المؤلفون: Artero NA; Laboratory of Pain, Inflammation, Neuropathy and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina 86057-970, PR, Brazil., Manchope MF; Laboratory of Pain, Inflammation, Neuropathy and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina 86057-970, PR, Brazil., Carvalho TT; Laboratory of Pain, Inflammation, Neuropathy and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina 86057-970, PR, Brazil., Saraiva-Santos T; Laboratory of Pain, Inflammation, Neuropathy and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina 86057-970, PR, Brazil., Bertozzi MM; Laboratory of Pain, Inflammation, Neuropathy and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina 86057-970, PR, Brazil., Carneiro JA; Laboratory of Pain, Inflammation, Neuropathy and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina 86057-970, PR, Brazil., Franciosi A; Laboratory of Pain, Inflammation, Neuropathy and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina 86057-970, PR, Brazil., Dionisio AM; Laboratory of Pain, Inflammation, Neuropathy and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina 86057-970, PR, Brazil., Zaninelli TH; Laboratory of Pain, Inflammation, Neuropathy and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina 86057-970, PR, Brazil., Fattori V; Laboratory of Pain, Inflammation, Neuropathy and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina 86057-970, PR, Brazil., Ferraz CR; Laboratory of Pain, Inflammation, Neuropathy and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina 86057-970, PR, Brazil., Piva M; Laboratory of Pain, Inflammation, Neuropathy and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina 86057-970, PR, Brazil., Mizokami SS; Laboratory of Pain, Inflammation, Neuropathy and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina 86057-970, PR, Brazil., Camilios-Neto D; Department of Biochemistry and Biotechnology, Centre of Exact Sciences, Londrina State University, Londrina 86057-970, PR, Brazil., Casagrande R; Department of Pharmaceutical Sciences, Centre of Health Science, Londrina State University, Londrina 86039-440, PR, Brazil., Verri WA; Laboratory of Pain, Inflammation, Neuropathy and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina 86057-970, PR, Brazil.

المصدر: Molecules (Basel, Switzerland) [Molecules] 2023 Jan 15; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

مواضيع طبية MeSH: Hesperidin* , Chalcones*/therapeutic use , Arthritis*/drug therapy, Mice ; Animals ; Nociceptors/metabolism ; Inflammation/drug therapy ; Inflammation/metabolism ; Oxidative Stress ; Antioxidants/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Hyperalgesia/drug therapy ; Cytokines/metabolism

المؤلفون: Borghi SM; Department of Pathology, Londrina State University, Londrina, Brazil.; Center for Research in Health Sciences, University of Northern Paraná, Rua Marselha, 591, Jardim Piza, Brazil., Casagrande R; Department of Pharmaceutical Sciences, Londrina State University, Londrina, Brazil., Verri WA; Department of Pathology, Londrina State University, Londrina, Brazil.

المصدر: Current medicinal chemistry [Curr Med Chem] 2023; Vol. 30 (5), pp. 601-603.

نوع المنشور: Editorial

بيانات الدورية: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9440157 Publication Model: Print Cited Medium: Internet ISSN: 1875-533X (Electronic) Linking ISSN: 09298673 NLM ISO Abbreviation: Curr Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Chalcones* , Hesperidin* , Chalcone*, Humans ; Inflammation/drug therapy ; Pain/drug therapy

المؤلفون: Guazelli CFS; Laboratório de Dor, Inflamação, Neuropatia e Câncer, Departamento de Ciências Patológicas, Universidade Estadual de Londrina, Londrina, PR, Brazil., Fattori V; Laboratório de Dor, Inflamação, Neuropatia e Câncer, Departamento de Ciências Patológicas, Universidade Estadual de Londrina, Londrina, PR, Brazil., Ferraz CR; Laboratório de Dor, Inflamação, Neuropatia e Câncer, Departamento de Ciências Patológicas, Universidade Estadual de Londrina, Londrina, PR, Brazil; Laboratório de Antioxidantes e Inflamação, Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina Londrina, Londrina, PR, Brazil., Borghi SM; Laboratório de Dor, Inflamação, Neuropatia e Câncer, Departamento de Ciências Patológicas, Universidade Estadual de Londrina, Londrina, PR, Brazil; Center for Research in Health Sciences, University of Northern Paraná, Londrina, PR, Brazil., Casagrande R; Laboratório de Antioxidantes e Inflamação, Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina Londrina, Londrina, PR, Brazil; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Londrina, PR, Brazil., Baracat MM; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Londrina, PR, Brazil., Verri WA Jr; Laboratório de Dor, Inflamação, Neuropatia e Câncer, Departamento de Ciências Patológicas, Universidade Estadual de Londrina, Londrina, PR, Brazil. Electronic address: waldiceujr@yahoo.com.br.

