نتائج البحث - "Lucio H. Freitas-Junior"

1

Nano-multilamellar lipid vesicles promote the induction of SARS-CoV-2 immune responses by a protein-based vaccine formulation

المؤلفون: Monica Josiane Rodrigues-Jesus, Marianna Teixeira de Pinho Favaro, Aléxia Adrianne Venceslau-Carvalho, Maria Fernanda de Castro-Amarante, Bianca da Silva Almeida, Mariângela de Oliveira Silva, Robert Andreata-Santos, Cecilia Gomes Barbosa, Samantha Carvalho Maia Brito, Lucio H. Freitas-Junior, Silvia Beatriz Boscardin, Luís Carlos de Souza Ferreira

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a26619821e81ec29f33e42eeba8645

2

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform

المؤلفون: Flavio Di Pisa, Elisa Uliassi, Lucio H. Freitas-Junior, Maria Laura Bolognesi, Antonio Quotadamo, Maria Paola Costi, Claudia Danielli Pereira Bertolacini, Joachim Clos, Joanna Panecka-Hofman, Chiara Borsari, María Jesús Corral, G. Landi, Maria Kuzikov, Deepa Karunakaran, Pasquale Linciano, Wolfgang Müller, Birte Behrens, Kyriakos C. Prousis, Carolina B. Moraes, Lucia Dello Iacono, Markus Wolf, Oliver Keminer, Cecilia Pozzi, Rebecca C. Wade, Bruno dos Santos Pascoalino, José María Alunda, Stefania Ferrari, Martina Fenske, Alberto Venturelli, Sheraz Gul, Jeanette Reinshagen, Nuno Santarém, Matteo Santucci, Jennifer Leu, Stephen Wrigley, Ina Pöhner, Bethlehem Kebede, Theodora Calogeropoulou, Bernhard Ellinger, Stefano Mangani, Anabela Cordeiro-da-Silva, Gesa Witt

المساهمون: Carolina B. Moraes, Gesa Witt, Maria Kuzikov, Bernhard Ellinger, Theodora Calogeropoulou, Kyriakos C. Prousis, Stefano Mangani, Flavio Di Pisa, Giacomo Landi, Lucia Dello Iacono, Cecilia Pozzi, Lucio H. Freitas-Junior, Bruno dos Santos Pascoalino, Claudia P. Bertolacini, Birte Behrens, Oliver Keminer, Jennifer Leu, Markus Wolf, Jeanette Reinshagen, Anabela Cordeiro-da-Silva, Nuno Santarem, Alberto Venturelli, Stephen Wrigley, Deepa Karunakaran, Bethlehem Kebede, Ina Pöhner, Wolfgang Müller, Joanna Panecka-Hofman, Rebecca C. Wade, Martina Fenske, Joachim Clos, José María Alunda, María Jesús Corral, Elisa Uliassi, Maria Laura Bolognesi, Pasquale Linciano, Antonio Quotadamo, Stefania Ferrari, Matteo Santucci, Chiara Borsari, Maria Paola Costi, Sheraz Gul, Publica

المصدر: Slas Discovery

مصطلحات موضوعية: Chagas disease, cell-based assays, Antiparasitic, medicine.drug_class, cell-based assay, Computational biology, liquid handling, Trypanosoma brucei, 01 natural sciences, Biochemistry, Article, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Trypanosomiasis, anti-infective drugs, Drug Discovery, parasitic diseases, medicine, Humans, compound repositories, enzyme assays or enzyme kinetics, Biotechnology, Molecular Medicine, 030304 developmental biology, 0303 health sciences, Biological Products, Natural product, biology, Drug discovery, Leishmaniasis, biology.organism_classification, medicine.disease, Trypanocidal Agents, anti-infective drug, 0104 chemical sciences, 3. Good health, 010404 medicinal & biomolecular chemistry, chemistry, compound repositorie, Neglected tropical diseases, enzyme assays or enzyme kinetic

وصف الملف: ELETTRONICO

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5b64ff9e20812ab96c4f3ad8331d20
https://hdl.handle.net/11380/1175165

3

A Multi-Species Phenotypic Screening Assay for Leishmaniasis Drug Discovery Shows That Active Compounds Display a High Degree of Species-Specificity

المؤلفون: Thalita Camêlo da Silva Ferreira, Vanessa Fontana, Laura M. Alcântara, Carolina B. Moraes, Lucio H. Freitas-Junior, Eric Chatelain

المصدر: Molecules
Volume 25
Issue 11
Molecules, Vol 25, Iss 2551, p 2551 (2020)

مصطلحات موضوعية: THP-1 Cells, Phenotypic screening, 030231 tropical medicine, Antiprotozoal Agents, Drug Evaluation, Preclinical, Pharmaceutical Science, Biology, Article, Leishmania, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, Mice, 0302 clinical medicine, lcsh:Organic chemistry, Species Specificity, Leishmania species, Drug Discovery, Multi species, medicine, leishmaniasis drug discovery, Animals, Humans, Physical and Theoretical Chemistry, Protriptyline, Leishmaniasis, 030304 developmental biology, 0303 health sciences, Drug discovery, Organic Chemistry, phenotypic screening, medicine.disease, biology.organism_classification, Phenotype, Small molecule, Biochemistry, Maprotiline, Chemistry (miscellaneous), Molecular Medicine, Leishmaniasis, Visceral

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40958fcafa258e8a1a7f3c6e4e965aa3
http://europepmc.org/articles/PMC7321149

