المؤلفون: Riau AK; Tissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore, Singapore.; Duke-NUS Medical School, Ophthalmology and Visual Sciences Academic Clinical Programme, Singapore, Singapore., Htoon HM; Duke-NUS Medical School, Ophthalmology and Visual Sciences Academic Clinical Programme, Singapore, Singapore.; Data Science Unit, Singapore Eye Research Institute, Singapore, Singapore., Alió Del Barrio JL; Cornea, Cataract, and Refractive Surgery Unit, Vissum (Grupo Miranza), Alicante, Spain.; Division of Ophthalmology, Universidad Miguel Hernández, Alicante, Spain., Nubile M; Department of Medicine and Sciences of Ageing, Ophthalmic Clinic, University 'G. D'Annunzio' of Chieti-Pescara, Chieti, Italy., El Zarif M; Optica General, Saida, Lebanon., Mastropasqua L; Department of Medicine and Sciences of Ageing, Ophthalmic Clinic, University 'G. D'Annunzio' of Chieti-Pescara, Chieti, Italy., Alió JL; Cornea, Cataract, and Refractive Surgery Unit, Vissum (Grupo Miranza), Alicante, Spain.; Division of Ophthalmology, Universidad Miguel Hernández, Alicante, Spain., Mehta JS; Tissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore, Singapore. jodmehta@gmail.com.; Duke-NUS Medical School, Ophthalmology and Visual Sciences Academic Clinical Programme, Singapore, Singapore. jodmehta@gmail.com.; Singapore National Eye Centre, Singapore, Singapore. jodmehta@gmail.com.

المصدر: International ophthalmology [Int Ophthalmol] 2021 May; Vol. 41 (5), pp. 1965-1979. Date of Electronic Publication: 2021 Feb 20.

نوع المنشور: Journal Article; Meta-Analysis; Review; Systematic Review

بيانات الدورية: Publisher: Kluwer Country of Publication: Netherlands NLM ID: 7904294 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2630 (Electronic) Linking ISSN: 01655701 NLM ISO Abbreviation: Int Ophthalmol Subsets: MEDLINE

مواضيع طبية MeSH: Keratoconus*/diagnosis , Keratoconus*/surgery, Cornea/surgery ; Corneal Stroma/surgery ; Humans ; Lasers ; Refraction, Ocular

مستخلص: Purpose: Femtosecond lasers have revived the possibility of stromal keratophakia or tissue additive keratoplasty, a technique originally introduced by Prof. Jose Ignacio Barraquer in the 1960s. The surgical technique offers a unique solution to treat keratoconus. In the current study, we reviewed and performed a meta-analysis of the clinical outcomes of the femtosecond laser-assisted stromal keratophakia in the treatment of keratoconus.
Methods: This is a systematic review and meta-analysis of the estimated outcome difference between pre- and post-lenticule implantations.
Results: A total of related 10 studies were found in the literature. No studies reported adverse events, such as persistent haze or graft rejection, at last patients' visits. We further narrowed down the article selection in accordance to our inclusion criteria to report the composite outcomes (9 studies) and meta-analysis (4 studies). In the composite analysis, we demonstrated that lenticule implantation in keratoconus and post-LASIK ectasia patients appeared to expand the stromal volume of the thin corneas, flattened the cones, and significantly improved uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA) and spherical equivalent (SE). The meta-analysis showed that the random estimated UCVA, BCVA, SE and mean keratometry (K m ) differences following the lenticule implantation was -0.214 (95% CI: -0.367 to 0.060; p = 0.006), -0.169 (-0.246 to 0.091; p < 0.001), -2.294 D (-3.750 to -0.839 D; p = 0.002), and 2.909 D (0.805 to 5.012 D; p = 0.007), respectively.
Conclusions: Femtosecond laser-assisted stromal keratophakia is a feasible technique to correct the refractive aberrations, expand corneal volume and regularize corneal curvature in patients with keratoconus. However, there is a need to standardize the technique (e.g., whether to crosslink or not or to use convex or concave lenticules) and to formulate a mathematical model that accounts for the long-term epithelial thickness changes and stromal remodeling to determine the shape or profile of the lenticules, in order to improve the efficacy of the keratophakia further.

