المؤلفون: Burrough ER, Magstadt DR, Petersen B, Timmermans SJ, Gauger PC, Zhang J, Siepker C, Mainenti M, Li G, Thompson AC, Gorden PJ, Plummer PJ, Main R

المصدر: Emerging infectious diseases [Emerg Infect Dis] 2024 Jul; Vol. 30 (7), pp. 1335-1343. Date of Electronic Publication: 2024 Apr 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Cat Diseases*/virology , Cat Diseases*/epidemiology , Cattle Diseases*/virology , Cattle Diseases*/epidemiology , Cattle Diseases*/transmission , Orthomyxoviridae Infections*/virology , Orthomyxoviridae Infections*/veterinary , Orthomyxoviridae Infections*/epidemiology , Influenza A Virus, H5N1 Subtype*/pathogenicity , Influenza A Virus, H5N1 Subtype*/genetics, Animals ; Cats ; Cattle ; United States/epidemiology ; Influenza in Birds/virology ; Influenza in Birds/epidemiology ; Influenza in Birds/transmission ; Milk/virology ; Female

مستخلص: We report highly pathogenic avian influenza A(H5N1) virus in dairy cattle and cats in Kansas and Texas, United States, which reflects the continued spread of clade 2.3.4.4b viruses that entered the country in late 2021. Infected cattle experienced nonspecific illness, reduced feed intake and rumination, and an abrupt drop in milk production, but fatal systemic influenza infection developed in domestic cats fed raw (unpasteurized) colostrum and milk from affected cows. Cow-to-cow transmission appears to have occurred because infections were observed in cattle on Michigan, Idaho, and Ohio farms where avian influenza virus-infected cows were transported. Although the US Food and Drug Administration has indicated the commercial milk supply remains safe, the detection of influenza virus in unpasteurized bovine milk is a concern because of potential cross-species transmission. Continued surveillance of highly pathogenic avian influenza viruses in domestic production animals is needed to prevent cross-species and mammal-to-mammal transmission.

المؤلفون: Ly H; Department of Veterinary & Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, Minnesota, USA.

المصدر: Journal of medical virology [J Med Virol] 2024 Jun; Vol. 96 (6), pp. e29766.

نوع المنشور: Journal Article; Letter

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE

مواضيع طبية MeSH: Animals, Domestic*/virology , Goats* , Influenza A Virus, H5N1 Subtype*/genetics , Influenza A Virus, H5N1 Subtype*/pathogenicity , Influenza, Human*/epidemiology , Influenza, Human*/virology , Orthomyxoviridae Infections*/virology , Orthomyxoviridae Infections*/veterinary , Orthomyxoviridae Infections*/epidemiology, Animals ; Cats ; Cattle ; Humans ; Poultry/virology ; United States/epidemiology

المؤلفون: Cohen J

المصدر: Science (New York, N.Y.) [Science] 2024 Apr 26; Vol. 384 (6694), pp. 370-371. Date of Electronic Publication: 2024 Apr 25.

نوع المنشور: News; Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Cattle Diseases*/epidemiology , Cattle Diseases*/prevention & control , Cattle Diseases*/virology , Cattle Diseases*/transmission , Disease Outbreaks*/prevention & control , Milk*/virology , Orthomyxoviridae Infections*/epidemiology , Orthomyxoviridae Infections*/transmission , Orthomyxoviridae Infections*/prevention & control , Orthomyxoviridae Infections*/virology , Influenza A Virus, H5N1 Subtype*, Animals ; Cattle ; Humans ; United States/epidemiology

مستخلص: Veterinarians and researchers say it has taken too long to share data on viral changes, spread, and milk safety.

المصدر: The Veterinary record [Vet Rec] 2024 May 04; Vol. 194 (9), pp. 324.

نوع المنشور: News

بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 0031164 Publication Model: Print Cited Medium: Internet ISSN: 2042-7670 (Electronic) Linking ISSN: 00424900 NLM ISO Abbreviation: Vet Rec Subsets: MEDLINE

مواضيع طبية MeSH: Cattle Diseases*/virology , Cattle Diseases*/epidemiology , Influenza A Virus, H5N1 Subtype*/isolation & purification, Animals ; Cattle ; United States/epidemiology ; Influenza in Birds/virology ; Influenza in Birds/epidemiology ; Orthomyxoviridae Infections/veterinary ; Orthomyxoviridae Infections/virology ; Orthomyxoviridae Infections/epidemiology ; Birds ; Disease Outbreaks/veterinary

المؤلفون: Guan Y, Webby R, Capua I, Waldenström J

المصدر: Nature [Nature] 2012 Mar 28; Vol. 483 (7391), pp. 535-6. Date of Electronic Publication: 2012 Mar 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Birds/*virology , Ducks/*virology , Influenza A Virus, H5N1 Subtype/*isolation & purification , Orthomyxoviridae Infections/*veterinary , Swine/*virology, Animals ; Animals, Domestic/virology ; Animals, Wild/virology ; Asia/epidemiology ; Disease Outbreaks/veterinary ; Egypt/epidemiology ; Humans ; Influenza A Virus, H5N1 Subtype/genetics ; Influenza A Virus, H5N1 Subtype/pathogenicity ; Influenza in Birds/epidemiology ; Influenza in Birds/transmission ; Influenza in Birds/virology ; Influenza, Human/epidemiology ; Influenza, Human/transmission ; Influenza, Human/virology ; Middle East/epidemiology ; Orthomyxoviridae Infections/epidemiology ; Orthomyxoviridae Infections/transmission ; Orthomyxoviridae Infections/virology ; Population Surveillance ; United States/epidemiology ; Zoonoses/epidemiology ; Zoonoses/transmission ; Zoonoses/virology

المؤلفون: Malakoff D

المصدر: Science (New York, N.Y.) [Science] 2012 Dec 21; Vol. 338 (6114), pp. 1533.

