المؤلفون: Kamran Khan, Tuomas Huovinen, Eeva-Christine Brockmann, Urpo Lamminmäki, Heidi Hannula, Mikko Pyykkö

المصدر: New Biotechnology. 60:173-182

مصطلحات موضوعية: 0106 biological sciences, clone (Java method), Phage display, Antibody Affinity, chemical and pharmacologic phenomena, Bioengineering, Computational biology, 01 natural sciences, Affinity maturation, 03 medical and health sciences, chemistry.chemical_compound, Peptide Library, 010608 biotechnology, mental disorders, Humans, Digoxigenin, Molecular Biology, Gene, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, General Medicine, Complementarity Determining Regions, Synthetic antibody, Amino acid, chemistry, Hapten, Single-Chain Antibodies, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75b2a25a1568b04136ebd2ac2acf581
https://doi.org/10.1016/j.nbt.2020.09.002

المؤلفون: Edward W. Masters, Sophie Mayle, Daniel T. Griffiths, Maheen Sattar, John McCafferty, Rachael A. Leah, Yanchao Huang, Kothai Parthiban, Rajika L. Perera, Michael R. Dyson, Sachin Surade

المصدر: mAbs

مصطلحات موضوعية: Immunology, Programmed Cell Death 1 Receptor, Antibody Affinity, Locus (genetics), Computational biology, CHO Cells, Biology, Antibodies, Monoclonal, Humanized, TALE nuclease, gene targeting, Affinity maturation, 03 medical and health sciences, 0302 clinical medicine, Cricetulus, Genome editing, IgG antibody library, Report, Immunology and Allergy, CRISPR, Animals, Humans, Gene, CRISPR/Cas9, 030304 developmental biology, affinity maturation, Gene Editing, 0303 health sciences, human therapeutic antibody discovery, Mammalian display, Endodeoxyribonucleases, Cas9, Gene targeting, magnetic-activated cell sorting, Flow Cytometry, Complementarity Determining Regions, HEK293 Cells, 030220 oncology & carcinogenesis, Mutagenesis, Site-Directed, Paratope, Binding Sites, Antibody, CRISPR-Cas Systems, Immunoglobulin Heavy Chains, fluorescence-activated cell sorting

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e85ac50a098360a84026aead007c972
http://europepmc.org/articles/PMC6601556

المؤلفون: Kunihiro Ohta, Shu-ichi Hashimoto, Chika Koyama, Ke-Yi Lin, Hitomi Masuda, Yukoh Nakazaki, Atsushi Sawada, Kenjiro Asagoshi, Tomoaki Uchiki, Kanako Tamai, Kohei Kurosawa, Shigehisa Kawata, Takashi Yabuki, Goh Sasaki, Aki Takaiwa, Shunsuke Miyai, Naoki Takahashi, Hidetaka Seo

المصدر: Cellular and Molecular Immunology

مصطلحات موضوعية: Vascular Endothelial Growth Factor A, 0301 basic medicine, Cell biology, medicine.drug_class, Immunology, Gene Conversion, Gene Dosage, homologous recombination, Computational biology, Hydroxamic Acids, Monoclonal antibody, Article, Antibodies, drug discovery, Cell Line, Affinity maturation, 03 medical and health sciences, 0302 clinical medicine, Antigen, medicine, Animals, Humans, Immunology and Allergy, Amino Acid Sequence, Gene, antibody therapeutics, Immunoglobulin rearrangements, B-Lymphocytes, antibody engineering, Base Sequence, biology, Tumor Necrosis Factor-alpha, Drug discovery, Antibodies, Monoclonal, Genetic Variation, Directed evolution, Antibodies, Neutralizing, 030104 developmental biology, Infectious Diseases, 030220 oncology & carcinogenesis, Antibody Formation, biology.protein, Antibody, Homologous recombination, Chickens, Pseudogenes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2cff56176d8c9517dc714c64c334ac
https://doi.org/10.1038/s41423-020-0440-9

