المؤلفون: Ueno H; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan. h-ueno@taiho.co.jp., Hoshino T; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan., Yano W; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan., Tsukioka S; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan., Suzuki T; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan., Hara S; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan., Ogino Y; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan., Chong KT; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan., Suzuki T; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan., Tsuji S; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan., Itadani H; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan., Yamamiya I; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan., Otsu Y; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan., Ito S; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan., Yonekura T; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan., Terasaka M; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan., Tanaka N; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan., Miyahara S; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan. sei-miyahara@taiho.co.jp.

المصدر: Communications biology [Commun Biol] 2022 Jun 09; Vol. 5 (1), pp. 571. Date of Electronic Publication: 2022 Jun 09.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Enzyme Inhibitors*/pharmacology , Ribonucleotide Reductases*/antagonists & inhibitors, Animals ; DNA Replication ; Humans ; Nuclear Proteins/metabolism

المؤلفون: Safiarian MS; Department of Chemistry and Biochemistry and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, United States., Watson RA; Department of Chemistry and Biochemistry and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, United States., Lieberman RL; Department of Chemistry and Biochemistry and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, United States., Barry BA; Department of Chemistry and Biochemistry and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, United States., Offenbacher AR; Department of Chemistry, East Carolina University, Greenville, North Carolina 27858, United States.

المصدر: The journal of physical chemistry letters [J Phys Chem Lett] 2021 Sep 23; Vol. 12 (37), pp. 9020-9025. Date of Electronic Publication: 2021 Sep 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101526034 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7185 (Electronic) Linking ISSN: 19487185 NLM ISO Abbreviation: J Phys Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*chemistry , Escherichia coli/*enzymology , Escherichia coli Proteins/*metabolism , Ferrous Compounds/*chemistry , Pyridines/*chemistry , Ribonucleotide Reductases/*metabolism , Thiosemicarbazones/*chemistry, Enzyme Inhibitors/metabolism ; Escherichia coli Proteins/antagonists & inhibitors ; Free Radicals/chemistry ; Free Radicals/metabolism ; Hydroxyurea/chemistry ; Protein Binding ; Protein Subunits/antagonists & inhibitors ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Ribonucleotide Reductases/antagonists & inhibitors ; Spectrophotometry, Ultraviolet ; Spectroscopy, Fourier Transform Infrared

المؤلفون: Misko TA; a Department of Pharmacology, School of Medicine , Case Western Reserve University , Cleveland , OH , USA., Liu YT; b School of Pharmacy, College of Pharmacy , Taipei Medical University , Taipei , Taiwan., Harris ME; c Department of Chemistry , University of Florida , Gainesville , FL , United States., Oleinick NL; d Department of Radiation Oncology, School of Medicine , Case Western Reserve University , Cleveland , OH , USA., Pink J; e Case Comprehensive Cancer Center, School of Medicine , Case Western Reserve University , Cleveland , OH , USA., Lee HY; b School of Pharmacy, College of Pharmacy , Taipei Medical University , Taipei , Taiwan.; f Ph.D Program in Biotechnology Research and Development, College of Pharmacy , Taipei Medical University , Taipei , Taiwan., Dealwis CG; a Department of Pharmacology, School of Medicine , Case Western Reserve University , Cleveland , OH , USA.; g Department of Chemistry, Center for Proteomics , Case Western Reserve University , Cleveland , OH , USA.

المصدر: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2019 Dec; Vol. 34 (1), pp. 438-450.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Enzyme Inhibitors/*pharmacology , Ribonucleotide Reductases/*antagonists & inhibitors, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Models, Molecular ; Molecular Structure ; Ribonucleotide Reductases/metabolism ; Structure-Activity Relationship