نوع المنشور: News

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Biomedical Research*/economics, Influenza A Virus, H5N1 Subtype/*genetics , Influenza A Virus, H5N1 Subtype/*pathogenicity , Influenza, Human/*virology , Orthomyxoviridae Infections/*virology, Animals ; Financing, Government ; Humans ; Influenza, Human/transmission ; Mammals ; Orthomyxoviridae Infections/transmission ; Publishing ; Research Support as Topic ; Security Measures ; United States

المؤلفون: Enserink M

المصدر: Science (New York, N.Y.) [Science] 2011 Dec 02; Vol. 334 (6060), pp. 1192-3.

نوع المنشور: News

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Host Specificity* , Pandemics*, Influenza A Virus, H5N1 Subtype/*genetics , Influenza A Virus, H5N1 Subtype/*pathogenicity , Influenza, Human/*virology , Orthomyxoviridae Infections/*virology, Animals ; Bioterrorism ; Ferrets ; Humans ; Influenza in Birds/virology ; Influenza, Human/epidemiology ; Influenza, Human/mortality ; Influenza, Human/transmission ; International Cooperation ; Netherlands ; Orthomyxoviridae Infections/epidemiology ; Orthomyxoviridae Infections/transmission ; Orthomyxoviridae Infections/veterinary ; Poultry ; Publishing ; Serial Passage ; United States ; United States Dept. of Health and Human Services

المؤلفون: Fauci AS; National Institutes of Health, Bethesda, MD 20892, USA. afauci@niaid.nih.gov, Collins FS

المصدر: Science (New York, N.Y.) [Science] 2012 Jun 22; Vol. 336 (6088), pp. 1522-3.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Biomedical Research* , Publishing*, Influenza A Virus, H5N1 Subtype/*genetics , Influenza A Virus, H5N1 Subtype/*pathogenicity , Influenza, Human/*virology , Orthomyxoviridae Infections/*virology, Advisory Committees ; Animals ; Bioterrorism ; Disease Models, Animal ; Evolution, Molecular ; Ferrets ; Humans ; Influenza, Human/mortality ; Influenza, Human/transmission ; Mutation ; National Institutes of Health (U.S.) ; Orthomyxoviridae Infections/transmission ; Public Health ; Public Policy ; Reassortant Viruses/genetics ; Reassortant Viruses/pathogenicity ; Risk Assessment ; Security Measures ; United States

مستخلص: Given the yearly challenge of seasonal influenza and the potential catastrophic consequences of future pandemics, the need for intensive basic and clinical influenza research is unquestionable. Although the fruits of decades of research have enabled dramatic improvements in our ability to prevent and treat influenza, many fundamental questions remain, including those related to the complex factors associated with host switching and transmission of influenza viruses. Recent public concern over two H5N1 influenza manuscripts that studied the transmissibility of influenza viruses has triggered intense discussion on dual-use research and the way forward.

المؤلفون: Lipsitch M; Center for Communicable Disease Dynamics and Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. mlipsitc@hsph.harvard.edu, Plotkin JB, Simonsen L, Bloom B

المصدر: Science (New York, N.Y.) [Science] 2012 Jun 22; Vol. 336 (6088), pp. 1529-31.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Containment of Biohazards* , Evolution, Molecular* , Safety*, Influenza A Virus, H5N1 Subtype/*pathogenicity , Influenza A virus/*pathogenicity , Influenza, Human/*virology , Orthomyxoviridae Infections/*virology, Animals ; Antigenic Variation ; Antigens, Viral ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Biohazard Release ; Drug Resistance, Viral ; Ferrets ; Humans ; Influenza A Virus, H5N1 Subtype/genetics ; Influenza A virus/drug effects ; Influenza A virus/genetics ; Influenza A virus/immunology ; Influenza, Human/drug therapy ; Influenza, Human/transmission ; Laboratory Infection/epidemiology ; Mutation ; Orthomyxoviridae Infections/transmission ; Public Policy ; Risk Assessment ; Security Measures ; United States/epidemiology

مستخلص: Experience with influenza has shown that predictions of virus phenotype or fitness from nucleotide sequence are imperfect and that predicting the timing and course of evolution is extremely difficult. Such uncertainty means that the risk of experiments with mammalian-transmissible, possibly highly virulent influenza viruses remains high even if some aspects of their laboratory biology are reassuring; it also implies limitations on the ability of laboratory observations to guide interpretation of surveillance of strains in the field. Thus, we propose that future experiments with virulent pathogens whose accidental or deliberate release could lead to extensive spread in human populations should be limited by explicit risk-benefit considerations.

المؤلفون: Cohen J

المصدر: Science (New York, N.Y.) [Science] 2012 Feb 24; Vol. 335 (6071), pp. 899-900.

نوع المنشور: News

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Publishing* , World Health Organization*, Influenza A Virus, H5N1 Subtype/*pathogenicity , Orthomyxoviridae Infections/*virology, Advisory Committees ; Animals ; Ferrets ; Humans ; Influenza A Virus, H5N1 Subtype/genetics ; Influenza, Human/transmission ; Influenza, Human/virology ; National Institute of Allergy and Infectious Diseases (U.S.) ; National Institutes of Health (U.S.) ; Orthomyxoviridae Infections/transmission ; Research Support as Topic ; United States