المؤلفون: Lagou V; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Department of Microbiology and Immunology, Laboratory of Adaptive Immunity, KU Leuven, Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, VU University medical center, Amsterdam, the Netherlands., Grallert H; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD, München-Neuherberg, Germany., Perry JRB; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Bouatia-Naji N; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; INSERM U970, Paris Cardiovascular Research Center PARCC, 75006, Paris, France., Marullo L; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Rybin D; Boston University Data Coordinating Center, Boston, MA, USA., Jansen R; Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands., Min JL; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, University of Bristol, Bristol, United Kingdom., Dimas AS; Institute for Bioinnovation, Biomedical Sciences Research Center Al. Fleming, Vari, Greece., Ulrich A; Department of Medicine, Imperial College London, London, UK., Zudina L; Department of Medicine, Imperial College London, London, UK., Gådin JR; Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Karolinska University Hospital, Solna, Sweden., Jiang L; Department of Medicine, Imperial College London, London, UK.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Faggian A; Department of Medicine, Imperial College London, London, UK., Bonnefond A; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; Department of Medicine, Imperial College London, London, UK., Fadista J; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Stathopoulou MG; Université de Lorraine, IGE-PCV, F-54000, Nancy, France., Isaacs A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; CARIM School for Cardiovascular Diseases and Maastricht Centre for Systems Biology (MaCSBio, Maastricht University, Maastricht, the Netherlands.; Department of Physiology, Maastricht University, Maastricht, the Netherlands., Willems SM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Navarro P; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Tanaka T; Translational Gerontology Branch, Longitudinal Study Section, National Institute on Aging, Baltimore, MD, USA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Montasser ME; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA., O'Connell JR; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Webster RJ; Laboratory for Cancer Medicine, Harry Perkins Institute of Medical Research, University of Western Australia Centre for Medical Research, Nedlands, WA, Australia., Saxena R; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Departmentartment of Anesthesia, Critical Care and Pain Medicine, MGH, Boston, MA, USA., Stafford JM; Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Pourcain BS; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, University of Bristol, Bristol, United Kingdom., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, University of Bristol, Bristol, United Kingdom., Salo P; Public Health Genomics Unit, Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland., Shin SY; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Amin N; Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands., Smith AV; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Li G; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Ford I; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK., Johnson PCD; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.; Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Glasgow, UK., Johnson T; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Kapur K; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland., Thorleifsson G; deCODE Genetics, Reykjavik, Iceland., Strawbridge RJ; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.; Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK., Rasmussen-Torvik LJ; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Esko T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Mihailov E; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Fall T; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Fraser RM; Usher Institute, University of Edinburgh, Edinburgh, UK.; Synpromics Ltd, Roslin Innovation Centre, Easter Bush Campus, Edinburgh, EH25 9RG, UK., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Genentech, 340 Point San Bruno Boulevard, South San Francisco, CA, 94080, USA., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Wellcome Trust Sanger Institute, Hinxton, UK., Giedraitis V; Department of Public Health and Caring Sciences, Uppsala Universitet, Uppsala, Sweden., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Silbernagel G; Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Meyer J; Institute of Genetic Epidemiology,Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology,Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology and Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI, University Medical Center, Johannes Gutenberg University, 55101, Mainz, Germany., Ganna A; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sarin AP; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Public Health Genomics Unit, Finnish Institute for Health and Welfare, Helsinki, Finland., Yengo L; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Shungin D; Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden.; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.; Department of Odontology, Umeå University, Umeå, Sweden., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Horikoshi M; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; RIKEN, Center for Integrative Medical Sciences, Laboratory for Endocrinology, Metabolism and Kidney Disease, Yokohama, Japan., An P; Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA., Sanna S; Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy.; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Boettcher Y; Department of Medicine, University of Leipzig, Leipzig, Germany.; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Rayner NW; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Wellcome Trust Sanger Institute, Hinxton, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Zemunik T; Faculty of