المؤلفون: Kovvali S; Department of Microbiology, The Ohio State University, Columbus, Ohio, USA.; Department of Chemistry & Biochemistry, The Ohio State University, Columbus, Ohio, USA., Gao Y; Department of Chemistry & Biochemistry, The Ohio State University, Columbus, Ohio, USA.; Resource for Native MS-Guided Structural Biology, The Ohio State University, Columbus, Ohio, USA., Cool A; Department of Chemistry & Biochemistry, The Ohio State University, Columbus, Ohio, USA., Lindert S; Department of Chemistry & Biochemistry, The Ohio State University, Columbus, Ohio, USA., Wysocki VH; Department of Chemistry & Biochemistry, The Ohio State University, Columbus, Ohio, USA.; Resource for Native MS-Guided Structural Biology, The Ohio State University, Columbus, Ohio, USA., Bell CE; Department of Chemistry & Biochemistry, The Ohio State University, Columbus, Ohio, USA.; Department of Biological Chemistry & Pharmacology, The Ohio State University, Columbus, Ohio, USA., Gopalan V; Department of Microbiology, The Ohio State University, Columbus, Ohio, USA.; Department of Chemistry & Biochemistry, The Ohio State University, Columbus, Ohio, USA.

المصدر: Protein science : a publication of the Protein Society [Protein Sci] 2023 Jul; Vol. 32 (7), pp. e4695.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

مواضيع طبية MeSH: Lysine* , Amino Acids*, Animals ; Bacteria ; Escherichia coli/genetics ; Sugars ; Fructose

SCR Disease Name: Glioma of Brain, Familial

المؤلفون: Leandro J; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Khamrui S; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Suebsuwong C; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Chen PJ; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Secor C; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Dodatko T; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Yu C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Mount Sinai Genomics, Inc, Stamford, CT 06902, USA., Sanchez R; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., DeVita RJ; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Houten SM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Lazarus MB; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

المصدر: Open biology [Open Biol] 2022 Sep; Vol. 12 (9), pp. 220179. Date of Electronic Publication: 2022 Sep 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Royal Society Pub Country of Publication: England NLM ID: 101580419 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2046-2441 (Electronic) Linking ISSN: 20462441 NLM ISO Abbreviation: Open Biol Subsets: MEDLINE

مواضيع طبية MeSH: Lysine*/metabolism , Saccharopine Dehydrogenases*/chemistry , Saccharopine Dehydrogenases*/metabolism, Amino Acid Metabolism, Inborn Errors ; Animals ; Brain Diseases, Metabolic ; Cysteine ; Ethylmaleimide ; Glutaryl-CoA Dehydrogenase/deficiency ; Humans ; Mice

SCR Disease Name: Glutaric Acidemia I

المؤلفون: Bhatt DP; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA; Department of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, Missouri, USA., Mills CA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA., Anderson KA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA; Sarah W. Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, North Carolina, USA; Departments of Medicine and Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Henriques BJ; Biosystems and Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal; Departmento de Química e Bioquimica, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal., Lucas TG; Biosystems and Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal; Departmento de Química e Bioquimica, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal., Francisco S; Biosystems and Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal; Departmento de Química e Bioquimica, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal., Liu J; Departments of Medicine and Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Ilkayeva OR; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA; Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University School of Medicine, Durham, North Carolina, USA., Adams AE; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA., Kulkarni SR; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA., Backos DS; Computational Chemistry and Biology Core Facility, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Major MB; Department of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, Missouri, USA., Grimsrud PA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA; Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University School of Medicine, Durham, North Carolina, USA., Gomes CM; Biosystems and Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal; Departmento de Química e Bioquimica, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal., Hirschey MD; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA; Sarah W. Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, North Carolina, USA; Departments of Medicine and Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA; Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University School of Medicine, Durham, North Carolina, USA. Electronic address: matthew.hirschey@duke.edu.

