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المؤلفون: Katherine Q. Chen, Aaron Anderson, Hiroko Kawakami, Jennifer Kim, Janaya Barrett, Yasuhiko Kawakami
المصدر: PloS one. 17(4)
مصطلحات موضوعية: DNA-Binding Proteins, Mice, Stem Cell Factor, Multidisciplinary, Pregnancy, Animals, Embryonic Development, Female, Embryonic Stem Cells, Transcription Factors
الوصف: Sall4 encodes a transcription factor and is known to participate in the pluripotency network of embryonic stem cells. Sall4 expression is known to be high in early stage post-implantation mouse embryos. During early post-gastrulation stages, Sall4 is highly expressed in the tail bud and distal limb buds, where progenitor cells are maintained in an undifferentiated status. The expression of Sall4 is rapidly downregulated during embryonic development. We previously demonstrated that Sall4 is required for limb and posterior axial skeleton development by conditional deletion of Sall4 in the T (Brachyury) lineage. To gain insight into Sall4 functions in embryonic development and postnatal digit regeneration, we genetically overexpressed Sall4 in the mesodermal lineage by the TCre transgene and a novel knockin allele of Rosa26-loxP-stop-loxP-Sall4. In significant contrast to severe defects by Sall4 loss of function reported in previous studies, overexpression of Sall4 resulted in normal morphology and pattern in embryos and neonates. The length of limb long bones showed subtle reduction in Sall4-overexpression mice. It is known that the digit tip of neonatal mice has level-specific regenerative ability after experimental amputation. We observed Sall4 expression in the digit tip by using a sensitive Sall4-LacZ knock-in reporter expression. Sall4 overexpression did not alter the regenerative ability of the terminal phalange that normally regenerates after amputation. Moreover, Sall4 overexpression did not confer regenerative ability to the second phalange that normally does not regenerate after amputation. These genetic experiments show that overexpression of Sall4 does not alter the development of the appendicular and axial skeleton, or neonatal digit regeneration. The results suggest that Sall4 acts as a permissive factor rather than playing an instructive role.
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2Development and Validation of a Mortality Prediction Model in Extremely Low Gestational Age Neonates
المؤلفون: Alvaro Moreira, Domenico Benvenuto, Christopher Fox-Good, Yasmeen Alayli, Mary Evans, Baldvin Jonsson, Stellan Hakansson, Nathan Harper, Jennifer Kim, Mikael Norman, Matteo Bruschettini
المصدر: Neonatology
مصطلحات موضوعية: Male, Perinatal Death, Infant, Newborn, Infant, Gestational Age, Article, Cohort Studies, Infant, Extremely Premature, Pediatrics, Perinatology and Child Health, Infant Mortality, Birth Weight, Humans, Female, Hospital Mortality, Developmental Biology
الوصف: Introduction: Understanding factors that associate with neonatal death may lead to strategies or interventions that can aid clinicians and inform families. Objective: The aim of the study was to develop an early prediction model of neonatal death in extremely low gestational age (ELGA, Methods: A predictive cohort study of ELGA neonates was derived from the Swedish Neonatal Quality Register between the years 2011 to May 2021. The goal was to use readily available clinical variables, collected within the first hour of birth, to predict in-hospital death. Data were split into a train cohort (80%) to build the model and tested in 20% of randomly selected neonates. Model performance was assessed via area under the receiver operating characteristic curve (AUC) and compared to validated mortality prediction models and an external cohort of neonates. Results: Among 3,752 live-born extremely preterm infants (46% girls), in-hospital mortality was 18% (n = 685). The median gestational age and birth weight were 25.0 weeks (interquartile range [IQR] 24.0, 27.0) and 780 g (IQR 620, 940), respectively. The proposed model consisted of three variables: birth weight (grams), Apgar score at 5 min of age, and gestational age (weeks). The BAG model had an AUC of 76.9% with a 95% confidence interval (CI) (72.6%, 81.3%), while birth weight and gestational age had an AUC of 73.1% (95% CI: 68.4%,77.9%) and 71.3% (66.3%, 76.2%). In the validation cohort, the BAG model had an AUC of 68.9%. Conclusion: The BAG model is a new mortality prediction model in ELGA neonates that was developed using readily available information.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8c00cd794c3b7d028bb50f005cf858
