المؤلفون: van der Koog L; Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy, Faculty of Science and Engineering, University of Groningen, Groningen, the Netherlands; GRIAC, Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, the Netherlands., Boerrigter MJ; Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy, Faculty of Science and Engineering, University of Groningen, Groningen, the Netherlands; GRIAC, Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, the Netherlands., Gorter IC; Aquilo BV, Groningen, the Netherlands., Gosens R; Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy, Faculty of Science and Engineering, University of Groningen, Groningen, the Netherlands; GRIAC, Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, the Netherlands., Nagelkerke A; Department of Pharmaceutical Analysis, Groningen Research Institute of Pharmacy, Faculty of Science and Engineering, University of Groningen, Groningen, the Netherlands. Electronic address: a.p.nagelkerke@rug.nl.

المصدر: European journal of pharmacology [Eur J Pharmacol] 2024 Jul 05; Vol. 974, pp. 176612. Date of Electronic Publication: 2024 Apr 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Extracellular Vesicles*/metabolism , Extracellular Vesicles*/transplantation , Fibroblasts*/drug effects , Fibroblasts*/metabolism , Pancreatic Elastase* , Lung*/pathology , Lung*/drug effects, Animals ; Mice ; Humans ; Lung Injury/pathology ; Lung Injury/chemically induced ; Lung Injury/metabolism ; Cell Line ; Male ; Mice, Inbred C57BL ; Disease Models, Animal ; Solubility

المؤلفون: Kortekaas RK; Department of Molecular Pharmacology, University of Groningen, Groningen, Netherlands.; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Geillinger-Kästle KE; Department of Immunology and Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Fuentes-Mateos R; Department of Molecular Pharmacology, University of Groningen, Groningen, Netherlands.; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, Netherlands., van Orsoy R; Department of Molecular Pharmacology, University of Groningen, Groningen, Netherlands.; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Al-Alyan N; Department of Molecular Pharmacology, University of Groningen, Groningen, Netherlands.; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Burgess JK; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, Netherlands.; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Gosens R; Department of Molecular Pharmacology, University of Groningen, Groningen, Netherlands.; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

المصدر: Frontiers in immunology [Front Immunol] 2024 Jun 07; Vol. 15, pp. 1346491. Date of Electronic Publication: 2024 Jun 07 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Pulmonary Disease, Chronic Obstructive*/metabolism , Pulmonary Disease, Chronic Obstructive*/pathology , Pulmonary Disease, Chronic Obstructive*/immunology , Fibroblasts*/metabolism , Epithelial Cells*/metabolism , Organoids*, Animals ; Humans ; Mice ; Cytokines/metabolism ; Lung/pathology ; Lung/immunology ; Lung/metabolism ; Cells, Cultured ; Disease Progression ; Respiratory Mucosa/metabolism ; Respiratory Mucosa/immunology ; Respiratory Mucosa/pathology ; Mice, Inbred C57BL

المؤلفون: Wójcik-Pszczoła K; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland., Chłoń-Rzepa G; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland., Jankowska A; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland., Ślusarczyk M; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland., Ferdek PE; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland., Kusiak AA; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland., Świerczek A; Department of Pharmacokinetics and Physical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland., Pociecha K; Department of Pharmacokinetics and Physical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland., Koczurkiewicz-Adamczyk P; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland., Wyska E; Department of Pharmacokinetics and Physical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland., Pękala E; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland., Gosens R; Department of Molecular Pharmacology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2020 Jun 03; Vol. 21 (11). Date of Electronic Publication: 2020 Jun 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Cyclic AMP/*metabolism , Cyclic AMP-Dependent Protein Kinases/*metabolism , Fibroblasts/*drug effects , Lung/*drug effects , Phosphodiesterase Inhibitors/*pharmacology , Transforming Growth Factor beta1/*metabolism, 3',5'-Cyclic-AMP Phosphodiesterases/metabolism ; Calcium/metabolism ; Cell Movement ; Cell Proliferation ; Cell Survival ; Cyclic AMP Response Element-Binding Protein/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 7/metabolism ; Drug Design ; Drug Evaluation, Preclinical ; Fibroblasts/metabolism ; Fibrosis ; Humans ; Lung/metabolism ; Myofibroblasts/metabolism ; Signal Transduction ; TRPA1 Cation Channel/metabolism