المصدر: The Journal of biological chemistry [J Biol Chem] 2022 Apr; Vol. 298 (4), pp. 101723. Date of Electronic Publication: 2022 Feb 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Glutaryl-CoA Dehydrogenase*/metabolism , Lysine*/metabolism , Sirtuins*/metabolism, Animals ; Mice ; Oxidation-Reduction ; Protein Processing, Post-Translational ; Tryptophan/metabolism

المؤلفون: Kirupananthan, Dalshini, Bertolo, Robert F, Brunton, Janet A

المصدر: Journal of Nutrition; Aug2022, Vol. 152 Issue 8, p1843-1850, 8p

مصطلحات موضوعية: LYSINE metabolism, AMINO acid metabolism, GLYCINE metabolism, OLIGOPEPTIDES, ANIMAL experimentation, SWINE, ATROPHY, LYSINE, RESEARCH funding, INTESTINAL mucosa

المؤلفون: Matthews DE; Departments of Chemistry and Medicine, University of Vermont, Burlington, VT, USA.

المصدر: The Journal of nutrition [J Nutr] 2020 Oct 01; Vol. 150 (Suppl 1), pp. 2548S-2555S.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0404243 Publication Model: Print Cited Medium: Internet ISSN: 1541-6100 (Electronic) Linking ISSN: 00223166 NLM ISO Abbreviation: J Nutr Subsets: MEDLINE

مواضيع طبية MeSH: Diet* , Gastrointestinal Microbiome* , Nutritional Requirements* , Nutritional Status*, Lysine/*metabolism, 2-Aminoadipic Acid/metabolism ; Acetyl Coenzyme A/metabolism ; Ammonia/metabolism ; Animals ; Bacteria/metabolism ; Body Weight ; Deficiency Diseases/metabolism ; Humans ; Lysine/analogs & derivatives ; Lysine/biosynthesis ; Lysine/deficiency ; Nitrogen/metabolism ; Proteins/metabolism ; Urea/metabolism

المؤلفون: Tessier, Romain, Calvez, Juliane, Airinei, Gheorghe, Khodorova, Nadezda, Kapel, Romain, Quinsac, Alain, Galet, Olivier, Piedcoq, Julien, Benamouzig, Robert, Tomé, Daniel, Gaudichon, Claire

المصدر: Journal of Nutrition; Mar2022, Vol. 152 Issue 3, p698-706, 9p

مصطلحات موضوعية: BISCUITS, AMINO acids, ISOTOPES, LYSINE, THREONINE, HUMAN beings, AMINO acid metabolism, LYSINE metabolism, RESEARCH, RESEARCH methodology, EVALUATION research, COMPARATIVE studies, FOOD, DIGESTION, RESEARCH funding, ILEUM

المؤلفون: Paoletti, Alyssa, Fakiha, Abrar, Tul-Noor, Zujaja, Pencharz, Paul B, Levesque, Crystal L, Ball, Ronald O, Kong, Dehan, Elango, Rajavel, Courtney-Martin, Glenda

المصدر: Journal of Nutrition; Mar2022, Vol. 152 Issue 3, p770-778, 9p

مصطلحات موضوعية: SORGHUM, LENTILS, AMINO acids, LYSINE, PHENYLALANINE, OXIDATION, DIET, PHENYLALANINE metabolism, AMINO acid metabolism, LYSINE metabolism, PLANT metabolism, RESEARCH, RESEARCH methodology, COOKING, NUTRITIONAL requirements, EVALUATION research, COMPARATIVE studies, RANDOMIZED controlled trials, RESEARCH funding, DIETARY proteins, OXIDATION-reduction reaction

المؤلفون: Liu, Jialing, Hu, Junhao, Tan, Lanlan, Zhou, Qi, Wu, Xiaojing

المصدر: BMC Cardiovascular Disorders; 8/21/2021, Vol. 21 Issue 1, p1-11, 11p

مصطلحات موضوعية: PATHOLOGICAL physiology, RATS, LYSINE, SPRAGUE Dawley rats, CARDIAC hypertrophy, LYSINE metabolism, HEART metabolism, ENERGY metabolism, LEFT heart ventricle, BIOLOGICAL models, BLOOD pressure, BIOCHEMISTRY, RESEARCH, MYOCARDIUM, VENTRICULAR remodeling, LEFT ventricular hypertrophy, ANIMAL experimentation, ARTERIES, TIME, RESEARCH methodology, METABOLISM, FIBROSIS, THORACIC aorta, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, HEART physiology, LIGATURE (Surgery)

المؤلفون: Hartmann M; Department of Biology, Institute for Molecular Ecophysiology of Plants, Heinrich Heine University, Universitätsstraße 1, D-40225, Düsseldorf, Germany., Zeier J; Department of Biology, Institute for Molecular Ecophysiology of Plants, Heinrich Heine University, Universitätsstraße 1, D-40225, Düsseldorf, Germany.; Cluster of Excellence on Plant Sciences (CEPLAS), Heinrich Heine University, Universitätsstraße 1, D-40225, Düsseldorf, Germany.

