المؤلفون: Gucer H; Department of Pathology, Recep Tayyip Erdogan University, Rize, Turkey. hasangucer@gmail.com., Caliskan S; Department of Pathology, Ondokuz Mayis University, Samsun, Turkey., Kefeli M; Department of Pathology, Ondokuz Mayis University, Samsun, Turkey., Mete O; Department of Pathology, University Health Network, Toronto, ON, Canada. ozgur.mete2@uhn.ca.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. ozgur.mete2@uhn.ca.

المصدر: Endocrine pathology [Endocr Pathol] 2020 Mar; Vol. 31 (1), pp. 33-38.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9009288 Publication Model: Print Cited Medium: Internet ISSN: 1559-0097 (Electronic) Linking ISSN: 10463976 NLM ISO Abbreviation: Endocr Pathol Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal*, Biomarkers, Tumor/*analysis , Carcinoma, Neuroendocrine/*diagnosis , Immunohistochemistry/*methods , PAX8 Transcription Factor/*analysis , Thyroid Neoplasms/*diagnosis, Humans

مستخلص: Medullary thyroid carcinomas display cytologic and architectural features that can simulate various primary and metastatic neoplasms. PAX8 immunoexpression in neuroendocrine neoplasms yielded antibody-dependent findings. Since the data regarding the expression profile of monoclonal PAX8 (MRQ-50) antibody is limited in large series of medullary thyroid carcinomas, this study investigated the expression profile of PAX8 (MRQ-50) in a series of 45 medullary thyroid carcinomas. PAX8 (MRQ-50) expression was noted in the thyroid follicular epithelial cells surrounding the tumor and was negative in all medullary thyroid carcinomas. In addition, twenty medullary thyroid carcinomas showed scattered entrapped thyroid follicular epithelial cells at the periphery of the tumor. Entrapped follicular epithelial cells were positive for PAX8 and thyroglobulin, and were negative for monoclonal CEA and calcitonin. A panel approach combining monoclonal antibodies to transcription factors, hormones and cell-specific peptides often assist diagnosticians in the workup of the cellular origin of a neuroendocrine neoplasm. Since PAX8 immunostaining is dependent on the antibody characteristics in neuroendocrine neoplasms, pathologists should be aware of the details of the PAX8 antibody used in a particular case.

SCR Disease Name: Thyroid cancer, medullary

المؤلفون: Asa SL; Department of Pathology, Laboratory Medicine Program, University Health Network, 200 Elizabeth Street, 11th Floor, Toronto, Ontario, M5G 2M9, Canada. sylvia.asa@uhn.ca.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, M5G 2M9, Canada. sylvia.asa@uhn.ca., Mete O; Department of Pathology, Laboratory Medicine Program, University Health Network, 200 Elizabeth Street, 11th Floor, Toronto, Ontario, M5G 2M9, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, M5G 2M9, Canada.

المصدر: Endocrine pathology [Endocr Pathol] 2018 Jun; Vol. 29 (2), pp. 130-136.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9009288 Publication Model: Print Cited Medium: Internet ISSN: 1559-0097 (Electronic) Linking ISSN: 10463976 NLM ISO Abbreviation: Endocr Pathol Subsets: MEDLINE

مواضيع طبية MeSH: Biomarkers, Tumor/*analysis , Immunohistochemistry/*methods , Pituitary Neoplasms/*diagnosis, Humans ; Pathology, Clinical/methods ; Pituitary Diseases/diagnosis

مستخلص: Pituitary pathology is one area of endocrine pathology that is highly dependent on immunohistochemistry. There is a wide range of disorders that occur in and around the sella turcica, and the distinction of tumor-like lesions from neoplasms requires careful evaluation. The diagnosis, prognosis, and predictive features of neoplasms in the sellar region are all dependent on the application and interpretation of biomarkers of cell differentiation, hormonal activity, subcellular morphology, and proliferation. As in hematopathology, the number of biomarkers has increased dramatically and continues to increase. Fortunately, some of the biomarkers provide information that was initially dependent on electron microscopy; therefore, the need for this additional technology has been reduced to only rare unusual tumors. In this review, we provide a simple approach to understanding the importance of the various biomarkers that are used to ensure the correct diagnosis and provide the treating clinicians with tools to guide appropriate patient management and surveillance.

