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المؤلفون: L Benitez-Quintanilla, Raigam Jafet Martinez-Portilla, Marta López, Liona C. Poon, Diana Lucia Lip-Sosa, Alexandros Sotiriadis, F. Figueras
المصدر: Ultrasound in Obstetrics & Gynecology. 58:519-528
مصطلحات موضوعية: Heart Defects, Congenital, Gestational hypertension, medicine.medical_specialty, HELLP syndrome, Pregnancy Complications, Cardiovascular, Risk Assessment, Preeclampsia, law.invention, Pre-Eclampsia, Randomized controlled trial, Pregnancy, law, medicine, Humans, Radiology, Nuclear Medicine and imaging, Eclampsia, Radiological and Ultrasound Technology, business.industry, Obstetrics, Incidence, Incidence (epidemiology), Obstetrics and Gynecology, General Medicine, Publication bias, medicine.disease, Reproductive Medicine, Heart Disease Risk Factors, Meta-analysis, Female, business
الوصف: Objective It has recently been proposed that preeclampsia (PE) may be originating from maternal cardiac maladaptation rather than primary placental insult. As congenital heart disease (CHD) is associated with reduced adaptation to the hemodynamic needs of pregnancy, it is hypothesized that women with CHD would have an increased risk of PE. The aim of this study was to investigate the risk of PE in women with CHD. Data sources A systematic search was performed to identify relevant studies published in English, Spanish, French, Italian, Chinese, or German with no time restrictions, using databases such as PubMed, Web of Science, and Scopus. Study eligibility criteria Randomized controlled trials and observational studies (prospective and retrospective cohorts) of pregnant women with a history of CHD were selected. Study appraisal and synthesis methods The main outcome was the incidence of PE (including eclampsia and HELLP syndrome). For quality assessment, two reviewers independently assessed the risk of bias of the included studies. For the meta-analysis, the incidence of PE in completed pregnancies (those beyond 20 weeks' gestation) was calculated using a single-proportion analysis by random-effects modeling (weighted by inverse-variance). Heterogeneity between studies was assessed using the X2 (Cochrane Q), H, and I2 statistics. Subgroup analyses were performed as well as meta-regression to explain the influence of several covariates on the pooled results. Results After the systematic review, a total of 33 studies were retained for the meta-analysis, comprising 40,449 women with CHD and a total of 40,701 completed pregnancies. The incidence of PE was 3.1% (95% CI: 2.2-4.0%), true-effect heterogeneity was 93% by I2 , and no publication bias was found. No differences were found in the incidence of PE between studies including cyanotic CHD vs. studies without cyanotic CHD (2.5% [95% CI: 1.6%-3.4%] vs. 3.8% [95% CI: 2.4%-5.2%]; p=0.112). The meta-regression analysis showed that the only cofactor significantly influencing the incidence of PE was the incidence of aortic stenosis reported in each article; articles with a higher incidence of aortic stenosis had a higher incidence of PE (estimate: 0.0005; p=0.038). Conclusions In women with CHD, we have failed to demonstrate an incidence of PE above the expected baseline, an observation that disagrees with the theory of the cardiac origin of PE. This article is protected by copyright. All rights reserved.
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المؤلفون: Morgan Schellenberg, Areti Tillou, Kent Garber, Walter L. Biffl, Galinos Barmparas, Graal Diaz, Georgi Mladenov, Jarrett Santorelli, Ryan Arthur Figueras, Terry Curry, Diane Wintz, Thomas K. Duncan, Sigrid Burruss, Natthida Owattanapanich, Arianne Johnson, Catherine Juillard, Justine Chinn, Ariana Naaseh, Daniel R. Margulies, Eric O. Yeates, Christopher Firek, Jeffry Nahmias, Amanda Leung, Megan Brenner, Christina Grabar, Areg Grigorian, Casey Barbaro, Henry Cryer, Kathryn B. Schaffer, Todd W. Costantini
المصدر: European Journal of Trauma and Emergency Surgery
European journal of trauma and emergency surgery : official publication of the European Trauma Society, vol 47, iss 5مصطلحات موضوعية: medicine.medical_specialty, Clinical Sciences, Population, Critical Care and Intensive Care Medicine, Trauma, law.invention, 03 medical and health sciences, Injury Severity Score, 0302 clinical medicine, Trauma Centers, Clinical Research, law, Internal medicine, medicine, Humans, Orthopedics and Sports Medicine, 030212 general & internal medicine, Mortality, education, Lung, Retrospective Studies, education.field_of_study, SARS-CoV-2, business.industry, Glasgow Coma Scale, COVID-19, 030208 emergency & critical care medicine, Retrospective cohort study, Pneumonia, Length of Stay, Emergency & Critical Care Medicine, Intensive care unit, Coronavirus, Intensive Care Units, Orthopedics, Blood pressure, Propensity score matching, Cohort, Injury (total) Accidents/Adverse Effects, Emergency Medicine, Length of stay, Original Article, Surgery, Patient Safety, business
الوصف: Purpose There is mounting evidence that surgical patients with COVID-19 have higher morbidity and mortality than patients without COVID-19. Infection is prevalent amongst the trauma population, but any effect of COVID-19 on trauma patients is unknown. We aimed to evaluate the effect of COVID-19 on a trauma population, hypothesizing increased mortality and pulmonary complications for COVID-19-positive (COVID) trauma patients compared to propensity-matched COVID-19-negative (non-COVID) patients. Methods A retrospective analysis of trauma patients presenting to 11 Level-I and II trauma centers in California between 1/1/2019–6/30/2019 and 1/1/2020–6/30/2020 was performed. A 1:2 propensity score model was used to match COVID to non-COVID trauma patients using age, blunt/penetrating mechanism, injury severity score, Glasgow Coma Scale score, systolic blood pressure, respiratory rate, and heart rate. Outcomes were compared between the two groups. Results A total of 20,448 trauma patients were identified during the study period. 53 COVID trauma patients were matched with 106 non-COVID trauma patients. COVID patients had higher rates of mortality (9.4% vs 1.9%, p = 0.029) and pneumonia (7.5% vs. 0.0%, p = 0.011), as well as a longer mean length of stay (LOS) (7.47 vs 3.28 days, p p = 0.008), compared to non-COVID patients. Conclusion This multicenter retrospective study found increased rates of mortality and pneumonia, as well as a longer LOS, for COVID trauma patients compared to a propensity-matched cohort of non-COVID patients. Further studies are warranted to validate these findings and to elucidate the underlying pathways responsible for higher mortality in COVID trauma patients.