Medicine, University of Split, Split, Croatia., Iperen EV; Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Kovacs P; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Hastie ND; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Wild SH; Usher Institute, University of Edinburgh, Edinburgh, UK., McLachlan S; Usher Institute, University of Edinburgh, Edinburgh, UK., Campbell S; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Polasek O; Faculty of Medicine, University of Split, Split, Croatia., Carlson O; Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, MD, USA., Egan J; Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, MD, USA., Kiess W; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.; Pediatric Research Center, Department of Women's & Child Health, University of Leipzig, Leipzig, Germany., Willemsen G; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands., Kuusisto J; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Dimitriou M; Department of Dietetics-Nutrition, Harokopio University, Athens, Greece., Hicks AA; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of LübeckLübeckGermany), Bolzano, Italy., Rauramaa R; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Bandinelli S; Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy., Thorand B; German Center for Diabetes Research (DZD, München-Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Liu Y; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Miljkovic I; Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA, USA., Lind L; Department of Medical Sciences, Uppsala University, Akademiska sjukhuset, Uppsala, Sweden., Doney A; Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Perola M; Public Health Genomics Unit, Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland.; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Estonian Genome Center, University of Tartu, Tartu, Estonia., Hingorani A; Department of Epidemiology and Public Health, University College London, London, UK., Kivimaki M; Department of Epidemiology and Public Health, University College London, London, UK., Kumari M; Department of Epidemiology and Public Health, University College London, London, UK.; University of Essex, Wivenhoe Park, Colchester, Essex, UK., Bennett AJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Herder C; German Center for Diabetes Research (DZD, München-Neuherberg, Germany.; Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Koistinen HA; Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland.; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, P.O. Box 340, Haartmaninkatu 4, Helsinki, FI-00029, Finland.; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Tukholmankatu 8, Helsinki, FI-00290, Finland., Kinnunen L; Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Faire U; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Bakker SJL; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Uusitupa M; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Palmer CNA; Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Jukema JW; Dept of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands., Sattar N; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom., Pouta A; Department of Government Services, Finnish Institute for Health and Welfare, Helsinki, Finland.; PEDEGO Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Boerwinkle E; IMM Center for Human Genetics, University of Texas Health Science Center at Houston, Houston, TX, USA.; Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MiI, USA., Magnusson PK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Krus U; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden., Scapoli C; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., de Geus EJCN; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, VU University medical center, Amsterdam, the Netherlands., Blüher M; Department of Medicine, University of Leipzig, Leipzig, Germany.; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Wolffenbuttel BHR; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Province MA; Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA., Abecasis GR; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Meigs JB; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; General Medicine Division, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hovingh GK; Department of Vascular Medicine, Amsterdam UMC, Amsterdam, the Netherlands.; Novo Nordisk A/S, Copenhagen, Denmark., Lindström J; Finnish Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland., Wilson JF; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Usher Institute, University of Edinburgh, Edinburgh, UK., Wright AF; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Dedoussis GV; Department of Dietetics-Nutrition, Harokopio University, Athens, Greece., Bornstein SR; Department of Medicine, Division for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Schwarz PEH; Department for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Tönjes A; Department of Medicine, University of Leipzig, Leipzig, Germany.; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Winkelmann BR; Cardiology Group, Frankfurt-Sachsenhausen, Germany., Boehm BO; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore and Imperial College London, Singapore, Singapore., März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany., Metspalu A; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Price JF; Usher Institute, University of Edinburgh, Edinburgh, UK., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Wellcome Trust Sanger Institute, Hinxton, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD, King Abdulaziz University, Jeddah, Saudi Arabia., Körner A; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.; Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA., Lakka TA; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland., Keinanen-Kiukaanniemi SM; Faculty of Medicine, Center for Life Course Health Research, University of Oulu, Oulu, Finland.; Unit of General Practice, Oulu University Hospital, Oulu, Finland., Saaristo TE; Finnish Diabetes Association, Tampere, Finland.; Pirkanmaa Hospital District, Tampere, Finland., Bergman RN; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Tuomilehto J; Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Centre for Vascular Prevention, Danube-University Krems, Krems, Austria.