المؤلفون: Luo H; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Cortés-López M; New York Genome Center, New York, NY, USA; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Institute of Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Tam CL; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Tri-Institutional Training Program in Computational Biology and Medicine, Weill Cornell Medicine, New York, NY, USA., Xiao M; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Wakiro I; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chu KL; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Pharmacology, Weill Cornell School of Medical Sciences, New York, NY, USA., Pierson A; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chan M; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chang K; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Yang X; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Fecko D; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Han G; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ahn EE; Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA., Morris QD; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Tri-Institutional Training Program in Computational Biology and Medicine, Weill Cornell Medicine, New York, NY, USA., Landau DA; New York Genome Center, New York, NY, USA; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Institute of Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Kharas MG; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: kharasm@mskcc.org.

المصدر: Cell stem cell [Cell Stem Cell] 2023 Dec 07; Vol. 30 (12), pp. 1658-1673.e10.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE

مواضيع طبية MeSH: Hematopoietic Stem Cells*/metabolism , Inflammation* , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism , RNA Methylation*/genetics, Animals ; Humans ; Mice ; Cell Differentiation/genetics ; Methylation ; Methyltransferases/genetics ; Methyltransferases/metabolism ; RNA, Messenger/metabolism

المؤلفون: Herrejon Chavez F; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Luo H; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Cifani P; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Pine A; Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chu KL; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pharmacology, Weill Cornell School of Medical Sciences, New York, NY, USA., Joshi S; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Barin E; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Pharmacology Program of the Weill Cornell Graduate School of Medicine Sciences, New York, NY, USA., Schurer A; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chan M; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chang K; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Han GYQ; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Pierson AJ; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Xiao M; Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA., Yang X; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kuehm LM; Cell Microsystems, Inc., Durham, NC, USA., Hong Y; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia., Nguyen DTT; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Chiosis G; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kentsis A; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Tow Center for Developmental Oncology, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Departments of Pediatrics, Pharmacology, and Physiology & Biophysics, Weill Medical College of Cornell University, New York, NY, USA., Leslie C; Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Vu LP; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. lvu@bccrc.ca.; Terry Fox Laboratory, British Columbia Cancer Research Centre, Vancouver, BC, Canada. lvu@bccrc.ca.; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada. lvu@bccrc.ca., Kharas MG; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. kharasm@mskcc.org.

المصدر: Nature communications [Nat Commun] 2023 Apr 21; Vol. 14 (1), pp. 2290. Date of Electronic Publication: 2023 Apr 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Hematopoietic Stem Cells*/metabolism , Heterogeneous-Nuclear Ribonucleoproteins*/genetics , Heterogeneous-Nuclear Ribonucleoproteins*/metabolism , Proteostasis*/genetics, Animals ; Mice ; Gene Expression Regulation ; Mice, Knockout ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism