المؤلفون: V. A. Sulimov, A. A. Svetankova, I. E. Deneka, A. V. Rodionov

المصدر: Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 9, Iss 3, Pp 274-279 (2015)

مصطلحات موضوعية: Denervation, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, business.industry, артериальная гипертензия, резистентная артериальная гипертензия, ренальная денервация, lcsh:RM1-950, Resistant hypertension, Urology, RM1-950, urologic and male genital diseases, arterial hypertension, resistant arterial hypertension, renal denervatio, lcsh:Therapeutics. Pharmacology, lcsh:RC666-701, RC666-701, Medicine, Diseases of the circulatory (Cardiovascular) system, Pharmacology (medical), Clinical case, Therapeutics. Pharmacology, Cardiology and Cardiovascular Medicine, business

الوصف: A new method of non-drug treatment of resistant hypertension – renal denervation is considered. General information about resistant hypertension, method of renal denervation, the results of clinical studies on efficacy and safety, as well as own clinical case are presented.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe92b70d8df8b1c0681ac9560d22ad2
http://www.rpcardio.ru/jour/article/view/4

المؤلفون: E. N. Golovenko, D. A. Napalkov

المصدر: Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 5, Iss 2, Pp 79-82 (2016)

مصطلحات موضوعية: Ramipril, medicine.medical_specialty, arterial hypertension, lcsh:Diseases of the circulatory (Cardiovascular) system, left ventricle hypertrophy, альбуминурия, ramipril, RM1-950, albuminuria, Nephropathy, фибрилляция предсердий, Internal medicine, Medicine, Diseases of the circulatory (Cardiovascular) system, Pharmacology (medical), ace inhibitor, atrial fibrillation, гипертрофия левого желудочка, ингибитор АПФ, biology, business.industry, lcsh:RM1-950, рамиприл, Atrial fibrillation, Angiotensin-converting enzyme, артериальная гипертензия, medicine.disease, lcsh:Therapeutics. Pharmacology, lcsh:RC666-701, RC666-701, ACE inhibitor, Cardiology, Albuminuria, biology.protein, Disease prevention, Therapeutics. Pharmacology, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Ischemic heart, medicine.drug

الوصف: There is grate interest to ACE inhibitors which have cardioprotective and neproprotective effects. Ramipril efficacy in ischemic heart disease prevention as well as ramipril positive effect on myocardium in adolescents is presented on the base of some trails. Ramipril ability to delay of diabetic and non-diabetic nephropathy progression is also discussed.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552905e65a8944b62cf7ffecf7767c0c
http://www.rpcardio.ru/jour/article/view/640

المؤلفون: N. N. Borovkov, N. J. Borovkova, T. I. Maslov

المصدر: Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 5, Iss 4, Pp 39-44 (2016)

مصطلحات موضوعية: Metoprolol Tartrate, Ramipril, medicine.medical_specialty, хронический гломерулонефрит, lcsh:Diseases of the circulatory (Cardiovascular) system, Ambulatory blood pressure, Urology, RM1-950, Internal medicine, medicine, Diseases of the circulatory (Cardiovascular) system, Pharmacology (medical), Amlodipine, Morning, renoparenchymal arterial hypertension, business.industry, lcsh:RM1-950, Rilmenidine, chronic glomerulonephritis, Endocrinology, Blood pressure, lcsh:Therapeutics. Pharmacology, Tolerability, lcsh:RC666-701, RC666-701, Therapeutics. Pharmacology, ренопаренхиматозная артериальная гипертензия, Cardiology and Cardiovascular Medicine, business, medicine.drug

الوصف: Aim. To evaluate efficacy and safety of combined antihypertensive therapy based on ramipril, metoprolol tartrate, amlodipine bensilate and rilmenidine dihydrogen phosphate in hypertensive patients with chronic glomerulonephritis (CGN) and normal renal function.Material and methods. 136 patients (39,2±14,6 y.o.) with hypertensive type of primary CGN and with normal renal function were examined. Clinical blood pressure (BP) and 24-hour ambulatory BP monitoring (ABPM) were evaluated initially and in 12 months of antihypertensive therapy.Results. Significant decrease of clinical BP was observed in 12 months of therapy in all patients. Target BP level was reached in 37 % of patients. ABPM indices were also improved: average BP levels and hypertensive burden time decreased, speed of morning BP raise was slow down, there was a tendency to 24-hour BP rhythm improvement. Tolerability of combined therapy was good.Conclusion. The combined antihypertensive therapy based on ramipril, metoprolol tartrate, amlodipine bensilate, rilmenidine dihydrogen phosphate showed good efficacy and safety in hypertensive patients with CGN and normal renal function.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7140767699a18c089faeb4094c5baac
http://www.rpcardio.ru/jour/article/view/684

