المؤلفون: Alarcan H; Service de Biochimie et Biologie Moléculaire, CHRU Bretonneau, Tours, France.; UMR 1253 iBrain, Université de Tours, Inserm, Tours, France., Bruno C; Service de Pharmacologie Médicale, CHRU Bretonneau, Tours, France., Emond P; UMR 1253 iBrain, Université de Tours, Inserm, Tours, France.; Laboratoire de Médecine nucléaire in vitro, CHRU Bretonneau, Tours, France., Raoul C; INM, University of Montpellier, INSERM, Montpellier, France.; ALS Reference Center, University of Montpellier, CHU Montpellier, Montpellier, France., Vourc'h P; Service de Biochimie et Biologie Moléculaire, CHRU Bretonneau, Tours, France.; UMR 1253 iBrain, Université de Tours, Inserm, Tours, France., Corcia P; UMR 1253 iBrain, Université de Tours, Inserm, Tours, France.; Service de Neurologie, CHRU Bretonneau, Tours, France., Camu W; INM, University of Montpellier, INSERM, Montpellier, France.; ALS Reference Center, University of Montpellier, CHU Montpellier, Montpellier, France., Veyrune JL; Institute of Human Genetics, University of Montepllier, Montpellier, France., Garlanda C; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; IRCCS Humanitas Research Hospital, Rozzano, Italy., Locati M; IRCCS Humanitas Research Hospital, Rozzano, Italy., Juntas-Morales R; Neuromuscular Diseases Unit, European Reference Network on Rare Neuromuscular Diseases (ERN EURO-NMD), Department of Neurology, Vall d'Hebron University Hospital, Barcelona, Spain., Saker S; Genethon, DNA and Cell bank, Evry, France., Suehs C; Laboratoire de Biostatistique, Epidémiologie clinique, Santé Publique, Innovation et Méthodologie (BESPIM), Université de Nîmes, Nîmes, France., Masseguin C; Delegation for Clinical Research and Innovation, Nîmes University Hospital, Nîmes, France., Kirby J; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK., Shaw P; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK., Malaspina A; UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, Queen Square, London, UK., De Vos J; Department of Cell and Tissue Engineering, University Montpellier, CHU Montpellier, Montpellier, France., Al-Chalabi A; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK., Leigh PN; Brighton and Sussex Medical School, Brighton, UK., Tree T; Department of Computer Science, University of Sheffield, Sheffield, UK., Bensimon G; Laboratoire de Biostatistique, Epidémiologie clinique, Santé Publique, Innovation et Méthodologie (BESPIM), Université de Nîmes, Nîmes, France., Blasco H; Service de Biochimie et Biologie Moléculaire, CHRU Bretonneau, Tours, France.; UMR 1253 iBrain, Université de Tours, Inserm, Tours, France.

المصدر: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2024 Jun; Vol. 1536 (1), pp. 82-91. Date of Electronic Publication: 2024 May 21.

نوع المنشور: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial

بيانات الدورية: Publisher: New York Academy of Sciences Country of Publication: United States NLM ID: 7506858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1749-6632 (Electronic) Linking ISSN: 00778923 NLM ISO Abbreviation: Ann N Y Acad Sci Subsets: MEDLINE

مواضيع طبية MeSH: Amyotrophic Lateral Sclerosis*/drug therapy , Amyotrophic Lateral Sclerosis*/metabolism , Interleukin-2*/administration & dosage , Interleukin-2*/metabolism , Metabolomics*/methods , T-Lymphocytes, Regulatory*/metabolism , T-Lymphocytes, Regulatory*/drug effects , T-Lymphocytes, Regulatory*/immunology, Humans ; Male ; Middle Aged ; Female ; Kynurenine/metabolism ; Aged ; Metabolome/drug effects

المؤلفون: Camu W; Clinique du Motoneurone, CHU Gui de Chauliac, University of Montpellier, Montpellier, France., Mickunas M; Department Immunobiology, Faculty of Life Sciences and Medicine, King's College London, London, UK; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK., Veyrune JL; Department of Cell and Tisue Engineering, University of Montpellier, CHU Montpellier, Montpellier France., Payan C; Department of Biostatistics, Clinical Epidemiology, Public Health and Innovation in Methodology (BESPIM), Nîmes University Hospital, Nîmes, France; Department of Pharmacology, AP-HP.Sorbonne Université, Pitié-Salpêtrière Hospital, 47, Bd de l'Hôpital, F-75013 Paris, France., Garlanda C; IRCCS Humanitas Clinical & Research Institute, Milan, Italy; Humanitas University, Pieve Emanuele, Milan, Italy., Locati M; IRCCS Humanitas Clinical & Research Institute, Milan, Italy; Department of Medical Biotechnologies and Translational Medicine, University Milan, Milan Italy., Juntas-Morales R; Clinique du Motoneurone, CHU Gui de Chauliac, University of Montpellier, Montpellier, France., Pageot N; Clinique du Motoneurone, CHU Gui de Chauliac, University of Montpellier, Montpellier, France., Malaspina A; Neuroscience and Trauma Centre, Institute of Cell and Molecular Medicine, Department of Neuroimmunology, Barts and the London School of Medicine and Dentistry, London, UK., Andreasson U; Department of Psychiatry & Neurochemistry, University of Gothenburg, Mölndal, Sweden., Kirby J; Sheffield Institute for Translational Neuroscience, Department of Neuroscience, University of Sheffield, Sheffield, UK., Suehs C; Departments of Medical Information and Respiratory Diseases, University of Montpellier, CHU Montpellier, Montpellier, France., Saker S; DNA and Cell Bank, Genethon, Evry, France., Masseguin C; Delegation for Clinical Research and Innovation, Nîmes University Hospital, Nîmes, France., De Vos J; Department of Cell and Tisue Engineering, University of Montpellier, CHU Montpellier, Montpellier France., Zetterberg H; Department of Psychiatry & Neurochemistry, University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK; UK Dementia Research Institute at UCL, London, UK., Shaw PJ; Sheffield Institute for Translational Neuroscience, Department of Neuroscience, University of Sheffield, Sheffield, UK., Al-Chalabi A; Institute of Psychiatry Psychology and Neuroscience, Department of Basic and Clinical Neuroscience, King's College London, London, UK; Department of Neurology, King's College Hospital, London, UK., Leigh PN; The Trafford Centre for Biomedical Research, Brighton and Sussex Medical School, Falmer, Brighton BN1 9RY, UK., Tree T; Department Immunobiology, Faculty of Life Sciences and Medicine, King's College London, London, UK; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK. Electronic address: timothy.tree@kcl.ac.uk., Bensimon G; Department of Biostatistics, Clinical Epidemiology, Public Health and Innovation in Methodology (BESPIM), Nîmes University Hospital, Nîmes, France; Department of Pharmacology, AP-HP.Sorbonne Université, Pitié-Salpêtrière Hospital, 47, Bd de l'Hôpital, F-75013 Paris, France; Department of Pharmacology, Sorbonne Université Médecine, F-75013 Paris, France. Electronic address: gbensimon.psl@gmail.com.

