المؤلفون: Saunders GRB; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Wang X; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA., Chen F; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA., Jang SK; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Liu M; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Wang C; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA., Gao S; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA., Jiang Y; Department of Epidemiology & Population Health at Stanford University, Stanford, CA, USA., Khunsriraksakul C; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA., Otto JM; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Addison C; Jackson Heart Study (JHS) Graduate Training and Education Center (GTEC), Department of Epidemiology and Biostatistics, School of Public Health, Jackson State University, Jackson, MS, USA., Akiyama M; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Ocular Pathology and Imaging Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan., Albert CM; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Aliev F; Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Alonso A; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Arnett DK; Dean's Office and Department of Epidemiology, College of Public Health, University of Kentucky, Lexington, KY, USA., Ashley-Koch AE; Department of Medicine and Duke Comprehensive Sickle Cell Center, Duke University School of Medicine, Durham, NC, USA.; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA., Ashrani AA; Division of Hematology, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Barnes KC; Division of Biomedical Informatics & Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Tempus, Chicago, IL, USA., Barr RG; Department of Medicine, Columbia University Medical Center, New York, NY, USA., Bartz TM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Becker DM; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Benjamin EJ; Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Bjornsdottir G; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Bleecker ER; Department of Medicine, University of Arizona, Tucson, AZ, USA., Boardman JD; Institute of Behavioral Science, University of Colorado Boulder, Boulder, CO, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Boomsma DI; Netherlands Twin Register, Dept Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Boorgula MP; Division of Biomedical Informatics & Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Cade BE; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Chavan S; Division of Biomedical Informatics & Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Chen YI; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Chen Z; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Cheng I; Department of Epidemiology & Biostatistics, University of California, San Francisco, CA, USA.; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA., Cho MH; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Choquet H; Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, CA, USA., Cole JW; Department of Neurology, Baltimore Veterans Affairs Medical Center, Baltimore, MD, USA.; Division of Vascular Neurology, Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA., Cornelis MC; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Cucca F; University of Sassari, Sassari SS, Italy., Curran JE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., de Andrade M; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Dick DM; Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Docherty AR; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Virginia, USA.; Huntsman Mental Health Institute, Salt Lake City, UT, USA., Duggirala R; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Eaton CB; Department of Family Medicine, Brown University, Providence, RI, USA., Ehringer MA; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., Esko T; Institute of Genomics, University of Tartu, Tartu, Estonia., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Fernandes Silva L; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Fiorillo E; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy., Fornage M; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Freedman BI; Department of Internal Medicine-Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA., Gabrielsen ME; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Garrett ME; Department of Medicine and Duke Comprehensive Sickle Cell Center, Duke University School of Medicine, Durham, NC, USA.; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA., Gharib SA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.; Center for Lung Biology, Department of Medicine, University of Washington, Seattle, WA, USA., Gieger C; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Gillespie N; Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Virginia, USA., Glahn DC; Department of Psychiatry & Behavioral Sciences, Boston Children's Hospital & Harvard Medical School, Boston, MA, USA., Gordon SD; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Gu CC; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA., Gu D; Department of Epidemiology and Key Laboratory of Cardiovascular Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Gudbjartsson DF; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Haessler J; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Hall ME; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Haller T; Institute of Genomics, University of Tartu, Tartu, Estonia., Harris KM; Department of Sociology and the Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA., He J; Department of Epidemiology, Tulane University, New Orleans, LA, USA.; Translational Sciences Institute, Tulane University, New Orleans, LA, USA., Herd P; McCourt School of Public Policy, Georgetown University, Washington, DC, USA., Hewitt JK; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.; Department Of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA., Hickie I; Youth Mental Health & Technology Team, Brain and Mind Centre, University of Sydney, Sydney, Australia., Hidalgo B; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Hokanson JE; Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Hopfer C; Department of Psychiatry, University of Colorado Anschutz Medical Center, Denver, CO, USA., Hottenga J; Netherlands Twin Register, Dept Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Hou L; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Huang H; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Hung YJ; Institute of Preventive Medicine, National Defense Medical Center, New Taipei City, Taiwan., Hunter DJ; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Hveem K; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Research, Innovation and Education, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Hwang SJ; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Hwu CM; Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Iacono W; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Irvin MR; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Jee YH; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Johnson EO; GenOmics, Bioinformatics, and Translational Research Center, RTI International, Research Triangle Park, NC, USA.; Fellow Program, RTI International, Research Triangle Park, NC, USA., Joo YY; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Institute of Data Science, Korea University, Seoul, South Korea., Jorgenson E; Regeneron Genetics Center, Tarrytown, NY, USA., Justice AE; Department of Population Health Sciences, Geisinger, Danville, PA, USA.; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Kamatani Y; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Kaplan RC; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Kaprio J; Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Helsinki, Finland., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Keller MC; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.; Department Of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA., Kelly TN; Department of Epidemiology, Tulane University, New Orleans, LA, USA.; Translational Sciences Institute, Tulane University, New Orleans, LA, USA., Kooperberg C; Department of Biostatistics, University of Washington, Seattle, WA, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Korhonen T; Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Helsinki, Finland., Kraft P; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Krauter K; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO, USA., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.; Center for Medicine and Clinical Research, Kuopio University Hospital, Kuopio, Finland., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Lasky-Su J; Brigham and Women's Hospital, Department of Medicine, Channing Division of Network Medicine, Boston, MA, USA., Lee WJ; Department of Medical Research, Taichung Veterans General Hospital, Taichung City, Taiwan., Lee JJ; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Levy D; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Li L; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China., Li K; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Li Y; Department of Epidemiology & Biostatistics, University of California, San Francisco, CA, USA., Lin K; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Lind PA; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Australia.; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia., Liu C; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Lloyd-Jones DM; Departments of Preventive Medicine, Medicine, and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Lutz SM; Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA.; Department of Biostatics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Ma J; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.; Division of Nutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA., Mägi R; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., Manichaikul A; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA., Martin NG; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Mathur R; GenOmics, Bioinformatics, and Translational Research Center, RTI International, Research Triangle Park, NC, USA., Matoba N; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Genetics, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., McArdle PF; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., McGue M; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., McQueen MB; Department of Integrative Physiology, University of Colorado, Boulder, CO, USA., Medland SE; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Metspalu A; Institute of Genomics, University of Tartu, Tartu, Estonia., Meyers DA; Department of Medicine, University of Arizona, Tucson, AZ, USA., Millwood IY; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Mitchell BD; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Moll M; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Montasser ME; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Mulas A; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy., Nielsen JB; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA., North KE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Oelsner EC; Department of Medicine, Columbia University Medical Center, New York, NY, USA., Okada Y; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.; Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan., Orrù V; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Palviainen T; Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Helsinki, Finland., Pandit A; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Park SL; Population Sciences of the Pacific Program, University of Hawaii Cancer Center, Honolulu, HI, USA., Peters U; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig Maximilians University Munich, Munich, Germany.; German Centre for Cardiovascular Research, DZHK, Partner Site Munich, Munich, Germany., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Polderman TJC; Department of Clinical Developmental Psychology, Vrije Universiteit, Amsterdam, The Netherlands.; Department of Child and Adolescent Psychiatry, Amsterdam UMC, Amsterdam, The Netherlands., Rafaels N; Division of Biomedical Informatics & Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Redline S; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.; Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Reed RM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Reiner AP; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Rice JP; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA., Rich SS; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA., Richmond NE; Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Roan C; Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rueschman MN; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., Runarsdottir V; SAA-National Center of Addiction Medicine, Vogur Hospital, Reykjavik, Iceland., Saccone NL; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Schwartz DA; Division of Pulmonary Sciences and Critical Care Medicine; Department of Medicine and Immunology, University of Colorado, Aurora, CO, USA., Shadyab AH; Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA., Shi J; 23andMe, Inc, Sunnyvale, CA, USA., Shringarpure SS; 23andMe, Inc, Sunnyvale, CA, USA., Sicinski K; Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI, USA., Skogholt AH; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Smith NL; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA, USA., Sotoodehnia N; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA., Stallings MC; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.; Department Of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA., Stefansson H; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Stefansson K; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Stitzel JA; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA., Sun X; Department of Epidemiology, Tulane University, New Orleans, LA, USA., Syed M; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Tal-Singer R; COPD Foundation, Washington, DC, USA., Taylor AE; MRC Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK.; National Institute for Health Research Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK.; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Telen MJ; Department of Medicine and Duke Comprehensive Sickle Cell Center, Duke University School of Medicine, Durham, NC, USA., Thai KK; Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, CA, USA., Tiwari H; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Turman C; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Tyrfingsson T; SAA-National Center of Addiction Medicine, Vogur Hospital, Reykjavik, Iceland., Wall TL; Department of Psychiatry, University of California San Diego, San Diego, CA, USA., Walters RG; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Weiss ST; Brigham and Women's Hospital, Department of Medicine, Channing Division of Network Medicine, Boston, MA, USA., White WB; Jackson Heart Study Undergraduate Training and Education Center, Tougaloo College, Tougaloo, MS, USA., Whitfield JB; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Wiggins KL; Department of Medicine, University of Washington, Seattle, WA, USA., Willemsen G; Netherlands Twin Register, Dept Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Willer CJ; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Winsvold BS; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.; Department of Neurology, Oslo University Hospital, Oslo, Norway., Xu H; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Yanek LR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Yin J; Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, CA, USA., Young KL; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Young KA; Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Yu B; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Zhou W; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Zöllner S; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Zuccolo L; MRC Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK.; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Health Data Science Centre, Fondazione Human Technopole, Milan, Italy., Batini C; Department of Population Health Sciences, University of Leicester, Leicester, UK., Bergen AW; Oregon Research Institute, Springfield, OR, USA.; BioRealm, LLC, Walnut, CA, USA., Bierut LJ; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA., David SP; Outcomes Research Network & Department of Family Medicine, NorthShore University HealthSystem, Evanston, IL, USA.; Department of Family Medicine, University of Chicago, Chicago, IL, USA., Gagliano Taliun SA; Department of Medicine, Université de Montréal, Montréal, Québec, Canada.; Department of Neurosciences, Université de Montréal, Montréal, Québec, Canada.; Research Centre, Montréal Heart Institute, Montréal, Québec, Canada., Hancock DB; GenOmics, Bioinformatics, and Translational Research Center, RTI International, Research Triangle Park, NC, USA., Jiang B; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA., Munafò MR; MRC Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK.; National Institute for Health Research Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK.; School of Psychological Science, University of Bristol, Bristol, UK., Thorgeirsson TE; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Liu DJ; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA. dajiang.liu@psu.edu., Vrieze S; Department of Psychology, University of Minnesota, Minneapolis, MN, USA. vrieze@umn.edu.