المؤلفون: Nobutoshi Ito, Masayuki Oda, Takachika Azuma, Nobutaka Numoto, Akihiro Nishiguchi

المصدر: Molecular Immunology. 114:545-552

مصطلحات موضوعية: 0301 basic medicine, Conformational change, Stereochemistry, Immunology, Antibody Affinity, Glycine, Somatic hypermutation, Nitrophenols, Affinity maturation, 03 medical and health sciences, Residue (chemistry), 0302 clinical medicine, Amino Acid Sequence, Molecular Biology, Gene, chemistry.chemical_classification, biology, Chemistry, Antibodies, Monoclonal, Amino acid, 030104 developmental biology, biology.protein, Somatic Hypermutation, Immunoglobulin, Antibody, Immunoglobulin Heavy Chains, Biosensor, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57316c1f3e10b7892a5ee9bdd13dab5
https://doi.org/10.1016/j.molimm.2019.09.001

المؤلفون: Carl-Magnus Svensson, Berit Jungnickel, Steffen Ullrich, Gianna Hirth, Katrin Böttcher, Marc Thilo Figge

المصدر: The Journal of Immunology. 203:1493-1501

مصطلحات موضوعية: Male, Immunology, Somatic hypermutation, Lymphocyte Activation, Affinity maturation, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cytidine Deaminase, Animals, Immunology and Allergy, Homologous Recombination, Gene, BRCA2 Protein, B-Lymphocytes, Genes, Immunoglobulin, Germinal center, DNA, Cytidine deaminase, Germinal Center, Cell biology, Mice, Inbred C57BL, Immunoglobulin class switching, chemistry, Mutation, Female, Somatic Hypermutation, Immunoglobulin, Homologous recombination, DNA Damage, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20626ab5159ca4fcc8444175b61c1aa0
https://doi.org/10.4049/jimmunol.1900483

المؤلفون: Pierre Milpied, Noudjoud Attaf, Laurine Binet, Sabrina Baaklini

المساهمون: Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), French Soc Immunol SFI (SFI), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), DUMENIL, Anita, ANR-17-CE15-0009,MoDEx-GC,Modélisation de la différenciation et la sortie dans les centres germinatifs par analyses intégratives sur cellules uniques(2017)

المصدر: European Journal of Immunology
European Journal of Immunology, Wiley-VCH Verlag, 2021, ⟨10.1002/eji.202149235⟩
European Journal of Immunology, 2021, ⟨10.1002/eji.202149235⟩

مصطلحات موضوعية: [SDV]Life Sciences [q-bio], Immunology, B-cell receptor, Cell, Somatic hypermutation, Biology, Lymphocyte Activation, Affinity maturation, 03 medical and health sciences, 0302 clinical medicine, Antigen, medicine, Animals, Humans, Immunology and Allergy, Gene, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, B-Lymphocytes, 0303 health sciences, breakpoint cluster region, Germinal center, Models, Theoretical, Germinal Center, Cell biology, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, 030220 oncology & carcinogenesis, Single-Cell Analysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b9728889d45d8a6f7fd9c883f43baf
https://hal-amu.archives-ouvertes.fr/hal-03374616

المؤلفون: Fan Zhang, Taiwen Li, Jun Liu, Peng Zhang, Bo Li, X. Shirley Liu, Peng Jiang, Michael C. Carroll, Kai W. Wucherpfennig, Binbin Wang, Jingxin Fu, Xiaomin Ying, Jin Wang, Jian Zhang, Shengqing Gu, Jing Zhang, Nir Hacohen, Xihao Hu, Xiaoqi Zheng, Jingyu Fan