المؤلفون: S. V. Malchikova, E. I. Tarlovskaya

المصدر: Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 5, Iss 5, Pp 35-40 (2016)

مصطلحات موضوعية: Drug, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, arterial hypertension, media_common.quotation_subject, Urology, RM1-950, Nephropathy, combined therapy, medicine, Perindopril, Diseases of the circulatory (Cardiovascular) system, Pharmacology (medical), Amlodipine, комбинированная терапия, cost-efficacy analysis, media_common, business.industry, Indapamide, lcsh:RM1-950, Lisinopril, артериальная гипертензия, medicine.disease, Surgery, lcsh:Therapeutics. Pharmacology, Bisoprolol, lcsh:RC666-701, анализ «затраты-эффективность», RC666-701, Albuminuria, Therapeutics. Pharmacology, medicine.symptom, Cardiology and Cardiovascular Medicine, business, medicine.drug

الوصف: Aim. To perform the comparative cost-efficacy analysis of various antihypertensive therapies in hypertensives patients.Material and methods. 140 hypertensive patients with history of ineffective antihypertensive therapy were randomized in to 4 groups, 35 patients in each one. Patients of Group A received indapamide retard plus perindopril; group B - indapamide retard plus amlodipine; group C - amlodipine plus lisinopril; group D - amlodipine plus bisoprolol. The Russian version of general questionnaire MOS-SF-36 was applied for quality of a life estimated. Endothelium function was evaluated with B-mode ultrasonography (Acuson 128 ХР/10). Albuminuria level was detected by immunoturbometric method (Integra-700, Roche).Results. The drug combination B had the least cost. The drug combination C was the most effective. The drug combination C was the most economically rational. The drug combination A was the least economically rational for BP reduction. However the drug combination A was comparable with drug combination C in effects on quality of life and on endothelium function, and it was the most economically rational for albuminuria reduction.Conclusion. Indapamide retard plus perindopril combination is the most economically rational in patients with target-organ lesions (nephropathy). Lisinopril plus amlodipine combination is economically rational in patients without target-organ lesions.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa3547c29accbdc818c31ec1503d762
https://www.rpcardio.com/jour/article/view/714

المؤلفون: V. I. Podzolkov, K. K. Osadchy

المصدر: Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 5, Iss 1, Pp 57-62 (2016)

مصطلحات موضوعية: arterial hypertension, lcsh:Diseases of the circulatory (Cardiovascular) system, RM1-950, Pharmacology, Pharmacotherapy, medicine, Diseases of the circulatory (Cardiovascular) system, Pharmacology (medical), Hypertension treatment, business.industry, lisinopril, lcsh:RM1-950, Lisinopril, артериальная гипертензия, lcsh:Therapeutics. Pharmacology, ace inhibitors, лизиноприл, lcsh:RC666-701, RC666-701, ACE inhibitor, Therapeutics. Pharmacology, Cardiology and Cardiovascular Medicine, business, ингибиторы АПФ, medicine.drug, circulatory and respiratory physiology

الوصف: Approaches to the choice of antihypertensive pharmacotherapy are discussed. Evidence base of ACE inhibitor lisinopril is surveyed. Data about lisinopril effects on different endpoints, organoprotective action and advantages over other ACE inhibitors are presented.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce6e608f2a416417bb5703b402fee3a
http://www.rpcardio.ru/jour/article/view/598

المؤلفون: N. A. Dmitrieva, Yu. V. Lukina, V. V. Yakusevich, S. Yu. Martsevich, L. A. Sokolova, A. D. Deev

المصدر: Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 7, Iss 1, Pp 37-41 (2016)