المؤلفون: Ertas M; Department of Pharmaceutical Chemistry, School of Pharmacy, Istanbul Medipol University, Istanbul, Turkey., Sahin Z; Department of Pharmaceutical Chemistry, School of Pharmacy, Istanbul Medipol University, Istanbul, Turkey., Bulbul EF; Department of Pharmaceutical Chemistry, School of Pharmacy, Istanbul Medipol University, Istanbul, Turkey., Bender C; Department of Pharmaceutical Chemistry, School of Pharmacy, Istanbul Medipol University, Istanbul, Turkey., Biltekin SN; Department of Pharmaceutical Microbiology, School of Pharmacy, Istanbul Medipol University, Istanbul, Turkey., Berk B; Department of Pharmaceutical Chemistry, School of Pharmacy, Istanbul Medipol University, Istanbul, Turkey., Yurttas L; Department of Pharmaceutical Chemistry, School of Pharmacy, Anadolu University, Eskişehir, Turkey., Nalbur AM; Department of Analytical Chemistry, School of Pharmacy, Yeditepe University, Istanbul, Turkey., Celik H; Department of Analytical Chemistry, School of Pharmacy, Yeditepe University, Istanbul, Turkey., Demirayak Ş; Department of Pharmaceutical Chemistry, School of Pharmacy, Istanbul Medipol University, Istanbul, Turkey.

المصدر: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2019 Nov; Vol. 352 (11), pp. e1900033. Date of Electronic Publication: 2019 Sep 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Enzyme Inhibitors/*pharmacology , Ribonucleotide Reductases/*antagonists & inhibitors , Thiazoles/*pharmacology , Thiosemicarbazones/*pharmacology, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; HEK293 Cells ; Humans ; Ligands ; MCF-7 Cells ; Molecular Structure ; Ribonucleotide Reductases/metabolism ; Structure-Activity Relationship ; Thiazoles/chemistry ; Thiosemicarbazones/chemical synthesis ; Thiosemicarbazones/chemistry

المؤلفون: Wu Y; Computational Drug Discovery Laboratory, School of Electrical and Computer Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA., Hsieh TC; Department of Biochemistry & Molecular Biology, New York Medical College, Valhalla, NY 10595, USA., Wu JM; Department of Biochemistry & Molecular Biology, New York Medical College, Valhalla, NY 10595, USA., Wang X; Department of Biochemistry & Molecular Biology, New York Medical College, Valhalla, NY 10595, USA., Christopher JS; Computational Drug Discovery Laboratory, School of Electrical and Computer Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA.; The Franklin College of Arts and Sciences, University of Georgia, Athens, GA 30602, USA., Pham AH; Computational Drug Discovery Laboratory, School of Electrical and Computer Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA.; The Franklin College of Arts and Sciences, University of Georgia, Athens, GA 30602, USA., Swaby JD; Computational Drug Discovery Laboratory, School of Electrical and Computer Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA.; The Franklin College of Arts and Sciences, University of Georgia, Athens, GA 30602, USA., Lou L; Computational Drug Discovery Laboratory, School of Electrical and Computer Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA., Xie ZR; Computational Drug Discovery Laboratory, School of Electrical and Computer Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA.

المصدر: Biomolecules [Biomolecules] 2020 Aug 22; Vol. 10 (9). Date of Electronic Publication: 2020 Aug 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*chemistry , Enzyme Inhibitors/*pharmacology , Resveratrol/*analogs & derivatives, Binding, Competitive ; Catalytic Domain ; DNA Polymerase I/antagonists & inhibitors ; DNA Polymerase I/chemistry ; DNA Polymerase III/antagonists & inhibitors ; DNA Polymerase III/chemistry ; Drug Discovery ; HIV Reverse Transcriptase/antagonists & inhibitors ; HIV Reverse Transcriptase/chemistry ; Humans ; Hydrogen Bonding ; In Vitro Techniques ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Molecular Structure ; Protein Conformation ; Resveratrol/chemistry ; Resveratrol/pharmacology ; Ribonucleotide Reductases/antagonists & inhibitors ; Ribonucleotide Reductases/chemistry ; Structure-Activity Relationship