مؤلفون مشاركون: 23andMe Research Team, Biobank Japan Project

المصدر: Nature [Nature] 2022 Dec; Vol. 612 (7941), pp. 720-724. Date of Electronic Publication: 2022 Dec 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Predisposition to Disease*/genetics , Genetic Variation*/genetics , Multifactorial Inheritance*/genetics , Tobacco Use*/genetics , Alcohol Drinking*/genetics , Internationality*, Humans ; Genome-Wide Association Study/methods ; Risk Factors ; Transcriptome ; Sample Size ; Genetic Loci/genetics ; Europe/ethnology

المؤلفون: Goodrich JK; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Singer-Berk M; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Son R; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sveden A; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wood J; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., England E; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cole JB; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Weisburd B; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Watts N; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Caulkins L; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dornbos P; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Koesterer R; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zappala Z; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zhang H; School of Medicine, University of Maryland Baltimore, Baltimore, MD, USA., Maloney KA; School of Medicine, University of Maryland Baltimore, Baltimore, MD, USA., Dahl A; Department of Neurology, UCLA, Los Angeles, CA, USA., Aguilar-Salinas CA; Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico., Atzmon G; Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.; Faculty of Natural Science, University of Haifa, Haifa, Israel.; Department of Genetics, Albert Einstein College of Medicine, New York, NY, USA., Barajas-Olmos F; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Barzilai N; Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.; Department of Genetics, Albert Einstein College of Medicine, New York, NY, USA., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX, USA., Boerwinkle E; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Bottinger E; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bowden DW; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Centeno-Cruz F; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Chami N; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Ichan School of Medicine at Mount Sinai, New York, NY, USA., Chan E; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Chan J; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, South Korea., Contreras-Cubas C; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Córdova E; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., DeFronzo RA; Department of Medicine, University of Texas Health San Antonio (aka University of Texas Health Science Center at San Antonio), San Antonio, TX, USA., Duggirala R; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX, USA., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Garay-Sevilla ME; Department of Medical Science, División of Health Science, University of Guanjuato. Campus León. León, Guanjuato, Mexico., García-Ortiz H; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Gieger C; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Glaser B; Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., González-Villalpando C; Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Instituto Nacional de Salud Publica, Cuernavaca, Mexico., Gonzalez ME; Centro de Estudios en Diabetes, Mexico City, Mexico., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Groop L; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Institute for Molecular Genetics Finland, University of Helsinki, Helsinki, Finland., Gross M; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Haiman C; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Han S; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, South Korea., Hanis CL; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Heard-Costa NL; Boston University and National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Henderson BE; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Hernandez JMM; Department of Medical Science, División of Health Science, University of Guanjuato. Campus León. León, Guanjuato, Mexico., Hwang MY; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, South Korea., Islas-Andrade S; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Jørgensen ME; Steno Diabetes Center Copenhagen, Gentofte, Denmark.; National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.; Greenland Centre for Health Research, University of Greenland, Nuuk, Greenland., Kang HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Kim BJ; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, South Korea., Kim YJ; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, South Korea., Koistinen HA; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.; University of Helsinki and Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Kooner JS; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Kwak SH; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Lange L; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Lee JY; Oneomics Soonchunhyang Mirae Medical Center, Bucheon-si Gyeonggi-do, Republic of Korea., Lee J; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, South Korea., Lehman DM; Department of Medicine, University of Texas Health San Antonio (aka University of Texas Health Science Center at San Antonio), San Antonio, TX, USA., Linneberg A; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark., Liu J; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Ichan School of Medicine at Mount Sinai, New York, NY, USA., Lyssenko V; Centro de Estudios en Diabetes, Mexico City, Mexico.; Department of Clinical Science, University of Bergen, Bergen, Norway., Ma RCW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China., Martínez-Hernández A; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Meigs JB; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Meitinger T; Institute of Human Genetics, Technical University of Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Mendoza-Caamal E; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Mohlke KL; Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, NC, USA., Morris AD; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK., Morrison AC; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Ng MCY; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Nilsson PM; Department of Clinical Sciences, Medicine, Lund University, Malmö, Sweden., O'Donnell CJ; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Section of Cardiology, Department of Medicine, VA Boston Healthcare, Boston, MA, USA.; Brigham and Women's Hospital, Boston, MA, USA.; Intramural Administration Management Branch, National Heart Lung and Blood Institute, NIH, Framingham, MA, USA., Orozco L; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Palmer CNA; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, University of Dundee, Dundee, UK., Park KS; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea., Post WS; Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Preuss M; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Research Institute, Seattle, WA, USA., Reiner AP; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Revilla-Monsalve C; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Rich SS; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA., Saleheen D; Division of Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan., Schurmann C; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Digital Health Center, Hasso Plattner Institute, University of Potsdam, Prof.-Dr.-Helmert-Str. 2-3, Potsdam, Germany.; Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Sladek R; Department of Human Genetics, McGill University, Montreal, QC, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, QC, Canada.; McGill University and Génome Québec Innovation Centre, Montreal, QC, Canada., Small KS; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., So WY; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.; Institute for Medical Informatics Biometry and Epidemiology, Ludwig-Maximilians University, Munich, Germany., Strom TM; Institute of Human Genetics, Technical University of Munich, Munich, Germany.; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Tai ES; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Tam CHT; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore., Thameem F; Department of Biochemistry, Faculty of Medicine, Health Science Center, Kuwait University, Safat, Kuwait., Tomlinson B; Faculty of Medicine, Macau University of Science & Technology, Macau, China., Tracy RP; Department of Pathology and Laboratory Medicine, The Robert Larner M.D. College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Biochemistry, The Robert Larner M.D. College of Medicine, University of Vermont, Burlington, VT, USA., Tuomi T; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Institute for Molecular Genetics Finland, University of Helsinki, Helsinki, Finland.; Folkhälsan Research Centre, Helsinki, Finland.; Department of Endocrinology, Abdominal Centre, Helsinki University Hospital, Helsinki, Finland.; Research Programs Unit, Clinical and Molecular Medicine, University of Helsinki, Helsinki, Finland., Tuomilehto J; Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.; Department of International Health, National School of Public Health, Instituto de Salud Carlos III, Madrid, Spain., Tusié-Luna T; Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; Departamento de Medicina Genómica y Toxiología Ambiental, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico., van Dam RM; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA., Vasan RS; Boston University and National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; Preventive Medicine & Epidemiology, and Cardiovascular Medicine, Medicine, Boston University School of Medicine, and Epidemiology, Boston University School of Public health, Boston, MA, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA., Witte DR; Department of Public Health, Aarhus University, Aarhus, Denmark.; Danish Diabetes Academy, Odense, Denmark., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Burtt NP; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zaitlen N; Department of Neurology, UCLA, Los Angeles, CA, USA., McCarthy MI; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Pollin TI; School of Medicine, University of Maryland Baltimore, Baltimore, MD, USA., Flannick J; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Mercader JM; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., O'Donnell-Luria A; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Baxter S; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Florez JC; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., MacArthur DG; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Centre for Population Genomics, Garvan Institute of Medical Research, UNSW Sydney, Sydney, NSW, Australia.; Centre for Population Genomics, Murdoch Children's Research Institute, Melbourne, VIC, Australia., Udler MS; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. mudler@mgh.harvard.edu.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. mudler@mgh.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, USA. mudler@mgh.harvard.edu.

