المؤلفون: Black WC; Merck Frosst Centre for Therapeutic Research, PO Box 1005, Pointe-Claire-Dorval, Quebec, Canada H9R 4P8. blackc@merck.com, Brideau C, Chan CC, Charleson S, Cromlish W, Gordon R, Grimm EL, Hughes G, Leger S, Li CS, Riendeau D, Thérien M, Wang Z, Xu LJ, Prasit P

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2003 Mar 24; Vol. 13 (6), pp. 1195-8.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Cyclooxygenase Inhibitors/*chemical synthesis , Cyclooxygenase Inhibitors/*pharmacology , Furans/*chemical synthesis , Furans/*pharmacology , Isoenzymes/*metabolism , Prostaglandin-Endoperoxide Synthases/*metabolism, Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Arthritis, Experimental/drug therapy ; CHO Cells ; Chemical Phenomena ; Chemistry, Physical ; Cricetinae ; Cyclooxygenase 2 ; Cyclooxygenase 2 Inhibitors ; Edema/chemically induced ; Edema/prevention & control ; Fever/chemically induced ; Fever/drug therapy ; Humans ; Membrane Proteins ; Pain/chemically induced ; Pain/drug therapy ; Rats ; Solubility ; Structure-Activity Relationship ; Substrate Specificity

المؤلفون: Li CS; Merck Frosst Centre for Therapeutic Research, Pointe-Clarie-Dorval, Quebec, Canada., Black WC, Brideau C, Chan CC, Charleson S, Cromlish WA, Claveau D, Gauthier JY, Gordon R, Greig G, Grimm E, Guay J, Lau CK, Riendeau D, Thérien M, Visco DM, Wong E, Xu L, Prasit P

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Nov 15; Vol. 9 (22), pp. 3181-6.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Inflammatory Agents, Non-Steroidal/*chemistry , Cyclooxygenase Inhibitors/*chemistry , Furans/*chemistry , Isoenzymes/*drug effects , Prostaglandin-Endoperoxide Synthases/*drug effects, Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; CHO Cells ; Cricetinae ; Cyclooxygenase 2 ; Cyclooxygenase 2 Inhibitors ; Cyclooxygenase Inhibitors/pharmacokinetics ; Cyclooxygenase Inhibitors/pharmacology ; Furans/pharmacokinetics ; Furans/pharmacology ; Rats ; Structure-Activity Relationship

المؤلفون: Lau CK; Merck Frosst Centre for Therapeutic Research, Pointe Claire-Dorval, Québec, Canada., Brideau C, Chan CC, Charleson S, Cromlish WA, Ethier D, Gauthier JY, Gordon R, Guay J, Kargman S, Li CS, Prasit P, Riendeau D, Thérien M, Visco DM, Xu L

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Nov 15; Vol. 9 (22), pp. 3187-92.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Cyclooxygenase Inhibitors/*chemical synthesis , Cyclooxygenase Inhibitors/*pharmacology , Furans/*chemical synthesis , Furans/*pharmacology , Isoenzymes/*drug effects , Prostaglandin-Endoperoxide Synthases/*drug effects, Animals ; Biological Availability ; CHO Cells ; Cricetinae ; Cyclooxygenase 2 ; Cyclooxygenase 2 Inhibitors ; Cyclooxygenase Inhibitors/pharmacokinetics ; Furans/pharmacokinetics ; Humans ; Membrane Proteins ; Pyridines/chemical synthesis ; Pyridines/pharmacokinetics ; Pyridines/pharmacology ; Rats

المؤلفون: Riendeau D; Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada., Percival MD, Boyce S, Brideau C, Charleson S, Cromlish W, Ethier D, Evans J, Falgueyret JP, Ford-Hutchinson AW, Gordon R, Greig G, Gresser M, Guay J, Kargman S, Léger S, Mancini JA, O'Neill G, Ouellet M, Rodger IW, Thérien M, Wang Z, Webb JK, Wong E, Chan CC, et. al.

المصدر: British journal of pharmacology [Br J Pharmacol] 1997 May; Vol. 121 (1), pp. 105-17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print Cited Medium: Print ISSN: 0007-1188 (Print) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Inflammatory Agents, Non-Steroidal/*pharmacology , Cyclooxygenase Inhibitors/*pharmacology , Furans/*pharmacology , Isoenzymes/*metabolism , Peroxidases/*antagonists & inhibitors , Prostaglandin-Endoperoxide Synthases/*metabolism, Administration, Oral ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; CHO Cells/cytology ; CHO Cells/drug effects ; Cricetinae ; Cyclooxygenase 1 ; Cyclooxygenase 2 ; Cyclooxygenase 2 Inhibitors ; Cyclooxygenase Inhibitors/administration & dosage ; Cyclooxygenase Inhibitors/therapeutic use ; Digestive System/drug effects ; Dinoprostone/biosynthesis ; Dose-Response Relationship, Drug ; Edema/drug therapy ; Fever/drug therapy ; Furans/administration & dosage ; Furans/therapeutic use ; Humans ; Hyperalgesia/drug therapy ; Indomethacin/toxicity ; Isoenzymes/blood ; Isoenzymes/drug effects ; Lipopolysaccharides/toxicity ; Male ; Membrane Proteins ; Peroxidases/metabolism ; Prostaglandin-Endoperoxide Synthases/blood ; Prostaglandin-Endoperoxide Synthases/drug effects ; Rats ; Rats, Sprague-Dawley ; Recombinant Proteins/metabolism ; Saimiri ; Structure-Activity Relationship ; Thromboxane B2/biosynthesis ; Transfection

المؤلفون: Riendeau, D, Percival, M D, Boyce, S, Brideau, C, Charleson, S, Cromlish, W, Ethier, D, Evans, J, Falgueyret, J -P, Ford-Hutchinson, A W, Gordon, R, Greig, G, Gresser, M, Guay, J, Kargman, S, Léger, S, Mancini, J A, O'Neill, G, Ouellet, M, Rodger, I W, Thérien, M, Wang, Z, Webb, J K, Wong, E, Xu, L, Young, R N, Zamboni, R, Prasit, P, Chan, C -C

مصطلحات موضوعية: Lipopolysaccharides, Male, Fever, Indomethacin, Administration, Oral, CHO Cells, Transfection, Dinoprostone, Rats, Sprague-Dawley, Structure-Activity Relationship, Cricetinae, Animals, Edema, Humans, Cyclooxygenase Inhibitors, Furans, Saimiri, Cyclooxygenase 2 Inhibitors, Dose-Response Relationship, Drug, Anti-Inflammatory Agents, Non-Steroidal, Membrane Proteins, Recombinant Proteins, Rats, Isoenzymes, Thromboxane B2, Peroxidases, Cyclooxygenase 2, Hyperalgesia, Prostaglandin-Endoperoxide Synthases, Papers, Cyclooxygenase 1, Digestive System

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::e75d03cc4c667a1cbd09d8eaa2000e7d
https://europepmc.org/articles/PMC1564640/