المؤلفون: Xiang-Rong Cheng, Chun-Hui Wang, Hui-Zi Jin, Qi Zeng, Xu-Feng Zhang, Shi-Kai Yan, Wei-Dong Zhang, Pan-Lei Wei

المصدر: Fitoterapia. 95:139-146

مصطلحات موضوعية: Lipopolysaccharides, Magnetic Resonance Spectroscopy, Stereochemistry, Crystallography, X-Ray, Nitric Oxide, Inhibitory Concentration 50, Mice, Sesquiterpenes, Germacrane, Drug Discovery, Animals, Organic chemistry, Medicine, Chinese Traditional, No production, Pharmacology, Plants, Medicinal, Inula, Molecular Structure, biology, Chemistry, Macrophages, General Medicine, Plant Components, Aerial, Asteraceae, biology.organism_classification, Sesquiterpenes, Two-dimensional nuclear magnetic resonance spectroscopy

الوصف: Eight new (1-8) and two known (9 and 10) sesquiterpenic acids featuring α-methylene-γ-carboxyl units were isolated from the whole plants of Inula wissmanniana, along with two new germacranolides (11 and 12). Their structures were elucidated based on detailed spectroscopic analysis, including HRESIMS, 1D and 2D NMR, and X-ray crystallography. Notably, the skeleton of 1 was firstly discovered from nature, while that of 2 was discovered for the second time. All the compounds were evaluated for their inhibition against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages. Compound 11 exhibited the strongest activity with the IC50 value of 1.04 μM.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f8d2d033dd79b54b885f6053a1075a
https://doi.org/10.1016/j.fitote.2014.03.013

المؤلفون: Jiang-Jiang Qin, Wei-Dong Zhang, Jia-Xian Zhu, Xiang-Rong Cheng, Qi Zeng, Shou-De Zhang, Hui-Zi Jin

المصدر: Planta Medica. 78:1002-1009

مصطلحات موضوعية: Lipopolysaccharides, Magnetic Resonance Spectroscopy, Cell Survival, Stereochemistry, Pharmaceutical Science, Nitric Oxide, Sesquiterpene, 01 natural sciences, Cell Line, Analytical Chemistry, Nitric oxide, Inhibitory Concentration 50, Lactones, Mice, Sesquiterpenes, Germacrane, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Structure–activity relationship, Organic chemistry, Inula hupehensis, IC50, Pharmacology, Inula, Molecular Structure, biology, 010405 organic chemistry, Macrophages, Anti-Inflammatory Agents, Non-Steroidal, Organic Chemistry, Plant Components, Aerial, Asteraceae, biology.organism_classification, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Complementary and alternative medicine, Phytochemical, chemistry, Molecular Medicine, Sesquiterpenes

الوصف: Phytochemical investigation of the aerial parts of Inula hupehensis Ling. led to the isolation and identification of 27 sesquiterpene lactones (1-27), including three new eudesmanolides (3-5), three new germacranolides (9-11), one new xanthanolide (16), two new carabrone derivatives (25-26), and 18 known sesquiterpene lactones. The structures were elucidated by extensive spectroscopic methods and comparison to previously reported spectroscopic data. All compounds were evaluated for their inhibitory effects against LPS-induced nitric oxide production in RAW264.7 macrophages, and compound 5 showed the strongest activity with the IC₅₀ value of 3.2 ± 0.4 µM.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d353249fe01f9b4ac8e7f8a656b721
https://doi.org/10.1055/s-0031-1298621

المؤلفون: Jia-Xian Zhu, Yun-Heng Shen, Qi Zeng, Wei-Dong Zhang, Rui-Jie Chang, Shou-De Zhang, Hui-Zi Jin, Jie Ren, Jiang-Jiang Qin, Fei Zhang, Yan Zhu, Xiang-Rong Cheng

المصدر: European Journal of Medicinal Chemistry. 46:5408-5415

مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Anti-Inflammatory Agents, Nitric oxide biosynthesis, Positive control, Nitric Oxide, Sesquiterpene, Sesquiterpene lactone, Anti-inflammatory, Cell Line, Lactones, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Pharmacology, chemistry.chemical_classification, Inula, biology, Chemistry, Macrophages, Organic Chemistry, Anti inflammation, General Medicine, biology.organism_classification, Phytochemical, Sesquiterpenes

