المؤلفون: Nelson PT; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky.; Department of Pathology, University of Kentucky, Lexington, Kentucky., Fardo DW; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky.; Department of Biostatistics, University of Kentucky, Lexington, Kentucky., Katsumata Y; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky.; Department of Biostatistics, University of Kentucky, Lexington, Kentucky.

المصدر: Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 2020 Jun 01; Vol. 79 (6), pp. 568-584.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 2985192R Publication Model: Print Cited Medium: Internet ISSN: 1554-6578 (Electronic) Linking ISSN: 00223069 NLM ISO Abbreviation: J Neuropathol Exp Neurol Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Predisposition to Disease* , Polymorphism, Single Nucleotide*, Adaptor Protein Complex 2/*genetics , Adaptor Protein Complex alpha Subunits/*genetics , Alzheimer Disease/*genetics , Mucin-6/*genetics, Alzheimer Disease/pathology ; DNA Copy Number Variations ; Humans

المؤلفون: Katsumata Y; Department of Biostatistics, University of Kentucky, Lexington, KY, 40536-0082, USA. katsumata.yuriko@uky.edu.; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA. katsumata.yuriko@uky.edu., Fardo DW; Department of Biostatistics, University of Kentucky, Lexington, KY, 40536-0082, USA.; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.

المصدر: BMC medical genetics [BMC Med Genet] 2020 May 15; Vol. 21 (1), pp. 106. Date of Electronic Publication: 2020 May 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968552 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2350 (Electronic) Linking ISSN: 14712350 NLM ISO Abbreviation: BMC Med Genet Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Association Studies*/methods , Genetic Predisposition to Disease* , Genetic Variation* , Phenotype*, Alzheimer Disease/*diagnosis , Alzheimer Disease/*genetics, Algorithms ; Alleles ; Alzheimer Disease/metabolism ; Biomarkers ; Humans ; Linkage Disequilibrium ; Models, Genetic ; Models, Statistical ; Neuroimaging/methods ; Reproducibility of Results