المصدر: Chemico-biological interactions [Chem Biol Interact] 2021 Jan 05; Vol. 333, pp. 109315. Date of Electronic Publication: 2020 Nov 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Inflammatory Agents/*pharmacology , Antioxidants/*pharmacology , Chalcones/*pharmacology , Colitis, Ulcerative/*drug therapy , Hesperidin/*analogs & derivatives, Animals ; Anti-Inflammatory Agents/therapeutic use ; Antioxidants/therapeutic use ; Chalcones/therapeutic use ; Colitis, Ulcerative/complications ; Colitis, Ulcerative/immunology ; Colitis, Ulcerative/metabolism ; Colon/drug effects ; Colon/pathology ; Cytokines/biosynthesis ; Disease Models, Animal ; Edema/complications ; Hesperidin/pharmacology ; Hesperidin/therapeutic use ; Male ; Mice ; NF-kappa B/metabolism ; Neutrophil Infiltration/drug effects ; Oxidative Stress/drug effects

المؤلفون: Rasquel-Oliveira FS; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil., Manchope MF; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil., Staurengo-Ferrari L; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil., Ferraz CR; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil., Saraiva-Santos T; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil., Zaninelli TH; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil., Fattori V; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil., Artero NA; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil., Badaro-Garcia S; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil., de Freitas A; Departament of Physiological Sciences, Centre of Biological Sciences, Londrina State University, Londrina, PR, Brazil., Casagrande R; Departament of Pharmaceutical Sciences, Centre of Health Sciences, Londrina State University, Londrina, PR, Brazil., Verri WA Jr; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil. waldiceujr@yahoo.com.br.; Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rod. Celso Garcia Cid PR 445, KM 380, PO Box 10.011, Londrina, Parana, 86057-970, Brazil. waldiceujr@yahoo.com.br.

المصدر: Inflammopharmacology [Inflammopharmacology] 2020 Aug; Vol. 28 (4), pp. 979-992. Date of Electronic Publication: 2020 Feb 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9112626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5608 (Electronic) Linking ISSN: 09254692 NLM ISO Abbreviation: Inflammopharmacology Subsets: MEDLINE

مواضيع طبية MeSH: Arthralgia/*drug therapy , Chalcones/*pharmacology , Hesperidin/*analogs & derivatives , Inflammation/*drug therapy , Macrophage Activation/*drug effects , Macrophages/*drug effects , NF-kappa B/*metabolism , Zymosan/*pharmacology, Analgesics/pharmacology ; Animals ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/physiology ; Arthralgia/chemically induced ; Arthralgia/metabolism ; Arthritis, Experimental/chemically induced ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/metabolism ; Cell Line ; Cytokines/metabolism ; Disease Models, Animal ; Edema/chemically induced ; Edema/drug therapy ; Edema/metabolism ; Hesperidin/pharmacology ; Inflammation/chemically induced ; Inflammation/metabolism ; Macrophages/metabolism ; Mice ; Molecular Docking Simulation/methods ; Oxidative Stress/drug effects ; RAW 264.7 Cells ; Signal Transduction/drug effects