المؤلفون: Ng-Blichfeldt JP; Department of Molecular Pharmacology, Groningen Research Institute for Asthma and COPD, University of Groningen , Groningen , The Netherlands.; Lung Repair and Regeneration Unit, Helmholtz-Zentrum München, Ludwig-Maximilians-University, University Hospital Grosshadern, Member of the German Center of Lung Research , Munich , Germany., de Jong T; European Research Institute for Biology of Ageing, University Medical Centre Groningen, University of Groningen , Groningen , The Netherlands., Kortekaas RK; Department of Molecular Pharmacology, Groningen Research Institute for Asthma and COPD, University of Groningen , Groningen , The Netherlands., Wu X; Department of Molecular Pharmacology, Groningen Research Institute for Asthma and COPD, University of Groningen , Groningen , The Netherlands., Lindner M; Translational Lung Research and CPC-M bioArchive, Helmholtz Zentrum München, Comprehensive Pneumology Center , Munich , Germany., Guryev V; European Research Institute for Biology of Ageing, University Medical Centre Groningen, University of Groningen , Groningen , The Netherlands., Hiemstra PS; Department of Pulmonology, Leiden University Medical Center , Leiden , The Netherlands., Stolk J; Department of Pulmonology, Leiden University Medical Center , Leiden , The Netherlands., Königshoff M; Lung Repair and Regeneration Unit, Helmholtz-Zentrum München, Ludwig-Maximilians-University, University Hospital Grosshadern, Member of the German Center of Lung Research , Munich , Germany.; Translational Lung Research and CPC-M bioArchive, Helmholtz Zentrum München, Comprehensive Pneumology Center , Munich , Germany.; Division of Pulmonary Sciences and Critical Care Medicine, School of Medicine, University of Colorado , Aurora, Colorado., Gosens R; Department of Molecular Pharmacology, Groningen Research Institute for Asthma and COPD, University of Groningen , Groningen , The Netherlands.

المصدر: American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2019 Jul 01; Vol. 317 (1), pp. L14-L28. Date of Electronic Publication: 2019 Apr 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901229 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1504 (Electronic) Linking ISSN: 10400605 NLM ISO Abbreviation: Am J Physiol Lung Cell Mol Physiol Subsets: MEDLINE

مواضيع طبية MeSH: Adult Stem Cells/*metabolism , Epithelial Cells/*metabolism , Fibroblasts/*metabolism , Organoids/*metabolism , Pulmonary Disease, Chronic Obstructive/*genetics , Transforming Growth Factor beta/*metabolism, Adult Stem Cells/drug effects ; Adult Stem Cells/pathology ; Aged ; Animals ; Cell Communication/drug effects ; Cell Differentiation/drug effects ; Coculture Techniques ; Epithelial Cell Adhesion Molecule/genetics ; Epithelial Cell Adhesion Molecule/metabolism ; Epithelial Cells/drug effects ; Epithelial Cells/pathology ; Female ; Fibroblast Growth Factor 7/pharmacology ; Fibroblasts/pathology ; Gene Expression Profiling ; Gene Expression Regulation ; Hepatocyte Growth Factor/pharmacology ; Humans ; Lung/metabolism ; Lung/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Myofibroblasts/drug effects ; Myofibroblasts/metabolism ; Myofibroblasts/pathology ; Organoids/drug effects ; Organoids/pathology ; Pulmonary Disease, Chronic Obstructive/metabolism ; Pulmonary Disease, Chronic Obstructive/pathology ; Pyridines/pharmacology ; Pyrimidines/pharmacology ; Transforming Growth Factor beta/pharmacology ; Wnt Proteins/genetics ; Wnt Proteins/metabolism ; Wnt Signaling Pathway ; beta Catenin/genetics ; beta Catenin/metabolism