وصف الملف: application/pdf
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المصدر: IEEE Geoscience and Remote Sensing Letters. 18:642-646
مصطلحات موضوعية: Physics, Offset (computer science), Correlation coefficient, 0211 other engineering and technologies, Polarimetry, Order (ring theory), 02 engineering and technology, Radome, Geotechnical Engineering and Engineering Geology, Differential phase, law.invention, Computational physics, law, Spatial variability, Weather radar, Electrical and Electronic Engineering, 021101 geological & geomatics engineering
الوصف: This letter illustrates the effects that the regular pattern of the metallic unions of a four-panel radome had on the polarimetric variables [differential reflectivity $Z_{\text {dr}}$ , copolar differential phase $\phi _{\text {dp}}$ offset, and copolar correlation coefficient ( $\rho _{hv}$ )] as well as on the sun measurements of a mobile X-band weather radar. In particular, we focus on the analysis of the spatial distribution of the biases and the temporal variability of the sun measurements. We show that the metallic unions result in a nonnegligible sinusoidal-like spatial variability of the estimated biases (on the order of 7°–8° for $\phi _{\text {dp}}$ offset and 0.4–0.5 dB for $Z_{\text {dr}}$ bias), as well as a drop in $\rho _{hv}$ in rain and a large temporal variability in the power measured by sun scans. These effects are compared with the measurements collected without a radome and with the measurements collected with a seamless monoblock radome on the same radar system. It is shown that operating without radome, when possible, has a positive impact on the data quality, largely reducing the spatial variability of the biases and increasing the $\rho _{hv}$ in rain. Similar performances, without the inherent risks, can be obtained as well with a seamless radome. Nevertheless, regardless of the form of operation, we advocate for monitoring the data quality as accurately as possible if quantitative applications are desired.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8342ce1be555e23a0cf93ca868a13174
https://doi.org/10.1109/lgrs.2020.2981993
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المؤلفون: Raul Coimbra, Christina Grabar, Galinos Barmparas, Ryan Arthur Figueras, Amanda Leung, Areg Grigorian, Thomas K. Duncan, Daniel R. Margulies, Diane Wintz, Sigrid Burruss, Ann Lin, Jarrett Santorelli, Catherine Juillard, Areti Tillou, Jeffry Nahmias, Arianne Johnson, Casey Barbaro, Walter L. Biffl, Eric O. Yeates, Ariana Naaseh, Henry Cryer, Liz Penaloza-Villalobos, Natthida Owattanapanich, Justine Chinn, Kathryn B. Schaffer, Megan Brenner, Kent Garber, Graal Diaz, Todd W. Costantini, Terry Curry, Morgan Schellenberg
المصدر: Pediatric surgery international, vol 38, iss 2
Pediatric Surgery Internationalمصطلحات موضوعية: Adult, medicine.medical_specialty, Physical Injury - Accidents and Adverse Effects, Coronavirus disease 2019 (COVID-19), Adolescent, Population, Trauma, Pediatrics, California, law.invention, Paediatrics and Reproductive Medicine, Injury Severity Score, Penetrating, Trauma Centers, law, Clinical Research, Internal medicine, Pandemic, Pediatric surgery, Medicine, Humans, education, Child, Pandemics, Retrospective Studies, Pediatric, education.field_of_study, business.industry, SARS-CoV-2, Prevention, COVID-19, Retrospective cohort study, General Medicine, Length of Stay, medicine.disease, Intensive care unit, Good Health and Well Being, Pediatrics, Perinatology and Child Health, Surgery, Original Article, Patient Safety, business, Penetrating trauma, Pediatric trauma
الوصف: Purpose The COVID-19 pandemic resulted in increased penetrating trauma and decreased length of stay (LOS) amongst the adult trauma population, findings important for resource allocation. Studies regarding the pediatric trauma population are sparse and mostly single-center. This multicenter study examined pediatric trauma patients, hypothesizing increased penetrating trauma and decreased LOS after the 3/19/2020 stay-at-home (SAH) orders. Methods A multicenter retrospective analysis of trauma patients ≤ 17 years old presenting to 11 centers in California was performed. Demographic data, injury characteristics, and outcomes were collected. Patients were divided into three groups based on injury date: 3/19/2019–6/30/2019 (CONTROL), 1/1/2020–3/18/2020 (PRE), 3/19/2020–6/30/2020 (POST). POST was compared to PRE and CONTROL in separate analyses. Results 1677 patients were identified across all time periods (CONTROL: 631, PRE: 479, POST: 567). POST penetrating trauma rates were not significantly different compared to both PRE (11.3 vs. 9.0%, p = 0.219) and CONTROL (11.3 vs. 8.2%, p = 0.075), respectively. POST had a shorter mean LOS compared to PRE (2.4 vs. 3.3 days, p = 0.002) and CONTROL (2.4 vs. 3.4 days, p = 0.002). POST was also not significantly different than either group regarding intensive care unit (ICU) LOS, ventilator days, and mortality (all p > 0.05). Conclusions This multicenter retrospective study demonstrated no difference in penetrating trauma rates among pediatric patients after SAH orders but did identify a shorter LOS.
