المؤلفون: Okamoto SI; Scintillon Institute, San Diego, CA 92121, USA., Prikhodko O; Biomedical Sciences Graduate Program, University of California San Diego, School of Medicine, La Jolla, CA 92093, USA., Pina-Crespo J; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA., Adame A; Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, CA 92093, USA., McKercher SR; Scintillon Institute, San Diego, CA 92121, USA; Neuroscience Translational Center, Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA., Brill LM; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA., Nakanishi N; Scintillon Institute, San Diego, CA 92121, USA., Oh CK; Scintillon Institute, San Diego, CA 92121, USA; Neuroscience Translational Center, Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA., Nakamura T; Scintillon Institute, San Diego, CA 92121, USA; Neuroscience Translational Center, Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA., Masliah E; Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, CA 92093, USA., Lipton SA; Scintillon Institute, San Diego, CA 92121, USA; Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, CA 92093, USA; Neuroscience Translational Center, Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: slipton@scripps.edu.

المصدر: Neurobiology of disease [Neurobiol Dis] 2019 Jul; Vol. 127, pp. 390-397. Date of Electronic Publication: 2019 Mar 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE

مواضيع طبية MeSH: Excitatory Amino Acid Antagonists/*therapeutic use , Hippocampus/*drug effects , Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors , Tuberous Sclerosis/*drug therapy, Animals ; Disease Models, Animal ; Excitatory Amino Acid Antagonists/pharmacology ; Hippocampus/metabolism ; Mice ; Mice, Knockout ; Tuberous Sclerosis/genetics ; Tuberous Sclerosis/metabolism ; Tuberous Sclerosis Complex 2 Protein/genetics ; Tuberous Sclerosis Complex 2 Protein/metabolism

المؤلفون: Tu S; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA, 92121, USA. shichuntu@scintillon.org.; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA. shichuntu@scintillon.org., Akhtar MW; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA, 92121, USA.; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Escorihuela RM; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.; Departament de PsiquiatriaiMedicina Legal, Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain., Amador-Arjona A; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Swarup V; Center for Autism Research and Treatment (CART), University of California, Los Angeles, CA, 90095, USA., Parker J; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA, 92121, USA.; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Zaremba JD; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Holland T; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Bansal N; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Holohan DR; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Lopez K; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA, 92121, USA.; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Ryan SD; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada, N1G 2W1., Chan SF; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Yan L; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Zhang X; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Huang X; Bioinformatics Core Facility, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Sultan A; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA, 92121, USA.; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., McKercher SR; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA, 92121, USA.; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.; Department of Molecular Medicine and Neuroscience, Neuroscience Translational Center, The Scripps Research Institute, La Jolla, CA, 92037, USA., Ambasudhan R; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA, 92121, USA.; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Xu H; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Wang Y; Institute of New Drug Research, Jinan University College of Pharmacy, Guangzhou, 510632, China., Geschwind DH; Center for Autism Research and Treatment (CART), University of California, Los Angeles, CA, 90095, USA., Roberts AJ; Department of Neuroscience and Mouse Behavioral Assessment Core, The Scripps Research Institute, La Jolla, CA, 92037, USA., Terskikh AV; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Rissman RA; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA, 92093, USA.; Veterans Affairs San Diego Healthcare System, San Diego, CA, 92161, USA., Masliah E; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA, 92093, USA.; National Institute on Aging, NIH, Bethesda, MD, 20892, USA., Lipton SA; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA, 92121, USA. slipton@scripps.edu.; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA. slipton@scripps.edu.; Department of Molecular Medicine and Neuroscience, Neuroscience Translational Center, The Scripps Research Institute, La Jolla, CA, 92037, USA. slipton@scripps.edu.; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA, 92093, USA. slipton@scripps.edu., Nakanishi N; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA, 92121, USA. nnakanishi@scintillon.org.; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA. nnakanishi@scintillon.org.

المصدر: Nature communications [Nat Commun] 2017 Nov 14; Vol. 8 (1), pp. 1488. Date of Electronic Publication: 2017 Nov 14.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Haploinsufficiency*, Autistic Disorder/*genetics , Brain/*growth & development , Excitatory Amino Acid Antagonists/*therapeutic use , Memantine/*analogs & derivatives , Memantine/*therapeutic use, Animals ; Autistic Disorder/pathology ; Autistic Disorder/physiopathology ; Behavior, Animal ; Biomarkers/metabolism ; Brain/pathology ; Brain/physiopathology ; Cell Death ; Disease Models, Animal ; Down-Regulation ; Excitatory Amino Acid Antagonists/pharmacology ; Gene Expression Profiling ; Humans ; Long-Term Potentiation/genetics ; MEF2 Transcription Factors/genetics ; Memantine/pharmacology ; Mice, Inbred C57BL ; Neurogenesis/genetics ; Neurons/pathology ; Phenotype ; Receptors, N-Methyl-D-Aspartate/drug effects ; Synapses/pathology ; Synaptic Transmission/genetics