المؤلفون: Nubile M; Department of Medicine and Sciences of Ageing, Ophthalmic Clinic, University 'G. D'Annunzio' of Chieti-Pescara, Via dei Vestini, 66100, Chieti, Italy., Salgari N; Department of Medicine and Sciences of Ageing, Ophthalmic Clinic, University 'G. D'Annunzio' of Chieti-Pescara, Via dei Vestini, 66100, Chieti, Italy. nic.salgari@gmail.com., Mehta JS; Singapore National Eye Centre, Singapore, Singapore., Calienno R; Department of Medicine and Sciences of Ageing, Ophthalmic Clinic, University 'G. D'Annunzio' of Chieti-Pescara, Via dei Vestini, 66100, Chieti, Italy., Erroi E; Department of Medicine and Sciences of Ageing, Ophthalmic Clinic, University 'G. D'Annunzio' of Chieti-Pescara, Via dei Vestini, 66100, Chieti, Italy., Bondì J; Department of Medicine and Sciences of Ageing, Ophthalmic Clinic, University 'G. D'Annunzio' of Chieti-Pescara, Via dei Vestini, 66100, Chieti, Italy., Lanzini M; Department of Medicine and Sciences of Ageing, Ophthalmic Clinic, University 'G. D'Annunzio' of Chieti-Pescara, Via dei Vestini, 66100, Chieti, Italy., Liu YC; Singapore National Eye Centre, Singapore, Singapore., Mastropasqua L; Department of Medicine and Sciences of Ageing, Ophthalmic Clinic, University 'G. D'Annunzio' of Chieti-Pescara, Via dei Vestini, 66100, Chieti, Italy.

المصدر: Scientific reports [Sci Rep] 2021 Jan 27; Vol. 11 (1), pp. 2293. Date of Electronic Publication: 2021 Jan 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Cornea/*surgery , Corneal Stroma/*surgery , Corneal Transplantation/*methods , Keratoconus/*surgery, Corneal Stroma/physiopathology ; Humans ; Keratoconus/physiopathology ; Prospective Studies ; Tomography, Optical Coherence ; Visual Acuity/physiology

مستخلص: The purpose of this study was to evaluate corneal epithelium and stromal remodelling with anterior segment optical coherence tomography in patients who have undergone stromal lenticule addition keratoplasty (SLAK) for advanced keratoconus. This was a prospective non-comparative observational study. Fifteen eyes of 15 patients with advanced keratoconus underwent implantation with a cadaveric, donor negative meniscus-shaped intrastromal lenticule, produced with a femtosecond laser, into a stromal pocket dissected in the recipient cornea at a depth of 120 μm. Simulated keratometry, central corneal thickness (CTT), corneal thinnest point (CTP), central epithelial thickness (CET), central and peripheral lenticule thickness, anterior and posterior stromal thickness were measured. Regional central corneal epithelial thickness (CET) and variations in the inner annular area (IAT) and outer annular area (OAT) were also analysed. All parameters were measured preoperatively and 1, 3, and 6 months postoperatively. The average anterior Sim-k decreased from 59.63 ± 7.58 preoperatively to 57.19 ± 6.33 D 6 months postoperatively. CCT, CTP, CET, and OAT increased and IAT decreased significantly after 1 month. All parameters appeared unchanged at 6-months except that of OAT that further increased. Lenticule thickness was stable. In conclusion we observed that SLAK reshapes the cornea by central flattening with stromal thickening and epithelial thickness restoration.

المؤلفون: Mastropasqua L, Salgari N, D'Ugo E, Lanzini M, Alió Del Barrio JL, Alió JL, Cochener B, Nubile M

المصدر: Journal of refractive surgery (Thorofare, N.J. : 1995) [J Refract Surg] 2020 Aug 01; Vol. 36 (8), pp. 544-550.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: SLACK Inc Country of Publication: United States NLM ID: 9505927 Publication Model: Print Cited Medium: Internet ISSN: 1081-597X (Print) Linking ISSN: 1081597X NLM ISO Abbreviation: J Refract Surg Subsets: MEDLINE