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7481e92556c88b59d3ec2970ba4354f8
https://escholarship.org/uc/item/20t4j285 -
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المؤلفون: Francesc Illas, Ángel Morales-García, Ramon Costa, Marc Figueras
المصدر: Physical Chemistry Chemical Physics. 23:1558-1565
مصطلحات موضوعية: Quantum chemical, Materials science, Graphene, Binding energy, Ab initio, General Physics and Astronomy, Molecular physics, law.invention, X-ray photoelectron spectroscopy, law, Cluster (physics), Core level, Physical and Theoretical Chemistry, Doped graphene
الوصف: Ab initio quantum chemical calculations using large enough cluster models have been used to predict the core level binding energies of B(1s) and N(1s), including initial and final state effects, in several possible atomic arrangements in B,N-codoped graphene, such as isolated atoms, different types of B,N pairs and BN domains. To a large extent, the observed trends are dominated by initial state effects that support assigning the experimental features to the neutral samples. For the BN domains the present theoretical results are in full agreement with the experimental assignment thus providing support to the rest of the assignments. In particular, the present results strongly suggest that some of the features observed in the experiments are likely to correspond to isolated B or N atoms in graphene and, others fit well to the prediction corresponding to different types of B,N pairs. The importance of having an unambiguous, rigorous way to assign experimental features is emphasized.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e1c97ac61ba245f5ae899070701bc62d
https://doi.org/10.1039/d0cp05361a -
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المؤلفون: Mantegazza, R., Wolfe, G. I., Muppidi, S., Wiendl, H., Fujita, K. P., O'Brien, F. L., Booth, H. D. E., Howard, J. F., Claudio Gabriel Mazia, Miguel, Wilken, Fabio, Barroso, Juliet, Saba, Marcelo, Rugiero, Mariela, Bettini, Marcelo, Chaves, Gonzalo, Vidal, Alejandra Dalila Garcia, Jan De Bleecker, Guy Van den Abeele, Kathy de Koning, Katrien De Mey, Rudy, Mercelis, Délphine, Mahieu, Linda, Wagemaekers, Philip Van Damme, Annelies, Depreitere, Caroline, Schotte, Charlotte, Smetcoren, Olivier, Stevens, Sien Van Daele, Nicolas, Vandenbussche, Annelies, Vanhee, Sarah, Verjans, Jan, Vynckier, Ann, D'Hont, Petra, Tilkin, Alzira Alves de Siqueira Carvalho, Igor Dias Brockhausen, David, Feder, Daniel, Ambrosio, Gabor Lovasamela César, Ana Paula Melo, Renata Martins Ribeiro, Rosana, Rocha, Bruno Bezerra Rosa, Thabata, Veiga, Luiz Augusto da Silva, Murilo Santos Engel, Jordana Gonçalves Geraldo, Maria da Penha Ananias Morita, Erica Nogueira Coelho, Gabriel, Paiva, Marina, Pozo, Natalia, Prando, Debora Dada Martineli Torres, Cristiani Fernanda Butinhao, Gustavo, Duran, Tomás Augusto Suriane Fialho, Tamires Cristina Gomes da Silva, Luiz Otavio Maia Gonçalves, Lucas Eduardo Pazetto, Luciana Renata Cubas Volpe, Luciana Souza Duca, Maurício AndréGheller Friedrich, Alexandre, Guerreiro, Henrique, Mohr, Maurer Pereira Martins, Daiane da Cruz Pacheco, Luciana, Ferreira, Ana Paula Macagnan, Graziela, Pinto, Aline de Cassia Santos, Acary Souza Bulle Oliveira, Ana Carolina Amaral de Andrade, Marcelo, Annes, Liene Duarte Silva, Valeria Cavalcante Lino, Wladimir, Pinto, Natália, Assis, Fernanda, Carrara, Carolina, Miranda, Iandra, Souza, Patrícia, Fernandes, Zaeem, Siddiqi, Cecile, Phan, Jeffrey, Narayan, Derrick, Blackmore, Ashley, Mallon, Rikki, Roderus, Elizabeth, Watt, Stanislav, Vohanka, Josef, Bednarik, Magda, Chmelikova, Marek, Cierny, Stanislava, Toncrova, Jana, Junkerova, Barbora, Kurkova, Katarina, Reguliova, Olga, Zapletalova, Jiri, Pitha, Iveta, Novakova, Michaela, Tyblova, Ivana, Jurajdova, Marcela, Wolfova, Henning, Andersen, Thomas, Harbo, Lotte, Vinge, Susanne, Krogh, Anita, Mogensen, John, Vissing, Joan, Højgaard, Nanna, Witting, Anne Mette Ostergaard Autzen, Jane, Pedersen, Juha-Pekka, Erälinna, Mikko, Laaksonen, Olli, Oksaranta, Tuula, Harrison, Jaana, Eriksson, Csilla, Rozsa, Melinda, Horvath, Gabor, Lovas, Judit, Matolcsi, Gedeonne, Jakab, Gyorgyi, Szabo, Brigitta, Szabadosne, Laszlo, Vecsei, Livia, Dezsi, Edina, Varga, Monika, Konyane, Antonini, Giovanni, Antonella