المؤلفون: Macrez R; INSERM U919, University of Caen Normandy, Caen, France., Stys PK; Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Vivien D; INSERM U919, University of Caen Normandy, Caen, France., Lipton SA; Scintillon Institute San Diego, CA, USA; Scripps Research Institute, La Jolla, CA, USA; School of Mecicine, University of California, San Diego, CA, USA., Docagne F; INSERM U919, University of Caen Normandy, Caen, France. Electronic address: docagne@cyceron.fr.

المصدر: The Lancet. Neurology [Lancet Neurol] 2016 Sep; Vol. 15 (10), pp. 1089-102. Date of Electronic Publication: 2016 Aug 08.

نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 101139309 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4465 (Electronic) Linking ISSN: 14744422 NLM ISO Abbreviation: Lancet Neurol Subsets: MEDLINE

مواضيع طبية MeSH: Biomarkers/*metabolism , Excitatory Amino Acid Antagonists/*therapeutic use , Glutamic Acid/*metabolism , Multiple Sclerosis/*drug therapy , Multiple Sclerosis/*metabolism, Humans

المؤلفون: Nakanishi N; Center for Neuroscience and Aging Research, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.; Present Address: Scintillon Institute, 6868 Nancy Ridge Drive, San Diego, CA, 92121, USA., Kang YJ; Center for Neuroscience and Aging Research, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Tu S; Center for Neuroscience and Aging Research, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., McKercher SR; Center for Neuroscience and Aging Research, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.; Present Address: Scintillon Institute, 6868 Nancy Ridge Drive, San Diego, CA, 92121, USA., Masliah E; Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Lipton SA; Center for Neuroscience and Aging Research, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA. slipton@ucsd.edu.; Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA. slipton@ucsd.edu.; Present Address: Scintillon Institute, 6868 Nancy Ridge Drive, San Diego, CA, 92121, USA. slipton@ucsd.edu.

المصدر: Journal of molecular neuroscience : MN [J Mol Neurosci] 2016 Jan; Vol. 58 (1), pp. 59-65. Date of Electronic Publication: 2015 Sep 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9002991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1166 (Electronic) Linking ISSN: 08958696 NLM ISO Abbreviation: J Mol Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: AIDS Dementia Complex/*therapy , Excitatory Amino Acid Antagonists/*therapeutic use , Memantine/*therapeutic use , Neurons/*metabolism , Receptors, N-Methyl-D-Aspartate/*genetics, AIDS Dementia Complex/drug therapy ; AIDS Dementia Complex/etiology ; Animals ; Excitatory Amino Acid Antagonists/pharmacology ; Genetic Therapy ; HIV Envelope Protein gp120/toxicity ; Memantine/pharmacology ; Mice ; Neurons/drug effects ; Neurons/pathology ; Receptors, N-Methyl-D-Aspartate/metabolism

المؤلفون: Xia P; Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA., Chen HS, Zhang D, Lipton SA

المصدر: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2010 Aug 18; Vol. 30 (33), pp. 11246-50.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Excitatory Amino Acid Antagonists/*pharmacology , Hippocampus/*drug effects , Memantine/*pharmacology , Neurons/*drug effects , Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors , Synapses/*drug effects, Animals ; Cells, Cultured ; Excitatory Postsynaptic Potentials/drug effects ; Excitatory Postsynaptic Potentials/physiology ; Female ; Hippocampus/physiology ; Male ; Membrane Potentials/drug effects ; Membrane Potentials/physiology ; Neurons/physiology ; Patch-Clamp Techniques ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/metabolism ; Synapses/physiology ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology

المؤلفون: Schifitto G; University of Rochester, Rochester, New York 14620, USA. giovanni.schifitto@ctcc.rochester.edu, Navia BA, Yiannoutsos CT, Marra CM, Chang L, Ernst T, Jarvik JG, Miller EN, Singer EJ, Ellis RJ, Kolson DL, Simpson D, Nath A, Berger J, Shriver SL, Millar LL, Colquhoun D, Lenkinski R, Gonzalez RG, Lipton SA

مؤلفون مشاركون: Adult AIDS Clinical Trial Group (ACTG) 301, 700 Teams, HIV MRS Consortium

المصدر: AIDS (London, England) [AIDS] 2007 Sep 12; Vol. 21 (14), pp. 1877-86.

