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1دورية أكاديمية
المؤلفون: Kamenik, Anna S, Singh, Isha, Lak, Parnian, Balius, Trent E, Liedl, Klaus R, Shoichet, Brian K
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 118(36)
مصطلحات موضوعية: Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance, Binding Sites, Crystallography, X-Ray, Kinetics, Ligands, Molecular Docking Simulation, Molecular Dynamics Simulation, Protein Binding, Protein Conformation, Proteins, Retrospective Studies, Thermodynamics, docking, flexible receptor, molecular dynamics, model cavity
وصف الملف: application/pdf
URL الوصول: https://escholarship.org/uc/item/57g176jh
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2دورية أكاديمية
المصدر: Journal of Medicinal Chemistry. 64(7)
مصطلحات موضوعية: Adsorption, Bacterial Proteins, Colloids, Enzyme Assays, Fulvestrant, Kinetics, Malate Dehydrogenase, Protein Binding, Sorafenib, beta-Lactamases, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry
وصف الملف: application/pdf
URL الوصول: https://escholarship.org/uc/item/5605j267
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3دورية أكاديمية
المؤلفون: Liu, Xiangyu, Kaindl, Jonas, Korczynska, Magdalena, Stößel, Anne, Dengler, Daniela, Stanek, Markus, Hübner, Harald, Clark, Mary J, Mahoney, Jake, Matt, Rachel Ann, Xu, Xinyu, Hirata, Kunio, Shoichet, Brian K, Sunahara, Roger K, Kobilka, Brian K, Gmeiner, Peter
المصدر: Nature chemical biology. 16(7)
مصطلحات موضوعية: Humans, Water, Norepinephrine, Alprenolol, Receptors, Adrenergic, beta-2, Adrenergic beta-Antagonists, Ligands, Allosteric Regulation, Allosteric Site, Protein Structure, Secondary, Protein Binding, Kinetics, Thermodynamics, Protein Interaction Domains and Motifs, Molecular Dynamics Simulation, HEK293 Cells, Adrenergic beta-2 Receptor Agonists, Molecular Docking Simulation, Salmeterol Xinafoate, Underpinning research, 1.1 Normal biological development and functioning, Medicinal and Biomolecular Chemistry, Biochemistry and Cell Biology, Biochemistry & Molecular Biology
وصف الملف: application/pdf
URL الوصول: https://escholarship.org/uc/item/9923t98r
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4دورية أكاديمية
المؤلفون: Wang, Sheng, Che, Tao, Levit, Anat, Shoichet, Brian K, Wacker, Daniel, Roth, Bryan L
المصدر: Nature. 555(7695)
مصطلحات موضوعية: Schizophrenia, Mental Health, Brain Disorders, Neurosciences, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Antipsychotic Agents, Binding Sites, Crystallography, X-Ray, Drug Design, Humans, Hydrophobic and Hydrophilic Interactions, Kinetics, Ligands, Models, Molecular, Mutant Proteins, Mutation, Receptors, Dopamine D2, Receptors, Dopamine D3, Receptors, Dopamine D4, Risperidone, General Science & Technology
وصف الملف: application/pdf
URL الوصول: https://escholarship.org/uc/item/8r93v5k6
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5دورية أكاديمية
المؤلفون: Korczynska, Magdalena, Clark, Mary J, Valant, Celine, Xu, Jun, Moo, Ee Von, Albold, Sabine, Weiss, Dahlia R, Torosyan, Hayarpi, Huang, Weijiao, Kruse, Andrew C, Lyda, Brent R, May, Lauren T, Baltos, Jo-Anne, Sexton, Patrick M, Kobilka, Brian K, Christopoulos, Arthur, Shoichet, Brian K, Sunahara, Roger K
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 115(10)
مصطلحات موضوعية: Animals, Humans, Rats, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Receptor, Muscarinic M2, Muscarinic Agonists, Ligands, Allosteric Regulation, Allosteric Site, Protein Binding, Phosphorylation, Kinetics, Molecular Docking Simulation, GPCR, PAM antagonist, docking, structure-based ligand discovery, subtype selectivity, Prevention, Neurosciences, 5.1 Pharmaceuticals, 1.1 Normal biological development and functioning, Development of treatments and therapeutic interventions, Underpinning research
وصف الملف: application/pdf
URL الوصول: https://escholarship.org/uc/item/1d24t5gm
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6دورية أكاديمية
المؤلفون: McCorvy, John D, Butler, Kyle V, Kelly, Brendan, Rechsteiner, Katie, Karpiak, Joel, Betz, Robin M, Kormos, Bethany L, Shoichet, Brian K, Dror, Ron O, Jin, Jian, Roth, Bryan L
المصدر: Nature Chemical Biology. 14(2)