المصدر: EBioMedicine [EBioMedicine] 2020 Sep; Vol. 59, pp. 102844. Date of Electronic Publication: 2020 Jul 07.

نوع المنشور: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial

بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE

مواضيع طبية MeSH: Amyotrophic Lateral Sclerosis/*drug therapy , Antineoplastic Agents/*administration & dosage , Interleukin-2/*analogs & derivatives, Aged ; Aged, 80 and over ; Amyotrophic Lateral Sclerosis/diagnosis ; Amyotrophic Lateral Sclerosis/etiology ; Amyotrophic Lateral Sclerosis/metabolism ; Biomarkers ; Chemokines ; Cytokines ; Female ; Humans ; Immunophenotyping ; Interleukin-2/administration & dosage ; Interleukin-2/metabolism ; Male ; Middle Aged ; Recombinant Proteins/administration & dosage ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Treatment Outcome

المؤلفون: Hartemann A; Department of Diabetology, Hôpital Pitié-Salpêtrière, Paris, France., Bensimon G; Department of Clinical Pharmacology, Hôpital Pitié-Salpêtrière, Paris, France; Pharmacologie, Paris, France., Payan CA; Department of Clinical Pharmacology, Hôpital Pitié-Salpêtrière, Paris, France., Jacqueminet S; Department of Diabetology, Hôpital Pitié-Salpêtrière, Paris, France., Bourron O; Department of Diabetology, Hôpital Pitié-Salpêtrière, Paris, France., Nicolas N; Clinical Investigation Center Paris-Est-CIC-9304, Hôpital Pitié-Salpêtrière, Paris, France., Fonfrede M; Department of Biochemistry, Hôpital Pitié-Salpêtrière, Paris, France., Rosenzwajg M; Clinical Investigation Center for Biotherapies and Inflammation-Immunopathology-Biotherapy Department AP-HP, Hôpital Pitié-Salpêtrière, Paris, France; Immunology-Immunopathology-Immunotherapy UPMC Univ Paris 06, Paris, France; INSERM, UMR_S 959, Immunology-Immunopathology-Immunotherapy, Paris, France; CNRS, UMR 7211, Immunology-Immunopathology-Immunotherapy, Paris, France., Bernard C; Clinical Investigation Center for Biotherapies and Inflammation-Immunopathology-Biotherapy Department AP-HP, Hôpital Pitié-Salpêtrière, Paris, France; Immunology-Immunopathology-Immunotherapy UPMC Univ Paris 06, Paris, France; INSERM, UMR_S 959, Immunology-Immunopathology-Immunotherapy, Paris, France; CNRS, UMR 7211, Immunology-Immunopathology-Immunotherapy, Paris, France., Klatzmann D; Clinical Investigation Center for Biotherapies and Inflammation-Immunopathology-Biotherapy Department AP-HP, Hôpital Pitié-Salpêtrière, Paris, France; Immunology-Immunopathology-Immunotherapy UPMC Univ Paris 06, Paris, France; INSERM, UMR_S 959, Immunology-Immunopathology-Immunotherapy, Paris, France; CNRS, UMR 7211, Immunology-Immunopathology-Immunotherapy, Paris, France. Electronic address: david.klatzmann@upmc.fr.

المصدر: The lancet. Diabetes & endocrinology [Lancet Diabetes Endocrinol] 2013 Dec; Vol. 1 (4), pp. 295-305. Date of Electronic Publication: 2013 Oct 08.

نوع المنشور: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Lancet, Diabetes & Endocrinology Country of Publication: England NLM ID: 101618821 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-8595 (Electronic) Linking ISSN: 22138587 NLM ISO Abbreviation: Lancet Diabetes Endocrinol Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes Mellitus, Type 1/*drug therapy , Diabetes Mellitus, Type 1/*immunology , Interleukin-2/*administration & dosage, Adult ; Diabetes Mellitus, Type 1/diagnosis ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; Young Adult