نوع المنشور: Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8710219 Publication Model: Print Cited Medium: Print ISSN: 0269-9370 (Print) Linking ISSN: 02699370 NLM ISO Abbreviation: AIDS Subsets: MEDLINE

مواضيع طبية MeSH: Cognition Disorders/*drug therapy , Excitatory Amino Acid Antagonists/*therapeutic use , HIV Infections/*complications , Memantine/*therapeutic use, Adult ; Anti-Retroviral Agents/therapeutic use ; Brain/drug effects ; Brain/metabolism ; Cognition Disorders/complications ; Double-Blind Method ; Drug Therapy, Combination ; Excitatory Amino Acid Antagonists/adverse effects ; Female ; Humans ; Magnetic Resonance Spectroscopy/methods ; Male ; Memantine/adverse effects ; Middle Aged ; Neuropsychological Tests ; RNA, Viral/blood ; RNA, Viral/cerebrospinal fluid ; Treatment Outcome

المؤلفون: Chen HS; Burnham Institute for Medical Research and the University of California-San Diego, La Jolla, California 92037, USA. hsv_chen@burnham.org, Lipton SA

المصدر: Journal of neurochemistry [J Neurochem] 2006 Jun; Vol. 97 (6), pp. 1611-26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print Cited Medium: Print ISSN: 0022-3042 (Print) Linking ISSN: 00223042 NLM ISO Abbreviation: J Neurochem Subsets: MEDLINE

مواضيع طبية MeSH: Excitatory Amino Acid Antagonists/*therapeutic use , Nervous System Diseases/*drug therapy , Neuroprotective Agents/*therapeutic use , Receptors, N-Methyl-D-Aspartate/*physiology, Apoptosis/drug effects ; Ion Channel Gating/drug effects ; Models, Biological ; Neurotoxins/toxicity ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors

المؤلفون: Lipton SA; Burnham Institute for Medical Research, University of California at San Diego, 10901 North Torrey Pines Road, La Jolla, California 92037, USA. slipton@burnham.org

المصدر: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2006 Feb; Vol. 5 (2), pp. 160-70.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124171 Publication Model: Print Cited Medium: Print ISSN: 1474-1776 (Print) Linking ISSN: 14741776 NLM ISO Abbreviation: Nat Rev Drug Discov Subsets: MEDLINE

مواضيع طبية MeSH: Excitatory Amino Acid Antagonists/*pharmacology , Memantine/*pharmacology , Neuroprotective Agents/*pharmacology , Neuroprotective Agents/*therapeutic use , Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors, Animals ; Humans ; Memantine/analogs & derivatives ; Neurotoxins/pharmacology

المؤلفون: Chen HS; Center for Neuroscience and Aging, The Burnham Institute, La Jolla, CA 92037, USA. hsv_chen@burnham.org, Lipton SA

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2005 Sep; Vol. 314 (3), pp. 961-71. Date of Electronic Publication: 2005 May 18.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0022-3565 (Print) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Ion Channel Gating*, Excitatory Amino Acid Antagonists/*pharmacology , Ion Channels/*drug effects , Memantine/*pharmacology , Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors, Amino Acid Sequence ; Animals ; Binding Sites ; Dose-Response Relationship, Drug ; Magnesium/metabolism ; Memantine/metabolism ; Models, Molecular ; Molecular Sequence Data ; Receptors, N-Methyl-D-Aspartate/chemistry ; Xenopus

المؤلفون: Lipton SA; The Burnham Institute, The Salk Institute for Biological Studies, The Scripps Research Institute, and the University of California-San Diego, La Jolla, California 92037, USA. slipton@burnham.org

المصدر: Current Alzheimer research [Curr Alzheimer Res] 2005 Apr; Vol. 2 (2), pp. 155-65.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review

بيانات الدورية: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101208441 Publication Model: Print Cited Medium: Print ISSN: 1567-2050 (Print) Linking ISSN: 15672050 NLM ISO Abbreviation: Curr Alzheimer Res Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease/*drug therapy , Excitatory Amino Acid Antagonists/*therapeutic use , Memantine/*therapeutic use, Alzheimer Disease/metabolism ; Animals ; Excitatory Amino Acid Antagonists/pharmacology ; Humans ; Memantine/pharmacology ; Nervous System Diseases/drug therapy ; Nervous System Diseases/metabolism ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/metabolism