Di Pasquale, Garibaldi, Matteo, Morino, Stefania, Troili, Fernanda, Fionda, Laura, Amelia, Evoli, Paolo Emilio Alboini, Valentina, D'Amato, Raffaele, Iorio, Inghilleri, Maurizio, Frasca, Vittorio, Elena, Giacomelli, Gori, MARIA CRISTINA, Diego, Lopergolo, Onesti, Emanuela, Maria, Gabriele, Francesco, Saccà, Alessandro, Filla, Teresa, Costabile, Enrico, Marano, Angiola, Fasanaro, Angela, Marsili, Giorgia, Puorro, Carlo, Antozzi, Silvia, Bonanno, Giorgia, Camera, Alberta, Locatelli, Lorenzo, Maggi, Maria, Pasanisi, Angela, Campanella, Akiyuki, Uzawa, Tetsuya, Kanai, Naoki, Kawaguchi, Masahiro, Mori, Yoko, Kaneko, Akiko, Kanzaki, Eri, Kobayashi, Hiroyuki, Murai, Katsuhisa, Masaki, Dai, Matsuse, Takuya, Matsushita, Taira, Uehara, Misa, Shimpo, Maki, Jingu, Keiko, Kikutake, Yumiko, Nakamura, Yoshiko, Sano, Kimiaki, Utsugisawa, Yuriko, Nagane, Ikuko, Kamegamori, Tomoko, Tsuda, Yuko, Fujii, Kazumi, Futono, Yukiko, Ozawa, Aya, Mizugami, Yuka, Saito, Makoto, Samukawa, Hidekazu, Suzuki, Miyuki, Morikawa, Sachiko, Kamakura, Eriko, Miyawaki, Meinoshin, Okumura, Soichiro, Funaka, Tomohiro, Kawamura, Masayuki, Nakamori, Masanori, Takahashi, Namie, Taichi, Tomoya, Hasuike, Eriko, Higuchi, Hisako, Kobayashi, Kaori, Osakada, Hirokazu, Shiraishi, Teiichiro, Miyazaki, Masakatsu, Motomura, Akihiro, Mukaino, Shunsuke, Yoshimura, Shizuka, Asada, Seiko, Yoshida, Shoko, Amamoto, Tomomi, Kobashikawa, Megumi, Koga, Maeda, Yasuko, Kazumi, Takada, Mihoko, Takada, Masako, Tsurumaru, Yumi, Yamashita, Yasushi, Suzuki, Tetsuya, Akiyama, Koichi, Narikawa, Ohito, Tano, Kenichi, Tsukita, Rikako, Kurihara, Fumie, Meguro, Yusuke, Fukuda, Miwako, Sato, Tomihiro, Imai, Emiko, Tsuda, Shun, Shimohama, Takashi, Hayashi, Shin, Hisahara, Jun, Kawamata, Takashi, Murahara, Masaki, Saitoh, Shuichiro, Suzuki, Daisuke, Yamamoto, Yoko, Ishiyama, Naoko, Ishiyama, Mayuko, Noshiro, Rumi, Takeyama, Kaori, Uwasa, Ikuko, Yasuda, Anneke van der Kooi, Marianne de Visser, Tamar, Gibson, Byung-Jo, Kim, Chang Nyoung Lee, Yong Seo Koo, Hung Youl Seok, Hoo Nam Kang, Hyejin, Ra, Byoung Joon Kim, Eun Bin Cho, Misong, Choi, Hyelim, Lee, Ju-Hong, Min, Jinmyoung, Seok, Jieun, Lee, Da Yoon Koh, Juyoung, Kwon, Sangae, Park, Eun Haw Choi, Yoon-Ho, Hong, So-Hyun, Ahn, Dae Lim Koo, Jae-Sung, Lim, Chae Won Shin, Ji Ye Hwang, Miri, Kim, Seung Min Kim, Ha-Neul, Jeong, Jinwoo, Jung, Yool-Hee, Kim, Hyung Seok Lee, Ha Young Shin, Eun Bi Hwang, Miju, Shin, Carlos, Casasnovas, Maria Antonia Alberti Aguilo, Christian, Homedes-Pedret, Natalia Julia Palacios, Laura Diez Porras, Valentina Velez Santamaria, Ana, Lazaro, Josep Gamez Carbonell, Pilar, Sune, Maria Salvado Figueras, Gisela, Gili, Gonzalo, Mazuela, Isabel, Illa, Elena Cortes Vicente, Jordi, Diaz-Manera, Luis Antonio Querol Gutiérrez, Ricardo Rojas Garcia, Nuria, Vidal, Elisabet, Arribas-Ibar, Exuperio Diez Tejedor, Pilar Gomez Salcedo, Mireya, Fernandez-Fournier, Pedro Lopez Ruiz, Francisco Javier Rodriguez de Rivera, Maria, Sastre, Fredrik, Piehl, Albert, Hietala, Lena, Bjarbo, Ihsan, Sengun, Arzu, Meherremova, Pinar, Ozcelik, Bengu, Balkan, Celal, Tuga, Muzeyyen, Ugur, Sevim, Erdem-Ozdamar, Can Ebru Bekircan-Kurt, Nazire Pinar Acar, Ezgi, Yilmaz, Yagmur, Caliskan, Gulsah, Orsel, Husnu, Efendi, Seda, Aydinlik, Hakan, Cavus, Ayse, Kutlu, Gulsah, Becerikli, Cansu, Semiz, Ozlem, Tun, Murat, Terzi, Baki, Dogan, Musa Kazim Onar, Sedat, Sen, Tugce Kirbas Cavdar, Adife, Veske, Fiona, Norwood, Aikaterini, Dimitriou, Jakit, Gollogly, Mohamed, Mahdi-Rogers, Arshira, Seddigh, Giannis, Sokratous, Gal, Maier, Faisal, Sohail, Saiju, Jacob, Girija, Sadalage, Pravin, Torane, Claire, Brown, Amna, Shah, Sivakumar, Sathasivam, Heike, Arndt, Debbie, Davies, Dave, Watling, Anthony, Amato, Thomas, Cochrane, Mohammed, Salajegheh, Kristen, Roe, Katherine, Amato, Shirli, Toska, Nicholas, Silvestri, Kara, Patrick, Karen, Zakalik, Jonathan, Katz, Robert, Miller, Marguerite, Engel, Dallas, Forshew, Elena, Bravver, Benjamin, Brooks, Mohammed, Sanjak, Sarah, Plevka, Maryanne, Burdette, Scott, Cunningham, Megan, Kramer, Joanne, Nemeth, Clara, Schommer, Tierney, Scott, Vern, Juel, Jeffrey, Guptill, Lisa, Hobson-Webb, Janice, Massey, Kate, Beck, Donna, Carnes, John, Loor, Amanda, Anderson, Robert, Pascuzzi, Cynthia, Bodkin, John, Kincaid, Riley, Snook, Sandra, Guingrich, Angela, Micheels, Vinay, Chaudhry, Andrea, Corse, Betsy, Mosmiller, Andrea, Kelley, Doreen, Ho, Jayashri, Srinivasan, Michal, Vytopil, Jordan, Jara, Nicholas, Ventura, Cynthia, Carter, Craig, Donahue, Carol, Herbert, Stephanie, Scala, Elaine, Weiner, Sharmeen, Alam, Jonathan, Mckinnon, Laura, Haar, Naya, Mckinnon, Karan, Alcon, Kaitlyn, Mckenna, Nadia, Sattar, Kevin, Daniels, Dennis, Jeffery, Miriam, Freimer, Joseph