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1دورية أكاديمية
المؤلفون: Okondo MC; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Johnson DC; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Sridharan R; Graduate Program in Pharmacology, Weill Cornell Graduate School of Medical Sciences, New York, New York, USA., Go EB; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Chui AJ; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Wang MS; Graduate Program in Pharmacology, Weill Cornell Graduate School of Medical Sciences, New York, New York, USA., Poplawski SE; Department of Developmental, Chemical &Molecular Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, USA., Wu W; Department of Developmental, Chemical &Molecular Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, USA., Liu Y; Department of Developmental, Chemical &Molecular Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, USA., Lai JH; Department of Developmental, Chemical &Molecular Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, USA., Sanford DG; Department of Developmental, Chemical &Molecular Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, USA., Arciprete MO; Department of Developmental, Chemical &Molecular Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, USA., Golub TR; The Eli and Edythe L. Broad Institute, Cambridge, Massachusetts, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Howard Hughes Medical Institute, Chevy Chase, Maryland, USA., Bachovchin WW; Department of Developmental, Chemical &Molecular Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, USA.; Arisaph Pharmaceuticals, Boston, Massachusetts, USA., Bachovchin DA; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Graduate Program in Pharmacology, Weill Cornell Graduate School of Medical Sciences, New York, New York, USA.
المصدر: Nature chemical biology [Nat Chem Biol] 2017 Jan; Vol. 13 (1), pp. 46-53. Date of Electronic Publication: 2016 Nov 07.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
مواضيع طبية MeSH: Boronic Acids/*pharmacology , Caspase 1/*metabolism , Dipeptidases/*antagonists & inhibitors , Dipeptides/*pharmacology , Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/*antagonists & inhibitors , Leukocytes, Mononuclear/*drug effects , Macrophages/*drug effects , Pyroptosis/*drug effects , Serine Proteinase Inhibitors/*pharmacology, Animals ; Boronic Acids/chemistry ; Caspase 1/deficiency ; Cell Line ; Dipeptidases/metabolism ; Dipeptides/chemistry ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/metabolism ; Dose-Response Relationship, Drug ; Humans ; Leukocytes, Mononuclear/enzymology ; Leukocytes, Mononuclear/pathology ; Macrophages/enzymology ; Macrophages/pathology ; Mice ; Molecular Conformation ; Serine Proteinase Inhibitors/chemistry ; Structure-Activity Relationship