المؤلفون: Huff SE; Department of Chemistry, College of Arts and Sciences, Case Western Reserve University , Millis Science Center, Room 216, 2074 Adelbert Road, Cleveland, Ohio 44106, United States., Mohammed FA; Department of Pharmacology, School of Medicine, Case Western Reserve University , 10900 Euclid Avenue, Cleveland, Ohio 44106, United States., Yang M; Department of Chemistry, College of Arts and Sciences, Case Western Reserve University , Millis Science Center, Room 216, 2074 Adelbert Road, Cleveland, Ohio 44106, United States., Agrawal P; Department of Chemistry, College of Arts and Sciences, Case Western Reserve University , Millis Science Center, Room 216, 2074 Adelbert Road, Cleveland, Ohio 44106, United States., Pink J; Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University , 10900 Euclid Avenue, Cleveland, Ohio 44106, United States., Harris ME; Department of Chemistry, University of Florida , PO Box 117200, Gainseville, Florida 32611, United States., Dealwis CG; Department of Pharmacology, School of Medicine, Case Western Reserve University , 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.; Center for Proteomics and the Department of Chemistry, Case Western Reserve University , 10900 Euclid Avenue, Cleveland, Ohio 44106, United States., Viswanathan R; Frank Hovorka Assistant Professor of Chemistry and Scientific Oversight Board Member-Small Molecule Drug Discovery Core, Case Western Reserve University , 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.; Department of Chemistry, College of Arts and Sciences, Case Western Reserve University , Millis Science Center, Room 216, 2074 Adelbert Road, Cleveland, Ohio 44106, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2018 Feb 08; Vol. 61 (3), pp. 666-680. Date of Electronic Publication: 2018 Jan 05.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*chemical synthesis , Enzyme Inhibitors/*pharmacology , Hydrazones/*chemical synthesis , Hydrazones/*pharmacology , Ribonucleotide Reductases/*antagonists & inhibitors, Chemistry Techniques, Synthetic ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/metabolism ; Humans ; Hydrazones/chemistry ; Molecular Docking Simulation ; Protein Conformation ; Ribonucleotide Reductases/chemistry ; Ribonucleotide Reductases/metabolism ; Structure-Activity Relationship

المؤلفون: Epting CL; Department of Pediatrics, Northwestern University, Chicago, Illinois, USA c-epting@northwestern.edu david.engman@csmc.edu.; Department of Pathology, Northwestern University, Chicago, Illinois, USA., Emmer BT; Department of Pathology, Northwestern University, Chicago, Illinois, USA.; Department of Microbiology-Immunology, Northwestern University, Chicago, Illinois, USA., Du NY; Department of Pediatrics, Northwestern University, Chicago, Illinois, USA.; Department of Pathology, Northwestern University, Chicago, Illinois, USA., Taylor JM; Department of Pediatrics, Northwestern University, Chicago, Illinois, USA.; Department of Pathology, Northwestern University, Chicago, Illinois, USA., Makanji MY; Department of Pediatrics, Northwestern University, Chicago, Illinois, USA., Olson CL; Department of Pathology, Northwestern University, Chicago, Illinois, USA., Engman DM; Department of Pathology, Northwestern University, Chicago, Illinois, USA c-epting@northwestern.edu david.engman@csmc.edu.; Department of Microbiology-Immunology, Northwestern University, Chicago, Illinois, USA.; Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA.

المصدر: MBio [mBio] 2017 Sep 19; Vol. 8 (5). Date of Electronic Publication: 2017 Sep 19.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

مواضيع طبية MeSH: Cell Cycle/*drug effects , Enzyme Inhibitors/*therapeutic use , Hydroxyurea/*therapeutic use , Ribonucleotide Reductases/*antagonists & inhibitors , Trypanocidal Agents/*therapeutic use , Trypanosoma brucei brucei/*drug effects , Trypanosomiasis, African/*drug therapy, Animals ; Drug Discovery ; Enzyme Inhibitors/pharmacology ; Humans ; Hydroxyurea/administration & dosage ; Hydroxyurea/pharmacology ; Mice ; Ribonucleotide Reductases/metabolism ; Trypanocidal Agents/pharmacology ; Trypanosoma brucei brucei/enzymology ; Trypanosoma brucei brucei/genetics ; Trypanosoma brucei brucei/physiology ; Trypanosomiasis, African/parasitology

المؤلفون: Mannargudi MB; Clinical Pharmacology Program, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, USA., Deb S; Department of Biopharmaceutical Sciences, Roosevelt University College of Pharmacy, 1400 N. Roosevelt Blvd., Schaumburg, IL, 60173, USA. sdeb@alumni.ubc.ca.