مصطلحات موضوعية: Biochemistry and Cell Biology, Medicinal and Biomolecular Chemistry, Chemical Sciences, Biological Sciences, Aripiprazole, Crystallography, X-Ray, Cyclic AMP, Drug Design, Drug Discovery, HEK293 Cells, Humans, Hydrogen Bonding, Indoles, Kinetics, Ligands, Molecular Dynamics Simulation, Mutation, Protein Binding, Protein Conformation, Receptors, G-Protein-Coupled, Serine, Signal Transduction, beta-Arrestin 1, Biochemistry & Molecular Biology, Biochemistry and cell biology, Medicinal and biomolecular chemistry
وصف الملف: application/pdf
URL الوصول: https://escholarship.org/uc/item/10j0b7ss
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7دورية أكاديمية
المؤلفون: Balius, Trent E, Fischer, Marcus, Stein, Reed M, Adler, Thomas B, Nguyen, Crystal N, Cruz, Anthony, Gilson, Michael K, Kurtzman, Tom, Shoichet, Brian K
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 114(33)
مصطلحات موضوعية: Theory Of Computation, Medicinal and Biomolecular Chemistry, Chemical Sciences, Built Environment and Design, Information and Computing Sciences, Design, Algorithms, Binding Sites, Computational Biology, Crystallography, X-Ray, Kinetics, Ligands, Molecular Docking Simulation, Molecular Structure, Protein Binding, Protein Conformation, Solutions, Solvents, Thermodynamics, Water, water, inhomogeneous solvation theory, ligand discovery, structure-based drug design, docking
وصف الملف: application/pdf
URL الوصول: https://escholarship.org/uc/item/9jp0969s
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8دورية أكاديمية
المؤلفون: Wacker, Daniel, Wang, Sheng, McCorvy, John D, Betz, Robin M, Venkatakrishnan, AJ, Levit, Anat, Lansu, Katherine, Schools, Zachary L, Che, Tao, Nichols, David E, Shoichet, Brian K, Dror, Ron O, Roth, Bryan L
المصدر: Cell. 168(3)
مصطلحات موضوعية: Generic health relevance, Arrestin, Crystallography, X-Ray, Humans, Kinetics, Lysergic Acid Diethylamide, Models, Chemical, Molecular Dynamics Simulation, Receptor, Serotonin, 5-HT2B, GPCR, crystallography, hallucinogens, serotonin receptor, structure-function, Biological Sciences, Medical and Health Sciences, Developmental Biology
وصف الملف: application/pdf
URL الوصول: https://escholarship.org/uc/item/0dz559cj
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9دورية أكاديمية
المؤلفون: Yee, Sook Wah, Lin, Lawrence, Merski, Matthew, Keiser, Michael J, Gupta, Aakash, Zhang, Youcai, Chien, Huan-Chieh, Shoichet, Brian K, Giacomini, Kathleen M
المصدر: Journal of Pharmacokinetics and Pharmacodynamics. 42(5)
مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Digestive Diseases, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Amine Oxidase (Copper-Containing), Biological Transport, Cell Line, Diabetes Mellitus, Type 2, HEK293 Cells, Humans, Intestinal Mucosa, Kinetics, Membrane Transport Proteins, Metformin, Octamer Transcription Factor-3, Organic Cation Transporter 1, Serotonin Plasma Membrane Transport Proteins, Organic cation transporter, Histamine, Serotonin, Putrescine, Diamine oxidase, Pharmacology & Pharmacy, Pharmacology and pharmaceutical sciences
وصف الملف: application/pdf
URL الوصول: https://escholarship.org/uc/item/69c8r1pj
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10دورية أكاديمية
المؤلفون: Rocklin, Gabriel J, Boyce, Sarah E, Fischer, Marcus, Fish, Inbar, Mobley, David L, Shoichet, Brian K, Dill, Ken A
المصدر: Journal of Molecular Biology. 425(22)
مصطلحات موضوعية: Microbiology, Biochemistry and Cell Biology, Biological Sciences, Bioengineering, Benzimidazoles, Binding Sites, Crystallography, X-Ray, Cytochrome-c Peroxidase, Kinetics, Ligands, Models, Molecular, Molecular Docking Simulation, Molecular Dynamics Simulation, Protein Binding, Protein Conformation, Proteins, free-energy calculations, electrostatics, ligand binding, molecular dynamics, CCP, ESP, ITC, MSD, QM, RMSE, cytochrome c peroxidase, electrostatic potential, isothermal titration calorimetry, mean signed deviation, quantum mechanics, root-mean-square error, Medicinal and Biomolecular Chemistry, Biochemistry & Molecular Biology, Biochemistry and cell biology
وصف الملف: application/pdf
URL الوصول: https://escholarship.org/uc/item/2qb9g96p