المؤلفون: Mete O; Department of Pathology, University Health Network, 200 Elizabeth Street, 11th floor, Toronto, ON, M5G 2C4, Canada. ozgur.mete2@uhn.ca., Asa SL; Department of Pathology, University Health Network, 200 Elizabeth Street, 11th floor, Toronto, ON, M5G 2C4, Canada., Giordano TJ; Departments of Pathology and Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA., Papotti M; Department of Pathology, Turin University at Molinette Hospital, Turin, Italy., Sasano H; Department of Pathology, Tohoku University School of Medicine, Sendai, Japan., Volante M; Department of Oncology, University of Turin at San Luigi Hospital, Turin University, Orbassano, Turin, Italy.

المصدر: Endocrine pathology [Endocr Pathol] 2018 Jun; Vol. 29 (2), pp. 137-149.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9009288 Publication Model: Print Cited Medium: Internet ISSN: 1559-0097 (Electronic) Linking ISSN: 10463976 NLM ISO Abbreviation: Endocr Pathol Subsets: MEDLINE

مواضيع طبية MeSH: Adrenal Cortex Neoplasms/*diagnosis , Adrenocortical Carcinoma/*diagnosis , Biomarkers, Tumor/*analysis , Immunohistochemistry/*methods, Humans ; Pathology, Clinical/methods

مستخلص: Careful morphological evaluation forms the basis of the workup of an adrenal cortical neoplasm. However, the adoption of immunohistochemical biomarkers has added tremendous value to enhance diagnostic accuracy. The authors provide a brief review of immunohistochemical biomarkers that have been used in the confirmation of adrenal cortical origin and in the detection of the source of functional adrenal cortical proliferations, as well as diagnostic, predictive, and prognostic biomarkers of adrenal cortical carcinoma. In addition, a brief section on potential novel theranostic biomarkers in the prediction of treatment response to mitotane and other relevant chemotherapeutic agents is also provided. In the era of precision and personalized medical practice, adoption of combined morphology and immunohistochemistry provides a new approach to the diagnostic workup of adrenal cortical neoplasms, reflecting the evolution of clinical responsibility of pathologists.

المؤلفون: Erickson LA; Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. erickson.lori@mayo.edu., Mete O; Department of Pathology, Laboratory Medicine Program, University Health System, Toronto, Canada.

المصدر: Endocrine pathology [Endocr Pathol] 2018 Jun; Vol. 29 (2), pp. 113-129.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9009288 Publication Model: Print Cited Medium: Internet ISSN: 1559-0097 (Electronic) Linking ISSN: 10463976 NLM ISO Abbreviation: Endocr Pathol Subsets: MEDLINE

مواضيع طبية MeSH: Adenoma/*diagnosis , Biomarkers, Tumor/*analysis , Immunohistochemistry/*methods , Parathyroid Neoplasms/*diagnosis, Humans ; Pathology, Clinical/methods

مستخلص: Pathologists are usually readily able to diagnose parathyroid tissues and diseases, particularly when they have knowledge of the clinical information, laboratory findings, and radiographic imaging studies. However, the identification of parathyroid tissue or lesions can be difficult in small biopsies, ectopic locations, supranumerary glands, and in some oxyphil/oncocytic lesions. Widely available immunohistochemical studies such as chromogranin-A, synaptophysin, keratin, parathyroid hormone, thyroglobulin, and thyroid transcription factor-1 can help in difficult cases. One of the most difficult diagnostic aspects faced by the pathologist in evaluating parathyroid is distinguishing between parathyroid adenoma, particularly atypical adenoma, and parathyroid carcinoma. Many markers have and continue to be evaluated for diagnostic utility, and are even beginning to be studied for prognostic utility. Single immunohistochemical markers such as parafibromin and Ki-67 are among the most studied and most utilized, but many additional markers have and continue to be evaluated such as galectin-3, PGP9.5, Rb, bcl2, p27, hTERT, mdm2, and APC. Although not widely available in many laboratories, a panel of immunohistochemical markers may prove most useful as an adjunct in the evaluation of challenging parathyroid tumors.

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