المؤلفون: Kunkle BW; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. bkunkle@miami.edu., Grenier-Boley B; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Sims R; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Damotte V; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Naj AC; Department of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Boland A; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Vronskaya M; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., van der Lee SJ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Amlie-Wolf A; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Bellenguez C; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Frizatti A; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Chouraki V; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Martin ER; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Sleegers K; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory for Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Badarinarayan N; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Jakobsdottir J; Icelandic Heart Association, Kopavogur, Iceland., Hamilton-Nelson KL; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Moreno-Grau S; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Olaso R; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Raybould R; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Chen Y; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Kuzma AB; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Morgan T; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Ahmad S; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Vardarajan BN; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., Epelbaum J; UMR 894, Center for Psychiatry and Neuroscience, Inserm, Université Paris Descartes, Paris, France., Hoffmann P; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.; Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland., Boada M; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Beecham GW; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Garnier JG; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Harold D; School of Biotechnology, Dublin City University, Dublin, Ireland., Fitzpatrick AL; Department of Family Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Valladares O; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Moutet ML; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Gerrish A; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Smith AV; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Qu L; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Bacq D; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Denning N; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Jian X; Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA., Zhao Y; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Del Zompo M; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Fox NC; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Choi SH; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain., Mateo I; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Hughes JT; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Adams HH; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Malamon J; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Sanchez-Garcia F; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Patel Y; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Dombroski BA; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Naranjo MCD; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Daniilidou M; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Eiriksdottir G; Icelandic Heart Association, Kopavogur, Iceland., Mukherjee S; Department of Medicine, University of Washington, Seattle, WA, USA., Wallon D; Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France., Uphill J; Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK., Aspelund T; Icelandic Heart Association, Kopavogur, Iceland.; Centre for Public Health, University of Iceland, Reykjavik, Iceland., Cantwell LB; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Garzia F; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Galimberti D; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy.; University of Milan, Centro Dino Ferrari, Milan, Italy., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Butkiewicz M; Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Fin B; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Scarpini E; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy.; University of Milan, Centro Dino Ferrari, Milan, Italy., Sarnowski C; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Bush WS; Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Meslage S; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Kornhuber J; Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany., White CC; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Song Y; Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Barber RC; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA., Engelborghs S; Laboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium., Sordon S; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Voijnovic D; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Adams PM; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Vandenberghe R; Laboratory for Cognitive Neurology, Department of Neurology, University Hospital and University of Leuven, Leuven, Belgium., Mayhaus M; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Cupples LA; Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Albert MS; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA., De Deyn PP; Laboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium., Gu W; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Himali JJ; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Beekly D; National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA., Squassina A; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Hartmann AM; Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany., Orellana A; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain., Blacker D; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Rodriguez-Rodriguez E; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Lovestone S; Department of Psychiatry, University of Oxford, Oxford, UK., Garcia ME; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA., Doody RS; Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX, USA., Munoz-Fernadez C; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Sussams R; Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK., Lin H; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Fairchild TJ; Office of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, TX, USA., Benito YA; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Holmes C; Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK., Karamujić-Čomić H; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Frosch MP; C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, MA, USA., Thonberg H; Theme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden.; Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Research Center, Division of Neurogeriatrics, Solna, Sweden., Maier W; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Roshchupkin G; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Ghetti B; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA., Giedraitis V; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Kawalia A; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany., Li S; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Huebinger RM; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA., Kilander L; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany., Hernández I; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Kamboh MI; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA., Brundin R; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Turton J; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Yang Q; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Katz MJ; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA., Concari L; Section of Neuroscience, DIMEC-University of Parma, Parma, Italy.; FERB-Alzheimer Center, Gazzaniga (Bergamo), Italy., Lord J; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Beiser AS; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Keene CD; Department of Pathology, University of Washington, Seattle, WA, USA., Helisalmi S; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Kloszewska I; Elderly and Psychiatric Disorders Department, Medical University of Lodz, Lodz, Poland., Kukull WA; Department of Epidemiology, University of Washington, Seattle, WA, USA., Koivisto AM; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Lynch A; Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.; St. James's Hospital and Trinity College, Dublin, Ireland., Tarraga L; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Larson EB; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Haapasalo A; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Lawlor B; Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.; St. James's Hospital and Trinity College, Dublin, Ireland., Mosley TH; Departments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, MS, USA., Lipton RB; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA., Solfrizzi V; Interdisciplinary Department of Medicine, Geriatric Medicine and Memory Unity, University of Bari, Bari, Italy., Gill M; Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.; St. James's Hospital and Trinity College, Dublin, Ireland., Longstreth WT Jr; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Neurology, University of Washington, Seattle, WA, USA., Montine TJ; Department of Pathology, University of Washington, Seattle, WA, USA., Frisardi V; Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy., Diez-Fairen M; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain., Rivadeneira F; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdamt, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Deramecourt V; CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France., Alvarez I; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain., Salani F; Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Ciaramella A; Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Boerwinkle E; School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Reiman EM; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.; Arizona Alzheimer's Consortium, Phoenix, AZ, USA.; Banner Alzheimer's Institute, Phoenix, AZ, USA.; Department of Psychiatry, University of Arizona, Phoenix, AZ, USA., Fievet N; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Rotter JI; Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Reisch JS; Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA., Hanon O; University Paris Descartes, EA 4468, AP-HP, Geriatrics Department, Hôpital Broca, Paris, France., Cupidi C; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Andre Uitterlinden AG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdamt, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands., Royall DR; Departments of Psychiatry, Medicine, Family & Community Medicine, South Texas Veterans Health Administration Geriatric Research Education & Clinical Center (GRECC), UT Health Science Center at San Antonio, San Antonio, TX, USA., Dufouil C; University of Bordeaux, Inserm 1219, Bordeaux, France.; Department of Neurology, Bordeaux University Hospital / CHU de Bordeaux, Bordeaux, France., Maletta RG; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., de Rojas I; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Sano M; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Brice A; Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.; AP-HP, Department of Genetics, Pitié-Salpêtrière Hospital, Paris, France., Cecchetti R; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., George-Hyslop PS; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada., Ritchie K; Inserm U1061 Neuropsychiatry, La Colombière Hospital, Montpellier, France.; Montpellier University, Montpellier, France.; Department of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Tsolaki M; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Tsuang DW; VA Puget Sound Health Care System/>GRECC, Seattle, WA, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA., Dubois B; Institut de la Mémoire et de la