https://europepmc.org/articles/PMC9296601/ -
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المؤلفون: Jennifer Kim, Sara Pourhassan Shamchi, Thomas Werner, Niels Abildgaard, Raheleh Taghvaei, Anne Lerberg Nielsen, Poul Flemming Høilund-Carlsen, Mona-Elisabeth Revheim, Mohsen Khosravi, Oke Gerke, Paw Christian Holdgaard, Brian Østergaard, Abass Alavi, Mahdi Zirakchian Zadeh, William Raynor
المصدر: Pourhassan Shamchi, S, Zirakchian Zadeh, M, Østergaard, B, Kim, J, Raynor, W Y, Khosravi, M, Taghvaei, R, Nielsen, A L, Gerke, O, Werner, T J, Holdgaard, P, Abildgaard, N, Revheim, M-E, Høilund-Carlsen, P F & Alavi, A 2020, ' Brain glucose metabolism in patients with newly diagnosed multiple myeloma significantly decreases after high-dose chemotherapy followed by autologous stem cell transplantation ', Nuclear Medicine Communications, vol. 41, no. 3, pp. 288-293 . https://doi.org/10.1097/MNM.0000000000001144
مصطلحات موضوعية: Male, medicine.medical_treatment, F-fluorodeoxyglucose, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, Autologous stem-cell transplantation, Multiple myeloma, Cerebellum, Positron Emission Tomography Computed Tomography, Prospective Studies, Chemo-brain, Prospective cohort study, Aged, 80 and over, Observer Variation, Bortezomib, Brain, General Medicine, Middle Aged, Combined Modality Therapy, 030220 oncology & carcinogenesis, Female, Multiple Myeloma, Chemo brain, medicine.drug, medicine.medical_specialty, Urology, Antineoplastic Agents, Transplantation, Autologous, Disease-Free Survival, 03 medical and health sciences, Fluorodeoxyglucose F18, medicine, Chemotherapy, High-dose treatment, Humans, Radiology, Nuclear Medicine and imaging, Aged, Brain Chemistry, business.industry, Supratentorial Neoplasms, medicine.disease, Transplantation, PET, Glucose, Radiopharmaceuticals, business, Stem Cell Transplantation
الوصف: PURPOSE: The aim of this study was to compare the effect of intensive therapy [consisting of high-dose chemotherapy followed by autologous stem cell transplantation (HDC/ASCT)] and conventional standard-dose chemotherapy (CDC) on brain FDG uptake, as an indicator of glucose metabolism, in multiple myeloma patients.MATERIALS AND METHODS: Twenty-four patients with newly diagnosed multiple myeloma were included. Sixteen patients received HDC/ASCT, including bortezomib-based induction therapy, and eight patients received CDC. F-fluorodeoxyglucose (FDG)-PET/computed tomography (CT) was performed 1 and 3 hours following tracer administration before and after the treatment. The manual segmentation of supratentorial and cerebellum of each patient was performed by two independent observers. The data were expressed as global mean standardized uptake values (GSUVmean). Wilcoxon signed-rank test was used to compare changes from before to after treatment.RESULTS: A significant decrease in the GSUVmean of supratentorial brain and cerebellum was observed after treatment in the patients who received HDC/ASCT (1 hour scans: 7.03 ± 1.18 vs. 6.56 ± 0.94; P = 0.03 and 7.01 ± 1.08 vs. 6.34 ± 0.93; P = 0.01, respectively). GSUVmean changes in the patients who received CDC were not significantly different after treatment (1 hour scans: 6.47 ± 1.16 vs. 6.21 ± 0.91; P = 0.40 and 6.30 ± 1.21 vs. 6.09 ± 0.86; P = 0.62, respectively). The same findings were observed for 3 hours scans. A high level of agreement was observed between two operators.CONCLUSION: Multiple myeloma patients who received HDC/ASCT demonstrated a significant decrease in FDG uptake in the supratentorial brain and cerebellum, while patients who received CDC did not demonstrate significant changes in the brain FDG uptake.