مواضيع طبية MeSH: Corneal Stroma/*transplantation , Corneal Surgery, Laser/*methods , Keratoconus/*surgery, Adult ; Corneal Keratocytes/pathology ; Corneal Stroma/innervation ; Corneal Stroma/pathology ; Corneal Topography ; Female ; Follow-Up Studies ; Humans ; Keratoconus/physiopathology ; Male ; Microscopy, Confocal ; Middle Aged ; Ophthalmic Nerve/pathology ; Refraction, Ocular/physiology ; Slit Lamp Microscopy ; Visual Acuity/physiology

مستخلص: Purpose: To investigate the in vivo corneal microscopic changes after femtosecond laser-assisted stromal lenticule addition keratoplasty in keratoconus by means of in vivo confocal microscopy.
Methods: Patients affected by advanced keratoconus were included in the study. Negative meniscus-shaped stromal lenticules, produced with a femtosecond laser (VisuMax; Carl Zeiss Meditec) from eye bank corneas were transplanted into a stromal pocket dissected in the recipient cornea at a depth of 120 µm. In vivo confocal microscopy was performed during the 12-month follow-up to investigate changes of the corneal and lenticule structure.
Results: Ten patients were enrolled in the study. No changes of the dendritic cell population were documented during the follow-up period. Mild edema and stromal keratocyte activation gradually decreased during the first month. Subbasal nerve density returned to preoperative values after 6 months. Donor-recipient interfaces appeared hyperreflective but gradually improved over time with significantly reduced reflectivity after 3 months. No evidence of stromal inflammatory cell migration or matrix opacification was observed. Endothelial and keratocyte density remained stable over time. A variable degree of stromal radially distributed folds, not visible on biomicroscopy, was observed in the lenticule and in the posterior recipient stroma.
Conclusions: Stromal lenticule addition keratoplasty produces transitory nerve plexus density reduction and minor inflammatory reaction that rapidly decreases during the first month. Donor-recipient interface reflectivity is comparable to a femtosecond laser refractive procedure with no sign of stromal opacification or stromal rejection in 1 year of follow-up. [J Refract Surg. 2020;36(8):544-550.].
(Copyright 2020, SLACK Incorporated.)

المؤلفون: Mastropasqua L, Nubile M, Salgari N, Mastropasqua R

المصدر: Journal of refractive surgery (Thorofare, N.J. : 1995) [J Refract Surg] 2018 Jan 01; Vol. 34 (1), pp. 36-44.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: SLACK Inc Country of Publication: United States NLM ID: 9505927 Publication Model: Print Cited Medium: Internet ISSN: 1938-2391 (Electronic) Linking ISSN: 1081597X NLM ISO Abbreviation: J Refract Surg Subsets: MEDLINE

مواضيع طبية MeSH: Corneal Stroma/*transplantation , Corneal Surgery, Laser/*methods , Keratoconus/*surgery, Adult ; Corneal Topography ; Corneal Transplantation/methods ; Female ; Humans ; Keratoconus/physiopathology ; Male ; Middle Aged ; Pilot Projects ; Refraction, Ocular/physiology ; Tissue Donors ; Tissue Preservation ; Tomography, Optical Coherence ; Visual Acuity/physiology

مستخلص: Purpose: To investigate the in vivo effect of a novel femtosecond laser-assisted procedure termed stromal lenticule addition keratoplasty for advanced keratoconus.
Methods: Ten patients with stage III and IV stable keratoconus were included. Negative meniscus-shaped stromal lenticules were produced from corneoscleral eye bank buttons with a refractive lenticule extraction procedure with a 500-kHz VisuMax femtosecond laser (Carl Zeiss Meditec, Jena, Germany). Recipient corneas underwent a modified femtosecond laser flap-cut procedure to produce an intrastromal pocket and lenticules were implanted. Patients were followed up for 6 months after surgery with determination of uncorrected (UDVA) and corrected (CDVA) distance visual acuity, subjective refraction and topographic corneal curvature changes, anterior segment optical coherence tomography (AS-OCT), and in vivo confocal microscopy.
Results: Comparison of preoperative and 6-month postoperative UDVA and CDVA showed statistically significant improvements (P = .024 and .007, respectively) from 1.58 ± 0.36 to 1.22 ± 0.37 and from 1.07 ± 0.17 to 0.70 ± 0.23 logMAR. Eight of 10 eyes showed an improvement in UDVA (P < .001) that ranged between one and three lines, whereas all but one eye presented improved CDVA. Corneal topography documented a decrease between preoperative and 6-month postoperative anterior mean curvature (AVG-K at 3 mm) and anterior Q values (P = .005). AS-OCT showed a significant increase in thickness of the central and mid-peripheral cornea produced by the lenticule implantation (P = .005).
Conclusions: The stromal lenticule addition keratoplasty procedure was clinically efficient in improving the corneal shape and vision in patients with keratoconus. Negative meniscus-shaped lenticule addition induced a flattening of the cone while increasing corneal thickness. [J Refract Surg. 2018;34(1):36-44.].
(Copyright 2018, SLACK Incorporated.)