Maladie d'Alzheimer and Institut du Cerveau et de la Moelle Épinière, Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France.; Institut des Neurosciences Translationnelles de Paris, Institut du Cerveau et de la Moelle Épinière, Paris, France.; Inserm, CNRS, UMR-S975, Institut du Cerveau et de la Moelle Epinière, Paris, France.; Sorbonne Universités, Université Pierre et Marie Curie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France., Craig D; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Wu CK; Departments of Neurology, Pharmacology & Neuroscience, Texas Tech University Health Science Center, Lubbock, TX, USA., Soininen H; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Avramidou D; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Albin RL; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.; Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, MI, USA.; Michigan Alzheimer Disease Center, Ann Arbor, MI, USA., Fratiglioni L; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Germanou A; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Apostolova LG; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.; Department of Neurology, Indiana University, Indianapolis, IN, USA.; Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, USA., Keller L; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Koutroumani M; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Arnold SE; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Panza F; Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy., Gkatzima O; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Asthana S; Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, WI, USA.; Department of Medicine, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA., Hannequin D; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Whitehead P; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Atwood CS; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.; Department of Neurology, Indiana University, Indianapolis, IN, USA.; Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, USA., Caffarra P; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Hampel H; AXA Research Fund & Sorbonne University Chair, Paris, France.; Sorbonne University, GRC n° 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Paris, France.; Brain & Spine Institute, Inserm U 1127, CNRS UMR 7225, Paris, France.; Institute of Memory and Alzheimer's Disease, Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France., Quintela I; Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Santiago de Compostela, Spain., Carracedo Á; Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Santiago de Compostela, Spain., Lannfelt L; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Rubinsztein DC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge, UK., Barnes LL; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Pasquier F; CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France., Frölich L; Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany., Barral S; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., McGuinness B; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Beach TG; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, AZ, USA., Johnston JA; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Becker JT; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Passmore P; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Bigio EH; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Schott JM; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Bird TD; Department of Neurology, University of Washington, Seattle, WA, USA.; VA Puget Sound Health Care System/>GRECC, Seattle, WA, USA., Warren JD; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Lupton MK; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Bowen JD; Swedish Medical Center, Seattle, WA, USA., Proitsi P; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Boxer A; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Powell JF; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Burke JR; Department of Neurology, Duke University, Durham, NC, USA., Kauwe JSK; Departments of Biology, Brigham Young University, Provo, UT, USA., Burns JM; University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, USA., Mancuso M; Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy., Buxbaum JD; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bonuccelli U; Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy., Cairns NJ; Department of Pathology and Immunology, Washington University, St. Louis, MO, USA., McQuillin A; Division of Psychiatry, University College London, London, UK., Cao C; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA., Livingston G; Division of Psychiatry, University College London, London, UK., Carlson CS; Department of Medicine, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA., Bass NJ; Division of Psychiatry, University College London, London, UK., Carlsson CM; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Hardy J; Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK., Carney RM; Mental Health & Behavioral Science Service, Bruce W. Carter VA Medical Center, Miami, FL, USA., Bras J; UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Carrasquillo MM; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Guerreiro R; UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Allen M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Chui HC; Department of Neurology, University of Southern California, Los Angeles, CA, USA., Fisher E; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Masullo C; Department of Neurology, Catholic University of Rome, Rome, Italy., Crocco EA; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA., DeCarli C; Department of Neurology, University of California, Davis, Sacramento, CA, USA., Bisceglio G; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Dick M; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA., Ma L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Duara R; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA., Graff-Radford NR; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Evans DA; Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA., Hodges A; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Faber KM; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA., Scherer M; Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Fallon KB; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA., Riemenschneider M; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Fardo DW; Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, KY, USA., Heun R; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Farlow MR; Department of Neurology, Indiana University, Indianapolis, IN, USA., Kölsch H; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Ferris S; Department of Psychiatry, New York University, New York, NY, USA., Leber M; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Foroud TM; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA., Heuser I; Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany., Galasko DR; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA., Giegling I; Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany., Gearing M; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.; Emory Alzheimer's Disease Center, Emory University, Atlanta, GA, USA., Hüll M; Department of Psychiatry, University of Freiburg, Freiburg, Germany., Geschwind DH; Neurogenetics Program, University of California, Los Angeles, Los Angeles, CA, USA., Gilbert JR; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Morris J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA., Green RC; Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Mayo K; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; Department of Neurology, Washington University, St. Louis, MO, USA.; Department of Genetics, Washington University, St. Louis, MO, USA., Growdon JH; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Feulner T; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Hamilton RL; Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, PA, USA., Harrell LE; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Drichel D; Cologne Center for Genomics, University of Cologne, Cologne, Germany., Honig LS; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA., Cushion TD; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Huentelman MJ; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA., Hollingworth P; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Hulette CM; Department of Pathology, Duke University, Durham, NC, USA., Hyman BT; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Marshall R; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Jarvik GP; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA., Meggy A; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Abner E; Sanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, KY, USA., Menzies GE; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Jin LW; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Leonenko G; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Real LM; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Jun GR; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Baldwin CT; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Grozeva D; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Karydas A; Swedish Medical Center, Seattle, WA, USA., Russo G; Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland., Kaye JA; Department of Neurology, Oregon Health &Science University, Portland, OR, USA.; Department of Neurology, Portland Veterans Affairs Medical Center, Portland, OR, USA., Kim R; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA., Jessen F; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Kowall NW; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Pathology, Boston University School of Medicine, Boston University, Boston, MA, USA., Vellas B; Inserm U558, University of Toulouse, Toulouse, France., Kramer JH; Department of Neuropsychology, University of California San Francisco, San Francisco, CA, USA., Vardy E; Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK., LaFerla FM; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA., Jöckel KH; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany., Lah JJ; Department of Neurology, Emory University, Atlanta, GA, USA., Dichgans M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases, Munich, Germany., Leverenz JB; Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA., Mann D; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., Levey AI; Department of Neurology, Emory University, Atlanta, GA, USA., Pickering-Brown S; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., Lieberman AP; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Klopp N; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Munich, Germany., Lunetta KL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Wichmann HE; Helmholtz Center Munich, Institute of Epidemiology, Neuherberg, Munich, Germany.; Ludwig-Maximilians University Chair of Epidemiology, Munich, Germany.; Joint Biobank Munich and KORA Biobank, Baltimore, MD, USA., Lyketsos CG; Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA., Morgan K; Human Genetics, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK., Marson DC; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Brown K; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Martiniuk F; Department of Medicine-Pulmonary, New York University, New York, NY, USA., Medway C; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Mash DC; Department of Neurology, University of Miami, Miami, FL, USA., Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Masliah E; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.; Department of Pathology, University of California, San Diego, La Jolla, CA, USA., Hooper NM; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., McCormick WC; Department of Medicine, University of Washington, Seattle, WA, USA., Daniele A; Institute of Neurology, Catholic University of Sacred Hearth, Rome, Italy., McCurry SM; School of Nursing Northwest Research Group on Aging, University of Washington, Seattle, WA, USA., Bayer A; Institute of Primary Care and Public Health, Cardiff University, University Hospital of Wales, Cardiff, UK., McDavid AN; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA., Gallacher J; Department of Psychiatry, University