المؤلفون: Hilbert K; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany; Department of Psychology, HMU Health and Medical University Erfurt, Erfurt, Germany., Böhnlein J; Institute for Translational Psychiatry, University of Münster, Germany. Electronic address: joscha.boehnlein@uni-muenster.de., Meinke C; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany., Chavanne AV; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany; Université Paris-Saclay, INSERM U1299 'Trajectoires développementales et psychiatrie', CNRS UMR 9010 Centre Borelli, Ecole Normale Supérieure Paris-Saclay, France., Langhammer T; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany., Stumpe L; Institute for Translational Psychiatry, University of Münster, Germany., Winter N; Institute for Translational Psychiatry, University of Münster, Germany., Leenings R; Institute for Translational Psychiatry, University of Münster, Germany., Adolph D; Mental Health Research and Treatment Center, Faculty of Psychology, Ruhr-Universität Bochum, Bochum, Germany., Arolt V; Institute for Translational Psychiatry, University of Münster, Germany., Bischoff S; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany., Cwik JC; Department of Clinical Psychology and Psychotherapy, Faculty of Human Sciences, Universität zu Köln, Germany., Deckert J; Center for Mental Health, Department of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital of Würzburg, Germany., Domschke K; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Fydrich T; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany., Gathmann B; Institute of Medical Psychology and Systems Neuroscience, University of Münster, Germany., Hamm AO; Department of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany., Heinig I; Institute of Clinical Psychology & Psychotherapy, Technische Universität Dresden, Dresden, Germany., Herrmann MJ; Center for Mental Health, Department of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital of Würzburg, Germany., Hollandt M; Department of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany., Hoyer J; Institute of Clinical Psychology & Psychotherapy, Technische Universität Dresden, Dresden, Germany., Junghöfer M; Institute for Biomagnetism and Biosignalanalysis, University of Münster, Germany., Kircher T; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Koelkebeck K; LVR-University-Hospital Essen, Department of Psychiatry and Psychotherapy, University of Duisburg-Essen, Essen, Germany., Lotze M; Functional Imaging Unit. Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany., Margraf J; Mental Health Research and Treatment Center, Faculty of Psychology, Ruhr-Universität Bochum, Bochum, Germany., Mumm JLM; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany., Neudeck P; Protect-AD Study Site Cologne, Cologne, Germany; Institut für Klinische Psychologie und Psychotherapie, TU Chemnitz, Germany., Pauli P; Department of Psychology, University of Würzburg, Würzburg, Germany., Pittig A; Translational Psychotherapy, Institute of Psychology, University of Göttingen, Germany., Plag J; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, Alexianer Krankenhaus Hedwigshoehe, St. Hedwig Kliniken, Berlin, Germany., Richter J; Department of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany; Department of Experimental Psychopathology, University of Hildesheim, Hildesheim, Germany., Ridderbusch IC; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Rief W; Department of Clinical Psychology and Psychotherapy, Faculty of Psychology & Center for Mind, Brain and Behavior - CMBB, Philipps-University of Marburg, Marburg, Germany., Schneider S; Faculty of Psychology, Clinical Child and Adolescent Psychology, Mental Health Research and Treatment Center, Ruhr-Universität Bochum, Bochum, Germany., Schwarzmeier H; Center for Mental Health, Department of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital of Würzburg, Germany., Seeger FR; Center for Mental Health, Department of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital of Würzburg, Germany., Siminski N; Center for Mental Health, Department of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital of Würzburg, Germany., Straube B; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Straube T; Institute of Psychology, Unit of Clinical Psychology and Psychotherapy in Childhood and Adolescence, University of Osnabrueck, Osnabruck, Germany., Ströhle A; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany., Wittchen HU; Psychiatric University Hospital, Ludwig-Maximilians-University München, Germany., Wroblewski A; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Yang Y; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Roesmann K; Institute for Biomagnetism and Biosignalanalysis, University of Münster, Germany; Institute of Psychology, Unit of Clinical Psychology and Psychotherapy in Childhood and Adolescence, University of Osnabrueck, Osnabruck, Germany., Leehr EJ; Institute for Translational Psychiatry, University of Münster, Germany., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Germany., Lueken U; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany; German Center for Mental Health (DZPG), partner site Berlin/Potsdam, Germany.

المصدر: NeuroImage [Neuroimage] 2024 Jul 15; Vol. 295, pp. 120639. Date of Electronic Publication: 2024 May 25.

نوع المنشور: Journal Article; Multicenter Study

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9215515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9572 (Electronic) Linking ISSN: 10538119 NLM ISO Abbreviation: Neuroimage Subsets: MEDLINE

مواضيع طبية MeSH: Magnetic Resonance Imaging*/methods , Machine Learning* , Anxiety Disorders*/therapy , Anxiety Disorders*/diagnostic imaging , Anxiety Disorders*/physiopathology , Cognitive Behavioral Therapy*/methods, Humans ; Female ; Male ; Adult ; Middle Aged ; Treatment Outcome ; Brain/diagnostic imaging ; Brain/physiopathology ; Young Adult ; Implosive Therapy/methods

مستخلص: Data-based predictions of individual Cognitive Behavioral Therapy (CBT) treatment response are a fundamental step towards precision medicine. Past studies demonstrated only moderate prediction accuracy (i.e. ability to discriminate between responders and non-responders of a given treatment) when using clinical routine data such as demographic and questionnaire data, while neuroimaging data achieved superior prediction accuracy. However, these studies may be considerably biased due to very limited sample sizes and bias-prone methodology. Adequately powered and cross-validated samples are a prerequisite to evaluate predictive performance and to identify the most promising predictors. We therefore analyzed resting state functional magnet resonance imaging (rs-fMRI) data from two large clinical trials to test whether functional neuroimaging data continues to provide good prediction accuracy in much larger samples. Data came from two distinct German multicenter studies on exposure-based CBT for anxiety disorders, the Protect-AD and SpiderVR studies. We separately and independently preprocessed baseline rs-fMRI data from n = 220 patients (Protect-AD) and n = 190 patients (SpiderVR) and extracted a variety of features, including ROI-to-ROI and edge-functional connectivity, sliding-windows, and graph measures. Including these features in sophisticated machine learning pipelines, we found that predictions of individual outcomes never significantly differed from chance level, even when conducting a range of exploratory post-hoc analyses. Moreover, resting state data never provided prediction accuracy beyond the sociodemographic and clinical data. The analyses were independent of each other in terms of selecting methods to process resting state data for prediction input as well as in the used parameters of the machine learning pipelines, corroborating the external validity of the results. These similar findings in two independent studies, analyzed separately, urge caution regarding the interpretation of promising prediction results based on neuroimaging data from small samples and emphasizes that some of the prediction accuracies from previous studies may result from overestimation due to homogeneous data and weak cross-validation schemes. The promise of resting-state neuroimaging data to play an important role in the prediction of CBT treatment outcomes in patients with anxiety disorders remains yet to be delivered.
Competing Interests: Declaration of competing interest The authors declare there is no conflict of interests.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)

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