المؤلفون: van Dijk EM; Department of Molecular Pharmacology, University of Groningen, Groningen, the Netherlands; Groningen Research Institute for Asthma and Chronic Obstructive Pulmonary Disease, University Medical Center, Groningen, University of Groningen, Groningen, the Netherlands e.m.van.dijk@rug.nl., Menzen MH; Department of Molecular Pharmacology, University of Groningen, Groningen, the Netherlands; Groningen Research Institute for Asthma and Chronic Obstructive Pulmonary Disease, University Medical Center, Groningen, University of Groningen, Groningen, the Netherlands., Spanjer AI; Department of Molecular Pharmacology, University of Groningen, Groningen, the Netherlands; Groningen Research Institute for Asthma and Chronic Obstructive Pulmonary Disease, University Medical Center, Groningen, University of Groningen, Groningen, the Netherlands., Middag LD; Department of Molecular Pharmacology, University of Groningen, Groningen, the Netherlands; Groningen Research Institute for Asthma and Chronic Obstructive Pulmonary Disease, University Medical Center, Groningen, University of Groningen, Groningen, the Netherlands., Brandsma CA; Department of Pathology and Medical Biology, University of Groningen, Groningen, the Netherlands; and Groningen Research Institute for Asthma and Chronic Obstructive Pulmonary Disease, University Medical Center, Groningen, University of Groningen, Groningen, the Netherlands., Gosens R; Department of Molecular Pharmacology, University of Groningen, Groningen, the Netherlands; Groningen Research Institute for Asthma and Chronic Obstructive Pulmonary Disease, University Medical Center, Groningen, University of Groningen, Groningen, the Netherlands.

المصدر: American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2016 Jun 01; Vol. 310 (11), pp. L1166-76. Date of Electronic Publication: 2016 Apr 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901229 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1504 (Electronic) Linking ISSN: 10400605 NLM ISO Abbreviation: Am J Physiol Lung Cell Mol Physiol Subsets: MEDLINE

مواضيع طبية MeSH: Wnt Signaling Pathway*, Fibroblasts/*metabolism , Pulmonary Disease, Chronic Obstructive/*metabolism , Wnt Proteins/*metabolism, Case-Control Studies ; Cell Line ; Fibroblasts/immunology ; Frizzled Receptors/metabolism ; Gene Expression ; Humans ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Interleukin-8/genetics ; Interleukin-8/metabolism ; Lung/immunology ; Lung/metabolism ; Lung/pathology ; Pulmonary Disease, Chronic Obstructive/immunology

المؤلفون: Burgess JK; Woolcock Institute of Medical Research, The University of Sydney, Australia; Discipline of Pharmacology, The University of Sydney, Australia., Gosens R; Department of Molecular Pharmacology and Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, The Netherlands. Electronic address: r.gosens@rug.nl.

المصدر: Pulmonary pharmacology & therapeutics [Pulm Pharmacol Ther] 2014 Dec; Vol. 29 (2), pp. 91-2. Date of Electronic Publication: 2014 Aug 23.

نوع المنشور: Editorial; Introductory Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: England NLM ID: 9715279 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-9629 (Electronic) Linking ISSN: 10945539 NLM ISO Abbreviation: Pulm Pharmacol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Fibroblasts/*physiology , Muscle, Smooth/*physiology , Respiratory System/*anatomy & histology, Humans ; Lung/cytology ; Lung/physiology ; Research Personnel ; Respiratory Physiological Phenomena ; Respiratory System/cytology

المؤلفون: Baarsma HA; Department of Molecular Pharmacology, GRIAC Research Institute, University of Groningen, Groningen, The Netherlands. h.a.baarsma@rug.nl, Engelbertink LH, van Hees LJ, Menzen MH, Meurs H, Timens W, Postma DS, Kerstjens HA, Gosens R