المصدر: Nature genetics

مصطلحات موضوعية: Somatic cell, Immunoglobulin Variable Region, Somatic hypermutation, Biology, Subclass, Article, Affinity maturation, 03 medical and health sciences, 0302 clinical medicine, Immune system, Neoplasms, Genetics, medicine, Humans, Gene, B cell, Immune Evasion, 030304 developmental biology, B-Lymphocytes, 0303 health sciences, Base Sequence, Sequence Analysis, RNA, Complementarity Determining Regions, 3. Good health, medicine.anatomical_structure, Immunoglobulin G, Cancer research, biology.protein, Somatic Hypermutation, Immunoglobulin, Antibody, Immunoglobulin Heavy Chains, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25340f6fbbe39827225f327eb0acdb1f
http://europepmc.org/articles/PMC6773274

المؤلفون: Yang Gao, Su Jin, Wen Tian, Xiaoxu Han, Hong Shang, Yangtao Ji, Linqi Zhang

المصدر: Vaccine. 36:7700-7707

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Glycosylation, Heterologous, HIV Infections, HIV Antibodies, HIV Envelope Protein gp120, Biology, Virus, Affinity maturation, 03 medical and health sciences, chemistry.chemical_compound, Humans, Longitudinal Studies, Gene, Coevolution, Immune Evasion, General Veterinary, General Immunology and Microbiology, Public Health, Environmental and Occupational Health, Viral Envelope Gene, Antibodies, Neutralizing, Virology, 030104 developmental biology, Infectious Diseases, chemistry, Host-Pathogen Interactions, HIV-1, biology.protein, Molecular Medicine, Antibody

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4621a39498b1c54d3217c0cbb83240d
https://doi.org/10.1016/j.vaccine.2018.10.084

المؤلفون: Thierry Mora, Natanael Spisak, Aleksandra M. Walczak

المساهمون: Physique Statistique et Inférence pour la Biologie, Laboratoire de physique de l'ENS - ENS Paris (LPENS), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Sorbonne Université (SU)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Sorbonne Université (SU)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Laboratoire de physique de l'ENS - ENS Paris (LPENS (UMR_8023)), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)

المصدر: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2020, 48, pp.10702-10712. ⟨10.1093/nar/gkaa825⟩

مصطلحات موضوعية: AcademicSubjects/SCI00010, [SDV]Life Sciences [q-bio], Somatic hypermutation, Immunoglobulins, Context (language use), Complementarity determining region, Computational biology, Biology, Affinity maturation, 03 medical and health sciences, 0302 clinical medicine, Genetics, Humans, Quantitative Biology - Genomics, Cell Lineage, Gene Rearrangement, B-Lymphocyte, Gene, 030304 developmental biology, Narese/7, [PHYS]Physics [physics], Genomics (q-bio.GN), 0303 health sciences, Phylogenetic tree, Repertoire, Computational Biology, Gene rearrangement, Sequence Analysis, DNA, Narese/24, FOS: Biological sciences, Mutation (genetic algorithm), Immunoglobulin heavy chain, Somatic Hypermutation, Immunoglobulin, Algorithms, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab52fb858dd726ca5b03a9abd44a0cc
https://pubmed.ncbi.nlm.nih.gov/33035336

المؤلفون: Chaim A. Schramm, Daniel C. Douek

المصدر: Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology

مصطلحات موضوعية: lcsh:Immunologic diseases. Allergy, 0301 basic medicine, Immunology, Somatic hypermutation, Locus (genetics), Review, Computational biology, Biology, Evolution, Molecular, Affinity maturation, 03 medical and health sciences, Immunogenicity, Vaccine, 0302 clinical medicine, Antigen, Animals, Humans, Immunology and Allergy, Amino Acid Sequence, Nucleotide Motifs, Vaccine Potency, Gene, affinity maturation, B-Lymphocytes, Vaccines, Base Sequence, Repertoire, Immunity, Rational design, substitution profiles, somatic hypermutation, 030104 developmental biology, vaccine design, biology.protein, Somatic Hypermutation, Immunoglobulin, hot spot motifs, Antibody, lcsh:RC581-607, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5594d1561287a740c00f87349da337e2
https://doi.org/10.3389/fimmu.2018.01876