مصطلحات موضوعية: Drug, фармакоэкономический анализ, lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, arterial hypertension, media_common.quotation_subject, дженерический препарат, Urology, RM1-950, amlodipine, pharmacoeconomic analysis, Indirect costs, Hydrochlorothiazide, Generic drug, medicine, Diseases of the circulatory (Cardiovascular) system, Pharmacology (medical), Amlodipine, media_common, business.industry, lcsh:RM1-950, Lisinopril, амлодипин, Economic feasibility, артериальная гипертензия, Surgery, lcsh:Therapeutics. Pharmacology, Blood pressure, lcsh:RC666-701, RC666-701, generic drug, Therapeutics. Pharmacology, Cardiology and Cardiovascular Medicine, business, medicine.drug

الوصف: Aim. Тo compare the cost-effectiveness of antihypertensive therapy based on a generic and original drugs of amlodipine in patients with arterial hypertension (HT) degree 1-2 in NORST study. Material and methods. Patients (n=60) with HT degree 1-2 were involved in NORST study. After wash-out period they were randomized to receive generic (Group 1) or original (Group 2) amlodipine in the initial dose of 5 mg daily. In case of insufficient antihypertensive effect dose of amlodipine was increased to 10 mg per day and then successively lisinopril 10 mg daily and hydrochlorothiazide 12.5 mg one time per day were added. The total duration of treatment was 10 weeks (70 days). Achieving target blood pressure (BP) (

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11a79917ecf03b370ea35bcef623ad6
https://www.rpcardio.com/jour/article/view/687

المؤلفون: Rafael G. Oganov, E. G. Kurumlidu, V. A. Lyusov, N. V. Teplova, M. H. Zhapoeva, E. M. Evsikov, R. A. Sharipov

المصدر: Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 11, Iss 6, Pp 590-594 (2015)

مصطلحات موضوعية: lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, Infrarenal aorta, Resistant hypertension, RM1-950, Essential hypertension, Gastroenterology, vasorenal lesions, medicine.artery, Internal medicine, заболевания почек, medicine, Diseases of the circulatory (Cardiovascular) system, Pharmacology (medical), In patient, Treatment resistance, General hospital, вазоренальные поражения, business.industry, lcsh:RM1-950, Abdominal aorta, resistant hypertension, medicine.disease, Surgery, lcsh:Therapeutics. Pharmacology, lcsh:RC666-701, RC666-701, renal diseases, Renal vessels, Therapeutics. Pharmacology, резистентная артериальная гипертензия, Cardiology and Cardiovascular Medicine, business

الوصف: Aim. To study the prevalence of renal and renovascular disorders in the development and progression of primary arterial hypertension (HT) resistant to combination antihypertensive therapy (AHT) in cardiac and therapeutic patients of general hospital.Material and methods. 286 patients with essential HT stages 1-3, including 105 patients with stages 2-3 with the signs of treatment resistance were included into the study. All patients were treated with personalized AHT in accordance with current guidelines for the management of HT. Laboratory and instrumental assessment of a functional status of kidneys was performed.Results. A group of patients with resistant HT made 36.7% of the total number of examined patients. The most significant distinction in patients with resistant HT was a high incidence of changes in renal vessels and infrarenal aorta. Deformation of the abdominal aorta (9.7%), renal arteries tortuosity (7.3%), vasourethral conflict (4.8%) were detected in this group significantly more often.Conclusion. Congenital and acquired lesions of renal arteries are detected several times more often in patients with resistant essential HT.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298766237c5b61222fca0ce347e0a207
https://doi.org/10.20996/1819-6446-2015-11-6-590-594

المؤلفون: N. I. Gaponova, V. R. Abdrakhmanov, S. N. Tereschenko

المصدر: Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 8, Iss 5, Pp 703-707 (2015)

مصطلحات موضوعية: lcsh:Diseases of the circulatory (Cardiovascular) system, arterial hypertension, Vasodilation, RM1-950, Urapidil, urapidil, антигипертензивная терапия, Medicine, Diseases of the circulatory (Cardiovascular) system, Pharmacology (medical), hypertensive crises, гипертонический криз, antihypertensive therapy, урапидил, business.industry, lcsh:RM1-950, артериальная гипертензия, Peripheral, Blood pressure, lcsh:Therapeutics. Pharmacology, Tolerability, lcsh:RC666-701, Anesthesia, RC666-701, Therapeutics. Pharmacology, Blood pressure increase, Cardiology and Cardiovascular Medicine, business