مؤلفون مشاركون: AMP-T2D-GENES Consortia

المصدر: Nature communications [Nat Commun] 2021 Jun 09; Vol. 12 (1), pp. 3505. Date of Electronic Publication: 2021 Jun 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes Mellitus, Type 2/*genetics , Dyslipidemias/*genetics , Genetic Predisposition to Disease/*genetics, Adult ; Biological Variation, Population ; Biomarkers/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Dyslipidemias/metabolism ; Exome/genetics ; Genotype ; Humans ; Multifactorial Inheritance ; Penetrance ; Risk Assessment

المؤلفون: Knowles EEM; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. emma.knowles@yale.edu., Curran JE; South Texas Diabetes and Obesity Institute and Department of Human Genetics, University of Texas of the Rio Grande Valley School of Medicine, Brownsville, TX, USA., Meikle PJ; Baker IDI Heart and Diabetes Institute, Melbourne, Australia., Huynh K; Baker IDI Heart and Diabetes Institute, Melbourne, Australia., Mathias SR; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA., Göring HHH; South Texas Diabetes and Obesity Institute and Department of Human Genetics, University of Texas of the Rio Grande Valley School of Medicine, Brownsville, TX, USA., VandeBerg JL; South Texas Diabetes and Obesity Institute and Department of Human Genetics, University of Texas of the Rio Grande Valley School of Medicine, Brownsville, TX, USA., Mahaney MC; South Texas Diabetes and Obesity Institute and Department of Human Genetics, University of Texas of the Rio Grande Valley School of Medicine, Brownsville, TX, USA., Jalbrzikowski M; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Mosior MK; Diabetes and Complications Therapeutic Area, Eli Lilly and Company, Indianapolis, IN, USA., Michael LF; Diabetes and Complications Therapeutic Area, Eli Lilly and Company, Indianapolis, IN, USA., Olvera RL; Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Duggirala R; South Texas Diabetes and Obesity Institute and Department of Human Genetics, University of Texas of the Rio Grande Valley School of Medicine, Brownsville, TX, USA., Almasy L; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Glahn DC; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USA., Blangero J; South Texas Diabetes and Obesity Institute and Department of Human Genetics, University of Texas of the Rio Grande Valley School of Medicine, Brownsville, TX, USA.

المصدر: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2018 Dec; Vol. 43 (13), pp. 2556-2563. Date of Electronic Publication: 2018 Jul 23.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE

مواضيع طبية MeSH: Suicidal Ideation*, Cholesterol/*blood , Cholesterol/*genetics , Genetic Predisposition to Disease/*genetics , Genetic Predisposition to Disease/*psychology , Suicide, Attempted/*psychology, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cohort Studies ; Disease Susceptibility/blood ; Disease Susceptibility/psychology ; Female ; Humans ; Male ; Mental Disorders/blood ; Mental Disorders/diagnosis ; Mental Disorders/psychology ; Middle Aged ; Pedigree ; Risk Factors ; Young Adult

المؤلفون: Jun G; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48105; goo.jun@uth.tmc.edu.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48105.; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77225., Manning A; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142., Almeida M; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX 78520., Zawistowski M; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48105.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48105., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, United Kingdom., Teslovich TM; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48105.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48105.; Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591., Fuchsberger C; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48105.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48105.; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck, 39100 Bolzano, Italy., Feng S; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48105.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48105., Cingolani P; Génome Québec Innovation Centre, McGill University, Montreal, QC H3A 0E9, Canada., Gaulton KJ; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom., Dyer T; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX 78520., Blackwell TW; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48105.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48105., Chen H; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77225.; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118.; Center for Precision Health, School of Public Health and School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030., Chines PS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892., Choi S; The Research Institute of Basic Sciences, Seoul National University, Seoul 08826, Republic of Korea., Churchhouse C; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142., Fontanillas P; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142., King R; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL 60637., Lee S; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 08826, Republic of Korea., Lincoln SE; Complete Genomics, Mountain View, CA 95134.; Invitae, San Francisco, CA 94103., Trubetskoy V; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL 60637., DePristo M; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142., Fingerlin T; Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO 80045., Grossman R; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL 60637., Grundstad J; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL 60637., Heath A; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL 60637., Kim J; Department of Statistics, Seoul National University, Seoul 08826, Republic of Korea., Kim YJ; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 08826, Republic of Korea.; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do 28159, Republic of Korea., Laramie J; Complete Genomics, Mountain View, CA 95134., Lee J; Department of Statistics, Seoul National University, Seoul 08826, Republic of Korea., Li H; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142., Liu X; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore 117549., Livne O; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL 60637., Locke AE; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48105.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48105., Maller J; Clinical Research Centre, Centre for Molecular Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom., Mazur A; Génome Québec Innovation Centre, McGill University, Montreal, QC H3A 0E9, Canada., Morris AP; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.; Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, United Kingdom., Pollin TI; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.; Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201.; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201., Ragona D; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL 60637., Reich D; Department of Genetics, Harvard Medical School, Boston, MA 02115., Rivas MA; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom., Scott LJ; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48105.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48105., Sim X; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48105.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48105.; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore 117549., Tearle RG; Complete Genomics, Mountain View, CA 95134., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore 117549.; Life Sciences Institute, National University of Singapore, Singapore 117549.; Department of Statistics and Applied Probability, National University of Singapore, Singapore 117549., Williams AL; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142., Zöllner S; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48105.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48105., Curran JE; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX 78520., Peralta J; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX 78520., Akolkar B; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda, MD 20892., Bell GI; Department of Medicine, The University of Chicago, Chicago, IL 60637.; Department of Human Genetics, The University of Chicago, Chicago, IL 60637., Burtt NP; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142., Cox NJ; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL 60637.; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN 37332., Florez JC; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142.; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Medicine, Harvard Medical School, Boston, MA.; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114., Hanis CL; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77225., McKeon C; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda, MD 20892., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599., Seielstad M; Department of Laboratory Medicine, University of California, San Francisco, CA 94143.; Institute for Human Genetics, University of California, San Francisco, CA 94143.; Blood Systems Research Institute, San Francisco, CA 94118., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216., Atzmon G; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461.; Department of Natural Science, University of Haifa, 3498838 Haifa, Israel., Below JE; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN 37332., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118.; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA 01702., Nicolae DL; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL 60637., Lehman D; Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229., Park T; Department of Statistics, Seoul National University, Seoul 08826, Republic of Korea., Won S; School of Public Health, Seoul National University, Seoul 08826, Republic of Korea., Sladek R; Génome Québec Innovation Centre, McGill University, Montreal, QC H3A 0E9, Canada.; Department of Human Genetics, McGill University, Montreal, QC H3A 0G1, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada., Altshuler D; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142.; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, United Kingdom.; Department of Medicine, Harvard Medical School, Boston, MA.; Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, MA 02115.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142., McCarthy MI; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, United Kingdom.; Oxford National Institute for Health Research Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX4 2PG, United Kingdom., Duggirala R; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX 78520., Boehnke M; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48105.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48105., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, United Kingdom., Abecasis GR; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48105.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48105., Blangero J; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX 78520.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Jan 09; Vol. 115 (2), pp. 379-384. Date of Electronic Publication: 2017 Dec 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Variation*, Diabetes Mellitus, Type 2/*genetics , Genetic Predisposition to Disease/*genetics , Mexican Americans/*genetics, Diabetes Mellitus, Type 2/ethnology ; Diabetes Mellitus, Type 2/pathology ; Family Health ; Female ; Gene Frequency ; Genetic Predisposition to Disease/ethnology ; Genome-Wide Association Study/methods ; Genotype ; Humans ; Male ; Pedigree ; Phenotype ; Quantitative Trait Loci/genetics ; Whole Genome Sequencing/methods

المؤلفون: Hodgson K; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA., Almasy L; South Texas Diabetes and Obesity Institute, University of Texas Health Science Center at San Antonio and University of Texas of the Rio Grande Valley, Brownsville, TX, USA., Knowles EE; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA., Kent JW Jr; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA., Curran JE; South Texas Diabetes and Obesity Institute, University of Texas Health Science Center at San Antonio and University of Texas of the Rio Grande Valley, Brownsville, TX, USA., Dyer TD; South Texas Diabetes and Obesity Institute, University of Texas Health Science Center at San Antonio and University of Texas of the Rio Grande Valley, Brownsville, TX, USA., Göring HH; South Texas Diabetes and Obesity Institute, University of Texas Health Science Center at San Antonio and University of Texas of the Rio Grande Valley, Brownsville, TX, USA., Olvera RL; Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Woolsey MD; Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Duggirala R; South Texas Diabetes and Obesity Institute, University of Texas Health Science Center at San Antonio and University of Texas of the Rio Grande Valley, Brownsville, TX, USA., Fox PT; Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; South Texas Veterans Health System, San Antonio, TX, USA., Blangero J; South Texas Diabetes and Obesity Institute, University of Texas Health Science Center at San Antonio and University of Texas of the Rio Grande Valley, Brownsville, TX, USA., Glahn DC; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USA.