المصدر: The Plant journal : for cell and molecular biology [Plant J] 2018 Oct; Vol. 96 (1), pp. 5-21. Date of Electronic Publication: 2018 Sep 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Blackwell Scientific Publishers and BIOS Scientific Publishers in association with the Society for Experimental Biology Country of Publication: England NLM ID: 9207397 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-313X (Electronic) Linking ISSN: 09607412 NLM ISO Abbreviation: Plant J Subsets: MEDLINE

مواضيع طبية MeSH: Plant Immunity*, Lysine/*metabolism , Pipecolic Acids/*metabolism, Arabidopsis/immunology ; Arabidopsis/metabolism ; Metabolic Networks and Pathways ; Plants/immunology ; Plants/metabolism

المؤلفون: Pena IA; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario K1H 8L1, Canada ipena2@uottawa.ca.; Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ontario K1H 8L1, Canada.; Department of Biology, University of Ottawa, Ontario K1N 6N5, Canada., Roussel Y; Department of Biology, University of Ottawa, Ontario K1N 6N5, Canada., Daniel K; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario K1H 8L1, Canada., Mongeon K; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario K1H 8L1, Canada.; Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ontario K1H 8L1, Canada., Johnstone D; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario K1H 8L1, Canada.; Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ontario K1H 8L1, Canada., Weinschutz Mendes H; Department of Biology, University of Ottawa, Ontario K1N 6N5, Canada., Bosma M; Departments of Pediatrics and Clinical Genetics, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands., Saxena V; Department of Biology, University of Ottawa, Ontario K1N 6N5, Canada., Lepage N; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario K1H 8L1, Canada., Chakraborty P; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario K1H 8L1, Canada., Dyment DA; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario K1H 8L1, Canada.; Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ontario K1H 8L1, Canada., van Karnebeek CDM; Departments of Pediatrics and Clinical Genetics, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands.; Department of Pediatrics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver V5Z 4H4, British Columbia, Canada., Verhoeven-Duif N; Department of Genetics, Center for Molecular Medicine, University Medical Center (UMC), 3584 EA Utrecht, The Netherlands., Bui TV; Department of Biology, University of Ottawa, Ontario K1N 6N5, Canada., Boycott KM; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario K1H 8L1, Canada ipena2@uottawa.ca.; Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ontario K1H 8L1, Canada., Ekker M; Department of Biology, University of Ottawa, Ontario K1N 6N5, Canada., MacKenzie A; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario K1H 8L1, Canada.; Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ontario K1H 8L1, Canada.

المصدر: Genetics [Genetics] 2017 Dec; Vol. 207 (4), pp. 1501-1518. Date of Electronic Publication: 2017 Oct 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0374636 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1943-2631 (Electronic) Linking ISSN: 00166731 NLM ISO Abbreviation: Genetics Subsets: MEDLINE

مواضيع طبية MeSH: Aldehyde Dehydrogenase/*genetics , Epilepsy/*genetics , Lysine/*metabolism , Seizures/*genetics, Aldehyde Dehydrogenase/deficiency ; Animals ; Disease Models, Animal ; Epilepsy/metabolism ; Epilepsy/physiopathology ; Gene Knockout Techniques ; Humans ; Lysine/deficiency ; Mutation ; Pyridoxine/metabolism ; Seizures/metabolism ; Seizures/physiopathology ; Vitamin B 6/genetics ; Vitamin B 6/metabolism ; Zebrafish/genetics ; gamma-Aminobutyric Acid/genetics ; gamma-Aminobutyric Acid/metabolism

SCR Disease Name: Pyridoxine-dependent epilepsy