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4

Aryl thiosemicarbazones for the treatment of trypanosomatidic infections

المؤلفون: Maria Kuzikov, Gesa Witt, Bruno dos Santos Pascoalino, Caio Haddad Franco, Luca Costantino, Rosaria Luciani, Laura M. Alcantara, Nuno Santarém, Sara Macedo, Antonio Quotadamo, Lucio H. Freitas-Junior, Bernhard Ellinger, Carolina B. Moraes, Stefania Ferrari, Maria Paola Costi, Sheraz Gul, Anabela Cordeiro-da-Silva, Pasquale Linciano

المساهمون: Publica

المصدر: European Journal of Medicinal Chemistry. 146:423-434

مصطلحات موضوعية: Thiosemicarbazones, 0301 basic medicine, Trypanosoma, Stereochemistry, hERG, Antiprotozoal Agents, Trypanosoma brucei, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Parasitic Sensitivity Tests, Thiadiazoles, Early-toxicity, Leishmania infantum, pan-anti-trypanosomatidic activity, Thiosemicarbazone, Trypanosoma cruzi, Pharmacology, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, parasitic diseases, Drug Discovery, medicine, Humans, Chagas Disease, Amastigote, Semicarbazone, Dose-Response Relationship, Drug, Molecular Structure, biology, Macrophages, General Medicine, biology.organism_classification, medicine.disease, 0104 chemical sciences, 3. Good health, 010404 medicinal & biomolecular chemistry, Mitochondrial toxicity, 030104 developmental biology, chemistry, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bebcff45eb81d168c200819955e00630
https://doi.org/10.1016/j.ejmech.2018.01.043

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5

Design, synthesis and antitrypanosomal activity of some nitrofurazone 1,2,4-triazolic bioisosteric analogues

المؤلفون: Caio Haddad Franco, Lucio H. Freitas-Junior, Denize C. Favaro, Fredson Torres Silva, Elizabeth Igne Ferreira, Carolina B. Moraes

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c52ca13b182cc48528df23eeb4f888
https://doi.org/10.1016/j.ejmech.2016.04.065

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6

Non-cytotoxic 1,2,3-triazole tethered fused heterocyclic ring derivatives display Tax protein inhibition and impair HTLV-1 infected cells

المؤلفون: Peterson de Andrade, Simone Kashima, Charlotte Vandermeulen, Paulo Sérgio Gonçalves Nunes, Ivone Carvalho, Jean-Claude Twizere, Lucio H. Freitas-Junior, Jorge Casseb, Denise Regina Bairros de Pilger, Daiane Fernanda dos Santos, Susimaire P. Mantoani, Ricardo Khouri, Luc Willems

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

مصطلحات موضوعية: Cell Survival, Clinical Biochemistry, Cell, Pharmaceutical Science, Antiviral Agents, 01 natural sciences, Biochemistry, Jurkat cells, Structure-Activity Relationship, Heterocyclic Compounds, Drug Discovery, medicine, Humans, Cytotoxic T cell, FÁRMACOS, Human T cell lymphotropic virus type 1, Molecular Biology, Cells, Cultured, Human T-lymphotropic virus 1, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Cell growth, Chemistry, Organic Chemistry, Cell Cycle Checkpoints, Gene Products, tax, Triazoles, Cell cycle, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Cell culture, Apoptosis, Cancer research, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec97776df95f80850aa882ea109c8d3d
https://doi.org/10.1016/j.bmc.2020.115746

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7

Discovery of new potent hits against intracellular Trypanosoma cruzi by QSAR-based virtual screening

المؤلفون: Lucio H. Freitas-Junior, Cleber C. Melo-Filho, Carolina Horta Andrade, Caio Haddad Franco, Eugene N. Muratov, Carolina B. Moraes, Rodolpho C. Braga

المصدر: European journal of medicinal chemistry. 163

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81c2f2448fb20c9545e37695bd60408
https://pubmed.ncbi.nlm.nih.gov/30562700

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8

Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections

المؤلفون: Maria Kuzikov, Maria Laura Bolognesi, Federica Belluti, Andrea Mazzanti, Bernhard Ellinger, Chiara Borsari, Sheraz Gul, Elisa Uliassi, Maria Paola Costi, Lorna Piazzi, Lucio H. Freitas-Junior, Carolina B. Moraes, Reto Brun, Marcel Kaiser

المساهمون: Uliassi, Elisa, Piazzi, Lorna, Belluti, Federica, Mazzanti, Andrea, Kaiser, Marcel, Brun, Reto, Moraes, Carolina B., Freitas-Junior, Lucio H., Gul, Sheraz, Kuzikov, Maria, Ellinger, Bernhard, Borsari, Chiara, Costi, Maria Paola, Bolognesi, Maria Laura

المصدر: ChemMedChem. 13(7)

مصطلحات موضوعية: 0301 basic medicine, ERG1 Potassium Channel, protozoan parasitic infection, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Parasitic Sensitivity Tests, Drug Discovery, Cytochrome P-450 Enzyme Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, media_common, Leishmania, biology, Molecular Structure, Drug discovery, 3. Good health, Molecular Medicine, privileged scaffold, Drug, Trypanosoma, media_common.quotation_subject, hERG, Plasmodium falciparum, Triazole, Antiprotozoal Agents, Phenylpiperazine, phenotypic screening, privileged scaffolds, protozoan parasitic infections, Small Molecule Libraries, 03 medical and health sciences, Phenothiazine, Cell Line, Tumor, Potassium Channel Blockers, Animals, Humans, Pharmacology, 010405 organic chemistry, Organic Chemistry, Cytochrome P450, Triazoles, biology.organism_classification, 0104 chemical sciences, Rats, 030104 developmental biology, chemistry, Pharmacology, Toxicology and Pharmaceutics (all), biology.protein