المصدر: Addiction (Abingdon, England) [Addiction] 2017 Jan; Vol. 112 (1), pp. 113-123. Date of Electronic Publication: 2016 Sep 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9304118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1360-0443 (Electronic) Linking ISSN: 09652140 NLM ISO Abbreviation: Addiction Subsets: MEDLINE

مواضيع طبية MeSH: Depressive Disorder, Major/*epidemiology , Genetic Predisposition to Disease/*epidemiology , Marijuana Abuse/*epidemiology, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Comorbidity ; Depressive Disorder, Major/genetics ; Ethnicity/psychology ; Ethnicity/statistics & numerical data ; Female ; Humans ; Male ; Marijuana Abuse/genetics ; Middle Aged ; Texas/epidemiology ; Young Adult

المؤلفون: Adams HH; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands., Hibar DP; Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA., Chouraki V; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.; Lille University, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Risk factors and molecular determinants of aging-related diseases, Lille, France.; Framingham Heart Study, Framingham, Massachusetts, USA., Stein JL; Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.; Department of Genetics and UNC Neuroscience Center, University of North Carolina (UNC), Chapel Hill, North Carolina, USA., Nyquist PA; Department of Neurology, Department of Anesthesia/Critical Care Medicine, Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland, USA., Rentería ME; QIMR Berghofer Medical Research Institute, Brisbane, Australia., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands., Arias-Vasquez A; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands., Seshadri S; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.; Framingham Heart Study, Framingham, Massachusetts, USA., Desrivières S; MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Beecham AH; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida, USA.; John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA., Jahanshad N; Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA., Wittfeld K; German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Greifswald, Germany.; Department of Psychiatry, University Medicine Greifswald, Greifswald, Germany., Van der Lee SJ; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Abramovic L; Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands., Alhusaini S; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada.; The Royal College of Surgeons in Ireland, Dublin 2, Ireland., Amin N; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Andersson M; Department of Integrative Medical Biology and Umeå center for Functional Brain Imaging, Umeå University, Umeå, Sweden., Arfanakis K; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.; Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, Illinois, USA., Aribisala BS; Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.; Department of Computer Science, Lagos State University, Lagos, Nigeria.; Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK., Armstrong NJ; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.; Mathematics and Statistics, Murdoch University, Perth, Australia., Athanasiu L; NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; NORMENT - KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Axelsson T; Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Beiser A; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.; Framingham Heart Study, Framingham, Massachusetts, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Bernard M; Hospital for Sick Children, University of Toronto, Toronto, Canada., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA., Blanken LM; Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands., Blanton SH; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida, USA.; John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA., Bohlken MM; Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands., Boks MP; Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands., Bralten J; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands., Brickman AM; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, USA.; G.H. Sergievsky Center, Columbia University Medical Center, New York, New York, USA.; Department of Neurology, Columbia University Medical Center, New York, New York, USA., Carmichael O; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA., Chakravarty MM; Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada.; Department of Psychiatry and Biomedical Engineering, McGill University, Montreal, Canada., Chauhan G; INSERM Unit U1219, University of Bordeaux, France., Chen Q; Lieber Institute for Brain Development, Baltimore, Maryland, USA., Ching CR; Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.; Interdepartmental Neuroscience Graduate Program, UCLA School of Medicine, Los Angeles, California, USA., Cuellar-Partida G; QIMR Berghofer Medical Research Institute, Brisbane, Australia., Braber AD; Biological Psychology, Neuroscience Campus Amsterdam, Vrije Universiteit University and Vrije Universiteit Medical Center, Amsterdam, the Netherlands., Doan NT; NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Ehrlich S; Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Germany.; Department of Psychiatry, Massachusetts General Hospital, Boston, Masschusetts, USA.; Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, North Carolina, USA., Filippi I; NSERM Unit 1000 ″Neuroimaging and Psychiatry″, University Paris Sud, University Paris Descartes, Paris, France.; Maison de Solenn, Adolescent Psychopathology and Medicine Department, APHP Hospital Cochin, Paris, France., Ge T; Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, North Carolina, USA.; Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Boston, Massachusetts, USA., Giddaluru S; NORMENT - KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Norway.; Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway., Goldman AL; Lieber Institute for Brain Development, Baltimore, Maryland, USA., Gottesman RF; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Greven CU; Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.; Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands.; King's College London, Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychology, Psychiatry and Neurosciene, London, UK., Grimm O; Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany., Griswold ME; Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, Mississippi, USA., Guadalupe T; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands.; International Max Planck Research School for Language Sciences, Nijmegen, the Netherlands., Hass J; Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Dresden, Germany., Haukvik UK; NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Research and Development, Diakonhjemmet Hospital, Oslo, Norway., Hilal S; Department of Pharmacology, National University of Singapore, Singapore.; Memory Aging and Cognition Centre (MACC), National University Health System, Singapore., Hofer E; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Austria, Graz, Austria.; Institute of Medical Informatics, Statistics and Documentation, Medical University Graz, Austria, Graz, Austria., Hoehn D; Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany., Holmes AJ; Department of Psychiatry, Massachusetts General Hospital, Boston, Masschusetts, USA.; Department of Psychology, Yale University, New Haven, Connecticut, USA., Hoogman M; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands., Janowitz D; Department of Psychiatry, University Medicine Greifswald, Greifswald, Germany., Jia T; MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Kasperaviciute D; UCL Institute of Neurology, London, United Kingdom and Epilepsy Society, Bucks, UK.; Department of Medicine, Imperial College London, London, UK., Kim S; Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, USA., Klein M; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands., Kraemer B; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany., Lee PH; Department of Psychiatry, Massachusetts General Hospital, Boston, Masschusetts, USA.; Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Boston, Massachusetts, USA.; Lurie Center for Autism, Massachusetts General Hospital, Harvard Medical School, Lexington, Massachusetts, USA., Liao J; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Liewald DC; Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK., Lopez LM; Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK., Luciano M; Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK., Macare C; MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Marquand A; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.; Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands., Matarin M; UCL Institute of Neurology, London, United Kingdom and Epilepsy Society, Bucks, UK.; Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK., Mather KA; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia., Mattheisen M; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus and Copenhagen, Denmark.; Center for integrated Sequencing, iSEQ, Aarhus University, Aarhus, Denmark., Mazoyer B; UMR5296 University of Bordeaux, CNRS, CEA, Bordeaux, France., McKay DR; Department of Psychiatry, Yale University, New Haven, Connecticut, USA.; Olin Neuropsychiatric Research Center, Hartford, Connecticut, USA., McWhirter R; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Milaneschi Y; Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam, The Netherlands., Mirza-Schreiber N; Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany., Muetzel RL; Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands., Maniega SM; Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.; Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK., Nho K; Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, USA., Nugent AC; Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA., Loohuis LM; Center for Neurobehavioral Genetics, University of California, Los Angeles, California, USA., Oosterlaan J; Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, the Netherlands., Papmeyer M; Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK.; Division of Systems Neuroscience of Psychopathology, Translational Research Center, University Hospital of Psychiatry, University of Bern, Switzerland., Pappa I; Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands.; School of Pedagogical and Educational Sciences, Erasmus University Rotterdam, Rotterdam, the Netherlands., Pirpamer L; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Austria, Graz, Austria., Pudas S; Department of Integrative Medical Biology and Umeå center for Functional Brain Imaging, Umeå University, Umeå, Sweden., Pütz B; Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany., Rajan KB; Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA., Ramasamy A; Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.; Department of Medical and Molecular Genetics, King's College London, London, UK.; The Jenner Institute Laboratories, University of Oxford, Oxford, UK., Richards JS; Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.; Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands., Risacher SL; Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, USA., Roiz-Santiañez R; Department of Medicine and Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.; CIBERSAM (Centro Investigación Biomédica en Red Salud Mental), Santander, Spain., Rommelse N; Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.; Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands., Rose EJ; Psychosis Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin., Royle NA; Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.; Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Rundek T; Department of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, USA.; Department of Epidemiology and Public Health Sciences, University of Miami, Miller School of Medicine, Miami, Florida, USA., Sämann PG; Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany., Satizabal CL; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.; Framingham Heart Study, Framingham, Massachusetts, USA., Schmaal L; Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, VIC, Australia.; Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia.; Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands., Schork AJ; Multimodal Imaging Laboratory, Department of Neurosciences, University of California, San Diego, USA.; Department of Cognitive Sciences, University of California, San Diego, USA., Shen L; Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, USA., Shin J; Hospital for Sick Children, University of Toronto, Toronto, Canada., Shumskaya E; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.; Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Sprooten