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Männistö S; Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.; Department of Public Health & Clinical Medicine, Units of Medicine and Nutritional Research, Umeå University, Umeå, Sweden., Hayward C; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Vitart V; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Kaprio J; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland., Visvikis-Siest S; Université de Lorraine, IGE-PCV, F-54000, Nancy, France., Balkau B; Inserm, CESP Center for Research in Epidemiology and Public Health, U1018, Villejuif, France.; Univ Paris-Saclay, Univ Paris Sud, UVSQ, UMRS 1018, UMRS 1018, Villejuif, France., Altshuler D; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Rudan I; Usher Institute, University of Edinburgh, Edinburgh, UK., Stumvoll M; Department of Medicine, University of Leipzig, Leipzig, Germany.; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Campbell H; Usher Institute, University of Edinburgh, Edinburgh, UK., van Duijn CM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Centre for Medical Systems Biology, Leiden, the Netherlands., Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD, München-Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Illig T; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.; Institute of Human Genetics, Hannover Medical School, Hannover, Germany., Ferrucci L; Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Pramstaller PP; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of LübeckLübeckGermany), Bolzano, Italy.; Department of Neurology, General Central Hospital, Bolzano, Italy.; Department of Neurology, University of Lübeck, Lübeck, Germany., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Frayling TM; Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, UK., Shuldiner AR; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA.; The Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Palmer LJ; School of Public Health, University of Adelaide, Adelaide, Australia., Penninx BW; Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands., Meneton P; U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, 75006, Paris, France., Harris TB; Geriatric Epidemiology Section, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA., Navis G; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Harst PV; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Smith GD; MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK., Forouhi NG; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Loos RJF; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Salomaa V; Finnish Institute for Health and Welfare, Helsinki, Finland., Soranzo N; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Boomsma DI; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands., Groop L; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden., Tuomi T; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden.; Endocrinology, Abdominal Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, University of Helsinki and Folkhälsan Research Center, Helsinki, Finland., Hofman A; Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands.; Netherlands Consortium for healthy ageing, the Hague, the Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine University of Iceland, Reykjavik, Iceland., Siscovick DS; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Lecoeur C; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France., Vollenweider P; Department of Medicine, University Hospital Lausanne, Lausanne, Switzerland., Franco-Cereceda A; Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Eriksson P; Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Karolinska University Hospital, Solna, Sweden., Jarvelin MR; Department of Epidemiology and Biostatistics and HPA-MRC Center, School of Public Health, Imperial College London, London, UK.; Institue of Health Sciences, University of Oulu, Oulu, Finland., Stefansson K; deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Hamsten A; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.; Department of Cardiology, Karolinska University Hospital Solna, Stockholm, Sweden., Nicholson G; Department of Statistics, University of Oxford, Oxford, UK., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK., Dermitzakis ET; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland., Lindgren CM; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK.; Genentech, 340 Point San Bruno Boulevard, South San Francisco, CA, 94080, USA., Froguel P; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; Department of Medicine, Imperial College London, London, UK., Kaakinen MA; Department of Medicine, Imperial College London, London, UK.; School of Biosciences and Medicine, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK., Lyssenko V; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden.; Department of Clinical Science, University of Bergen, Bergen, Norway., Watanabe RM; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA.; Department of Physiology & Neuroscience, Keck School of Medicine of USC, Los Angeles, CA, USA.; USC Diabetes and Obesity Research Institute, Los Angeles, CA, USA., Ingelsson E; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, 94305, USA., Florez JC; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Barroso I; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK.; Exeter Centre of ExcEllence in Diabetes (ExCEED), University of Exeter Medical School, Exeter, UK., Morris AP; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK., Prokopenko I; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom. i.prokopenko@surrey.ac.uk.; Department of Medicine, Imperial College London, London, UK. i.prokopenko@surrey.ac.uk.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. i.prokopenko@surrey.ac.uk.; School of Biosciences and Medicine, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.; Institute of Biochemistry and Genetics, Ufa Federal Research Centre Russian Academy of Sciences, Ufa, Russian Federation. i.prokopenko@surrey.ac.uk.

