المؤلفون: Wasson CW; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, West Yorkshire, UK., Abignano G; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, West Yorkshire, UK.; Rheumatology Department of Lucania San Carlo Hospital, Potenza, Italy, Rheumatology Institute of Lucania (IReL), Potenza, Italy.; Scleroderma Programme, NIHR Leeds Musculoskeletal Biomedical Research Centre, Leeds, UK., Hermes H; Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Malaab M; Rheumatology, Medical University of South Carolina, Charlestown, South Carolina, USA., Ross RL; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, West Yorkshire, UK., Jimenez SA; Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Chang HY; Center for Personal Dynamic Regulomes, University of Stanford, San Francisco, California, USA., Feghali-Bostwick CA; Rheumatology, Medical University of South Carolina, Charlestown, South Carolina, USA., Del Galdo F; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, West Yorkshire, UK f.delgaldo@leeds.ac.uk.; Scleroderma Programme, NIHR Leeds Musculoskeletal Biomedical Research Centre, Leeds, UK.

المصدر: Annals of the rheumatic diseases [Ann Rheum Dis] 2020 Apr; Vol. 79 (4), pp. 507-517. Date of Electronic Publication: 2020 Feb 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BMJ Country of Publication: England NLM ID: 0372355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2060 (Electronic) Linking ISSN: 00034967 NLM ISO Abbreviation: Ann Rheum Dis Subsets: MEDLINE

مواضيع طبية MeSH: Enhancer of Zeste Homolog 2 Protein/*metabolism , Fibroblasts/*metabolism , MicroRNAs/*metabolism , Myofibroblasts/*metabolism , RNA, Long Noncoding/*metabolism , Receptors, Notch/*metabolism , Scleroderma, Systemic/*metabolism, Amyloid Precursor Protein Secretases/antagonists & inhibitors ; Epigenesis, Genetic ; Fibrosis ; Histone Code ; Humans ; Indoles/pharmacology ; Phenotype ; Pyridones/pharmacology ; Receptors, Notch/antagonists & inhibitors ; Scleroderma, Systemic/genetics ; Scleroderma, Systemic/pathology ; Signal Transduction ; Skin/cytology ; Skin/metabolism ; Skin/pathology

المؤلفون: Piera-Velazquez S; Jefferson Institute of Molecular Medicine and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, USA. sonsoles.piera@jefferson.edu., Jimenez SA; Jefferson Institute of Molecular Medicine and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, USA.

المصدر: Clinical and experimental rheumatology [Clin Exp Rheumatol] 2018 Jul-Aug; Vol. 36 Suppl 113 (4), pp. 36-44. Date of Electronic Publication: 2018 Sep 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Clinical And Experimental Rheumatology S.A.S Country of Publication: Italy NLM ID: 8308521 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0392-856X (Print) Linking ISSN: 0392856X NLM ISO Abbreviation: Clin Exp Rheumatol Subsets: MEDLINE

مواضيع طبية MeSH: Aniline Compounds/*pharmacology , Fibroblasts/*drug effects , Nitriles/*pharmacology , Protein Kinase Inhibitors/*pharmacology , Proto-Oncogene Proteins c-abl/*antagonists & inhibitors , Quinolines/*pharmacology , Scleroderma, Diffuse/*drug therapy , Skin/*drug effects , src-Family Kinases/*antagonists & inhibitors, Case-Control Studies ; Cells, Cultured ; Extracellular Matrix Proteins/genetics ; Extracellular Matrix Proteins/metabolism ; Fibroblasts/enzymology ; Fibroblasts/pathology ; Fibrosis ; Gene Expression Regulation/drug effects ; Humans ; Myofibroblasts/drug effects ; Myofibroblasts/metabolism ; Myofibroblasts/pathology ; Proto-Oncogene Proteins c-abl/metabolism ; Scleroderma, Diffuse/enzymology ; Scleroderma, Diffuse/genetics ; Scleroderma, Diffuse/pathology ; Signal Transduction/drug effects ; Skin/enzymology ; Skin/pathology ; src-Family Kinases/metabolism

المؤلفون: Tsou PS; University of Michigan Medical School, Ann Arbor, MI, USA., Talia NN, Pinney AJ, Kendzicky A, Piera-Velazquez S, Jimenez SA, Seibold JR, Phillips K, Koch AE

المصدر: Arthritis and rheumatism [Arthritis Rheum] 2012 Jun; Vol. 64 (6), pp. 1978-89. Date of Electronic Publication: 2011 Dec 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 0370605 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-0131 (Electronic) Linking ISSN: 00043591 NLM ISO Abbreviation: Arthritis Rheum Subsets: MEDLINE