المؤلفون: Mastropasqua L; National Centre of High Technology (CNAT) in Ophthalmology, University of 'G d'Annunzio', Chieti-Pescara, Italy., Nubile M; National Centre of High Technology (CNAT) in Ophthalmology, University of 'G d'Annunzio', Chieti-Pescara, Italy. m.nubile@unich.it.

المصدر: International ophthalmology [Int Ophthalmol] 2017 Aug; Vol. 37 (4), pp. 893-904. Date of Electronic Publication: 2016 Sep 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Kluwer Country of Publication: Netherlands NLM ID: 7904294 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2630 (Electronic) Linking ISSN: 01655701 NLM ISO Abbreviation: Int Ophthalmol Subsets: MEDLINE

مواضيع طبية MeSH: Refraction, Ocular*, Corneal Stroma/*surgery , Corneal Surgery, Laser/*methods , Hyperopia/*surgery , Keratoconus/*surgery , Lasers, Excimer/*therapeutic use, Cornea/pathology ; Corneal Stroma/pathology ; Corneal Topography ; Female ; Humans ; Hyperopia/diagnosis ; Hyperopia/physiopathology ; Male ; Middle Aged ; Reoperation ; Tomography, Optical Coherence

مستخلص: Purpose: To investigate the feasibility of the procedure and the modifications of the corneal curvature and profile obtained with a novel technique of stromal-lentoid implantation in ex vivo human corneas.
Design: Experimental ex vivo study in human corneas.
Materials and Methods: Twelve stromal lentoids were produced by means of hyperopic femtosecond lenticule extraction (FLEx) with the VisuMax femtosecond laser (Carl Zeiss Meditec, Jena, Germany) with a refractive power of +8.00 D and optical zone of 6.0 (six lenticules) and 5.0 mm (six lenticules), respectively. The posterior surface of these stromal lentoids presented a higher curvature with respect to the anterior surface and, therefore, the thinnest point is located at the center of the lenticule, gradually thickening towards the periphery. Another 12 corneas underwent femtosecond laser intrastromal pocket creation at a depth of 115 microns, for lenticule insertion. After intrastromal lenticule implantation the changes of corneal profiles were evaluated by means of corneal topography and anterior segment optical coherence tomography (OCT).
Results: The implantations of intrastromal lenticules were successful in all cases with proper distention and centration. A mid-peripheral forward shift of the anterior corneal surface along with a thickening (greater in periphery) was induced. There was a significant flattening of anterior corneal central areas of 7.31 ± 1.52 D (p = 0.002). Diameters of the flattening area were found to be consistently correlated with the optical zone diameter of the implanted lenticules (p = 0.006). Central flattening was similar in both groups. OCT pachymetry maps showed an increase of corneal thickness consistently correlated with implanted lentoid thickness and diameter.
Conclusion: The implantation of modified hyperopic-shaped intra-corneal stromal lentoid is a feasible and reproducible technique for achieving central corneal flattening while increasing thickness. Whether this procedure may be beneficial in the treatment of refractive errors or ectatic corneal disorders such as keratoconus merits further study.

المؤلفون: Mastropasqua L; Chieti, Italy.

المصدر: Journal of cataract and refractive surgery [J Cataract Refract Surg] 2015 Jun; Vol. 41 (6), pp. 1338-9.