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b333bafb7f3b6465146eb62d1ba5b4d9
https://doi.org/10.1097/mnm.0000000000001144 -
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المؤلفون: Gareth L. Ackland, Stefan Van Duijvenboden, Tom E.F. Abbott, Ana Gutierrez del Arroyo, Matthew J. Wilson, Anna L. David, Amaan Ali, Matt Wikner, James Noblett, Nusrat Usman, Sarah Wray, Holly Blake, Ana G. del Arroyo, Valentin Weber, Constantinos Papoutsos, Rebecca Black, Kara Bruce-Hickman, Parvesh Verma, Chris Sadler, Alice Barrett, Laura Fulton, Tim Martin, Tabitha Tanqueray, Rebecca Longbottom, Lisa Cancili, India Nokes, Rachel Frowd, Natasha Kennedy, Matt Wilson, Vicki Wilson, Sarah Weist, Olivia Newth, Morenike Folorunsho, Jihana Ali, Yaa Achaempong, Miriam Bourke, Derek Brunnen, Jennifer Kim, Kei Mak, Pete Odor, Laura Sarmiento, Sarah Ciechanowicz
المصدر: Br J Anaesth
مصطلحات موضوعية: Adult, Risk, medicine.medical_specialty, Caesarean delivery, Maternal Fever, Cohort Studies, symbols.namesake, Young Adult, Pregnancy, medicine, Humans, Prospective Studies, Allele, Labor, Obstetric, Obstetrics, business.industry, Cesarean Section, Genetic Variation, Odds ratio, Mendelian Randomization Analysis, Confidence interval, United Kingdom, Clinical trial, Analgesia, Epidural, Interleukin 1 Receptor Antagonist Protein, Anesthesiology and Pain Medicine, Interleukin 1 receptor antagonist, Obstetric Anaesthesia, Mendelian inheritance, symbols, Analgesia, Obstetrical, Female, business
الوصف: Background\ud \ud Lower circulating levels of the anti-inflammatory cytokine interleukin-1 receptor antagonist (IL-1ra) are associated with intrapartum inflammation and epidural analgesia-related maternal fever, both of which increase the rate of obstetric interventions. We hypothesised that genetic variants determining IL-1ra levels would be associated with Caesarean delivery rates after the onset of labour.\ud \ud \ud \ud Methods\ud \ud We performed Mendelian randomisation analyses in parous women ≥16 yr old who received either non-neuraxial or neuraxial analgesia for their first two labours (UK Biobank). We used an established genetic score (calculated as 0–4, determined by the presence/absence of rs6743376 and rs1542176 alleles), in which the complete absence of both alleles causes the lowest IL-1ra levels. The primary outcome was Caesarean delivery after the onset of labour (odds ratio [OR]: 95% confidence intervals).\ud \ud \ud \ud Results\ud \ud There were 7731 women (mean [standard deviation] age at first birth: 25 [5] yr) who had complete genetic scores and delivery data. For women who received non-neuraxial analgesia, Caesarean delivery rates were different across allele scores (χ2=12.4; P=0.015): 104/596 (17.4%) women with zero allele score underwent Caesarean delivery, compared with 654/5015 (13.0%) with allele score ≥1 (OR 1.41; 1.12–1.77). For women who had neuraxial analgesia, Caesarean delivery was not different across allele scores, ranging from 18.1% to 20.8% (χ2=0.29; P=0.99). Caesarean delivery was independent of type of analgesia for 818/7731 (10.6%) women with zero allele scores (OR 0.93; 0.63–1.39), but was higher in women receiving neuraxial analgesia with allele scores ≥1 (OR 1.55; 1.35–1.79; P
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e220ef2d07fea9eac18163af18ad026f
https://pubmed.ncbi.nlm.nih.gov/34802694 -
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المؤلفون: Noam Y. Kirson, Phillip R. Hunt, Michael Hellstern, Kamlesh Khunti, J Mukherjee, Sarah King, Erich J. Trieschman, Jennifer Kim, Urvi Desai
المصدر: Diabetes Care. 41:2096-2104
مصطلحات موضوعية: Adult, Blood Glucose, Male, Research design, medicine.medical_specialty, Databases, Factual, medicine.drug_class, Endocrinology, Diabetes and Metabolism, Administration, Oral, 030209 endocrinology & metabolism, Type 2 diabetes, Time-to-Treatment, 03 medical and health sciences, 0302 clinical medicine, Pharmacotherapy, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, Hypoglycemic Agents, 030212 general & internal medicine, Aged, Retrospective Studies, Glycemic, Glycated Hemoglobin, Advanced and Specialized Nursing, Dose-Response Relationship, Drug, business.industry, Retrospective cohort study, Middle Aged, medicine.disease, Sulfonylurea, Metformin, United Kingdom, Sulfonylurea Compounds, Treatment Outcome, Diabetes Mellitus, Type 2, Drug Therapy, Combination, Female, business, medicine.drug
