المؤلفون: Maggie Roy, Mélanie Fortier, François Rheault, Manon Edde, Etienne Croteau, Christian‐Alexandre Castellano, Francis Langlois, Valérie St‐Pierre, Bernard Cuenoud, Christian Bocti, Tamas Fulop, Maxime Descoteaux, Stephen C. Cunnane

المصدر: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 7, Iss 1, Pp n/a-n/a (2021)

مصطلحات موضوعية: acetoacetate, Alzheimer's disease, beta‐hydroxybutyrate, brain metabolism, diffusion MRI, fascicle, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

الوصف: Abstract Introduction White matter (WM) energy supply is crucial for axonal function and myelin maintenance. An exogenous source of ketones, the brain's alternative fuel to glucose, bypasses the brain's glucose‐specific energy deficit and improves cognitive outcomes in mild cognitive impairment (MCI). How an additional supply of ketones affects glucose or ketone uptake in specific WM fascicles in MCI has not previously been reported. Methods This 6‐month interventional study included MCI participants randomized to a placebo (n = 16) or ketogenic medium chain triglyceride (kMCT; n = 17) drink. A neurocognitive battery and brain imaging were performed pre‐ and post‐intervention. WM fascicle uptake of ketone and glucose and structural properties were assessed using positron emission tomography and diffusion imaging, respectively. Results Ketone uptake was increased in the kMCT group by 2.5‐ to 3.2‐fold in all nine WM fascicles of interest (P

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2352-8737

URL الوصول: https://doaj.org/article/f17f9ac8108e4a0385b6bda34619378e