المؤلفون: Sanghvi VR; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Leibold J; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Mina M; Department of Computational Biology, University of Lausanne, 1005 Lausanne, Switzerland; Swiss Institute of Bioinformatics (SIB), 1005 Lausanne, Switzerland., Mohan P; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Berishaj M; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Li Z; Microchemistry and Proteomics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Miele MM; Microchemistry and Proteomics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Lailler N; Integrated Genomics Operation, Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Zhao C; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., de Stanchina E; Antitumor Assessment Core and Molecular Pharmacology Department, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Viale A; Integrated Genomics Operation, Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Akkari L; Oncode Institute, Tumor Biology and Immunology division, the Netherlands Cancer Institute, 1006 BE, Amsterdam, the Netherlands., Lowe SW; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, New York, NY 10065, USA., Ciriello G; Department of Computational Biology, University of Lausanne, 1005 Lausanne, Switzerland; Swiss Institute of Bioinformatics (SIB), 1005 Lausanne, Switzerland., Hendrickson RC; Microchemistry and Proteomics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Wendel HG; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: wendelh@mskcc.org.

المصدر: Cell [Cell] 2019 Aug 08; Vol. 178 (4), pp. 807-819.e21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Hepatocellular/*metabolism , Liver Neoplasms/*metabolism , NF-E2-Related Factor 2/*metabolism , Phosphotransferases (Alcohol Group Acceptor)/*metabolism, Animals ; Carcinoma, Hepatocellular/pathology ; Female ; Gene Knockdown Techniques ; Glucose/metabolism ; Glycosylation ; HEK293 Cells ; Hep G2 Cells ; Heterografts ; Humans ; Kelch-Like ECH-Associated Protein 1/metabolism ; Liver Neoplasms/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, Nude ; Mice, SCID ; Phosphotransferases (Alcohol Group Acceptor)/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Transduction, Genetic

المؤلفون: Lee D; Department of Pathology, The University of Hong Kong, Hong Kong., Xu IM; Department of Pathology, The University of Hong Kong, Hong Kong., Chiu DK; Department of Pathology, The University of Hong Kong, Hong Kong., Leibold J; Memorial Sloan Kettering Cancer Center, New York, NY., Tse AP; Department of Pathology, The University of Hong Kong, Hong Kong., Bao MH; Department of Pathology, The University of Hong Kong, Hong Kong., Yuen VW; Department of Pathology, The University of Hong Kong, Hong Kong., Chan CY; Department of Pathology, The University of Hong Kong, Hong Kong., Lai RK; Department of Pathology, The University of Hong Kong, Hong Kong., Chin DW; Department of Pathology, The University of Hong Kong, Hong Kong., Chan DF; Department of Pathology, The University of Hong Kong, Hong Kong., Cheung TT; Department of Surgery, The University of Hong Kong, Hong Kong.; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong., Chok SH; Department of Surgery, The University of Hong Kong, Hong Kong.; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong., Wong CM; Department of Pathology, The University of Hong Kong, Hong Kong.; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong., Lowe SW; Memorial Sloan Kettering Cancer Center, New York, NY., Ng IO; Department of Pathology, The University of Hong Kong, Hong Kong.; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong., Wong CC; Department of Pathology, The University of Hong Kong, Hong Kong.; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong.

المصدر: Hepatology (Baltimore, Md.) [Hepatology] 2019 Apr; Vol. 69 (4), pp. 1768-1786. Date of Electronic Publication: 2019 Mar 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE

مواضيع طبية MeSH: Auranofin/*therapeutic use , Carcinoma, Hepatocellular/*metabolism , Liver Neoplasms/*metabolism , Oxidative Stress/*drug effects , Thioredoxin Reductase 1/*metabolism, Animals ; Antineoplastic Agents/therapeutic use ; Auranofin/pharmacology ; Carcinoma, Hepatocellular/drug therapy ; Drug Screening Assays, Antitumor ; Hep G2 Cells ; Humans ; Kelch-Like ECH-Associated Protein 1/metabolism ; Liver Neoplasms/drug therapy ; Mice ; NF-E2-Related Factor 2/metabolism ; Sorafenib/therapeutic use ; Thioredoxin Reductase 1/antagonists & inhibitors