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المؤلفون: Lykke Sylow, Anne-Julie Oxboll, David E. James, Andreas Børsting Jordy, Daniel J. Fazakerley, Markus A. Rüegg, Kristen C. Thomas, James R. Krycer, Thomas E. Jensen, Guang Yang, Maximilian Kleinert, Peter Schjerling, Erik A. Richter, Bente Kiens
المساهمون: Fazakerley, Daniel [0000-0001-8241-2903], Apollo - University of Cambridge Repository
المصدر: Molecular Metabolism
مصطلحات موضوعية: medicine.medical_specialty, biology, Glucose uptake, Skeletal muscle, Cell Biology, mTORC1, medicine.disease, mTORC2, Rictor, Metabolism, Endocrinology, medicine.anatomical_structure, Insulin resistance, Internal medicine, medicine, biology.protein, Myocyte, Glucose homeostasis, Original Article, Glycolysis, Molecular Biology, GLUT4
وصف الملف: application/pdf
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المؤلفون: Pankaj S. Shende, Thierry Pedrazzini, Beat A. Kaufmann, Philippe Heim, Michael N. Hall, Markus A. Rüegg, Marijke Brink, Corinne Berthonneche, Laura Pentassuglia, Lifen Xu, Christian Morandi, Sonia Lebboukh
المصدر: Cardiovascular Research
مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Physiology, Apoptosis, Cardiomegaly, Mechanistic Target of Rapamycin Complex 2, mTORC1, Biology, mTORC2, Muscle hypertrophy, Mice, 03 medical and health sciences, Fibrosis, Physiology (medical), Internal medicine, medicine, Animals, Ventricular Function, Phosphorylation, Protein Kinase C, PI3K/AKT/mTOR pathway, Protein kinase C, Pressure overload, Myocardium, TOR Serine-Threonine Kinases, digestive, oral, and skin physiology, Phosphoproteins, medicine.disease, Mice, Inbred C57BL, Rapamycin-Insensitive Companion of mTOR Protein, 030104 developmental biology, Endocrinology, Multiprotein Complexes, Heart failure, Carrier Proteins, Cardiology and Cardiovascular Medicine, Proto-Oncogene Proteins c-akt, Signal Transduction
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156b49d428020934c9059a2575ea02c3
https://edoc.unibas.ch/40862/ -
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المؤلفون: Markus H. Heim, Pazit Polak, Charles Betz, Marion Cornu, Michael N. Hall, Luigi Terracciano, Asami Hagiwara, Francesca Trapani, Nadine Cybulski, Markus A. Rüegg
المصدر: Cell Metabolism
Cell metabolismمصطلحات موضوعية: Male, Physiology, FOXO1, mTORC1, mTORC2, Glycogen Synthase Kinase 3, Mice, 0302 clinical medicine, Glucokinase, Homeostasis, Insulin, Glycolysis, Phosphorylation, Mice, Knockout, 0303 health sciences, Forkhead Box Protein O1, TOR Serine-Threonine Kinases, Forkhead Transcription Factors, 3. Good health, Liver, 030220 oncology & carcinogenesis, Lipogenesis, Sterol Regulatory Element Binding Protein 1, Signal Transduction, medicine.medical_specialty, Mechanistic Target of Rapamycin Complex 2, Mechanistic Target of Rapamycin Complex 1, Biology, 03 medical and health sciences, Hyperinsulinism, Internal medicine, Glucose Intolerance, medicine, Animals, Molecular Biology, Protein kinase B, 030304 developmental biology, Glycogen Synthase Kinase 3 beta, Gluconeogenesis, Proteins, Cell Biology, Lipid Metabolism, Glucose, Endocrinology, Hyperglycemia, Multiprotein Complexes, Hepatocytes, Trans-Activators, Proto-Oncogene Proteins c-akt, Transcription Factors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280711189f4fb28a4f64e7705f1f8603
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المؤلفون: Götz Hartleben, Andrea Debreczeni-Mór, Maja T. Lindenmeyer, Gerd Walz, Nadja Herbach, Tobias B. Huber, Ken Inoki, Hermann Pavenstädt, Maria Pia Rastaldi, Markus Gödel, Shun Lu, Stefan Zschiedrich, Matthias Kretzler, Shuya Liu, Michael N. Hall, Alessia Fornoni, Markus A. Rüegg, Clemens D. Cohen, Dontscho Kerjaschki, Björn Hartleben, Thorsten Wiech, Robert G. Nelson, Rüdiger Wanke
المساهمون: University of Zurich
المصدر: The Journal of clinical investigation