E; Department of Psychiatry, Yale University, New Haven, Connecticut, USA.; Olin Neuropsychiatric Research Center, Hartford, Connecticut, USA.; Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Strike LT; QIMR Berghofer Medical Research Institute, Brisbane, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Australia., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Thomson R; School of Computing Engineering and Mathematics, Western Sydney University, Parramatta, Australia., Tordesillas-Gutierrez D; CIBERSAM (Centro Investigación Biomédica en Red Salud Mental), Santander, Spain.; Neuroimaging Unit,Technological Facilities. Valdecilla Biomedical Research Institute IDIVAL, Santander, Cantabria, Spain., Toro R; Institut Pasteur, Paris, France., Trabzuni D; Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.; Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia., Vaidya D; GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Van der Grond J; Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands., Van der Meer D; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Van Donkelaar MM; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands., Van Eijk KR; Brain Center Rudolf Magnus, Human Neurogenetics Unit, UMC Utrecht, Utrecht, the Netherlands., Van Erp TG; Department of Psychiatry and Human Behavior, University of California-Irvine, Irvine, California, USA., Van Rooij D; Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Walton E; Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Dresden, Germany., Westlye LT; NORMENT - KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; NORMENT - KG Jebsen Centre, Department of Psychology, University of Oslo, Oslo, Norway., Whelan CD; Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.; The Royal College of Surgeons in Ireland, Dublin 2, Ireland., Windham BG; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Winkler AM; Department of Psychiatry, Yale University, New Haven, Connecticut, USA.; FMRIB Centre, University of Oxford, Oxford, UK., Woldehawariat G; Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA., Wolf C; University of Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy, Wuerzburg, Germany., Wolfers T; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands., Xu B; MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Yanek LR; GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Yang J; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA., Zijdenbos A; Biospective Inc, Montreal, Quebec, Canada, Montréal, Québec, Canada., Zwiers MP; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.; Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands., Agartz I; NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Research and Development, Diakonhjemmet Hospital, Oslo, Norway.; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden., Aggarwal NT; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.; Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA., Almasy L; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine Brownsville/Edinburg/San Antonio, Texas, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Ames D; National Ageing Research Institute, Royal Melbourne Hospital, Melbourne, Australia.; Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Australia., Amouyel P; Lille University, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Risk factors and molecular determinants of aging-related diseases, Lille, France., Andreassen OA; NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; NORMENT - KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Arepalli S; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA., Assareh AA; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia., Barral S; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, USA., Bastin ME; Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.; Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Becker DM; GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Becker JT; Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA., Blangero J; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine Brownsville/Edinburg/San Antonio, Texas, USA., van Bokhoven H; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands., Boomsma DI; Biological Psychology, Neuroscience Campus Amsterdam, Vrije Universiteit University and Vrije Universiteit Medical Center, Amsterdam, the Netherlands., Brodaty H; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.; Dementia Collaborative Research Centre - Assessment and Better Care, UNSW, Sydney, Australia., Brouwer RM; Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands., Brunner HG; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands., Buckner RL; Department of Psychiatry, Massachusetts General Hospital, Boston, Masschusetts, USA.; Department of Psychology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA., Buitelaar JK; Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.; Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands., Bulayeva KB; Department of Evolution and Genetics, Dagestan State University, Makhachkala, Dagestan, Russia., Cahn W; Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands., Calhoun VD; The Mind Research Network and LBERI, Albuquerque, New Mexico, USA.; Department of ECE, University of New Mexico, Albuquerque, New Mexico, USA., Cannon DM; Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA.; Centre for Neuroimaging and Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland., Cavalleri GL; The Royal College of Surgeons in Ireland, Dublin 2, Ireland., Chen C; Department of Pharmacology, National University of Singapore, Singapore.; Memory Aging and Cognition Centre (MACC), National University Health System, Singapore., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Academic Medicine Research Institute, Duke-NUS Graduate Medical School, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Cichon S; Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany., Cookson MR; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA., Corvin A; Psychosis Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin., Crespo-Facorro B; Department of Medicine and Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.; CIBERSAM (Centro Investigación Biomédica en Red Salud Mental), Santander, Spain., Curran JE; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine Brownsville/Edinburg/San Antonio, Texas, USA., Czisch M; Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany., Dale AM; Center for Multimodal Imaging and Genetics, University of California, San Diego, California, USA.; Department of Neurosciences, University of California, San Diego, California, USA.; Department of Radiology, University of California, San Diego, California, USA.; Department of Psychiatry, University of California, San Diego, California, USA.; Department of Cognitive Science, University of California, San Diego, California, USA., Davies GE; Avera Institute for Human Genetics, Sioux Falls, South Dakota, USA.; Program in Translational NeuroPsychiatric Genomics, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., De Geus EJ; Biological Psychology, Neuroscience Campus Amsterdam, Vrije Universiteit University and Vrije Universiteit Medical Center, Amsterdam, the Netherlands., De Jager PL; Harvard Medical School, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Broad Institute, Cambridge, Massachusetts, USA., de Zubicaray GI; Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia., Delanty N; The Royal College of Surgeons in Ireland, Dublin 2, Ireland.; Neurology Division, Beaumont Hospital, Dublin, 9, Ireland., Depondt C; Department of Neurology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium., DeStefano AL; Framingham Heart Study, Framingham, Massachusetts, USA.; Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway., Dillman A; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA., Djurovic S; NORMENT - KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Norway.; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway., Donohoe G; Cognitive Genetics and Cognitive Therapy Group, Neuroimaging, Cognition and Genomics Centre (NICOG) and NCBES Galway Neuroscience Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Galway, Ireland.; Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Psychiatry, Trinity College Dublin, Dublin 8, Ireland., Drevets WC; Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA.; Janssen Research and Development, LLC, Titusville, New Jersey, USA., Duggirala R; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine Brownsville/Edinburg/San Antonio, Texas, USA., Dyer TD; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine Brownsville/Edinburg/San Antonio, Texas, USA., Erk S; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, CCM, Berlin, Germany., Espeseth T; NORMENT - KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; NORMENT - KG Jebsen Centre, Department of Psychology, University of Oslo, Oslo, Norway., Evans DA; Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA., Fedko IO; Biological Psychology, Neuroscience Campus Amsterdam, Vrije Universiteit University and Vrije Universiteit Medical Center, Amsterdam, the Netherlands., Fernández G; Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands., Ferrucci L; Intramural Research Program of the National Institute on Aging, Baltimore, Maryland, USA., Fisher SE; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands., Fleischman DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.; Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA., Ford I; Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK., Foroud TM; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Fox PT; University of Texas Health Science Center, San Antonio, Texas, USA., Francks C; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands., Fukunaga M; Division of Cerebral Integration, National Institute for Physiological Sciences, Aichi, Japan., Gibbs JR; Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA., Glahn DC; Department of Psychiatry, Yale University, New Haven, Connecticut, USA.; Olin Neuropsychiatric Research Center, Hartford, Connecticut, USA., Gollub RL; Department of Psychiatry, Massachusetts General Hospital, Boston, Masschusetts, USA.; Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, North Carolina, USA.; Harvard Medical School, Boston, Massachusetts, USA., Göring HH; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine Brownsville/Edinburg/San Antonio, Texas, USA., Grabe HJ; Department of Psychiatry, University Medicine Greifswald, Greifswald, Germany., Green RC; Harvard Medical School, Boston, Massachusetts, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Gruber O; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Guelfi S; Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK., Hansell NK; QIMR Berghofer Medical Research Institute, Brisbane, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Australia., Hardy J; Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK., Hartman CA; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Hashimoto R; Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.; Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan., Hegenscheid K; Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany., Heinz A; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, CCM, Berlin, Germany., Le Hellard S; NORMENT - KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Norway.; Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway., Hernandez DG; Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Heslenfeld DJ; Department of Psychology, VU University Amsterdam, Amsterdam, the Netherlands., Ho BC; Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA., Hoekstra PJ; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Hoffmann W; German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Hofman A; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Holsboer F; Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.; HMNC Brain Health, Munich, Germany., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Hosten N; Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany., Hottenga JJ; Biological Psychology, Neuroscience Campus Amsterdam, Vrije Universiteit University and Vrije Universiteit Medical Center, Amsterdam, the Netherlands., Hulshoff Pol HE; Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands., Ikeda M; Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan., Ikram MK; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.; Department of Pharmacology, National University of Singapore, Singapore.; Memory Aging and Cognition Centre (MACC), National University Health System, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Academic Medicine Research Institute, Duke-NUS Graduate Medical School, Singapore., Jack CR Jr; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Jenkinson