المصدر: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2017 Aug; Vol. 143 (8), pp. 1499-1529. Date of Electronic Publication: 2017 Jun 17.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7902060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1335 (Electronic) Linking ISSN: 01715216 NLM ISO Abbreviation: J Cancer Res Clin Oncol Subsets: MEDLINE

مواضيع طبية MeSH: Carcinogenesis/*drug effects , Enzyme Inhibitors/*therapeutic use , Neoplasms/*drug therapy , Ribonucleotide Reductases/*antagonists & inhibitors, Cell Proliferation/drug effects ; Clinical Trials as Topic ; Humans ; Neoplasms/genetics ; Neoplasms/pathology ; Oligodeoxyribonucleotides/therapeutic use ; Pharmacology, Clinical ; Ribonucleotide Reductases/genetics

المؤلفون: Plamthottam S; Department of Chemistry, University of California, Los Angeles, CA, 90095, USA.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095, USA., Sun D; Department of Chemistry, University of California, Los Angeles, CA, 90095, USA.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095, USA., Van Valkenburgh J; Department of Chemistry, University of California, Los Angeles, CA, 90095, USA.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095, USA., Valenzuela J; Department of Chemistry, University of California, Los Angeles, CA, 90095, USA., Ruehle B; Department of Chemistry, University of California, Los Angeles, CA, 90095, USA., Steele D; Department of Chemistry, University of California, Los Angeles, CA, 90095, USA.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095, USA., Poddar S; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095, USA., Marshalik M; Department of Chemistry, University of California, Los Angeles, CA, 90095, USA., Hernandez S; Department of Chemistry, University of California, Los Angeles, CA, 90095, USA., Radu CG; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095, USA., Zink JI; Department of Chemistry, University of California, Los Angeles, CA, 90095, USA. zink@chem.ucla.edu.

المصدر: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry [J Biol Inorg Chem] 2019 Aug; Vol. 24 (5), pp. 621-632. Date of Electronic Publication: 2019 Jun 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 9616326 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1327 (Electronic) Linking ISSN: 09498257 NLM ISO Abbreviation: J Biol Inorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*chemistry , Antineoplastic Agents/*pharmacology , Coordination Complexes/*chemistry , Enzyme Inhibitors/*chemistry , Enzyme Inhibitors/*pharmacology , Iron/*chemistry , Pyridines/*chemistry , Thiosemicarbazones/*chemistry, Cell Line, Tumor ; Cell Proliferation/drug effects ; Electrochemistry/methods ; Humans ; Molecular Structure ; Oxidation-Reduction/drug effects ; Ribonucleotide Reductases/antagonists & inhibitors ; Ribonucleotide Reductases/metabolism ; Tyrosine/chemistry

المؤلفون: Crona M; Department of Medicinal Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden., Codó P; Department of Medicinal Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden., Jonna VR; Department of Medical Biochemistry and Biophysics, Umeå University, 90187, Umeå, Sweden., Hofer A; Department of Medical Biochemistry and Biophysics, Umeå University, 90187, Umeå, Sweden., Fernandes AP; Department of Medicinal Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden., Tholander F; Department of Medicinal Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden. Electronic address: fredrik.tholander@ki.se.

المصدر: Molecular oncology [Mol Oncol] 2016 Nov; Vol. 10 (9), pp. 1375-1386. Date of Electronic Publication: 2016 Jul 26.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101308230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0261 (Electronic) Linking ISSN: 15747891 NLM ISO Abbreviation: Mol Oncol Subsets: MEDLINE

مواضيع طبية MeSH: Deoxyribonucleosides/*pharmacology , Enzyme Inhibitors/*pharmacology , Ribonucleotide Reductases/*antagonists & inhibitors, Biological Assay ; Cell Cycle/drug effects ; Cell Death/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemistry ; Flow Cytometry ; Gene Expression Regulation/drug effects ; HL-60 Cells ; Humans ; Hydroxyurea/pharmacology ; Protein Structure, Quaternary ; Protein Subunits/antagonists & inhibitors ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Ribonucleotide Reductases/chemistry ; Ribonucleotide Reductases/metabolism ; Temperature