مصطلحات موضوعية: Kidney Glomerulus, Gene Dosage, 030232 urology & nephrology, 2700 General Medicine, mTORC1, urologic and male genital diseases, mTORC2, 10052 Institute of Physiology, Podocyte, Diabetic nephropathy, Mice, 0302 clinical medicine, 10035 Clinic for Nephrology, Diabetic Nephropathies, Mice, Knockout, Mice, Inbred ICR, 0303 health sciences, Podocytes, TOR Serine-Threonine Kinases, General Medicine, Glomerular Hypertrophy, female genital diseases and pregnancy complications, 3. Good health, Proteinuria, medicine.anatomical_structure, Disease Progression, Research Article, medicine.drug, Adult, medicine.medical_specialty, 610 Medicine & health, Mice, Transgenic, Mechanistic Target of Rapamycin Complex 1, Biology, Diabetes Mellitus, Experimental, 03 medical and health sciences, Internal medicine, medicine, Animals, Humans, Genetic Predisposition to Disease, PI3K/AKT/mTOR pathway, Adaptor Proteins, Signal Transducing, 030304 developmental biology, Sirolimus, urogenital system, Nephrosis, Lipoid, Proteins, Glomerulosclerosis, Regulatory-Associated Protein of mTOR, medicine.disease, Mice, Inbred C57BL, Rapamycin-Insensitive Companion of mTOR Protein, Endocrinology, Multiprotein Complexes, Trans-Activators, Commentary, 570 Life sciences, biology, Carrier Proteins, Transcription Factors
وصف الملف: application/pdf; JCI-Gödel-2011.pdf - application/pdf
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المؤلفون: Johan Auwerx, Michael N. Hall, Nadine Cybulski, Pazit Polak, Markus A. Rüegg
المساهمون: Biozentrum [Basel, Suisse], University of Basel (Unibas), Institut Clinique de la Souris (ICS), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Peney, Maité
المصدر: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2009, 106 (24), pp.9902-7. ⟨10.1073/pnas.0811321106⟩
Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 (24), pp.9902-7. ⟨10.1073/pnas.0811321106⟩مصطلحات موضوعية: Male, medicine.medical_treatment, MESH: Insulin-Like Growth Factor I, Adipose tissue, Growth, mTORC1, MESH: Base Sequence, Polymerase Chain Reaction, MESH: Mice, Knockout, mTORC2, Mice, Absorptiometry, Photon, MESH: Cholesterol, 0302 clinical medicine, MESH: Animals, Insulin-Like Growth Factor I, MESH: Fatty Liver, Mice, Knockout, 0303 health sciences, Multidisciplinary, TOR Serine-Threonine Kinases, Biological Sciences, MESH: Adiponectin, Cholesterol, Adipose Tissue, Adiponectin, MESH: Adipose Tissue, MESH: DNA Primers, medicine.medical_specialty, Normal diet, MESH: Carrier Proteins, MESH: Absorptiometry, Photon, Biology, 03 medical and health sciences, Internal medicine, medicine, Animals, MESH: Mice, MESH: Protein Kinases, Protein kinase B, PI3K/AKT/mTOR pathway, DNA Primers, 030304 developmental biology, MESH: Growth, Base Sequence, Growth factor, RPTOR, MESH: Polymerase Chain Reaction, MESH: Male, Fatty Liver, Rapamycin-Insensitive Companion of mTOR Protein, Endocrinology, Carrier Proteins, Protein Kinases, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73dfaafc5957185d67228b0e9199f474
https://doi.org/10.1073/pnas.0811321106 -
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المؤلفون: Osvaldo Delbono, Ruben Lopez, C. Florian Bentzinger, Claudio Caputo, Klaas Romanino, Susan Treves, Francesco Zorzato, Juan C. Calderón, Marcin Maj, Markus A. Rüegg, Leda Bergamelli, Barbara Mosca, Michael N. Hall
المصدر: The Biochemical journal. 466(1)
مصطلحات موضوعية: Male, medicine.medical_specialty, Calcium Channels, L-Type, chemistry.chemical_element, mTORC1, Biology, Calcium, Mechanistic Target of Rapamycin Complex 1, Biochemistry, mTORC2, Article, Glycogen phosphorylase, Cav1.1, Mice, Internal medicine, Isometric Contraction, medicine, Animals, Muscle, Skeletal, Molecular Biology, Evoked Potentials, Excitation Contraction Coupling, Adaptor Proteins, Signal Transducing, Mice, Knockout, Voltage-dependent calcium channel, Ryanodine receptor, Ryanodine, TOR Serine-Threonine Kinases, Glycogen Phosphorylase, Skeletal muscle, Ryanodine Receptor Calcium Release Channel, Cell Biology, Regulatory-Associated Protein of mTOR, Sarcoplasmic Reticulum, Endocrinology, medicine.anatomical_structure, chemistry, Gene Expression Regulation, Multiprotein Complexes, Biophysics, biology.protein, Signal Transduction