Chad Hoyle, John, Kissel, Julie, Agriesti, Sharon, Chelnick, Louisa, Mezache, Colleen, Pineda, Filiz, Muharrem, Chafic, Karam, Julie, Khoury, Tessa, Marburger, Harpreet, Kaur, Diana, Dimitrova, James, Gilchrist, Brajesh, Agrawal, Mona, Elsayed, Stephanie, Kohlrus, Angela, Ardoin, Taylor, Darnell, Laura, Golden, Barbara, Lokaitis, Jenna, Seelbach, Neelam, Goyal, Sarada, Sakamuri, Yuen, T So, Shirley, Paulose, Sabrina, Pol, Lesly, Welsh, Ratna, Bhavaraju-Sanka, Alejandro Tobon Gonzalez, Lorraine, Dishman, Floyd, Jones, Anna, Gonzalez, Patricia, Padilla, Amy, Saklad, Marcela, Silva, Sharon, Nations, Jaya, Trivedi, Steve, Hopkins, Mohamed, Kazamel, Mohammad, Alsharabati, Liang, Lu, Kenkichi, Nozaki, Sandi, Mumfrey-Thomas, Amy, Woodall, Tahseen, Mozaffar, Tiyonnoh, Cash, Namita, Goyal, Gulmohor, Roy, Veena, Mathew, Fatima, Maqsood, Brian, Minton, H James Jones, Jeffrey, Rosenfeld, Rebekah, Garcia, Laura, Echevarria, Sonia, Garcia, Michael, Pulley, Shachie, Aranke, Alan Ross Berger, Jaimin, Shah, Yasmeen, Shabbir, Lisa, Smith, Mary, Varghese, Laurie, Gutmann, Ludwig, Gutmann, Nivedita, Jerath, Christopher, Nance, Andrea, Swenson, Heena, Olalde, Nicole, Kressin, Jeri, Sieren, Richard, Barohn, Mazen, Dimachkie, Melanie, Glenn, April, Mcvey, Mamatha, Pasnoor, Jeffery, Statland, Yunxia, Wang, Tina, Liu, Kelley, Emmons, Nicole, Jenci, Jerry, Locheke, Alex, Fondaw, Kathryn, Johns, Gabrielle, Rico, Maureen, Walsh, Laura, Herbelin, Charlene, Hafer-Macko, Justin, Kwan, Lindsay, Zilliox, Karen, Callison, Valerie, Young, Beth, Disanzo, Kerry, Naunton, Michael, Benatar, Martin, Bilsker, Khema, Sharma, Anne, Cooley, Eliana, Reyes, Sara-Claude, Michon, Danielle, Sheldon, Julie, Steele, Rebecca, Traub, Manisha, Chopra, Tuan, Vu, Lara, Katzin, Terry, Mcclain, Brittany, Harvey, Adam, Hart, Kristin, Huynh, Said, Beydoun, Amaiak, Chilingaryan, Victor, Doan, Brian, Droker, Hui, Gong, Sanaz, Karimi, Frank, Lin, Krishna, Polaka, Akshay, Shah, Anh, Tran, Salma, Akhter, Ali, Malekniazi, Rup, Tandan, Michael, Hehir, Waqar, Waheed, Shannon, Lucy, Michael, Weiss, Jane, Distad, Susan, Strom, Sharon, Downing, Bryan, Kim, Tulio, Bertorini, Thomas, Arnold, Kendrick, Henderson, Rekha, Pillai, Liu, Ye, Lauren, Wheeler, Jasmine, Hewlett, Mollie, Vanderhook, Richard, Nowak, Daniel, Dicapua, Benison, Keung, Aditya, Kumar, Huned, Patwa, Kimberly, Robeson, Irene, Yang, Joan, Nye, Hong, Vu
المصدر: NEUROLOGY
Neurology
article-version (Version of Record) 3مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Clinical Neurology, Antibodies, Monoclonal, Humanized, Placebo, Article, Antibodies, Post-intervention, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Refractory, law, Internal medicine, Monoclonal, Myasthenia Gravis, Medicine and Health Sciences, Humans, Medicine, Humanized, Science & Technology, business.industry, Middle Aged, Eculizumab, Complement Inactivating Agents, Female, Treatment Outcome, EFFICACY, medicine.disease, Myasthenia gravis, Clinical trial, 030104 developmental biology, SAFETY, Neurosciences & Neurology, Neurology (clinical), business, Life Sciences & Biomedicine, COMPLEMENT INHIBITOR ECULIZUMAB, 030217 neurology & neurosurgery, medicine.drug
الوصف: ObjectiveTo evaluate whether eculizumab helps patients with anti–acetylcholine receptor–positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension.MethodsPatients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study.ResultsA total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1–4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected.ConclusionEculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population.ClinicalTrials.gov IdentifierREGAIN, NCT01997229; REGAIN open-label extension, NCT02301624.Classification of EvidenceThis study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo.