M; FMRIB Centre, University of Oxford, Oxford, UK., Johnson R; NICHD Brain and Tissue Bank for Developmental Disorders, University of Maryland Medical School, Baltimore, Maryland, USA., Jönsson EG; NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; FMRIB Centre, University of Oxford, Oxford, UK., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands., Kahn RS; Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands., Kanai R; School of Psychology, University of Sussex, Brighton, UK.; Institute of Cognitive Neuroscience, University College London, London, UK.; Department of Neuroinformatics, Araya Brain Imaging, Tokyo, Japan., Kloszewska I; Medical University of Lodz, Lodz, Poland., Knopman DS; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Kochunov P; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA., Kwok JB; Neuroscience Research Australia, Sydney, Australia.; School of Medical Sciences, UNSW, Sydney, Australia., Lawrie SM; Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK., Lemaître H; NSERM Unit 1000 ″Neuroimaging and Psychiatry″, University Paris Sud, University Paris Descartes, Paris, France.; Maison de Solenn, Adolescent Psychopathology and Medicine Department, APHP Hospital Cochin, Paris, France., Liu X; Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA.; Columbia University Medical Center, New York, New York, USA., Longo DL; Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA., Longstreth WT Jr; Department of Neurology, University of Washington, Seattle, Washington, USA.; Department of Epidemiology, University of Washington, Seattle, Washington, USA., Lopez OL; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Lovestone S; Department of Psychiatry, University of Oxford, Oxford, UK.; NIHR Dementia Biomedical Research Unit, King's College London, London, UK., Martinez O; Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, California, USA., Martinot JL; NSERM Unit 1000 ″Neuroimaging and Psychiatry″, University Paris Sud, University Paris Descartes, Paris, France.; Maison de Solenn, Adolescent Psychopathology and Medicine Department, APHP Hospital Cochin, Paris, France., Mattay VS; Lieber Institute for Brain Development, Baltimore, Maryland, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., McDonald C; Centre for Neuroimaging and Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland., McIntosh AM; Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK.; Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK., McMahon KL; Centre for Advanced Imaging, University of Queensland, Brisbane, Australia., McMahon FJ; Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA., Mecocci P; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., Melle I; NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; NORMENT - KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Meyer-Lindenberg A; Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany., Mohnke S; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, CCM, Berlin, Germany., Montgomery GW; QIMR Berghofer Medical Research Institute, Brisbane, Australia., Morris DW; Cognitive Genetics and Cognitive Therapy Group, Neuroimaging, Cognition and Genomics Centre (NICOG) and NCBES Galway Neuroscience Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Galway, Ireland.; Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Psychiatry, Trinity College Dublin, Dublin 8, Ireland., Mosley TH; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Mühleisen TW; Centre for Neuroimaging and Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany., Müller-Myhsok B; Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; University of Liverpool, Institute of Translational Medicine, Liverpool, UK., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA., Nauck M; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.; German Center for Cardiovascular Research (DZHK e.V.), partner site Greifswald, Germany., Nichols TE; FMRIB Centre, University of Oxford, Oxford, UK.; Department of Statistics and Warwick Manufacturing Group, University of Warwick, Coventry, UK., Niessen WJ; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.; Department of Medical Informatics Erasmus MC, Rotterdam, the Netherlands.; Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands., Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany., Nyberg L; Department of Integrative Medical Biology and Umeå center for Functional Brain Imaging, Umeå University, Umeå, Sweden., Ohi K; Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan., Olvera RL; University of Texas Health Science Center, San Antonio, Texas, USA., Ophoff RA; Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands.; Center for Neurobehavioral Genetics, University of California, Los Angeles, California, USA., Pandolfo M; Department of Neurology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium., Paus T; Rotman Research Institute, University of Toronto, Toronto, Canada.; Departments of Psychology and Psychiatry, University of Toronto, Canada.; Child Mind Institute, New York, New York, USA., Pausova Z; Hospital for Sick Children, University of Toronto, Toronto, Canada.; Department of Physiology, University of Toronto, Toronto, Canada.; Department of Nutritional Sciences, University of Toronto, Toronto, Canada., Penninx BW; Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands., Pike GB; Department of Radiology, University of Calgary, Calgary, Canada.; Department of Clinical Neuroscience, University of Calgary, Calgary, Canada., Potkin SG; Department of Psychiatry and Human Behavior, University of California-Irvine, Irvine, California, USA., Psaty BM; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; Department of Medicine, University of Washington, Seattle, Washington, USA.; Department of Health Services, University of Washington, Seattle, Washington, USA.; Group Health Research Institute, Group Health, Seattle, Washington, USA., Reppermund S; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.; Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW Medicine, Australia., Rietschel M; Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany., Roffman JL; Department of Psychiatry, Massachusetts General Hospital, Boston, Masschusetts, USA., Romanczuk-Seiferth N; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, CCM, Berlin, Germany., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, California, USA., Ryten M; Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.; Department of Medical and Molecular Genetics, King's College London, London, UK., Sacco RL; John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA.; Department of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, USA.; Department of Epidemiology and Public Health Sciences, University of Miami, Miller School of Medicine, Miami, Florida, USA.; Evelyn F. McKnight Brain Institute, University of Miami, Miller School of Medicine, Miami, Florida, USA., Sachdev PS; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.; Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia., Saykin AJ; Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Schmidt R; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Austria, Graz, Austria., Schofield PR; Neuroscience Research Australia, Sydney, Australia.; School of Medical Sciences, UNSW, Sydney, Australia., Sigurdsson S; Icelandic Heart Association, Kopavogur, Iceland., Simmons A; Department of Neuroimaging, Institute of Psychiatry, King's College London, London, UK.; Biomedical Research Centre for Mental Health, King's College London, London, UK.; Biomedical Research Unit for Dementia, King's College London, London, UK., Singleton A; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA., Sisodiya SM; UCL Institute of Neurology, London, United Kingdom and Epilepsy Society, Bucks, UK., Smith C; MRC Edinburgh Brain Bank, University of Edinburgh, Academic Department of Neuropathology, Centre for Clinical Brain Sciences, Edinburgh, UK., Smoller JW; Department of Psychiatry, Massachusetts General Hospital, Boston, Masschusetts, USA.; Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Boston, Massachusetts, USA., Soininen H; Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland.; Neurocentre Neurology, Kuopio University Hospital, Finland., Srikanth V; Department of Medicine, Peninsula Health and Monash University, Melbourne, Australia., Steen VM; NORMENT - KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Norway.; Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway., Stott DJ; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK., Sussmann JE; Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK., Thalamuthu A; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia., Tiemeier H; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands., Toga AW; Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA., Traynor BJ; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA., Troncoso J; Brain Resource Center, Johns Hopkins University, Baltimore, Maryland, USA., Turner JA; Georgia State University, Atlanta, Georgia, USA., Tzourio C; Institute for Neurodegenerative Disorders, UMR 5293, CEA, CNRS, Université de Bordeaux, France., Uitterlinden AG; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands., Hernández MC; Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.; Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Van der Brug M; Genentech Inc., South San Francisco, California, USA., Van der Lugt A; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands., Van der Wee NJ; Department of Psychiatry and Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, The Netherlands., Van Duijn CM; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Van Haren NE; Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands., Van T Ent D; Biological Psychology, Neuroscience Campus Amsterdam, Vrije Universiteit University and Vrije Universiteit Medical Center, Amsterdam, the Netherlands., Van Tol MJ; Neuroimaging Centre, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Vardarajan BN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, USA., Veltman DJ; Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands., Vernooij MW; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Walter H; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, CCM, Berlin, Germany., Wardlaw JM; Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.; Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Wassink TH; Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Weale ME; Department of Medical and Molecular Genetics, King's College London, London, UK., Weinberger DR; Lieber Institute for Brain Development, Baltimore, Maryland, USA.; Departments of Psychiatry, Neurology, Neuroscience and the Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Weiner MW; Center for Imaging of Neurodegenerative Disease, San Francisco VA Medical Center, University of California, San Francisco, California, USA., Wen W; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia., Westman E; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., White T; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Evolution and Genetics, Dagestan State University, Makhachkala, Dagestan, Russia.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Wright CB; Department of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, USA.; Department of Epidemiology and Public Health Sciences, University of Miami, Miller School of Medicine, Miami, Florida, USA.; Evelyn F. McKnight Brain Institute, University of Miami, Miller School of Medicine, Miami, Florida, USA., Zielke HR; NICHD Brain and Tissue Bank for Developmental Disorders, University of Maryland Medical School, Baltimore, Maryland, USA., Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK., DeCarli C; Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, California, USA., Schmidt H; Institute of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Australia., De Craen AJ; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Wright MJ; Queensland Brain Institute, University of Queensland, Brisbane, Australia.; Centre for Advanced Imaging, University of Queensland, Brisbane, Australia., Launer LJ; Intramural Research Program, NIA, NIH, Bethesda, Maryland, USA., Schumann G; MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Fornage M; Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA., Franke B; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands., Debette S; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.; Lieber Institute for Brain Development, Baltimore, Maryland, USA.; Department of Neurology, Bordeaux University Hospital, Bordeaux, France., Medland SE; QIMR Berghofer Medical Research Institute, Brisbane, Australia., Ikram MA; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.; Department of Neurology, Erasmus MC, Rotterdam, the Netherlands., Thompson PM; Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.