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b767fc89cdd7ce4d7f32ff8e3d67676
https://pubmed.ncbi.nlm.nih.gov/25431931 -
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المؤلفون: Camilla Norrmén, Ueli Suter, Martin Trötzmüller, Frédéric Lebrun-Julien, Anne-Lieke F van Deijk, Harald Köfeler, Gianluca Figlia, Mark H. G. Verheijen, Markus A. Rüegg, Carsten Wessig, Ville Rantanen, August B. Smit, Jorge A. Pereira, Michael N. Hall
المساهمون: Molecular and Cellular Neurobiology, AIMMS, Neuroscience Campus Amsterdam - Brain Mechanisms in Health & Disease, Research Programs Unit, Medicum, Department of Biochemistry and Developmental Biology
المصدر: Cell Reports, 9(2), 646-660. Cell Press
Cell Reports, 9 (2)
Cell reports
Cell Reports, Vol 9, Iss 2, Pp 646-660 (2014)
Norrmen, C, Figlia, G, Lebrun-Julien, F, Pereira, J A, Trotzmuller, M, Kofeler, H C, Rantanen, V, Wessig, C, van Deijk, A L F, Smit, A B, Verheijen, M H G, Ruegg, M A, Hall, M N & Suter, U 2014, ' mTORC1 controls PNS myelination along the mTORC1-RXRgamma-SREBP-lipid biosynthesis axis in Schwann cells ', Cell Reports, vol. 9, no. 2, pp. 646-660 . https://doi.org/10.1016/j.celrep.2014.09.001مصطلحات موضوعية: PROTEIN, mTORC1, mTORC2, Mice, 0302 clinical medicine, COMPLEX 1, AXONAL INTEGRITY, Retinoid X Receptor gamma, lcsh:QH301-705.5, Cells, Cultured, Myelin Sheath, 0303 health sciences, CNS MYELINATION, TOR Serine-Threonine Kinases, Lipids, 3. Good health, Cell biology, medicine.anatomical_structure, Peripheral nervous system, GROWTH, lipids (amino acids, peptides, and proteins), biological phenomena, cell phenomena, and immunity, Sterol Regulatory Element Binding Protein 1, medicine.medical_specialty, education, Mechanistic Target of Rapamycin Complex 2, Mechanistic Target of Rapamycin Complex 1, Biology, SREBP, General Biochemistry, Genetics and Molecular Biology, PERIPHERAL NERVOUS-SYSTEM, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Lipid biosynthesis, Internal medicine, Peripheral Nervous System, medicine, Animals, ddc:610, Protein kinase B, PI3K/AKT/mTOR pathway, Adaptor Proteins, Signal Transducing, 030304 developmental biology, RAT HEPATOCYTES, Regulatory-Associated Protein of mTOR, Sterol regulatory element-binding protein, Endocrinology, lcsh:Biology (General), ELEMENT, Nuclear receptor, Multiprotein Complexes, 3111 Biomedicine, Schwann Cells, 030217 neurology & neurosurgery
وصف الملف: application/pdf; application/application/pdf
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المؤلفون: Claudio Punzo, Shan Ma, Markus A. Rüegg, Fernanda Langellotto, Michael N. Hall, Yun Z. Le, Aditya Venkatesh
المصدر: Experimental Eye Research. :1-13
مصطلحات موضوعية: Photoreceptors, medicine.medical_specialty, Cell Survival, medicine.medical_treatment, Visual function, Regulator, Mechanistic Target of Rapamycin Complex 2, mTORC1, Mechanistic Target of Rapamycin Complex 1, Biology, mTORC2, PI3K, Article, Transcriptome, Mice, Phosphatidylinositol 3-Kinases, Cellular and Molecular Neuroscience, Diabetic retinopathy, Internal medicine, Electroretinography, medicine, Animals, Eye Proteins, PI3K/AKT/mTOR pathway, Sirolimus, Kinase, TOR Serine-Threonine Kinases, Growth factor, RPTOR, Cone survival, Sensory Systems, Cell biology, Mice, Inbred C57BL, Retinitis pigmentosa, Disease Models, Animal, Ophthalmology, Endocrinology, Multiprotein Complexes, Retinal Cone Photoreceptor Cells, mTOR, Immunosuppressive Agents, Neuroprotective, Signal Transduction
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16b213171757b8478915a929546d184