المصدر: British journal of pharmacology [Br J Pharmacol] 2013 Jun; Vol. 169 (3), pp. 590-603.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Cell Differentiation*/drug effects, Cyclic AMP Response Element-Binding Protein/*agonists , Fibroblasts/*cytology , Glycogen Synthase Kinase 3/*metabolism , Lung/*cytology , Myofibroblasts/*cytology , Transforming Growth Factor beta1/*metabolism, Biomarkers/metabolism ; Cell Line ; Cells, Cultured ; Cyclic AMP Response Element-Binding Protein/metabolism ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Gene Expression Regulation/drug effects ; Gene Silencing ; Glycogen Synthase Kinase 3/antagonists & inhibitors ; Glycogen Synthase Kinase 3/genetics ; Humans ; Lung/drug effects ; Lung/metabolism ; Myofibroblasts/drug effects ; Myofibroblasts/metabolism ; Myofibroblasts/pathology ; Phosphorylation/drug effects ; Protein Kinase Inhibitors/pharmacology ; Protein Processing, Post-Translational/drug effects ; Pulmonary Disease, Chronic Obstructive/enzymology ; Pulmonary Disease, Chronic Obstructive/metabolism ; Pulmonary Disease, Chronic Obstructive/pathology ; RNA, Messenger/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Signal Transduction/drug effects ; Transforming Growth Factor beta1/antagonists & inhibitors ; Transforming Growth Factor beta1/genetics

المؤلفون: Lamyel F; Institute of Pharmacology & Toxicology, University of Bonn, Bonn, Germany., Warnken-Uhlich M, Seemann WK, Mohr K, Kostenis E, Ahmedat AS, Smit M, Gosens R, Meurs H, Miller-Larsson A, Racké K

المصدر: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2011 Aug; Vol. 384 (2), pp. 133-45. Date of Electronic Publication: 2011 May 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Cell Proliferation*/drug effects, Collagen/*biosynthesis , Fibroblasts/*metabolism , Pulmonary Fibrosis/*metabolism , Receptors, Adrenergic, beta-2/*physiology, Adrenergic beta-Agonists/pharmacology ; Blotting, Western ; Cell Culture Techniques ; Cell Line ; Cyclic AMP/metabolism ; Fibroblasts/drug effects ; Fibroblasts/pathology ; Humans ; Male ; Pulmonary Fibrosis/pathology ; RNA/metabolism ; Real-Time Polymerase Chain Reaction ; Receptors, Adrenergic, beta-2/genetics ; Receptors, Adrenergic, beta-2/metabolism

المؤلفون: Baarsma HA; Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands. H.A.Baarsma@rug.nl, Spanjer AI, Haitsma G, Engelbertink LH, Meurs H, Jonker MR, Timens W, Postma DS, Kerstjens HA, Gosens R

المصدر: PloS one [PLoS One] 2011; Vol. 6 (9), pp. e25450. Date of Electronic Publication: 2011 Sep 30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Fibroblasts/*drug effects , Lung/*pathology , Pulmonary Disease, Chronic Obstructive/*pathology , Signal Transduction/*drug effects , Transforming Growth Factor beta1/*pharmacology , Wnt Proteins/*metabolism , beta Catenin/*metabolism, Adaptor Proteins, Signal Transducing/genetics ; Aged ; Case-Control Studies ; Cell Differentiation/drug effects ; Cell Line ; Dishevelled Proteins ; Female ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Fibronectins/metabolism ; Frizzled Receptors/genetics ; Gene Expression Regulation/drug effects ; Humans ; Male ; Middle Aged ; Myofibroblasts/cytology ; Myofibroblasts/drug effects ; Myofibroblasts/pathology ; Phenotype ; Phosphoproteins/genetics ; Pulmonary Disease, Chronic Obstructive/metabolism

المؤلفون: P. P. S. J. Khedoe, W. A. A. M. van Schadewijk, M. Schwiening, J. P. Ng-Blichtfeldt, S. J. Marciniak, J. Stolk, R. Gosens, P. S. Hiemstra

المصدر: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

مصطلحات موضوعية: cigarette smoke extract, lung epithelial organoid, COPD, fibroblasts, oxidative stress, ER stress, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2023.1165581/full; https://doaj.org/toc/2296-634X

URL الوصول: https://doaj.org/article/6e8b07afb5534fd6992ec59bb2ab9c47