of Oxford, Oxford, UK., McKee AC; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Pathology, Boston University School of Medicine, Boston University, Boston, MA, USA., van den Bussche H; Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Mesulam M; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Brayne C; Cambridge Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK., Miller BL; Weill Institute for Neurosciences, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Riedel-Heller S; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany., Miller CA; Department of Pathology, University of Southern California, Los Angeles, CA, USA., Miller JW; Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, USA., Al-Chalabi A; Institute of Psychiatry, Psychology and Neuroscienceó, King's College London, London, UK., Morris JC; Department of Pathology and Immunology, Washington University, St. Louis, MO, USA.; Department of Neurology, Washington University, St. Louis, MO, USA., Shaw CE; Institute of Psychiatry, Psychology and Neuroscienceó, King's College London, London, UK.; UK Dementia Research Institute, King's College London, London, UK., Myers AJ; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; German Center for Neurodegenerative Diseases, Goettingen, Germany.; IBiMED, Medical Sciences Department, University of Aveiro, Aveiro, Portugal., O'Bryant S; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA., Olichney JM; Department of Neurology, University of California, Davis, Sacramento, CA, USA., Alvarez V; Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain., Parisi JE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Singleton AB; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Paulson HL; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.; Michigan Alzheimer Disease Center, Ann Arbor, MI, USA., Collinge J; Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK., Perry WR; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Mead S; Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK., Peskind E; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA., Cribbs DH; Department of Neurology, University of California, Irvine, Irvine, CA, USA., Rossor M; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Pierce A; Department of Neurology, University of California, Irvine, Irvine, CA, USA., Ryan NS; Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK., Poon WW; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA., Nacmias B; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy., Potter H; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA., Sorbi S; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Quinn JF; Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA., Sacchinelli E; Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Raj A; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA., Spalletta G; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.; Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA., Raskind M; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA., Caltagirone C; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Bossù P; Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Orfei MD; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Reisberg B; Department of Psychiatry, New York University, New York, NY, USA.; Alzheimer's Disease Center, New York University, New York, NY, USA., Clarke R; Oxford Healthy Aging Project, Clinical Trial Service Unit, University of Oxford, Oxford, UK., Reitz C; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Epidemiology, Columbia University, New York, NY, USA., Smith AD; Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK., Ringman JM; Department of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, Los Angeles, CA, USA., Warden D; Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK., Roberson ED; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Wilcock G; Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK., Rogaeva E; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada., Bruni AC; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Rosen HJ; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Gallo M; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Rosenberg RN; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Ben-Shlomo Y; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Sager MA; Department of Medicine, University of Wisconsin, Madison, WI, USA., Mecocci P; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., Saykin AJ; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Neurology, Indiana University, Indianapolis, IN, USA., Pastor P; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain., Cuccaro ML; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Vance JM; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Schneider JA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Pathology (Neuropathology), Rush University Medical Center, Chicago, IL, USA., Schneider LS; Department of Neurology, University of Southern California, Los Angeles, CA, USA.; Department of Psychiatry, University of Southern California, Los Angeles, CA, USA., Slifer S; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Seeley WW; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Smith AG; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA., Sonnen JA; Department of Pathology, University of Washington, Seattle, WA, USA., Spina S; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA., Stern RA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Swerdlow RH; University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, USA., Tang M; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Tanzi RE; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Trojanowski JQ; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Troncoso JC; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA., Van Deerlin VM; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Van Eldik LJ; Sanders-Brown Center on Aging, Department of Neuroscience, University of Kentucky, Lexington, KY, USA., Vinters HV; Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Vonsattel JP; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University, New York, NY, USA., Weintraub S; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Welsh-Bohmer KA; Department of Neurology, Duke University, Durham, NC, USA.; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA., Wilhelmsen KC; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Williamson J; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA., Wingo TS; Department of Neurology, Emory University, Atlanta, GA, USA.; Department of Human Genetics, Emory University, Atlanta, GA, USA., Woltjer RL; Department of Pathology, Oregon Health & Science University, Portland, OR, USA., Wright CB; National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Yu CE; Department of Medicine, University of Washington, Seattle, WA, USA., Yu L; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Saba Y; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria., Pilotto A; Gerontology and Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.; Department Geriatric Care, Orthogeriatrics and Rehabilitation, Galliera Hospital, Genova, Italy., Bullido MJ; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.; IdiPAZ, Instituto de Investigación Sanitaria la Paz, Madrid, Spain.; Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain., Peters O; Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany.; German Center for Neurodegenerative Diseases, Berlin, Germany., Crane PK; Department of Medicine, University of Washington, Seattle, WA, USA., Bennett D; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Bosco P; Instituto di Ricovero e Cura a Carattere Scientifico, Associazione Oasi Maria Santissima Srl, Troina, Italy., Coto E; Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain., Boccardi V; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., De Jager PL; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA., Lleo A; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University Barcelona, Barcelona, Spain., Warner N; Somerset Partnership NHS Trust, Somerset, UK., Lopez OL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA., Ingelsson M; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Deloukas P; The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA., Graff C; Theme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden.; Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Research Center, Division of Neurogeriatrics, Solna, Sweden., Gwilliam R; The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK., Fornage M; Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA., Goate AM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sanchez-Juan P; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Kehoe PG; University of Bristol Medical School, Learning & Research level 2, Southmead Hospital, Bristol, UK., Amin N; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Ertekin-Taner N; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Berr C; Inserm U1061 Neuropsychiatry, La Colombière Hospital, Montpellier, France.; Montpellier University, Montpellier, France., Debette S; Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.; AP-HP, Department of Genetics, Pitié-Salpêtrière Hospital, Paris, France., Love S; University of Bristol Medical School, Learning & Research level 2, Southmead Hospital, Bristol, UK., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA., Younkin SG; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Dartigues JF; Memory Research and Resources Center, CMRR de Bordeaux, Bordeaux, France., Corcoran C; Utah State University, Logan, UT, USA., Ikram MA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Departments of Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Nicolas G; Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France., Campion D; Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France.; Department of Research Rouvray Psychiatric Hospital, Sotteville-lès-Rouen, France., Tschanz J; Utah State University, Logan, UT, USA., Schmidt H; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria.; Department of Neurology, Medical University Graz, Graz, Austria., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Clarimon J; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University Barcelona, Barcelona, Spain., Munger R; Utah State University, Logan, UT, USA., Schmidt R; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria., Farrer LA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.; Department of Ophthalmology, Boston University School of Medicine, Boston University, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA., Van Broeckhoven C; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory for Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., C O'Donovan M; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., DeStefano AL; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Jones L; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Haines JL; Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Deleuze JF; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Owen MJ; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Mayeux R; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., Escott-Price V; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente, Washington Health Research Institute, Seattle, WA, USA., Ramirez A; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Wang LS; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Ruiz A; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., van Duijn CM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Holmans PA; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Seshadri S; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA., Williams J; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Amouyel P; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.; Centre Hospitalier Universitaire de Lille, Lille, France., Schellenberg GD; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Lambert JC; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France. jean-charles.lambert@pasteur-lille.fr.; Institut Pasteur de Lille, Lille, France. jean-charles.lambert@pasteur-lille.fr.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France. jean-charles.lambert@pasteur-lille.fr., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. mpericak@miami.edu.