مواضيع طبية MeSH: Fibroblasts/*metabolism , Oxidative Stress/*physiology , Protein Tyrosine Phosphatase, Non-Receptor Type 1/*metabolism , Reactive Oxygen Species/*metabolism , Scleroderma, Systemic/*metabolism , Skin/*metabolism, Acetylcysteine/pharmacology ; Cells, Cultured ; Collagen Type I/genetics ; Collagen Type I/metabolism ; Fibroblasts/drug effects ; Fibroblasts/pathology ; Free Radical Scavengers/pharmacology ; Humans ; Oxidative Stress/drug effects ; Phosphorylation/drug effects ; Platelet-Derived Growth Factor/genetics ; Platelet-Derived Growth Factor/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/genetics ; Receptors, Platelet-Derived Growth Factor/genetics ; Receptors, Platelet-Derived Growth Factor/metabolism ; Scleroderma, Systemic/genetics ; Scleroderma, Systemic/pathology ; Skin/drug effects ; Skin/pathology ; Superoxides/metabolism

المؤلفون: Piera-Velazquez S; Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Li Z, Jimenez SA

المصدر: The American journal of pathology [Am J Pathol] 2011 Sep; Vol. 179 (3), pp. 1074-80. Date of Electronic Publication: 2011 Jul 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0370502 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-2191 (Electronic) Linking ISSN: 00029440 NLM ISO Abbreviation: Am J Pathol Subsets: MEDLINE

مواضيع طبية MeSH: Epithelial-Mesenchymal Transition/*physiology , Fibroblasts/*pathology , Mesoderm/*pathology, Animals ; Cell Communication/physiology ; Fibrosis ; Humans ; Kidney/pathology ; Mice ; Myocardium/pathology ; Pulmonary Fibrosis/pathology

المؤلفون: Wermuth PJ; Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America., Addya S, Jimenez SA

المصدر: PloS one [PLoS One] 2011; Vol. 6 (11), pp. e27110. Date of Electronic Publication: 2011 Nov 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Fibroblasts/*metabolism , Protein Kinase C-delta/*antagonists & inhibitors , Scleroderma, Systemic/*pathology , Skin/*cytology , Skin/*pathology, Acetophenones/pharmacology ; Benzopyrans/pharmacology ; Cells, Cultured ; Enzyme Inhibitors/pharmacology ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Fibroblasts/pathology ; Humans ; Protein Kinase C-delta/metabolism ; Scleroderma, Systemic/metabolism ; Skin/metabolism

المؤلفون: Piera-Velazquez S; Department of Dermatology and Cutaneous Biology, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Louneva N, Fertala J, Wermuth PJ, Del Galdo F, Jimenez SA

المصدر: Annals of the rheumatic diseases [Ann Rheum Dis] 2010 Nov; Vol. 69 (11), pp. 2017-23. Date of Electronic Publication: 2010 Jun 22.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BMJ Country of Publication: England NLM ID: 0372355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2060 (Electronic) Linking ISSN: 00034967 NLM ISO Abbreviation: Ann Rheum Dis Subsets: MEDLINE

مواضيع طبية MeSH: Contrast Media/*adverse effects , Fibroblasts/*metabolism , Gadolinium/*adverse effects , Nephrogenic Fibrosing Dermopathy/*chemically induced , Skin/*metabolism, Actins/biosynthesis ; Cells, Cultured ; Collagen/biosynthesis ; Collagen Type I/biosynthesis ; Collagen Type I/genetics ; Collagen Type I, alpha 1 Chain ; Contrast Media/pharmacology ; Dose-Response Relationship, Drug ; Fibroblasts/drug effects ; Fibronectins/biosynthesis ; Gadolinium/pharmacology ; Gene Expression Regulation/drug effects ; Humans ; Hyaluronic Acid/biosynthesis ; Nephrogenic Fibrosing Dermopathy/metabolism ; Nephrogenic Fibrosing Dermopathy/pathology ; RNA, Messenger/genetics ; Skin/pathology

المؤلفون: Del Galdo F; Scleroderma Center and Jefferson Institute of Molecular Medicine, Philadelphia, Pennsylvania 19107-5541, USA., Shaw MA, Jimenez SA

المصدر: The American journal of pathology [Am J Pathol] 2010 Oct; Vol. 177 (4), pp. 1638-46. Date of Electronic Publication: 2010 Aug 19.