المصدر: Nature neuroscience [Nat Neurosci] 2016 Dec; Vol. 19 (12), pp. 1569-1582. Date of Electronic Publication: 2016 Oct 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Predisposition to Disease* , Genome-Wide Association Study*/methods, Cognition/*physiology , Polymorphism, Single Nucleotide/*genetics, Brain/growth & development ; Brain/pathology ; Genetic Loci/genetics ; Humans ; Oncogene Protein v-akt/genetics ; Parkinson Disease/genetics ; Phenotype ; Phosphatidylinositol 3-Kinases/genetics ; White People

المؤلفون: Fuchsberger C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.; Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.; Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC), affiliated with the University of Lübeck, Bolzano, Italy., Flannick J; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA., Teslovich TM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Mahajan A; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Agarwala V; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Gaulton KJ; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Ma C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Fontanillas P; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Moutsianas L; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., McCarthy DJ; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Statistics, University of Oxford, Oxford, UK., Rivas MA; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Perry JRB; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Sim X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Blackwell TW; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Robertson NR; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Rayner NW; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Cingolani P; School of Computer Science, McGill University, Montreal, Quebec, Canada.; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada., Locke AE; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Tajes JF; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Highland HM; Human Genetics Center, The University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA., Chines PS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Lindgren CM; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Hartl C; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Chen H; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.; Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA., Huyghe JR; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., van de Bunt M; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Pearson RD; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kumar A; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Gamazon ER; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, USA., Lee J; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Chen Y; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Below JE; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Chen P; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore., Huang J; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA., Go MJ; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Stitzel ML; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA., Pasko D; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Parker SCJ; Departments of Computational Medicine & Bioinformatics and Human Genetics, University of Michigan, Ann Arbor, Michigan, USA., Varga TV; Department of Clinical Sciences, Lund University Diabetes Centre, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden., Green T; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Beer NL; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Day-Williams AG; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Ferreira T; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Fingerlin T; Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colorado, USA., Horikoshi M; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Hu C; Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China., Huh I; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Ikram MK; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore., Kim BJ; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Kim Y; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Kim YJ; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Kwon MS; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea., Lee J; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Lee S; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Lin KH; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Maxwell TJ; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Nagai Y; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada., Wang X; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore., Welch RP; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Yoon J; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK., Barzilai N; Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, USA., Voight BF; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Department of Genetics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Han BG; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Jenkinson CP; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA.; Research, South Texas Veterans Health Care System, San Antonio, Texas, USA., Kuulasmaa T; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Kuusisto J; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland., Manning A; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Ng MCY; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Palmer ND; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Balkau B; Centre for Research in Epidemiology and Population Health, Inserm U1018, Villejuif, France., Stančáková A; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Abboud HE; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Boeing H; German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany., Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden., Prabhakaran D; Centre for Chronic Disease Control, New Delhi, India., Gottesman O; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA., Scott J; National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK., Carey J; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Kwan P; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Grant G; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Smith JD; Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, USA., Neale BM; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Purcell S; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Psychiatry, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, USA., Butterworth AS; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Howson JMM; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Lee HM; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Lu Y; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA., Kwak SH; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Zhao W; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Danesh J; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Lam VKL; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Park KS; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Republic of Korea., Saleheen D; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan., So WY; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Tam CHT; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Afzal U; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Aguilar D; Cardiovascular Division, Baylor College of Medicine, Houston, Texas, USA., Arya R; Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA., Aung T; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore., Chan E; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore., Navarro C; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Spain.; Unit of Preventive Medicine and Public Health, School of Medicine, University of Murcia, Spain., Cheng CY; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore., Palli D; Cancer Research and Prevention Institute (ISPO), Florence, Italy., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Curran JE; South Texas Diabetes and Obesity Institute, Regional Academic Health Center, University of Texas Rio Grande Valley, Brownsville, Texas, USA., Rybin D; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Farook VS; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA., Fowler SP; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Freedman BI; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Griswold M; Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, Mississippi, USA., Hale DE; Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA., Hicks PJ; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Khor CC; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; Division of Human Genetics, Genome Institute of Singapore, ASTAR, Singapore., Kumar S; South Texas Diabetes and Obesity Institute, Regional Academic Health Center, University of Texas Rio Grande Valley, Brownsville, Texas, USA., Lehne B; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Thuillier D; CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France., Lim WY; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore., Liu J; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore.; Division of Human Genetics, Genome Institute of Singapore, ASTAR, Singapore., van der Schouw YT; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands., Loh M; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Institute of Health Sciences, University of Oulu, Oulu, Finland.; Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (ASTAR), Singapore, Singapore., Musani SK; Jackson Heart Study, University of Mississippi Medical Center, Jackson, Mississippi, USA., Puppala S; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA., Scott WR; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Yengo L; CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France., Tan ST; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK.; National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK., Taylor HA Jr; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Thameem F; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Wilson G Sr; College of Public Services, Jackson State University, Jackson, Mississippi, USA., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore., Njølstad PR; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Pediatrics, Haukeland University Hospital, Bergen, Norway., Levy JC; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Schwarzmayr T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Fadista J; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Surdulescu GL; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Herder C; Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Wieland T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Bork-Jensen J; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brandslund I; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.; Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark., Christensen C; Department of Internal Medicine and Endocrinology, Vejle Hospital, Vejle, Denmark., Koistinen HA; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland.; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Doney ASF; Division of Cardiovascular and Diabetes Medicine, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK., Kinnunen L; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Esko T; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA., Farmer AJ; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Hakaste L; Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Folkhälsan Research Centre, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland., Hodgkiss D; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Kravic J; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Lyssenko V; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Hollensted M; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jørgensen ME; Steno Diabetes Center, Gentofte, Denmark., Jørgensen T; Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark.; Department of Public Health, Institute of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Medicine, Aalborg University, Aalborg, Denmark., Ladenvall C; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Justesen JM; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Käräjämäki A; Department of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland.; Diabetes Center, Vaasa Health Care Center, Vaasa, Finland., Kriebel J; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Rathmann W; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany., Lannfelt L; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden., Lauritzen T; Department of Public Health, Section of General Practice, Aarhus University, Aarhus, Denmark., Narisu N; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Linneberg A; Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark.; Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Melander O; Department of Clinical Sciences, Hypertension and Cardiovascular Disease, Lund University, Malmö, Sweden., Milani L; Estonian Genome Center, University of Tartu, Tartu, Estonia., Neville M; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Orho-Melander M; Department of Clinical Sciences, Diabetes and Cardiovascular Disease, Genetic Epidemiology, Lund University, Malmö, Sweden., Qi L; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Qi Q; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, USA., Roden M; Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Department of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Rolandsson O; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Swift A; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Rosengren AH; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Stirrups K; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Mihailov E; Estonian Genome Center, University of Tartu, Tartu, Estonia., Blancher C; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Carneiro MO; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Maguire J; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Poplin R; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Shakir K; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Fennell T; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., DePristo M; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., de Angelis MH; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Center of Life and Food Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia., Gjesing AP; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jun G; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Nilsson P; Department of Clinical Sciences, Medicine, Lund University, Malmö, Sweden., Murphy J; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Onofrio R; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Thorand B; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Meisinger C; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Hu FB; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA., Isomaa B; Folkhälsan Research Centre, Helsinki, Finland.; Department of Social Services and Health Care, Jakobstad, Finland., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Liang L; Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA., Peters A; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Huth C; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., O'Rahilly SP; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Palmer CNA; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Rauramaa R; Foundation for Research in Health, Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Tuomilehto J; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Center for Vascular Prevention, Danube University Krems, Krems, Austria.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.; Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), University Hospital LaPaz, Autonomous University of Madrid, Madrid, Spain.; National Institute for Health and Welfare, Helsinki, Finland., Salomaa V; National Institute for Health and Welfare, Helsinki, Finland., Watanabe RM; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Department of Physiology & Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Diabetes and Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Syvänen AC; Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Bergman RN; Cedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, California, USA., Bharadwaj D; Functional Genomics Unit, CSIR-Institute of Genomics & Integrative Biology (CSIR-IGIB), New Delhi, India., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, Republic of Korea., Chandak GR; CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India., Chan JCN; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Chia KS; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore., Daly MJ; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Ebrahim SB; Centre for Chronic Disease Control, New Delhi, India., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Elliott P; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK., Jablonski KA; The Biostatistics Center, The George Washington University, Rockville, Maryland, USA., Lehman DM; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Jia W; Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China., Ma RCW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Pollin TI; Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, and Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA., Sandhu M; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Tandon N; Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India., Froguel P; CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK., Barroso I; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore.; Life Sciences Institute, National University of Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore., Zeggini E; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA., Small KS; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Ried JS; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., DeFronzo RA; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Grallert H; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Glaser B; Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Walker M; The Medical School, Institute of Cellular Medicine, Newcastle University, Newcastle, UK., Banks E; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Ingelsson E; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Im HK; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, USA., Illig T; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Hannover Unified Biobank, Hannover Medical School, Hanover, Germany.; Institute for Human Genetics, Hannover Medical School, Hanover, Germany., Franks PW; Department of Clinical Sciences, Lund University Diabetes Centre, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Buck G; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Trakalo J; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Buck D; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Prokopenko I; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK., Mägi R; Estonian Genome Center, University of Tartu, Tartu, Estonia., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Farjoun Y; Data Sciences and Data Engineering, Broad Institute, Cambridge, Massachusetts, USA., Owen KR; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Gloyn AL; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany., Tuomi T; Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Folkhälsan Research Centre, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Kooner JS; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK.; National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK., Lee JY; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Park T; Department of Statistics, Seoul National University, Seoul, Republic of Korea.; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea., Donnelly P; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Statistics, University of Oxford, Oxford, UK., Morris AD; Clinical Research Centre, Centre for Molecular Medicine, Ninewells Hospital and Medical School, Dundee, UK.; The Usher Institute to the Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Hattersley AT; University of Exeter Medical School, University of Exeter, Exeter, UK., Bowden DW; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Atzmon G; Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, USA.; Department of Natural Science, University of Haifa, Haifa, Israel., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Laakso M; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland., Strom TM; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany., Bell GI; Departments of Medicine and Human Genetics, The University of Chicago, Chicago, Illinois, USA., Blangero J; South Texas Diabetes and Obesity Institute, Regional Academic Health Center, University of Texas Rio Grande Valley, Brownsville, Texas, USA., Duggirala R; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; Cardiovascular & Metabolic Disorders Program, Duke-NUS Medical School Singapore, Singapore., McVean G; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Hanis CL; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA., Seielstad M; Department of Laboratory Medicine & Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA.; Blood Systems Research Institute, San Francisco, California, USA., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Meigs JB; General Medicine Division, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Cox NJ; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, USA., Sladek R; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Quebec, Canada., Lander ES; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Gabriel S; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Burtt NP; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany., Groop L; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Abecasis G; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Florez JC; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Morris AP; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Department of Biostatistics, University of Liverpool, Liverpool, UK., Kang HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Altshuler D; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., McCarthy MI; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK.