مؤلفون مشاركون: Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)

المصدر: Nature communications [Nat Commun] 2021 Jan 05; Vol. 12 (1), pp. 24. Date of Electronic Publication: 2021 Jan 05.

نوع المنشور: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Anorexia Nervosa/*genetics , Blood Glucose/*metabolism , Glucose Intolerance/*genetics , Insulin/*blood , Insulin Receptor Substrate Proteins/*genetics , Insulin Resistance/*genetics , Kruppel-Like Transcription Factors/*genetics, Adult ; Anorexia Nervosa/blood ; Anorexia Nervosa/ethnology ; Anorexia Nervosa/physiopathology ; Fasting/blood ; Female ; Gene Expression ; Genetic Loci ; Genome-Wide Association Study ; Glucose Intolerance/blood ; Glucose Intolerance/ethnology ; Glucose Intolerance/physiopathology ; Humans ; Insulin Receptor Substrate Proteins/blood ; Kruppel-Like Transcription Factors/blood ; Male ; Middle Aged ; Phenotype ; Sex Characteristics ; Sex Factors ; Waist-Hip Ratio ; White People

المؤلفون: Silbernagel G; Department of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Eberhard-Karls-University Tübingen, Tübingen, Germany., Renner W, Grammer TB, Hügl SR, Bertram J, Kleber ME, Hoffmann MM, Winkelmann BR, März W, Boehm BO

المصدر: Diabetes/metabolism research and reviews [Diabetes Metab Res Rev] 2011 Jul; Vol. 27 (5), pp. 499-505.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883450 Publication Model: Print Cited Medium: Internet ISSN: 1520-7560 (Electronic) Linking ISSN: 15207552 NLM ISO Abbreviation: Diabetes Metab Res Rev Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes Mellitus, Type 2/*genetics , Glucagon-Like Peptide 1/*blood , Insulin/*blood , Proinsulin/*blood , Transcription Factor 7-Like 2 Protein/*genetics, Age of Onset ; Aged ; Diabetes Mellitus, Type 2/blood ; Female ; Glucose Tolerance Test ; Glycated Hemoglobin/analysis ; Humans ; Insulin/metabolism ; Insulin Secretion ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Risk ; White People/genetics

المؤلفون: Silbernagel G; Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, Department of Internal Medicine, Eberhard-Karls-University Tübingen, Otfried-Müller-Straße 10, 72076 Tübingen, Germany., Machann J, Unmuth S, Schick F, Stefan N, Häring HU, Fritsche A

المصدر: The British journal of nutrition [Br J Nutr] 2011 Jul; Vol. 106 (1), pp. 79-86. Date of Electronic Publication: 2011 Mar 14.

نوع المنشور: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Published on behalf of the Nutrition Society by CABI Publishing Country of Publication: England NLM ID: 0372547 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-2662 (Electronic) Linking ISSN: 00071145 NLM ISO Abbreviation: Br J Nutr Subsets: MEDLINE

مواضيع طبية MeSH: Fructose/*administration & dosage , Glucose/*administration & dosage , Insulin/*metabolism , Intra-Abdominal Fat/*drug effects , Lipid Metabolism/*drug effects , Liver/*drug effects, Adult ; Body Composition/drug effects ; Diet ; Dose-Response Relationship, Drug ; Female ; Fructose/pharmacology ; Glucose/pharmacology ; Glucose Tolerance Test ; Humans ; Liver/metabolism ; Male ; Middle Aged ; Nutritional Physiological Phenomena ; Uric Acid/blood ; Young Adult

المؤلفون: Müssig K; Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tübingen, Tübingen, Germany., Staiger H, Machicao F, Kirchhoff K, Guthoff M, Schäfer SA, Kantartzis K, Silbernagel G, Stefan N, Holst JJ, Gallwitz B, Häring HU, Fritsche A

المصدر: Diabetes [Diabetes] 2009 Jul; Vol. 58 (7), pp. 1715-20. Date of Electronic Publication: 2009 Apr 14.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Variation* , Polymorphism, Genetic* , Polymorphism, Single Nucleotide*, Diabetes Mellitus, Type 2/*genetics , Incretins/*metabolism , Insulin/*metabolism , KCNQ1 Potassium Channel/*genetics, Adult ; Chromosome Mapping ; Chromosomes, Human, Pair 11 ; Diabetes Mellitus, Type 2/physiopathology ; Exons ; Female ; Germany ; Glucose Tolerance Test ; Humans ; Insulin Secretion ; Male ; Middle Aged ; Protein Subunits/genetics ; White People/genetics