الوصف: OBJECTIVE The goal of this study was to evaluate the association between the timing of treatment intensification and subsequent glycemic control among patients with type 2 diabetes in whom monotherapy fails. RESEARCH DESIGN AND METHODS This retrospective analysis of the U.K. Clinical Practice Research Datalink database focused on patients with type 2 diabetes and one or more HbA1c measurements ≥7% (≥53 mmol/mol) after ≥3 months of metformin or sulfonylurea monotherapy (first measurement meeting these criteria was taken as the study index date). Baseline (6 months before the index date) characteristics were stratified by time from the index date to intensification (early: RESULTS Of the 93,515 patients who met the study criteria (mean age 60 years; ∼59% male; 80% taking metformin), 23,761 (25%) intensified CONCLUSIONS Earlier treatment intensification is associated with shorter time to subsequent glycemic control, independent of whether patients initiate first-line treatment with metformin or a sulfonylurea.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7836f284c3cc896e75ac91df28eea85
https://doi.org/10.2337/dc17-0662 -
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المؤلفون: Dorian Wilson, Cesar Mora-Esteves, Baburao Koneru, Bart Holland, Yuri Genyk, Jose Almeda, Kenneth Washburn, Anup Parikh, Lea Matsuoka, Linda Sher, Jennifer Kim, Glenn A. Halff, Urvashi Pandit
المصدر: Liver Transplantation. 21:1160-1168
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Time Factors, Health Status, medicine.medical_treatment, Liver transplantation, Risk Assessment, Severity of Illness Index, End Stage Liver Disease, Postoperative Complications, Model for End-Stage Liver Disease, Risk Factors, Severity of illness, medicine, Health Status Indicators, Humans, Renal replacement therapy, Retrospective Studies, Transplantation, Hepatology, business.industry, Graft Survival, Retrospective cohort study, Length of Stay, Middle Aged, United States, Liver Transplantation, Surgery, Treatment Outcome, Female, Complication, business, Cohort study
الوصف: Knowledge of risk factors for posttransplant complications is likely to improve patient outcomes. Few large studies of all early postoperative complications after deceased donor liver transplantation (DDLT) exist. Therefore, we conducted a retrospective, cohort study of 30-day complications, their risk factors, and the impact on outcomes after DDLT. Three centers contributed data for 450 DDLTs performed from January 2005 through December 2009. Data included donor, recipient, transplant, and outcome variables. All 30-day postoperative complications were graded by the Clavien-Dindo system. Complications per patient and severe (≥ grade III) complications were primary outcomes. Death within 30 days, complication occurrence, length of stay (LOS), and graft and patient survival were secondary outcomes. Multivariate associations of risk factors with complications and complications with LOS, graft survival, and patient survival were examined. Mean number of complications/patient was 3.3 ± 3.9. At least 1 complication occurred in 79.3%, and severe complications occurred in 62.8% of recipients. Mean LOS was 16.2 ± 22.9 days. Graft and patient survival rates were 84% and 86%, respectively, at 1 year and 74% and 76%, respectively, at 3 years. Hospitalization, critical care, ventilatory support, and renal replacement therapy before transplant and transfusions during transplant were the significant predictors of complications (not the Model for End-Stage Liver Disease score). Both number and severity of complications had a significant impact on LOS and graft and patient survival. Structured reporting of risk-adjusted complications rates after DDLT is likely to improve patient care and transplant center benchmarking. Despite the accomplished reductions in transfusions during DDLT, opportunities exist for further reductions. With increasing transplantation of sicker patients, reduction in complications would require multidisciplinary efforts and institutional commitment. Pretransplant risk characteristics for complications must factor in during payer contracting.