المصدر: Nature [Nature] 2016 Aug 04; Vol. 536 (7614), pp. 41-47. Date of Electronic Publication: 2016 Jul 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes Mellitus, Type 2/*genetics , Genetic Predisposition to Disease/*genetics , Genetic Variation/*genetics, Alleles ; DNA Mutational Analysis ; Europe/ethnology ; Exome ; Genome-Wide Association Study ; Genotyping Techniques ; Humans ; Sample Size

المؤلفون: Horikoshi M; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Pasquali L; Program of Predictive and Personalized Medicine of Cancer (PMPPC), Germans Trias i Pujol University Hospital and Research Institute, Badalona, Spain, Josep Carreras Leukaemia Research Institute, Badalona, Spain, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain., Wiltshire S; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Huyghe JR; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Mahajan A; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Asimit JL; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Ferreira T; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Locke AE; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Robertson NR; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Wang X; Saw Swee Hock School of Public Health., Sim X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA, Saw Swee Hock School of Public Health., Fujita H; Department of Diabetes and Endocrinology, JR Tokyo General Hospital, Tokyo, Japan., Hara K; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine and., Young R; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK., Zhang W; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK, Department of Epidemiology and Biostatistics., Choi S; Interdisciplinary Program in Bioinformatics and., Chen H; Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA, Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Kaur I; Genomics and Molecular Medicine, CSIR-Institute of Genomics & Integrative Biology, New Delhi, India., Takeuchi F; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Fontanillas P; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Thuillier D; Integrative Genomics and Modelization of Metabolic Diseases CNRS UMR8199, Lille Institute of Biology, E.G.I.D - FR3508 European Genomics Institute of Diabetes, Lille, France., Yengo L; Integrative Genomics and Modelization of Metabolic Diseases CNRS UMR8199, Lille Institute of Biology, E.G.I.D - FR3508 European Genomics Institute of Diabetes, Lille, France., Below JE; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Tam CH; Department of Medicine and Therapeutics., Wu Y, Abecasis G; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Altshuler D; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA, Department of Genetics and Department of Medicine, Harvard Medical School, Boston, MA, USA, Department of Molecular Biology, Diabetes Research Center (Diabetes Unit), Department of Medicine., Bell GI; Departments of Medicine and Human Genetics, University of Chicago, Chicago, IL, USA., Blangero J; Department of Genetics, Texas Biomedical Research Institute, Houston, TX, USA., Burtt NP; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Duggirala R; Department of Genetics, Texas Biomedical Research Institute, Houston, TX, USA., Florez JC; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA, Diabetes Research Center (Diabetes Unit), Department of Medicine, Department of Medicine, Harvard Medical School, Boston, MA, USA, Center for Human Genetic Research, Department of Medicine, and., Hanis CL; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Seielstad M; Blood Systems Research Institute, San Francisco, CA, USA, Department of Laboratory Medicine and Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA., Atzmon G; Department of Natural Science, University of Haifa, Haifa, Israel, Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, USA., Chan JC; Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity, and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China., Ma RC; Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity, and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China., Froguel P; Department of Genomics of Common Disease, School of Public Health, Integrative Genomics and Modelization of Metabolic Diseases CNRS UMR8199, Lille Institute of Biology, E.G.I.D - FR3508 European Genomics Institute of Diabetes, Lille, France., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA., Bharadwaj D; Genomics and Molecular Medicine, CSIR-Institute of Genomics & Integrative Biology, New Delhi, India, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA, National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA., Meigs JB; Department of Medicine, Harvard Medical School, Boston, MA, USA, General Medicine Division, Massachusetts General Hospital, Boston, MA, USA., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, Republic of Korea., Park T; Interdisciplinary Program in Bioinformatics and Department of Statistics, Seoul National University, Seoul, Republic of Korea., Kooner JS; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK, National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College Healthcare NHS Trust, and., Chambers JC; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK, Department of Epidemiology and Biostatistics, Imperial College Healthcare NHS Trust, and., Saleheen D; Department of Biostatistics and Epidemiology, Center for Non-Communicable Diseases, University of Pennsylvania, Philadelphia, PA, USA., Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine and Department of Integrated Molecular Science on Metabolic Diseases, 22nd Century Medical and Research Center, The University of Tokyo, Tokyo, Japan., Tai ES; Saw Swee Hock School of Public Health, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore, Cardiovascular & Metabolic Disorders Program, Duke-NUS Graduate Medical School Singapore, Singapore., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Cox NJ; School of Medicine, Vanderbilt University, Nashville, TN, USA., Ferrer J; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain, Genomic Programming of Beta-cells Laboratory, Institut d'Investigacions August Pi i Sunyer (IDIBAPS), Barcelona, Spain, Department of Medicine, Imperial College London, London, UK., Zeggini E; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Kato N; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Teo YY; Saw Swee Hock School of Public Health, Life Sciences Institute and Department of Statistics and Applied Probability, National University of Singapore, Singapore., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., McCarthy MI; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK, Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK and., Morris AP; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK, Department of Biostatistics, University of Liverpool, Liverpool, UK a.p.morris@liverpool.ac.uk.

مؤلفون مشاركون: T2D-GENES Consortium

المصدر: Human molecular genetics [Hum Mol Genet] 2016 May 15; Vol. 25 (10), pp. 2070-2081. Date of Electronic Publication: 2016 Feb 23.

نوع المنشور: Journal Article; Meta-Analysis

بيانات الدورية: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

مواضيع طبية MeSH: Chromosome Mapping* , Genetic Association Studies* , Genetic Predisposition to Disease*, Diabetes Mellitus, Type 2/*genetics, Black or African American/genetics ; Alleles ; Asian People/genetics ; Cyclin-Dependent Kinase Inhibitor p16 ; Cyclin-Dependent Kinase Inhibitor p18/genetics ; Diabetes Mellitus, Type 2/pathology ; Female ; Humans ; KCNQ1 Potassium Channel/genetics ; Linkage Disequilibrium ; Male ; Polymorphism, Single Nucleotide ; RNA-Binding Proteins/genetics ; Regulatory Elements, Transcriptional/genetics ; White People/genetics ; tRNA Methyltransferases/genetics

المؤلفون: Dager AD; 1] Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USA [2] Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA., McKay DR; 1] Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USA [2] Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA., Kent JW Jr; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA., Curran JE; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA., Knowles E; 1] Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USA [2] Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA., Sprooten E; 1] Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USA [2] Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA., Göring HH; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA., Dyer TD; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA., Pearlson GD; 1] Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USA [2] Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA., Olvera RL; Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, USA., Fox PT; 1] Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX, USA [2] South Texas Veterans Health System, San Antonio, TX, USA., Lovallo WR; Department of Psychiatry, Oklahoma University Heath Science Center and Veterans Administration Medical Center, Oklahoma City, OK, USA., Duggirala R; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA., Almasy L; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA., Blangero J; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA., Glahn DC; 1] Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USA [2] Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

المصدر: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2015 Jan; Vol. 40 (2), pp. 412-20. Date of Electronic Publication: 2014 Jul 31.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Pleiotropy* , Genetic Predisposition to Disease*, Alcohol-Related Disorders/*genetics , Alcohol-Related Disorders/*pathology , Amygdala/*pathology, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Family ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Mexican Americans/genetics ; Middle Aged ; Organ Size ; Risk ; Young Adult

المؤلفون: Kos MZ; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas., Glahn DC, Carless MA, Olvera R, McKay DR, Quillen EE, Gelernter J, Chen XD, Deng HW, Kent JW, Dyer TD, Göring HH, Curran JE, Duggirala R, Blangero J, Almasy L

المصدر: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics [Am J Med Genet B Neuropsychiatr Genet] 2014 Jun; Vol. 165B (4), pp. 294-302. Date of Electronic Publication: 2014 Apr 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101235742 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-485X (Electronic) Linking ISSN: 15524841 NLM ISO Abbreviation: Am J Med Genet B Neuropsychiatr Genet Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Predisposition to Disease*, Alcohol Drinking/*genetics , Alcoholism/*genetics , Chromosomes, Human, Pair 6/*genetics , Quantitative Trait Loci/*genetics, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Endophenotypes ; Female ; Genetic Association Studies ; Genetic Linkage ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Young Adult