نوع المنشور: Letter; Comment

بيانات الدورية: Publisher: Wolters Kluwer on behalf of ASCRS and ESCRS Country of Publication: United States NLM ID: 8604171 Publication Model: Print Cited Medium: Internet ISSN: 1873-4502 (Electronic) Linking ISSN: 08863350 NLM ISO Abbreviation: J Cataract Refract Surg Subsets: MEDLINE

مواضيع طبية MeSH: Corneal Stroma/*surgery , Corneal Surgery, Laser/*adverse effects , Keratoconus/*etiology, Humans ; Male

المؤلفون: Mastropasqua L; Department of Medicine and Ageing Sciences, Ophthalmology Clinic, University 'G. d'Annunzio' of Chieti-Pescara, Chieti and Pescara, Italy., Lanzini M, Curcio C, Calienno R, Mastropasqua R, Colasante M, Mastropasqua A, Nubile M

المصدر: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2014 Apr 17; Vol. 55 (4), pp. 2526-33. Date of Electronic Publication: 2014 Apr 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Electronic Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE

مواضيع طبية MeSH: Ultraviolet Rays*, Collagen/*metabolism , Cornea/*pathology , Cross-Linking Reagents/*pharmacology , Iontophoresis/*methods , Keratoconus/*therapy, Cadaver ; Cornea/drug effects ; Cornea/radiation effects ; Humans ; Immunohistochemistry ; Keratoconus/metabolism ; Keratoconus/pathology

مستخلص: Purpose: The aim of this study is to investigate modifications in human cadaver corneas after different crosslinking procedures, including standard epi-off treatment, iontophoresis imbibition, and different exposure to ultraviolet A (UVA) sources (30 minutes at 3 mW and 9 minutes at 10 mW).
Methods: A total of 12 human cadaver corneas was examined and divided as follows: 3 served as control (group 1), 3 were treated with a standard epi-off procedure (group 2), 6 underwent iontophoresis imbibition for 5 minutes, and then 3 were irradiated for 30 minutes with 3 mW UVA (group 3), and 3 for 9 minutes at 10 mW UVA (group 4). Deformation amplitude index was measured before and after the corneas underwent treatment. After treatment, corneas were prepared for hematoxylin-eosin and immunohistochemistry evaluation. The expression of TUNEL, matrix metalloproteinase-1 (MMP-1), collagen type I, and CD34 was investigate in all samples.
Results: The deformation amplitude index decreased in all groups, in particular in group 4, indicating an improvement of corneal biomechanical properties. Immunohistochemical staining showed a significant stromal alteration in group 2, mild damage in group 3, and no modifications in corneal morphology in group 4. The TUNEL (P < 0.001) and MMP-1 (P = 0.002) positivity was more evident in group 4. Collagen type I positivity significantly increased in groups 3 (P = 0.002) and 4 (P = 0.002). The CD34 expression was more evident in groups 2 (P = 0.003) and 3 (P = 0.003).
Conclusions: Iontophoresis imbibition followed by UVA irradiation for 9 minutes at 10 mW determined less tissue damage and better stromal remodeling.

المؤلفون: Schiano-Lomoriello D; IRCCS Bietti Foundation, Via Livenza 3, 00198 Rome, Italy., Colabelli-Gisoldi RA; Azienda Ospedaliera San Giovanni-Addolorata, Rome, Italy., Nubile M; Universita degli Studi 'Gabriele D'Annunzio', Chieti, Italy., Oddone F; IRCCS Bietti Foundation, Via Livenza 3, 00198 Rome, Italy., Ducoli G; IRCCS Bietti Foundation, Via Livenza 3, 00198 Rome, Italy., Villani CM; Azienda Ospedaliera San Giovanni-Addolorata, Rome, Italy., Mastropasqua L; Universita degli Studi 'Gabriele D'Annunzio', Chieti, Italy., Pocobelli A; Azienda Ospedaliera San Giovanni-Addolorata, Rome, Italy.