مؤلفون مشاركون: Alzheimer Disease Genetics Consortium (ADGC),, European Alzheimer’s Disease Initiative (EADI),, Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE),, Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES),

المصدر: Nature genetics [Nat Genet] 2019 Mar; Vol. 51 (3), pp. 414-430. Date of Electronic Publication: 2019 Feb 28.

نوع المنشور: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease/*genetics , Amyloid beta-Peptides/*genetics , Genetic Loci/*genetics , Genetic Predisposition to Disease/*genetics , Immunity/*genetics , Lipids/*genetics , tau Proteins/*genetics, Aged ; Case-Control Studies ; Female ; Genetic Testing/methods ; Genome-Wide Association Study/methods ; Haplotypes/genetics ; Humans ; Lipid Metabolism/genetics ; Male

المؤلفون: Mez J; Alzheimer's Disease Center, Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Mukherjee S; Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA, USA., Thornton T; Department of Biostatistics, University of Washington, Seattle, WA, USA., Fardo DW; Department of Biostatistics, University of Kentucky College of Public Health, Lexington, KY, USA., Trittschuh E; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA., Sutti S; G2P Program, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Sherva R; Biomedical Genetics, Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Kauwe JS; Department of Biology, Brigham Young University, Provo, UT, USA., Naj AC; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Beecham GW; Miller School of Medicine, Hussman Institute for Human Genomics and Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, FL, USA., Gross A; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA., Saykin AJ; IU Health Neuroscience Center, Department of Radiology, Indiana University, Indianapolis, IN, USA., Green RC; G2P Program, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Crane PK; Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address: pcrane@uw.edu.

مؤلفون مشاركون: Executive Prominent Alzheimer's Disease: Genetics and Risk Factors (EPAD:GRF), Alzheimer's Disease Neuroimaging Initiative (ADNI1), Alzheimer's Disease Genetics Consortium (ADGC)

المصدر: Neurobiology of aging [Neurobiol Aging] 2016 May; Vol. 41, pp. 115-121. Date of Electronic Publication: 2016 Feb 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 8100437 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-1497 (Electronic) Linking ISSN: 01974580 NLM ISO Abbreviation: Neurobiol Aging Subsets: MEDLINE

مواضيع طبية MeSH: Executive Function* , Memory*, Alzheimer Disease/*genetics , Alzheimer Disease/*psychology , Genetic Predisposition to Disease/*genetics, Aged ; Aged, 80 and over ; Chromosomes/genetics ; Databases, Genetic ; Female ; Humans ; Male ; Phenotype ; Polymorphism, Single Nucleotide

المؤلفون: Malik M; Department of Physiology and Sanders-Brown Center on Aging, University of Kentucky, 800 S. Limestone St, Lexington, KY, 40536, USA. manasi.malik@uky.edu., Parikh I; Department of Physiology and Sanders-Brown Center on Aging, University of Kentucky, 800 S. Limestone St, Lexington, KY, 40536, USA. ishita.parikh@uky.edu., Vasquez JB; Department of Physiology and Sanders-Brown Center on Aging, University of Kentucky, 800 S. Limestone St, Lexington, KY, 40536, USA. jared.vasquez@uky.edu., Smith C; Department of Anatomy and Cell Biology, University of Illinois, Chicago, IL, USA. conorsm@uic.edu., Tai L; Department of Anatomy and Cell Biology, University of Illinois, Chicago, IL, USA. leontai@uic.edu., Bu G; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. bu.guojun@mayo.edu., LaDu MJ; Department of Anatomy and Cell Biology, University of Illinois, Chicago, IL, USA. mladu@uic.edu., Fardo DW; Department of Biostatistics and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA. david.fardo@uky.edu., Rebeck GW; Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA. bill.rebeck@georgetown.edu., Estus S; Department of Physiology and Sanders-Brown Center on Aging, University of Kentucky, 800 S. Limestone St, Lexington, KY, 40536, USA. steve.estus@uky.edu.

المصدر: Molecular neurodegeneration [Mol Neurodegener] 2015 Oct 05; Vol. 10, pp. 52. Date of Electronic Publication: 2015 Oct 05.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Predisposition to Disease*, Alzheimer Disease/*genetics , Inflammation/*genetics , Microglia/*pathology , Polymorphism, Single Nucleotide/*genetics, Alzheimer Disease/pathology ; Animals ; Humans ; Risk Factors

المؤلفون: Parikh I, Medway C, Younkin S, Fardo DW, Estus S; Departments of Physiology, Sanders-Brown Center on Aging, University of Kentucky, 800 S, Limestone St,, Lexington, KY 40536, USA. Steve.estus@uky.edu.

المصدر: Molecular neurodegeneration [Mol Neurodegener] 2014 Aug 29; Vol. 9, pp. 32. Date of Electronic Publication: 2014 Aug 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE

مواضيع طبية MeSH: Polymorphism, Single Nucleotide*, Alzheimer Disease/*genetics , Genetic Predisposition to Disease/*genetics , Introns/*genetics , Monomeric Clathrin Assembly Proteins/*genetics, Aged, 80 and over ; Alleles ; Allelic Imbalance/genetics ; Female ; Genome-Wide Association Study ; Genotype ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Protein Isoforms/genetics ; Reverse Transcriptase Polymerase Chain Reaction

المؤلفون: Malik M; Department of Physiology, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536, USA., Simpson JF, Parikh I, Wilfred BR, Fardo DW, Nelson PT, Estus S

المصدر: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2013 Aug 14; Vol. 33 (33), pp. 13320-5.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Polymorphism, Single Nucleotide*, Alternative Splicing/*genetics , Alzheimer Disease/*genetics , Exons/*genetics , Genetic Predisposition to Disease/*genetics , Sialic Acid Binding Ig-like Lectin 3/*genetics, Genotype ; Humans ; Immunohistochemistry ; Promoter Regions, Genetic/genetics ; Protein Isoforms/genetics ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Risk Factors