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المؤلفون: Heather Tulloch, Aisha Siddique, Jennifer Kim Lian Chan, Shanthi Johnson, Christina Wist, Kayla Rustad, Roseann Nasser
المصدر: Journal of nutrition in gerontology and geriatrics. 37(3-4)
مصطلحات موضوعية: 0301 basic medicine, Male, Canada, Health Knowledge, Attitudes, Practice, Time Factors, Adult population, Nutritional Status, Interviews as Topic, 03 medical and health sciences, Nutrition care, Environmental health, Medicine, Homes for the Aged, Humans, Screening tool, Nutritionists, Geriatric Assessment, Aged, Skilled Nursing Facilities, 030109 nutrition & dietetics, Nutrition and Dietetics, Nutrition assessment, business.industry, Communication Barriers, Malnutrition, Nutritional status, medicine.disease, Long-Term Care, Phone interview, Long-term care, Nutrition Assessment, Female, Geriatrics and Gerontology, business, Needs Assessment
الوصف: The older adult population in Canada is growing, creating a greater demand for long-term care (LTC) facilities. Seniors living in LTC are more vulnerable to malnutrition, making it important to implement nutrition screening tools on a routine basis. The purpose of this study was to explore the practices of Registered Dietitians (RDs) related to nutritional screening, nutritional assessment, and follow-ups conducted within LTC facilities. This study also explored possible barriers hindering the application of these practices. Nine RDs from two health regions in Southern Saskatchewan completed a phone interview to address nutrition care practices/policies and barriers in LTC facilities. Results showed a considerable amount of variability in nutrition care practices for screening and assessment with lack of time identified as the greatest barrier. These findings highlight the importance of having consistent policies and a sufficient amount of RDs available in LTC facilities to provide the expected level of nutrition care for residents.
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المؤلفون: Whitney Tchoula, Heith Copes, Jennifer Kim, Jared Ragland
المصدر: The International journal on drug policy. 51
مصطلحات موضوعية: Adult, Male, Symbolism, media_common.quotation_subject, Amphetamine-Related Disorders, Medicine (miscellaneous), Shake, Methamphetamine, Health problems, Perception, Photography, Humans, Symbolic boundaries, Anthropology, Cultural, 0505 law, media_common, Point (typography), Social perception, Health Policy, 05 social sciences, Preference, Social Perception, 050501 criminology, Alabama, Central Nervous System Stimulants, Female, Psychology, Social psychology
الوصف: Background Although public perceptions of methamphetamine (meth) consider all forms of the drug as the same, this is not true among those who use it. Our aim is to examine how those who use meth perceive two forms of meth (ice and shake) using the theoretical framework of symbolic boundaries. Methods We rely on data collected from a photo-ethnography with people who use methamphetamine in rural Alabama. The ethnography consisted of formal interviews (with 52 participants), informal observations, and photography. Results Participants had a strong preference for ice (49 of 52 preferred ice over shake). In discussing why they prefer ice they point to the various short- and long-term health problems associated with shake. This distinction allowed them to create symbolic definitions of shake as being dirty due to impure chemicals and its users as desperate. Conclusion We argue that this symbolic differentiation of the two forms allows users to frame themselves as rational users (i.e., they avoid the unsafe form of meth) and shape use patterns and prevalence, with shake being used infrequently and often intravenously.
