistic Models, 030104 developmental biology, business, chronic kidney disease, Kidney disease
الوصف: Metallothioneins (MTs) are proteins that protect cells from toxic agents such as heavy metal ions or reactive oxygen species. MT2A A-5G is a single nucleotide polymorphism in the promoter region of the MT2A gene, and the minor G allele results in lower transcription efficiency. We aimed to elucidate associations between MT2A A-5G and risks of 2 diseases potentially related to lowered MT expression, chronic kidney disease (CKD), and diabetes mellitus (DM), in a community-dwelling population. Study subjects were Nagoya city residents participating in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC) Daiko Study, comprised 749 men and 2,025 women, aged 39–75 years. CKD (>stage 3) and DM were defined by standard guidelines. Associations were evaluated using logistic regression models with adjustments for age, sex and potential confounders in a cross-sectional study, and verified in a 5-year longitudinal study. Odds ratios (OR [95% confidence interval]) were calculated relative to the AA genotype. Serum MT (I + II), Cd and zinc levels were also determined by genotype. The OR of the GG genotype for CKD risk was 3.98 (1.50, 10.58) in the cross-sectional study and 5.17 (1.39, 19.28) in the longitudinal study. The OR of the GA genotype for DM was 1.86 (1.26, 2.75) in the cross-sectional study and 2.03 (1.19, 3.46) in the longitudinal study. MT2A A-5G may be associated with CKD and DM risks. This polymorphism is a promising target for evaluations of CKD and DM risks with possible involvement of low-dose chronic exposure to environmental pollutants.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ff1cb8258c4db1a4e29d8f3092cac1
https://doi.org/10.1093/toxsci/kfw080 -
8
المؤلفون: Yuichiro Nishida, Sadao Suzuki, Nobuyuki Hamajima, Hinako Nanri, Kazuyo Nakamura, Haruo Mikami, Daisuke Matsui, Hideo Tanaka, Yoshikuni Kita, Sayo Kawai, Isao Oze, Keizo Ohnaka, Eva Mariane Mantjoro, Hirokazu Uemura, Megumi Hara, Michiaki Kubo, Asahi Hishida
المصدر: Journal of Epidemiology
مصطلحات موضوعية: Adult, Blood Glucose, Male, medicine.medical_specialty, obesity, fasting blood glucose (FBG), Epidemiology, Cross-sectional study, Population, Type 2 diabetes, polymorphism, Body Mass Index, DNA Glycosylases, Insulin resistance, Japan, Internal medicine, Diabetes mellitus, Genotype, Genetics, Medicine, body mass index (BMI), Humans, Genetic Predisposition to Disease, education, human 8-oxoguanine glycosylase 1 (hOGG1), Aged, education.field_of_study, Polymorphism, Genetic, business.industry, General Medicine, Fasting, Middle Aged, medicine.disease, Obesity, Endocrinology, study area, Cholesterol, Cross-Sectional Studies, Original Article, Female, business, Body mass index
الوصف: Background Evidence suggests that Ser326Cys, a genetic polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1), is associated with insulin resistance and type 2 diabetes; however, the underlying mechanism is unclear. Recently, an animal study showed a significant association between the hOGG1 genotype and obesity, although evidence for such an association in humans is limited. The purpose of this study was to examine the association between the hOGG1 genotype and body mass index (BMI) and fasting blood glucose (FBG) levels. Methods Cross-sectional analysis was conducted using the baseline survey data from a Japan Multi-Institutional Collaborative Cohort Study, which included 1793 participants aged 40-69 years. The hOGG1 polymorphism was detected using a multiplex polymerase chain reaction-based invader assay. Multiple linear regression, analysis of covariance, and logistic regression were used to control for confounding variables. Results The Cys allele was significantly associated with increased BMI, FBG level, and total cholesterol (TC) level, even after adjustment for gender, age, energy intake, alcohol, smoking, physical activity, and family history of diabetes. An association with BMI was still observed after further adjustment for FBG and TC, but not for the study area (Amami or the mainland). The Cys/Cys genotype was significantly more prevalent in the participants with higher BMI (>27.5 kg/m(2)). However, the impact of genotype decreased and significance disappeared after adjusting for the study area. Conclusions The present results suggest that the study area being inside Japan confounds the association between hOGG1 genotype and obesity.
-
9
المؤلفون: Yasuki Higaki, Satoyo Hosono, Hideo Tanaka, Tanvir Chowdhury Turin, Rieko Okada, Sakurako Katsuura, Haruo Mikami, Isao Watanabe, Sadao Suzuki, Michiaki Kubo, Nobuyuki Hamajima, Emi Morita, Asahi Hishida, Naotaka Tashiro, Kheradmand Motahareh, Mariko Naito, Kenji Wakai
المصدر: Endocrine Journal. 60:237-243
مصطلحات موضوعية: medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Type 2 Diabetes Mellitus, Odds ratio, medicine.disease, Logistic regression, Confidence interval, Endocrinology, Polymorphism (computer science), Diabetes mellitus, Internal medicine, Genotype, medicine, Resistin, business
الوصف: We examined the association of the RETN (resistin) -420 C>G polymorphism (rs1862513) with risk of diabetes mellitus (DM), considering lifestyle factors, in Japanese. Subjects were participants of J-MICC Study, where 2,651 participants aged 35-69 years provided their blood for genotyping and lifestyle data after informed consent. Odds ratio (OR) of DM for RETN-420 G/G genotype was estimated using unconditional logistic regression model. Statistically significant interaction on risk of DM was observed between RETN-420 G/G genotype and BMI 25 (n = 10 for DM and 111 for non-DM), RETN-420 C/C+C/G and BMI
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bb6b88f3d1cfba77dc5f0462c8cfef01
https://doi.org/10.1507/endocrj.ej12-0307 -
10
المؤلفون: Takashi Tamura, Shun Kawai, Shino Suma, Yuta Hattori, Rieko Okada, Emi Morita, Hiroko Nakagawa, Mariko Naito, Nobuyuki Hamajima, Tae Sasakabe, Asahi Hishida, Kenji Wakai
المصدر: Oral diseases. 21(6)
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Genotype, Smoking habit, Physical activity, Dentistry, Polymorphism, Single Nucleotide, Tooth Loss, stomatognathic system, Japan, Internal medicine, Diabetes mellitus, Tooth loss, medicine, Humans, General Dentistry, Aged, business.industry, Interleukin-6, Smoking, Odds ratio, Middle Aged, medicine.disease, Confidence interval, stomatognathic diseases, Otorhinolaryngology, Female, Gene-Environment Interaction, medicine.symptom, business
الوصف: Objective To examine the association between an IL6 (Interleukin-6) polymorphism (C-634G or rs1800796) and tooth loss, and an interaction between the polymorphism and smoking habits for the loss. Material and Methods Our subjects were 4917 check-up examinees ages 35–69. They reported tooth loss and lifestyle in a questionnaire. We regressed the number of teeth on the IL6 genotype, gender, age, smoking, drinking, diabetes, hypertension, physical activity, energy intake, education, and brushing. We further estimated multivariate-adjusted odds ratios (ORs) for having
إعادة تعيين المنقحات
عرض المنقحات (%%عد%%)
Full Text Finder