الوصف: Results of experimental and clinical studies devoted to urapidil combining central antihypertensive effect with peripheral vasodilatation are discussed. Scope of urapidil application is described; its good tolerability and safety are highlighted. Urapidil mode of application in different clinical situations accompanying by acute increase in blood pressure is specified.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d0397fc7a8f9c4aa63b0a58b3d63cf
https://www.rpcardio.com/jour/article/view/586

المؤلفون: G. G. Ivanov, V. V. Popov, N. A. Bulanov

المصدر: Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 8, Iss 1, Pp 88-94 (2015)

مصطلحات موضوعية: Aldosterone synthase, arterial hypertension, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, RM1-950, Disease, Bioinformatics, гипотензивные препараты, фармакологические мишени, Internal medicine, Renin–angiotensin system, medicine, Diseases of the circulatory (Cardiovascular) system, Pharmacology (medical), Neprilysin, Renalase, clinical trials, biology, pharmacological targets, business.industry, lcsh:RM1-950, артериальная гипертензия, Angiotensin II, Clinical trial, Endocrinology, клинические исследования, lcsh:Therapeutics. Pharmacology, lcsh:RC666-701, antihypertensive drugs, RC666-701, biology.protein, Therapeutics. Pharmacology, Cardiology and Cardiovascular Medicine, Endothelin receptor, business

الوصف: Arterial hypertension (HT) takes leading position in the structure of morbidity and mortality among the cardiovascular diseases in the economically developed and developing countries of the world. Despite progress in treatment of this disease, a number of people with uncontrolled or resistant HT increases. There is a problem of inefficiency of therapy or lack of patients' adherence to treatment. Therefore, search for new approaches to treatment of HT continues. Current most effective agents for blood pressure control, and possible future antihypertensive agents, are related to groups of agents, which inhibit renin–angiotensin–aldosterone system (RAAS). Novel targets for antihypertensive therapy could include the angiotensin II type 2 and type 1 receptor , neutral endopeptidase, aldosterone synthase, renalase, endothelin receptors, (pro)renin receptors, vaccine against RAAS components. Development of novel agents and approaches to HT therapy is discussed.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94ccfe69792ddf6280ff57a75af65f2
http://www.rpcardio.ru/jour/article/view/421

المؤلفون: A. O. Konrady, O. A. Pleyko

المصدر: Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 3, Iss 1, Pp 21-27 (2015)

مصطلحات موضوعية: Drug, монотерапия, arterial hypertension, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, media_common.quotation_subject, RM1-950, combined therapy, Hydrochlorothiazide, Fosinopril, Internal medicine, Diseases of the circulatory (Cardiovascular) system, Medicine, Pharmacology (medical), Amlodipine, комбинированная терапия, media_common, business.industry, Indapamide, lcsh:RM1-950, артериальная гипертензия, Rilmenidine, Surgery, Blood pressure, lcsh:Therapeutics. Pharmacology, Bisoprolol, lcsh:RC666-701, monotherapy, RC666-701, Therapeutics. Pharmacology, Cardiology and Cardiovascular Medicine, business, medicine.drug

الوصف: Aim. To evaluate different tactics of initial antihypertensive therapy.Material and Methods. 120 patients with mild-to-moderate arterial hypertension were included and randomized into three groups: “A”, “B”, and “C”. 5 drugs from the main antihypertensive classes were used: indapamide, bisoprolol, amlodipine, fosinopril, and rilmenidine as well as fixed drug combination of fosinopril and hydrochlorothiazide. Patients included in group “A” received initial therapy according to individual leading pathogenic variant of hypertension. Patients from group “B” received standard stepped antihypertensive therapy with gradual dose increase and further addition of second (third) drug. Patients in group “C” were immediately administrated fixed drug combination and later added other drugs. Visits were scheduled after 2, 4, 6, 8, 10, etc weeks of treatment up to achievement of target blood pressure (BP).Results. In group “A” 33 patients (82,5%) achieved target BP after 6 visits, in group “B” - 37 patients (92,5%) after 8 visits and in group “C” - 100% of patents after 6 visits. Thus, in group “C” there was less number of visits and respectively lower number of therapy changes in order to achieve target BP. No significant discrepancies between group “A” and “B” were observed.Conclusion. Tactics of initial antihypertensive therapy with usage of fixed drug combination results in more effective and fast achievement of target BP.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9c77393d1fd8a9f3bf7a0c8e03e71e
http://www.rpcardio.ru/jour/article/view/380