المؤلفون: Ruiz-Miyazawa KW; Departamento de Ciências Patológicas , Universidade Estadual de Londrina-UEL , Rod. Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011 , 86057-970 Londrina , Paraná , Brazil., Pinho-Ribeiro FA; Departamento de Ciências Patológicas , Universidade Estadual de Londrina-UEL , Rod. Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011 , 86057-970 Londrina , Paraná , Brazil., Borghi SM; Departamento de Ciências Patológicas , Universidade Estadual de Londrina-UEL , Rod. Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011 , 86057-970 Londrina , Paraná , Brazil., Staurengo-Ferrari L; Departamento de Ciências Patológicas , Universidade Estadual de Londrina-UEL , Rod. Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011 , 86057-970 Londrina , Paraná , Brazil., Fattori V; Departamento de Ciências Patológicas , Universidade Estadual de Londrina-UEL , Rod. Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011 , 86057-970 Londrina , Paraná , Brazil., Amaral FA; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Laboratório de Imunofarmacologia , Universidade Federal de Minas Gerais , 31270-567 Belo Horizonte , Minas Gerais , Brazil., Teixeira MM; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Laboratório de Imunofarmacologia , Universidade Federal de Minas Gerais , 31270-567 Belo Horizonte , Minas Gerais , Brazil., Alves-Filho JC; Department of Pharmacology, Ribeirão Preto Medical School , University of São Paulo , Avenida Bandeirantes s/n , 14050-490 Ribeirão Preto , São Paulo , Brazil., Cunha TM; Department of Pharmacology, Ribeirão Preto Medical School , University of São Paulo , Avenida Bandeirantes s/n , 14050-490 Ribeirão Preto , São Paulo , Brazil., Cunha FQ; Department of Pharmacology, Ribeirão Preto Medical School , University of São Paulo , Avenida Bandeirantes s/n , 14050-490 Ribeirão Preto , São Paulo , Brazil., Casagrande R; Departamento de Ciências Farmacêuticas , Universidade Estadual de Londrina-UEL , Avenida Robert Koch, 60, Hospital Universitário , 86038-350 Londrina , Paraná , Brazil., Verri WA Jr; Departamento de Ciências Patológicas , Universidade Estadual de Londrina-UEL , Rod. Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011 , 86057-970 Londrina , Paraná , Brazil.

المصدر: Journal of agricultural and food chemistry [J Agric Food Chem] 2018 Jun 27; Vol. 66 (25), pp. 6269-6280. Date of Electronic Publication: 2018 Jun 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

مواضيع طبية MeSH: Arthritis, Gouty/*drug therapy , Chalcones/*administration & dosage , Hesperidin/*analogs & derivatives , NF-kappa B/*metabolism, Animals ; Arthritis, Gouty/genetics ; Arthritis, Gouty/metabolism ; Hesperidin/administration & dosage ; Humans ; Interleukin-1beta/genetics ; Interleukin-1beta/metabolism ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice ; NF-kappa B/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Oxidative Stress/drug effects ; Signal Transduction ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism

المؤلفون: Martinez RM; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, 86039-440 Londrina, Paraná, Brazil. rubiacasa@yahoo.com.br., Pinho-Ribeiro FA, Steffen VS, Caviglione CV, Pala D, Baracat MM, Georgetti SR, Verri WA, Casagrande R

المصدر: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology [Photochem Photobiol Sci] 2016 Apr; Vol. 15 (4), pp. 554-63. Date of Electronic Publication: 2016 Mar 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Country of Publication: England NLM ID: 101124451 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9092 (Electronic) Linking ISSN: 1474905X NLM ISO Abbreviation: Photochem Photobiol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Ultraviolet Rays*, Chalcones/*administration & dosage , Hesperidin/*analogs & derivatives , Inflammation/*prevention & control , Oxidative Stress/*drug effects , Skin/*drug effects, Administration, Topical ; Animals ; Chalcones/pharmacology ; Cytokines/biosynthesis ; Heme Oxygenase-1/genetics ; Hesperidin/administration & dosage ; Hesperidin/pharmacology ; Inflammation/metabolism ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Hairless ; NADPH Oxidase 2 ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism ; NF-E2-Related Factor 2/genetics ; RNA, Messenger/genetics ; Skin/metabolism ; Superoxides/metabolism