الوصف: A phytochemical investigation of Inula falconeri, a plant endemic to the Himalayas, afforded 10 new sesquiterpenoids and 26 known sesquiterpene lactones, including those bearing guaiane, pseudoguaiane, xanthane, eudesmane, germacrane, rare secocaryophyllane, chromolaevane, and carabrane frameworks. The structures were elucidated via spectroscopic analysis and compared with data from literature. All the isolates were assessed for their inhibitory effects against LPS-induced nitric oxide production in RAW264.7 macrophages. Compounds 4, 11, 24, and 31 showed stronger inhibitory activities than the positive control with IC(50) values of 0.13, 0.07, 0.11, and 0.11 μM, respectively. These studies also led to a better understanding of the structure-activity relationships for the sesquiterpene lactone family of compounds.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5037118dfb75eddcb17ee0e626a260
https://doi.org/10.1016/j.ejmech.2011.08.047

المؤلفون: Xiang-Rong Cheng, Shou-De Zhang, Jiang-Jiang Qin, Shi-Kai Yan, Fei Zhang, Hui-Zi Jin, Weidong Zhang, Qi Zeng

المصدر: Planta Medica. 77:2061-2065

مصطلحات موضوعية: Lipopolysaccharides, Magnetic Resonance Spectroscopy, Anti-Inflammatory Agents, Pharmaceutical Science, Nitric Oxide, Lignans, Cell Line, Analytical Chemistry, Mice, Triterpene, Drug Discovery, Animals, No production, Pharmacology, chemistry.chemical_classification, Ethanol, Molecular Structure, Traditional medicine, biology, Chemistry, Circular Dichroism, Hydrolysis, Macrophages, Organic Chemistry, Geum japonicum, Geum, biology.organism_classification, Triterpenes, Complementary and alternative medicine, Phytochemical, Molecular Medicine, Acids

الوصف: The phytochemical investigation of the ethanolic extract of the whole plants of Geum japonicum Thunb. var. chinense F. Bolle yielded four new compounds: 20 β,28-epoxy-28-hydroxytaraxasteran-3 β-ol (1), (7R,8R)-4-hydroxy-9'-O-(α-L-rhamnopyranosyl)-3,3',5'-trimethoxy-8-O-4'-neolignan (2), (7R,8S)-4-hydroxy-9'-O-(α-L-rhamnopyranosyl)-3,3',5'-trimethoxy-8-O-4'-neolignan (3), and (7S,8S)-5-methoxycupressoside A (4), as well as 40 other known compounds. Structures were elucidated by physical, chemical, and spectroscopic methods, including 1D and 2D NMR, HRESIMS, and CD experiments. The taraxasterane-type triterpene (1) and lignans (2- 6) are reported for the first time from the GEUM genus. Moreover, all compounds were evaluated for anti-inflammatory activities against NO production in RAW264.7 macrophages, and only moderate activities were detected.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409153241590ef9ee1c6581678e5d23a
https://doi.org/10.1055/s-0031-1280091

المؤلفون: Jiang-Jiang Qin, Qi Zeng, Wei-Dong Zhang, Xiang-Rong Cheng, Lei Shan, Hui-Zi Jin, Yan Zhu, Jia-Xian Zhu, Shou-De Zhang

المصدر: Journal of natural products. 74(9)

مصطلحات موضوعية: Lipopolysaccharides, Circular dichroism, Stereochemistry, medicine.drug_class, Cell Survival, Nitric oxide biosynthesis, Pharmaceutical Science, Nitric Oxide, Anti-inflammatory, Analytical Chemistry, Nitric oxide, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, Sesquiterpenes, Guaiane, Structure-Activity Relationship, Drug Discovery, medicine, Ic50 values, Structure–activity relationship, Organic chemistry, Inhibitory concentration 50, Animals, Inula hupehensis, Pharmacology, Molecular Structure, Chemistry, Macrophages, Organic Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Complementary and alternative medicine, Molecular Medicine, Inula, Drugs, Chinese Herbal

الوصف: Eight new pseudoguaianolides (1-8), two new guaianolides (9 and 10), and 14 known sesquiterpenes were isolated from the aerial parts of Inula hupehensis. The structures were elucidated using spectroscopic methods and circular dichroism analysis. All compounds were tested for inhibitory activities against LPS-induced nitric oxide production in RAW264.7 macrophages. Compounds 13 and 22 were found to inhibit nitric oxide production potently, with IC50 values of 0.9 and 0.6 μM, respectively. Preliminary structure-activity relationships for these compounds are proposed.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4ab3ca98603ae3761607167fc5e7b8
https://pubmed.ncbi.nlm.nih.gov/21894898