وصف الملف: application/pdf; Print-Electronic
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5532c007a69cd361a3ae6b31d2c31214
https://doi.org/10.1212/wnl.0000000000011207 -
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المؤلفون: Jordi Figueras i Ventura, Alessandro Hering, Marco Gabella, Urs Germann, Jacopo Grazioli, Andreas Leuenberger, Lionel Peyraud
المصدر: IEEE Geoscience and Remote Sensing Letters. 16:1673-1677
مصطلحات موضوعية: Radar tracker, Computer science, C band, Doppler radar, 0211 other engineering and technologies, X band, Context (language use), 02 engineering and technology, Geotechnical Engineering and Engineering Geology, law.invention, law, Thunderstorm, Electrical and Electronic Engineering, Radar, 021101 geological & geomatics engineering, Remote sensing
الوصف: This letter presents a proof of concept illustrating the possibility to integrate X-band radar scans of individual thunderstorm cells within an operational context of storm cells identification, tracking, and severity ranking performed by a long-range volume-scanning surveillance C-band radar network. The X-band radar performs adaptive 3-D scans of one automatically selected cell, i.e., the most intense storm cell within its domain, previously identified by the operational C-band radars. The scan aims to observe with high spatiotemporal resolution the core of the cell and the evolution of its vertical structure, providing a unique data set for microphysical and dynamical interpretations. The cells tracked with this method by the X-band radar can be characterized with a high spatiotemporal resolution, better with respect to the operational C-band measurements, as illustrated in the letter with a case study of a supercellular storm occurring in western Switzerland on June 7, 2015. This method is a valuable example of the potential added value of an X-band radar system of flexible scanning strategy, in addition to C-band operational measurements conducted with a fixed scanning protocol.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fd413c6c883df9e30b5f6374eaf403f5
https://doi.org/10.1109/lgrs.2019.2909970
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المؤلفون: Joan Maria Raurich, María Antonieta Ballesteros Vizoso, Antonia Barceló, Paula Argente del Castillo, Jon Pérez-Bárcena, Juan Antonio Llompart-Pou, Albert Figueras Castilla, Julio Velasco, Daniel Morell-Garcia
المصدر: Journal of Clinical Medicine, Vol 10, Iss 5057, p 5057 (2021)
Journal of Clinical Medicine
Volume 10
Issue 21مصطلحات موضوعية: medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, critically ill patients, intensive care unit, Article, law.invention, law, medicine, thyroid hormones, Receiver operating characteristic, business.industry, Critically ill, Incidence (epidemiology), Thyroid, Area under the curve, COVID-19, General Medicine, Intensive care unit, mortality, medicine.anatomical_structure, Emergency medicine, Medicine, business, Central venous catheter
الوصف: The incidence of thyroid disfunction has not been analyzed in critically ill COVID-19 patients. Our objective was to analyze the relationship of the thyroid profile and in-hospital mortality in critically ill COVID-19 patients. This was a prospective single-center study involving critically ill COVID-19 patients admitted to the ICU of a tertiary University Hospital. Thyroid hormones were measured through drawing blood samples from a central venous catheter at ICU admission and on the fifth day. A multiple logistic regression analysis was performed to analyze the variables associated with mortality. The ability of the different thyroid hormones to predict in-hospital mortality was evaluated by calculating the receiver operating characteristics (ROCs) and the area under the curve (AUC). A total of 78 patients were included in the study at ICU admission
72 had their thyroid profile measured at day 5. In-hospital mortality reached 29.5%. Multiple logistic regression analysis showed that variables associated with mortality were age and prior beta-blocker therapy at ICU admission and age fT4 at day 5. The AUC for in-hospital mortality predictions of fT4 at day 5 was 0.69. Thyroid responses are commonly observed in critically ill COVID-19 patients. fT4 at day 5 after ICU admission was associated with mortality.وصف الملف: application/pdf
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المؤلفون: Maria Goya, Carmen Garrido, Anna Peguero, Francesc Figueras, Eduard Gratacos, Cristina Paules, Eva Meler, Teresa Cobo, Victoria Aldecoa, Jose Luis Bartha, Fernando Bugatto, María Paz Carrillo-Badillo, Carmina Comas, Vicente Diago-Almeda, Silvia Ferrero, Ignacio Herraiz, Laia Martí-Malgosa, Anna Olivella, Àngels Vives, Montse Palacio, David Boada, Sara Ruiz-Martínez, Alberto Galindo, Laura Forcén, Patricia M Brañas, Itziar Garcia, Mirea Vargas, Alicia Martínez-Varea, Laia PratCorona, Marcos Cuerva, Tamara Illescas, Miguel Angel López-Guerrero, MºCarmen Facio, Carmen Medina, Cecilia Vilalain González
