المؤلفون: Stroud DA; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, 3800, Melbourne, Australia., Surgenor EE; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, 3800, Melbourne, Australia., Formosa LE; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, 3800, Melbourne, Australia.; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University 3086, Melbourne, Australia., Reljic B; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University 3086, Melbourne, Australia., Frazier AE; Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne 3052, Australia.; Department of Pediatrics, University of Melbourne, Melbourne 3052, Australia., Dibley MG; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, 3800, Melbourne, Australia., Osellame LD; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, 3800, Melbourne, Australia., Stait T; Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne 3052, Australia., Beilharz TH; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, 3800, Melbourne, Australia., Thorburn DR; Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne 3052, Australia.; Department of Pediatrics, University of Melbourne, Melbourne 3052, Australia.; Victorian Clinical Genetics Services, Royal Children's Hospital 3052, Melbourne, Australia., Salim A; Department of Mathematics and Statistics, La Trobe University 3086, Melbourne Australia., Ryan MT; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, 3800, Melbourne, Australia.

المصدر: Nature [Nature] 2016 Oct 06; Vol. 538 (7623), pp. 123-126. Date of Electronic Publication: 2016 Sep 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Mitochondria*/chemistry , Mitochondria*/genetics , Mitochondria*/metabolism, Electron Transport Complex I/*chemistry , Electron Transport Complex I/*metabolism , Mitochondrial Proteins/*chemistry , Mitochondrial Proteins/*metabolism , Protein Subunits/*metabolism, Cell Line ; Cell Respiration ; Cell Survival/genetics ; Electron Transport Complex I/genetics ; Gene Editing ; Gene Knockout Techniques ; HEK293 Cells ; Humans ; Membrane Proteins/metabolism ; Mitochondrial Proteins/deficiency ; Mitochondrial Proteins/genetics ; Mitochondrial Proton-Translocating ATPases/metabolism ; Models, Molecular ; Protein Stability ; Protein Subunits/chemistry ; Protein Subunits/deficiency ; Protein Subunits/genetics ; Proteomics