نوع المنشور: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0370502 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-2191 (Electronic) Linking ISSN: 00029440 NLM ISO Abbreviation: Am J Pathol Subsets: MEDLINE

مواضيع طبية MeSH: Dermis/*metabolism , Fibroblasts/*metabolism , Nephrogenic Fibrosing Dermopathy/*metabolism , Proteome/*analysis , Scleroderma, Systemic/*metabolism , Skin/*metabolism, Blotting, Western ; Calcium-Binding Proteins/metabolism ; Cells, Cultured ; Dermis/cytology ; Electrophoresis, Gel, Two-Dimensional ; Fibroblasts/pathology ; Humans ; Immunoenzyme Techniques ; Nephrogenic Fibrosing Dermopathy/pathology ; Scleroderma, Systemic/pathology ; Skin/cytology ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Up-Regulation

المؤلفون: Sotgia F; Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10 Street, Philadelphia, PA 19107, USA. federica.sotgia@jefferson.edu, Del Galdo F, Casimiro MC, Bonuccelli G, Mercier I, Whitaker-Menezes D, Daumer KM, Zhou J, Wang C, Katiyar S, Xu H, Bosco E, Quong AA, Aronow B, Witkiewicz AK, Minetti C, Frank PG, Jimenez SA, Knudsen ES, Pestell RG, Lisanti MP

المصدر: The American journal of pathology [Am J Pathol] 2009 Mar; Vol. 174 (3), pp. 746-61.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0370502 Publication Model: Print Cited Medium: Internet ISSN: 1525-2191 (Electronic) Linking ISSN: 00029440 NLM ISO Abbreviation: Am J Pathol Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms/*genetics , Breast Neoplasms/*pathology , Caveolin 1/*deficiency , Caveolin 1/*genetics , Fibroblasts/*pathology , Stromal Cells/*pathology, Blotting, Western ; Breast/cytology ; Breast/physiology ; Breast Neoplasms/mortality ; Cell Culture Techniques ; Cell Division ; Disease Progression ; Disease-Free Survival ; Epithelial Cells/cytology ; Epithelial Cells/pathology ; Epithelial Cells/physiology ; Female ; Fibroblasts/cytology ; Fibroblasts/physiology ; Humans ; Polymerase Chain Reaction ; RNA, Messenger/genetics ; RNA, Neoplasm/genetics ; Stromal Cells/cytology ; Stromal Cells/physiology ; Survival Analysis

المؤلفون: Kypriotou M; Laboratoire de Biochimie du Tissu Conjonctif, Université de Caen/Basse-Normandie, IFR ICORE 146, FacultédeMédecine, CHU Niveau 3, Avenue de la Côte de Nacre, 14032 Caen Cedex, France., Beauchef G, Chadjichristos C, Widom R, Renard E, Jimenez SA, Korn J, Maquart FX, Oddos T, Von Stetten O, Pujol JP, Galéra P

المصدر: The Journal of biological chemistry [J Biol Chem] 2007 Nov 02; Vol. 282 (44), pp. 32000-14. Date of Electronic Publication: 2007 Aug 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Print ISSN: 0021-9258 (Print) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Up-Regulation*, Collagen Type I/*genetics , DNA-Binding Proteins/*metabolism , Fibroblasts/*metabolism , Sp1 Transcription Factor/*metabolism , Sp3 Transcription Factor/*metabolism , Transcription Factors/*metabolism, Adult ; Base Sequence ; Child ; DNA-Binding Proteins/genetics ; Foreskin/cytology ; Foreskin/metabolism ; Humans ; Male ; Molecular Sequence Data ; RNA Interference ; RNA, Small Interfering ; Scleroderma, Systemic ; Skin/cytology ; Skin/metabolism ; Transcription Factors/genetics ; Transcription, Genetic

المؤلفون: Sandorfi N; Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Jimenez SA

المصدر: The Journal of investigative dermatology [J Invest Dermatol] 2005 Feb; Vol. 124 (2), pp. viii-xi.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print Cited Medium: Print ISSN: 0022-202X (Print) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE

مواضيع طبية MeSH: Fibroblasts/*cytology , Protein Serine-Threonine Kinases/*physiology , Proto-Oncogene Proteins/*physiology , Scleroderma, Systemic/*metabolism , Scleroderma, Systemic/*pathology, Animals ; Apoptosis/physiology ; Cell Survival/physiology ; Humans ; Proto-Oncogene Proteins c-akt