المساهمون: Materno-Infantil y Radiología, Institut Català de la Salut, [Cobo T] Hospital Clinic de Barcelona, Barcelona, Spain. CIBERER, Valencia, Spain. [Aldecoa V] Hospital Clinic de Barcelona, Barcelona, Spain. [Bartha JL] Hospital Universitario La Paz, Madrid, Spain. [Bugatto F] Hospital Universitario Puerta del Mar, Cadiz, Spain. [Carrillo-Badillo MP] Hospital Universitario Virgen de las Nieves, Granada, Spain. [Comas C] Hospital Universitario Germans Trias i Pujol, Badalona, Spain. [Goya M] Vall d'Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus
المصدر: BMJ Open
BMJ Open 2021;11:e054711
RODIN. Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz
instname
BMJ Open, Vol 11, Iss 9 (2021)
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Scientiaمصطلحات موضوعية: Part prematur, Otros calificadores::Otros calificadores::/prevención & control [Otros calificadores], fetal medicine, Amniotic liquid, law.invention, Randomized controlled trial, Part prematur - Prevenció, Informed consent, law, Pregnancy, Obstetrics and Gynaecology, Premature labor, Multicenter Studies as Topic, media_common, Avaluació del risc per la salut, Randomized Controlled Trials as Topic, Amniocentesi, medicine.diagnostic_test, diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::técnicas citológicas::citodiagnóstico::amniocentesis [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Ultrasonic imaging, Adrenocortical hormones, Gestational age, General Medicine, ultrasonography, Infeccions, Hospitalization, Ecografia, Maternal health services, Amniocentesis, Medicine, Female, Serveis de salut maternal, medicine.medical_specialty, enfermedades de los genitales femeninos y complicaciones del embarazo::complicaciones del embarazo::complicaciones del parto::parto prematuro [ENFERMEDADES], Infections, Other subheadings::Other subheadings::/prevention & control [Other subheadings], Health risk assessment, Obstetric Labor, Premature, medicine, media_common.cataloged_instance, Humans, European union, Protocol (science), maternal medicine, business.industry, Líquid amniòtic, SARS-CoV-2, Female Urogenital Diseases and Pregnancy Complications::Pregnancy Complications::Obstetric Labor Complications::Obstetric Labor, Premature [DISEASES], Infant, Newborn, COVID-19, medicine.disease, Corticosteroides, Clinical trial, Emergency medicine, Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Amniocentesis [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], business
الوصف: Introduction The majority of women admitted with threatened preterm labour (PTL) do not delivery prematurely. While those with microbial invasion of the amniotic cavity (MIAC) represent the highest risk group, this is a condition that is not routinely ruled out since it requires amniocentesis. Identification of low-risk or high-risk cases might allow individualisation of care, that is, reducing overtreatment with corticosteroids and shorten hospital stay in low-risk women, while allowing early antibiotic therapy in those with MIAC. Benefits versus risks of amniocentesis-based predictor models of spontaneous delivery within 7 days and/or MIAC have not been evaluated. Methods and analysis This will be a Spanish randomised, multicentre clinical trial in singleton pregnancies (23.0-34.6 weeks) with PTL, conducted in 13 tertiary centres. The intervention arm will consist in the use of amniocentesis-based predictor models: if low risk, hospital discharge within 24 hours of results with no further medication will be recommended. If high risk, antibiotics will be added to standard management. The control group will be managed according to standard institutional protocols, without performing amniocentesis for this indication. The primary outcome will be total antenatal doses of corticosteroids, and secondary outcomes will be days of maternal stay and the occurrence of clinical chorioamnionitis. A cost analysis will be undertaken. To observe a reduction from 90% to 70% in corticosteroid doses, a reduction in 1 day of hospital stay (SD of 2) and a reduction from 24% to 12% of clinical chorioamnionitis, a total of 340 eligible patients randomised 1 to 1 to each study arm is required (power of 80%, with type I error alpha=0.05 and two-sided test, considering a dropout rate of 20%). Randomisation will be stratified by gestational age and centre. Ethics and dissemination Prior to receiving approval from the Ethics Committee (HCB/2020/1356) and the Spanish Agency of Medicines and Medical Devices (AEMPS) (identification number: 2020-005-202-26), the trial was registered in the European Union Drug Regulating Authorities Clinical Trials database (2020-005202-26). AEMPS approved the trial as a low-intervention trial. All participants will be required to provide written informed consent. Findings will be disseminated through workshops, peer-reviewed publications and national/international conferences. Protocol version V.4 10 May 2021.