المؤلفون: Xicota, Laura, Cosentino, Stephanie, Vardarajan, Badri, Mayeux, Richard, Perls, Thomas T, Andersen, Stacy L, Zmuda, Joseph M, Thyagarajan, Bharat, Yashin, Anatoli, Wojczynski, Mary K, Krinsky‐McHale, Sharon, Handen, Benjamin L, Christian, Bradley T, Head, Elizabeth, Mapstone, Mark E, Schupf, Nicole, Lee, Joseph H, Barral, Sandra, Study, the Long‐Life Family, Abner, Erin, Adams, Perrie M, Aguirre, Alyssa, Albert, Marilyn S, Albin, Roger L, Allen, Mariet, Alvarez, Lisa, Andrews, Howard, Apostolova, Liana G, Arnold, Steven E, Asthana, Sanjay, Atwood, Craig S, Ayres, Gayle, Barber, Robert C, Barnes, Lisa L, Bartlett, Jackie, Beach, Thomas G, Becker, James T, Beecham, Gary W, Benchek, Penelope, Bennett, David A, Bertelson, John, Biber, Sarah A, Bird, Thomas D, Blacker, Deborah, Boeve, Bradley F, Bowen, James D, Boxer, Adam, Brewer, James B, Burke, James R, Burns, Jeffrey M, Bush, William S, Buxbaum, Joseph D, Byrd, Goldie, Cantwell, Laura B, Cao, Chuanhai, Carlsson, Cynthia M, Carrasquillo, Minerva M, Chan, Kwun C, Chasse, Scott, Chen, Yen‐Chi, Chesselet, Marie‐Francoise, Chin, Nathaniel A, Chui, Helena C, Chung, Jaeyoon, Craft, Suzanne, Crane, Paul K, Cranney, Marissa, Cruchaga, Carlos, Cuccaro, Michael L, Culhane, Jessica, Cullum, C Munro, Darby, Eveleen, Davis, Barbara, De Jager, Philip L, DeCarli, Charles, DeToledo, John C, Dickson, Dennis W, Dobbins, Nic, Duara, Ranjan, Ertekin‐Taner, Nilufer, Evans, Denis A, Faber, Kelley M, Fairchild, Thomas J, Fallin, Daniele, Fallon, Kenneth B, Fardo, David W, Farlow, Martin R, Farrell, John, Farrer, Lindsay A, Fernandez‐Hernandez, Victoria, Foroud, Tatiana M, Frosch, Matthew P, Galasko, Douglas R, Gamboa, Adriana, Gauthreaux, Kathryn M, Gefen, Tamar, Geschwind, Daniel H, Ghetti, Bernardino, Gilbert, John R

المصدر: Alzheimer's & Dementia. 20(4)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Biological Psychology, Clinical Sciences, Neurosciences, Psychology, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Acquired Cognitive Impairment, Neurodegenerative, Brain Disorders, Dementia, Alzheimer's Disease, Human Genome, Biotechnology, Aging, Genetics, 2.1 Biological and endogenous factors, Aetiology, Neurological, Humans, Alzheimer Disease, Amyloid beta-Peptides, Genetic Predisposition to Disease, Genome-Wide Association Study, Microtubule-Associated Proteins, Polymorphism, Single Nucleotide, Sequence Analysis, genetic risk, late-onset Alzheimer's disease, microtubule protein, MTUS2 gene, whole genome sequence, Long‐Life Family Study, Alzheimer's Disease Genetic Consortium, Alzheimer's Biomarkers Consortium‐Down Syndrome, late‐onset Alzheimer's disease, Geriatrics, Clinical sciences, Biological psychology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8h4405s2

المؤلفون: Prokopenko, Dmitry, Lee, Sanghun, Hecker, Julian, Mullin, Kristina, Morgan, Sarah, Katsumata, Yuriko, Weiner, Michael W, Fardo, David W, Laird, Nan, Bertram, Lars, Hide, Winston, Lange, Christoph, Tanzi, Rudolph E

المصدر: Molecular Psychiatry. 27(4)

مصطلحات موضوعية: Aging, Genetics, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Biotechnology, Acquired Cognitive Impairment, Human Genome, Neurodegenerative, Alzheimer's Disease, Dementia, Brain Disorders, 2.1 Biological and endogenous factors, Aetiology, Neurological, Good Health and Well Being, Alzheimer Disease, Dithionitrobenzoic Acid, Dystrophin-Associated Proteins, Genetic Predisposition to Disease, Genome-Wide Association Study, Genomics, Guanylate Kinases, Humans, Neuropeptides, Polymorphism, Single Nucleotide, Tumor Suppressor Proteins, Whole Genome Sequencing, Alzheimer’s Disease Neuroimaging Initiative, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/7896h0b3