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المؤلفون: Jennifer Kim, Douglas L. Martin, Mason A. Palmer, Karen K. Szumlinski, Sema G. Quadir, Eugenie Guzelian
المصدر: Physiol Behav
مصطلحات موضوعية: Male, Physiology, Alcohol, Underage Drinking, Medical and Health Sciences, Oral and gastrointestinal, Developmental psychology, Behavioral Neuroscience, chemistry.chemical_compound, Substance Misuse, Alcohol Use and Health, Mice, 0302 clinical medicine, Binge-drinking, Unpredictable chronic mild stress, Aetiology, Pediatric, Biological Sciences, Stroke, Alcoholism, Alcohol intake, Female, social and economic factors, Psychology, Locomotion, Binge drinking, Experimental and Cognitive Psychology, Motor Activity, Stress, Behavioral Science & Comparative Psychology, Basic Behavioral and Social Science, Article, Binge Drinking, 03 medical and health sciences, Reflex, Righting, Sex Factors, 2.3 Psychological, Reflex, Sex differences, Behavioral and Social Science, medicine, Animals, Righting, Righting reflex, Rotarod, Ethanol, Stressor, Psychology and Cognitive Sciences, Biological sex, medicine.disease, Comorbidity, 030227 psychiatry, Sexual dimorphism, Good Health and Well Being, chemistry, Psychological, 030217 neurology & neurosurgery, Stress, Psychological
الوصف: Alcohol use disorders, affective disorders and their comorbidity are sexually dimorphic in humans. However, it is difficult to disentangle the interactions between subject factors influencing alcohol sensitivity in studies of humans. Herein, we combined murine models of unpredictable, chronic, mild stress (UCMS) and voluntary binge-drinking to examine for sex differences in the interactions between prior histories of excessive ethanol-drinking and stress upon ethanol-induced changes in motor behavior and subsequent drinking. In Experiment 1, female mice were insensitive to the UCMS-induced increase in ethanol-induced locomotion and ethanol intake under continuous alcohol-access. Experiment 2 revealed interactions between ethanol dose and sex (females>males), binge-drinking history (water>ethanol), and UCMS history (UCMS>controls), with no additive effect of a sequential prior history of both binge drinking and UCMS observed. We also observed an interaction between UCMS history and sex for righting recovery. UCMS history potentiated subsequent binge-drinking in water controls of both sexes and in male binge-drinking mice. Conversely, a prior binge-drinking history increased subsequent ethanol intake in females only, irrespective of prior UCMS history. In Experiment 3, a concurrent history of binge-drinking and UCMS did not alter ethanol intake, nor did it influence the ethanol dose-locomotor response function, but it did augment alcohol-induced sedation and reduced subsequent alcohol intake over that produced by binge-drinking alone. Thus, the subject factors of biological sex, prior stressor history and prior binge-drinking history interact in complex ways in mice to impact sensitivity to alcohol's motor-stimulating, -incoordinating and intoxicating effects, as well as to influence subsequent heavy drinking.
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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5ae831b992d1a89da5bc21fbbfb5de
https://europepmc.org/articles/PMC6401319/ -
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المؤلفون: Sally Miller, Jennifer Kim
المصدر: The Nursing clinics of North America. 52(3)
مصطلحات موضوعية: Aged, 80 and over, Male, medicine.medical_specialty, Aging, 030214 geriatrics, business.industry, Health Services for the Aged, MEDLINE, Geriatric assessment, Syndrome, 03 medical and health sciences, 0302 clinical medicine, Chronic disease, Geriatrics, Chronic Disease, Medicine, Humans, Female, 030212 general & internal medicine, business, Intensive care medicine, Geriatric Assessment, General Nursing, Aged
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