This research has received a grant from the Instituto Carlos III (PI21/00972)وصف الملف: application/pdf
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المؤلفون: Lidia Segura, Josep Ramon López Olivares, María del Carmen Martí Martínez, Cristina Ligero, Rosa María González Cabezas, Juan Manuel Mendive Arbeloa, Natalia Sabat Vila, Marta R. Solé Dalfó, Renée Vink Schoenholzer, Antonia Leiva Pintado, MªCarme Parareda Plana, Eva María Ramírez Moreno, Olga Bohera Gracia, Marta Poch i Mora, Montserrat Espuga García, Almudena Alvarez, Manel Vila Vergaz, Paul K. Wallace, Gemma Comas Arnau, Montserrat Navarro Gilo, Nora Yanovksy Martí, Carme Danta Gómez, Sonia Martínez Lainez, Estela Díaz, Antoni Gual, Iris Alarcón Belmonte, José Francisco Doz Mora, Ana Morillo Ortega, Fernando Ferrer Keysers, Gemma Castillo Tirado, Susana Sostres Francás, María del Mar Sánchez Hernández, Francisco Cortés Hurtado, Silvia Crivillé Mauricio, Pere Sors i Cuffi, Mercè Ribot Igualada, M. Isabel Matilla Mont, Begoña Baena, Esther Bracero Alonso, Olga Navarro Martinez, Clara Calvó Blancafort, Angels Vicente Zamorano, Marta Beltran Vilella, M. Carmen Sánchez Herrero, Meritxell Ferrer Pujol, Rosa Blanca Muñoz Muñoz, M. Isabel López Castelló, Rosa Pla Martínez, Nuria Garcia Moron, Monica Mestres Massa, Elena Navarro Pou, Josep Maria Gifre Hipolit, Elena Campanera Samitier, Alicia Gómez Arroyo, Esther Boix Roqueta, Jakob Manthey, Elena Casajuana Andres, Rosaura Figueras Camós, Anna Santeugini Bosch, Teresa Sayrol Clols, Hugo López-Pelayo, Mireia Bernat Casals, Clara Oliveras, Angel Garcia Vilaubí, Núria Plana Closa, Carmen Garcia Corominas, Eva Casajuana Andres, Cleofé Mellado Rodríguez, Maite Fernandez Orriols, Marta Mas Regàs, Remedios Miralles Bacete, Carme Anglada Arisa, Juan Arenas Vidal, Montse Mendez Ribas, Silvia Duran Alcobet, Eulalia Duran Bellido, Davinia Vazquez Gonzalez, Xavier Cantano Navarro, Francisco Javier Avila Rivera, Gemma Capdevila Rodriguez, Elena Mañes López, Gloria Ribas Miquel, Elisenda Garcia Puig, Elvira Pou Rovira, Carme Comino Cereto, Carme Codorniu Junqué, Joan Colom, Pilar Flores Figueres, Dolors Ylla Murillo, Joana Hernandez Millan, Roser Urpinas Vilà, M. de la Serra Comas i Antich, Andrea Carolina Berengue Gonzalez, Beatriz Fernandez Najar, Elsa Caballeria, Cristina Bonaventura Sans, Judit Alsina Massana, Maria de las Nieves Vizcay Cruchaga, Pau Montoya Roldan, María Concepción Lasmarías Ugarte, Rosa Freixedas Casaponsa, M. Montserrat Melé Baena
المصدر: Internet Interventions
Internet Interventions, Vol 26, Iss, Pp 100446-(2021)مصطلحات موضوعية: medicine.medical_specialty, Alcohol Use Disorders Identification Test, business.industry, Confounding, Psychological intervention, Health Informatics, Information technology, Audit, T58.5-58.64, Missing data, Full length Article, BF1-990, law.invention, Risky alcohol use, Randomized controlled trial, Screening and brief intervention, law, Intervention (counseling), Physical therapy, eHealth, Psychology, Medicine, business, Primary healthcare
الوصف: Background Brief interventions (BI) for risky drinkers in primary healthcare have been demonstrated to be cost-effective but they are still poorly implemented. Digital BI seems to be a complementary strategy to overcome some barriers to implementation but there is a scarcity of studies in clinical environments. We present the results of a randomized controlled non-inferiority trial which tests the non-inferiority of facilitated access to a digital intervention (experimental condition) for risky drinkers against a face-to-face BI (control condition) provided by primary healthcare professionals. Method In a non-inferiority randomized controlled trial, unselected primary healthcare patients (≥ 18 years old) were given a brief introduction and asked to log on to the study website to fill in the 3-item version of the Alcohol Use Disorders Identification Test. Positively screened patients (4+ for women and 5+ for men) received further online assessment (AUDIT, socio-demographic characteristics and EQ-5D-5L) and were automatically randomized to either face-to-face or digital BI (1:1). The primary outcome was the proportion of patients classified as risky drinkers by the digitally administered AUDIT at month 3. A multiple imputation approach for the missing data was performed. Results Of the 4499 patients approached by 115 healthcare professionals, 1521 completed the AUDIT-C. Of the 368 positively screened patients, 320 agreed to participate and were randomized to either intervention. At month 3, there were more risky drinkers in the experimental group (59.8%) than in the control group (52%), which was similar to the distribution at baseline and less than the pre-specified margin of 10%. The difference was not significant when accounting for possible confounders. Conclusion Digital BI was not inferior to face-to-face BI, in line with previous findings and the a priori hypothesis. However, the low power of the final sample, due to the low recruitment and loss to follow-up, limits the interpretation of the findings. New approaches in this field are required to ensure the effective implementation of digital interventions in actual practice.
Highlights • Early identification and Brief Intervention is a cost-effective approach to risky drinkers in primary healthcare. • In our trial, digital Brief Intervention was not inferior to face-to-face Brief Intervention. • Several barriers hinder the engagement with Digital Brief Interventions. • New approaches in this field are required to ensure the effective implementation of digital intervention in real practices.
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