المؤلفون: Sims, Rebecca, Van Der Lee, Sven J, Naj, Adam C, Bellenguez, Céline, Badarinarayan, Nandini, Jakobsdottir, Johanna, Kunkle, Brian W, Boland, Anne, Raybould, Rachel, Bis, Joshua C, Martin, Eden R, Grenier-Boley, Benjamin, Heilmann-Heimbach, Stefanie, Chouraki, Vincent, Kuzma, Amanda B, Sleegers, Kristel, Vronskaya, Maria, Ruiz, Agustin, Graham, Robert R, Olaso, Robert, Hoffmann, Per, Grove, Megan L, Vardarajan, Badri N, Hiltunen, Mikko, Nöthen, Markus M, White, Charles C, Hamilton-Nelson, Kara L, Epelbaum, Jacques, Maier, Wolfgang, Choi, Seung-Hoan, Beecham, Gary W, Dulary, Cécile, Herms, Stefan, Smith, Albert V, Funk, Cory C, Derbois, Céline, Forstner, Andreas J, Ahmad, Shahzad, Li, Hongdong, Bacq, Delphine, Harold, Denise, Satizabal, Claudia L, Valladares, Otto, Squassina, Alessio, Thomas, Rhodri, Brody, Jennifer A, Qu, Liming, Sánchez-Juan, Pascual, Morgan, Taniesha, Wolters, Frank J, Zhao, Yi, Garcia, Florentino Sanchez, Denning, Nicola, Fornage, Myriam, Malamon, John, Naranjo, Maria Candida Deniz, Majounie, Elisa, Mosley, Thomas H, Dombroski, Beth, Wallon, David, Lupton, Michelle K, Dupuis, Josée, Whitehead, Patrice, Fratiglioni, Laura, Medway, Christopher, Jian, Xueqiu, Mukherjee, Shubhabrata, Keller, Lina, Brown, Kristelle, Lin, Honghuang, Cantwell, Laura B, Panza, Francesco, McGuinness, Bernadette, Moreno-Grau, Sonia, Burgess, Jeremy D, Solfrizzi, Vincenzo, Proitsi, Petra, Adams, Hieab H, Allen, Mariet, Seripa, Davide, Pastor, Pau, Cupples, L Adrienne, Price, Nathan D, Hannequin, Didier, Frank-García, Ana, Levy, Daniel, Chakrabarty, Paramita, Caffarra, Paolo, Giegling, Ina, Beiser, Alexa S, Giedraitis, Vilmantas, Hampel, Harald, Garcia, Melissa E, Wang, Xue, Lannfelt, Lars, Mecocci, Patrizia, Eiriksdottir, Gudny, Crane, Paul K, Pasquier, Florence, Boccardi, Virginia, Henández, Isabel, Barber, Robert C, Scherer, Martin, Tarraga, Lluis, Adams, Perrie M, Leber, Markus, Chen, Yuning, Albert, Marilyn S, Riedel-Heller, Steffi, Emilsson, Valur, Beekly, Duane, Braae, Anne, Schmidt, Reinhold, Blacker, Deborah, Masullo, Carlo, Schmidt, Helena, Doody, Rachelle S, Spalletta, Gianfranco, Longstreth, WT, Fairchild, Thomas J, Bossù, Paola, Lopez, Oscar L, Frosch, Matthew P, Sacchinelli, Eleonora, Ghetti, Bernardino, Yang, Qiong, Huebinger, Ryan M, Jessen, Frank, Li, Shuo, Kamboh, M Ilyas, Morris, John, Sotolongo-Grau, Oscar, Katz, Mindy J, Corcoran, Chris, Dunstan, Melanie, Braddel, Amy, Thomas, Charlene, Meggy, Alun, Marshall, Rachel, Gerrish, Amy, Chapman, Jade, Aguilar, Miquel, Taylor, Sarah, Hill, Matt, Fairén, Mònica Díez, Hodges, Angela, Vellas, Bruno, Soininen, Hilkka, Kloszewska, Iwona, Daniilidou, Makrina, Uphill, James, Patel, Yogen, Hughes, Joseph T, Lord, Jenny, Turton, James, Hartmann, Annette M, Cecchetti, Roberta, Fenoglio, Chiara, Serpente, Maria, Arcaro, Marina, Caltagirone, Carlo, Orfei, Maria Donata, Ciaramella, Antonio, Pichler, Sabrina, Mayhaus, Manuel, Gu, Wei, Lleó, Alberto, Fortea, Juan, Blesa, Rafael, Barber, Imelda S, Brookes, Keeley, Cupidi, Chiara, Maletta, Raffaele Giovanni, Carrell, David, Sorbi, Sandro, Moebus, Susanne, Urbano, Maria, Pilotto, Alberto, Kornhuber, Johannes, Bosco, Paolo, Todd, Stephen, Craig, David, Johnston, Janet, Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Fox, Nick C, Hardy, John, ARUK Consortium, Albin, Roger L, Apostolova, Liana G, Arnold, Steven E, Asthana, Sanjay, Atwood, Craig S, Baldwin, Clinton T, Barnes, Lisa L, Barral, Sandra, Beach, Thomas G, Becker, James T, Bigio, Eileen H, Bird, Thomas D, Boeve, Bradley F, Bowen, James D, Boxer, Adam, Burke, James R, Burns, Jeffrey M, Buxbaum, Joseph D, Cairns, Nigel J, Cao, Chuanhai, Carlson, Chris S, Carlsson, Cynthia M, Carney, Regina M, Carrasquillo, Minerva M, Carroll, Steven L, Diaz, Carolina Ceballos, Chui, Helena C, Clark, David G, Cribbs, David H, Crocco, Elizabeth A, DeCarli, Charles, Dick, Malcolm, Duara, Ranjan, Evans, Denis A, Faber, Kelley M, Fallon, Kenneth B, Fardo, David W, Farlow, Martin R, Ferris, Steven, Foroud, Tatiana M, Galasko, Douglas R, Gearing, Marla, Geschwind, Daniel H, Gilbert, John R, Graff-Radford, Neill R, Green, Robert C, Growdon, John H, Hamilton, Ronald L, Harrell, Lindy E, Honig, Lawrence S, Huentelman, Matthew J, Hulette, Christine M, Hyman, Bradley T, Jarvik, Gail