المصدر: BioMed research international [Biomed Res Int] 2014; Vol. 2014, pp. 123156. Date of Electronic Publication: 2014 Aug 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE

مواضيع طبية MeSH: Corneal Transplantation*, Descemet Membrane/*surgery , Keratoconus/*surgery, Descemet Membrane/pathology ; Humans ; Keratoconus/pathology ; Microscopy, Confocal ; Visual Acuity

مستخلص: Purpose: To evaluate the clinical outcomes and in vivo confocal microscopy (IVCM) features of keratoconus patients who underwent deep anterior lamellar keratoplasty (DALK).
Methods: DALK was performed using the big bubble technique in all the patients. If the bubble was not successful to bare the descemet membrane, a manual dissection layer-by layer was performed to expose a deep stromal plane close to the DM. The patients were divided in two groups depending on the intraoperative baring of the descemet membrane: predescemetic DALK (PD-DALK) and descemetic DALK (D-DALK) group.
Results: One month after surgery the D-DALK patients show an increase of mean BCVA. In the PD-DALK group mean BCVA did not show significant improvement as compared to preoperative values. At 6 months after surgery mean BCVA was found to be similar in both groups. At 1 month IVCM the peak of reflectivity of the interface was lower in D-DALK group compared to PD-DALK. At 6 months the values of reflectivity were comparable.
Conclusions: At 1 month D-DALK seems to lead to a minor interface reflectivity and to a better BCVA; these differences disappear after 6 months and the values of interface reflectivity and BCVA are comparable between D-DALK and PD-DALK.

المؤلفون: Mastropasqua L; Department of Medicine and Ageing Sciences, Ophthalmology Clinic, University G. D'Annunzio of Chieti and Pescara, Pescara, Italy., Nubile M, Lanzini M, Calienno R, Mastropasqua R, Agnifili L, Toto L

المصدر: Cornea [Cornea] 2013 Jun; Vol. 32 (6), pp. 855-61.

نوع المنشور: Comparative Study; Journal Article; Randomized Controlled Trial

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8216186 Publication Model: Print Cited Medium: Internet ISSN: 1536-4798 (Electronic) Linking ISSN: 02773740 NLM ISO Abbreviation: Cornea Subsets: MEDLINE

مواضيع طبية MeSH: Photochemotherapy*, Corneal Edema/*diagnosis , Corneal Keratocytes/*pathology , Cross-Linking Reagents/*therapeutic use , Keratoconus/*drug therapy, Adolescent ; Adult ; Cell Count ; Collagen/metabolism ; Corneal Pachymetry ; Corneal Stroma/metabolism ; Corneal Topography ; Female ; Humans ; Keratoconus/metabolism ; Male ; Microscopy, Confocal ; Photosensitizing Agents/therapeutic use ; Prospective Studies ; Riboflavin/therapeutic use ; Tomography, Optical Coherence ; Ultraviolet Rays ; Young Adult

مستخلص: Purpose: In vivo analysis of corneal modifications after traditional and transepithelial corneal cross-linking (CXL).
Methods: Forty eyes of 35 patients underwent traditional or transepithelial CXL; there was randomization of 20 eyes to each group. By means of in vivo confocal microscopy and anterior segment ocular coherence tomography, we evaluated corneal alterations at 1 week, 1 month, and 3, 6, and 12 months after the treatment.
Results: During follow-up, in vivo confocal microscopy showed a significant decrease in anterior keratocyte density (P = 0.001) and more evident stromal edema and keratocyte activation (P = 0.001) in the traditional group, whereas in the transepithelial group, no significant changes were observed (P > 0.05). Anterior segment ocular coherence tomography indicated the presence of hyperreflective stromal line significantly deeper and more persistent in the traditional group (P < 0.001).
Conclusions: The preliminary results suggest that traditional CXL induced marked corneal modifications, which were poorly evident in the transepithelial group.

المؤلفون: Vinciguerra P, Rechichi M, Rosetta P, Romano MR, Mastropasqua L, Scorcia V, Azzolini C, Vinciguerra R

المصدر: Journal of refractive surgery (Thorofare, N.J. : 1995) [J Refract Surg] 2013 Jun; Vol. 29 (6), pp. 376-7.

نوع المنشور: Letter; Comment

بيانات الدورية: Publisher: SLACK Inc Country of Publication: United States NLM ID: 9505927 Publication Model: Print Cited Medium: Print ISSN: 1081-597X (Print) Linking ISSN: 1081597X NLM ISO Abbreviation: J Refract Surg Subsets: MEDLINE

مواضيع طبية MeSH: Photochemotherapy*, Collagen/*metabolism , Corneal Stroma/*metabolism , Keratoconus/*metabolism , Photosensitizing Agents/*pharmacokinetics , Riboflavin/*pharmacokinetics, Humans