المؤلفون: Martinez RM; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina-UEL, Avenida Robert Koch, 60, Hospital Universitário, 86039-440 Londrina, Paraná, Brazil. Electronic address: renatamimartinez@gmail.com., Pinho-Ribeiro FA; Departamento de Ciências Patológicas, Universidade Estadual de Londrina-UEL, Rodovia Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011, 86057-970 Londrina, Paraná, Brazil. Electronic address: pinho.fe@gmail.com., Steffen VS; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina-UEL, Avenida Robert Koch, 60, Hospital Universitário, 86039-440 Londrina, Paraná, Brazil. Electronic address: vsteffen@gmail.com., Caviglione CV; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina-UEL, Avenida Robert Koch, 60, Hospital Universitário, 86039-440 Londrina, Paraná, Brazil. Electronic address: carla_venturelli@hotmail.com., Vignoli JA; Departamento de Bioquímica e Biotecnologia, Centro de Ciências Exatas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011, 86057-970 Londrina, Paraná, Brazil. Electronic address: josivignoli@yahoo.com.br., Baracat MM; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina-UEL, Avenida Robert Koch, 60, Hospital Universitário, 86039-440 Londrina, Paraná, Brazil. Electronic address: baracat1903@yahoo.com.br., Georgetti SR; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina-UEL, Avenida Robert Koch, 60, Hospital Universitário, 86039-440 Londrina, Paraná, Brazil. Electronic address: sangeorgetti@gmail.com., Verri WA Jr; Departamento de Ciências Patológicas, Universidade Estadual de Londrina-UEL, Rodovia Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011, 86057-970 Londrina, Paraná, Brazil. Electronic address: waldiceujr@yahoo.com.br., Casagrande R; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina-UEL, Avenida Robert Koch, 60, Hospital Universitário, 86039-440 Londrina, Paraná, Brazil. Electronic address: rubiacasa@yahoo.com.br.

المصدر: Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2015 Jul; Vol. 148, pp. 145-153. Date of Electronic Publication: 2015 Apr 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Sequoia Country of Publication: Switzerland NLM ID: 8804966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2682 (Electronic) Linking ISSN: 10111344 NLM ISO Abbreviation: J Photochem Photobiol B Subsets: MEDLINE

مواضيع طبية MeSH: Ultraviolet Rays*, Chalcones/*pharmacology , Hesperidin/*analogs & derivatives , Oxidative Stress/*drug effects , Skin/*drug effects, Animals ; Antioxidants/metabolism ; Cytokines/metabolism ; Disease Models, Animal ; Edema/etiology ; Edema/metabolism ; Glutathione/metabolism ; Hesperidin/pharmacology ; Inflammation/metabolism ; Lipid Peroxidation/drug effects ; Lipid Peroxidation/radiation effects ; Matrix Metalloproteinase 9/metabolism ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Hairless ; NADPH Oxidase 2 ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism ; Oxidative Stress/radiation effects ; RNA, Messenger/metabolism ; Skin/radiation effects ; Superoxides/metabolism

المؤلفون: Pinho-Ribeiro FA; Departamento de Ciências Patológicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paraná, Brazil., Hohmann MS; Departamento de Ciências Patológicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paraná, Brazil., Borghi SM; Departamento de Ciências Patológicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paraná, Brazil., Zarpelon AC; Departamento de Ciências Patológicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paraná, Brazil., Guazelli CF; Departamento de Ciências Patológicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paraná, Brazil., Manchope MF; Departamento de Ciências Patológicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paraná, Brazil., Casagrande R; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina Londrina-UEL, Avenida Robert Koch, 60, Hospital Universitário, 86038-350 Londrina, Paraná, Brazil., Verri WA Jr; Departamento de Ciências Patológicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paraná, Brazil. Electronic address: waldiceujr@yahoo.com.br.

المصدر: Chemico-biological interactions [Chem Biol Interact] 2015 Feb 25; Vol. 228, pp. 88-99. Date of Electronic Publication: 2015 Jan 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

مواضيع طبية MeSH: Analgesics/*pharmacology , Anti-Inflammatory Agents, Non-Steroidal/*pharmacology , Chalcones/*pharmacology , Cytokines/*metabolism , Hesperidin/*analogs & derivatives , NF-kappa B/*metabolism , Oxidative Stress/*drug effects , TRPV Cation Channels/*metabolism, Analgesics/chemistry ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Chalcones/chemistry ; Cytokines/antagonists & inhibitors ; Cytokines/biosynthesis ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Hesperidin/chemistry ; Hesperidin/pharmacology ; Inflammation/drug therapy ; Inflammation/metabolism ; Male ; Mice ; Molecular Structure ; NF-kappa B/antagonists & inhibitors ; Pain/drug therapy ; Pain/metabolism ; Structure-Activity Relationship ; TRPV Cation Channels/antagonists & inhibitors