P, Abner, Erin, Jin, Lee-Way, Jun, Gyungah, Karydas, Anna, Kaye, Jeffrey A, Kim, Ronald, Kowall, Neil W, Kramer, Joel H, LaFerla, Frank M, Lah, James J, Leverenz, James B, Levey, Allan I, Li, Ge, Lieberman, Andrew P, Lunetta, Kathryn L, Lyketsos, Constantine G, Marson, Daniel C, Martiniuk, Frank, Mash, Deborah C, Masliah, Eliezer, McCormick, Wayne C, McCurry, Susan M, McDavid, Andrew N, McKee, Ann C, Mesulam, Marsel, Miller, Bruce L, Miller, Carol A, Miller, Joshua W, Morris, John C, Murrell, Jill R, Myers, Amanda J, O'Bryant, Sid, Olichney, John M, Pankratz, Vernon S, Parisi, Joseph E, Paulson, Henry L, Perry, William, Peskind, Elaine, Pierce, Aimee, Poon, Wayne W, Potter, Huntington, Quinn, Joseph F, Raj, Ashok, Raskind, Murray, Reisberg, Barry, Reitz, Christiane, Ringman, John M, Roberson, Erik D, Rogaeva, Ekaterina, Rosen, Howard J, Rosenberg, Roger N, Sager, Mark A, Saykin, Andrew J, Schneider, Julie A, Schneider, Lon S, Seeley, William W, Smith, Amanda G, Sonnen, Joshua A, Spina, Salvatore, Stern, Robert A, Swerdlow, Russell H, Tanzi, Rudolph E, Thornton-Wells, Tricia A, Trojanowski, John Q, Troncoso, Juan C, Van Deerlin, Vivianna M, Van Eldik, Linda J, Vinters, Harry V, Vonsattel, Jean Paul, Weintraub, Sandra, Welsh-Bohmer, Kathleen A, Wilhelmsen, Kirk C, Williamson, Jennifer, Wingo, Thomas S, Woltjer, Randall L, Wright, Clinton B, Yu, Chang-En, Yu, Lei, Garzia, Fabienne, Golamaully, Feroze, Septier, Gislain, Engelborghs, Sebastien, Vandenberghe, Rik, De Deyn, Peter P, Fernadez, Carmen Muñoz, Benito, Yoland Aladro, Thonberg, Hakan, Forsell, Charlotte, Lilius, Lena, Kinhult-Stählbom, Anne, Kilander, Lena, Brundin, RoseMarie, Concari, Letizia, Helisalmi, Seppo, Koivisto, Anne Maria, Haapasalo, Annakaisa, Dermecourt, Vincent, Fievet, Nathalie, Hanon, Olivier, Dufouil, Carole, Brice, Alexis, Ritchie, Karen, Dubois, Bruno, Himali, Jayanadra J, Keene, C Dirk, Tschanz, JoAnn, Fitzpatrick, Annette L, Kukull, Walter A, Norton, Maria, Aspelund, Thor, Larson, Eric B, Munger, Ron, Rotter, Jerome I, Lipton, Richard B, Bullido, María J, Hofman, Albert, Montine, Thomas J, Coto, Eliecer, Boerwinkle, Eric, Petersen, Ronald C, Alvarez, Victoria, Rivadeneira, Fernando, Reiman, Eric M, Gallo, Maura, O'Donnell, Christopher J, Reisch, Joan S, Bruni, Amalia Cecilia, Royall, Donald R, Dichgans, Martin, Sano, Mary, Galimberti, Daniela, St George-Hyslop, Peter, Scarpini, Elio, Tsuang, Debby W, Mancuso, Michelangelo, Bonuccelli, Ubaldo, Winslow, Ashley R, Daniele, Antonio, Wu, Chuang-Kuo, GERAD/PERADES, CHARGE, Peters, Oliver, Nacmias, Benedetta, Riemenschneider, Matthias, Heun, Reinhard, Brayne, Carol, Rubinsztein, David C, Bras, Jose, Guerreiro, Rita, Al-Chalabi, Ammar, Shaw, Christopher E, Collinge, John, Mann, David, Tsolaki, Magda, Clarimón, Jordi, Sussams, Rebecca, Lovestone, Simon, O'Donovan, Michael C, Owen, Michael J, Behrens, Timothy W, Mead, Simon, Goate, Alison M, Uitterlinden, Andre G, Holmes, Clive, Cruchaga, Carlos, Ingelsson, Martin, Bennett, David A, Powell, John, Golde, Todd E, Graff, Caroline, De Jager, Philip L, Morgan, Kevin, Ertekin-Taner, Nilufer, Combarros, Onofre, Psaty, Bruce M, Passmore, Peter, Younkin, Steven G, Berr, Claudine, Gudnason, Vilmundur, Rujescu, Dan, Dickson, Dennis W, Dartigues, Jean-François, DeStefano, Anita L, Ortega-Cubero, Sara, Hakonarson, Hakon, Campion, Dominique, Boada, Merce, Kauwe, John Keoni, Farrer, Lindsay A, Van Broeckhoven, Christine, Ikram, M Arfan, Jones, Lesley, Haines, Jonathan L, Tzourio, Christophe, Launer, Lenore J, Escott-Price, Valentina, Mayeux, Richard, Deleuze, Jean-François, Amin, Najaf, Holmans, Peter A, Pericak-Vance, Margaret A, Amouyel, Philippe, Van Duijn, Cornelia M, Ramirez, Alfredo, Wang, Li-San, Lambert, Jean-Charles, Seshadri, Sudha, Williams, Julie, Schellenberg, Gerard D

مصطلحات موضوعية: Membrane Glycoproteins, Genotype, Sequence Homology, Amino Acid, Phospholipase C gamma, Gene Expression Profiling, Polymorphism, Single Nucleotide, Immunity, Innate, Linkage Disequilibrium, 3. Good health, Gene Frequency, Alzheimer Disease, Case-Control Studies, Odds Ratio, Humans, Exome, Genetic Predisposition to Disease, Amino Acid Sequence, Microglia, Protein Interaction Maps, Receptors, Immunologic, Adaptor Proteins, Signal Transducing

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