المؤلفون: Duan Y; Department of Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Medicine, VA San Diego Healthcare System, San Diego, CA, USA., Chu H; Department of Medicine, University of California San Diego, La Jolla, CA, USA.; Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022, Wuhan, China., Brandl K; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Jiang L; Department of Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Medicine, VA San Diego Healthcare System, San Diego, CA, USA., Zeng S; Department of Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Medicine, VA San Diego Healthcare System, San Diego, CA, USA., Meshgin N; Department of Medicine, University of California San Diego, La Jolla, CA, USA., Papachristoforou E; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK., Argemi J; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh Liver Research Center, Pittsburgh, PA, USA.; Hepatology Program, Centro de Investigacion Medica Aplicada (CIMA), Liver Unit, Clinica Universidad de Navarra (CUN), Instituto de Investigacion de Navarra (IdisNA), University of Navarra, Pamplona, Spain., Mendes BG; Department of Medicine, University of California San Diego, La Jolla, CA, USA., Wang Y; Department of Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Medicine, VA San Diego Healthcare System, San Diego, CA, USA., Su H; Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA., Sun W; Department of Medicine, University of California San Diego, La Jolla, CA, USA., Llorente C; Department of Medicine, University of California San Diego, La Jolla, CA, USA., Hendrikx T; Department of Medicine, University of California San Diego, La Jolla, CA, USA., Liu X; Department of Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Surgery, University of California San Diego, La Jolla, CA, USA., Hosseini M; Department of Pathology, University of California San Diego, La Jolla, CA, USA., Kisseleva T; Department of Surgery, University of California San Diego, La Jolla, CA, USA., Brenner DA; Department of Medicine, University of California San Diego, La Jolla, CA, USA., Bataller R; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh Liver Research Center, Pittsburgh, PA, USA., Ramachandran P; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK., Karin M; Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA., Fu W; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Department of Cancer Immunology, Genentech, South San Francisco, CA, USA., Schnabl B; Department of Medicine, University of California San Diego, La Jolla, CA, USA. beschnabl@ucsd.edu.; Department of Medicine, VA San Diego Healthcare System, San Diego, CA, USA. beschnabl@ucsd.edu.

المصدر: Nature communications [Nat Commun] 2021 Dec 09; Vol. 12 (1), pp. 7172. Date of Electronic Publication: 2021 Dec 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Enterococcus faecalis/*immunology , Gram-Positive Bacterial Infections/*immunology , Liver Diseases, Alcoholic/*immunology , Macrophages/*immunology , Receptors, Complement/*immunology , Receptors, Complement 3b/*immunology, Animals ; Bacterial Translocation ; Complement C3b/immunology ; Enterococcus faecalis/physiology ; Ethanol/adverse effects ; Female ; Gastrointestinal Tract/microbiology ; Gram-Positive Bacterial Infections/genetics ; Gram-Positive Bacterial Infections/microbiology ; Humans ; Liver/drug effects ; Liver/immunology ; Liver/microbiology ; Liver Diseases, Alcoholic/etiology ; Liver Diseases, Alcoholic/genetics ; Liver Diseases, Alcoholic/microbiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Complement/deficiency ; Receptors, Complement/genetics ; Receptors, Complement 3b/genetics

المؤلفون: Pouyanfard S; Department of Medicine, University of California, La Jolla, California, USA., Meshgin N; Department of Surgery, University of California San Diego, La Jolla, California, USA., Cruz LS; Department of Medicine, University of California, La Jolla, California, USA., Diggle K; Department of Surgery, University of California San Diego, La Jolla, California, USA., Hashemi H; Immunity and Pathogenesis Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA., Pham TV; Moores Cancer Center and Department of Medicine, University of California San Diego, La Jolla, California, USA., Fierro M; Department of Medicine, University of California, La Jolla, California, USA., Tamayo P; Moores Cancer Center and Department of Medicine, University of California San Diego, La Jolla, California, USA., Fanjul A; Gastroenterology Drug Discovery Unit, Takeda Pharmaceutical Company Limited, San Diego, California, USA., Kisseleva T; Department of Surgery, University of California San Diego, La Jolla, California, USA., Kaufman DS; Department of Medicine, University of California, La Jolla, California, USA.

المصدر: Stem cells (Dayton, Ohio) [Stem Cells] 2021 Dec; Vol. 39 (12), pp. 1701-1717. Date of Electronic Publication: 2021 Oct 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 9304532 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-4918 (Electronic) Linking ISSN: 10665099 NLM ISO Abbreviation: Stem Cells Subsets: MEDLINE

مواضيع طبية MeSH: Induced Pluripotent Stem Cells*/metabolism , Liver Cirrhosis*/therapy , Macrophages*/metabolism, Animals ; Cell Differentiation ; Cytokines/metabolism ; Humans ; Mice

المؤلفون: Guillot A; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism (NIAAA), NIH, Bethesda, Maryland, USA.; Department of Hepatology and Gastroenterology, Charité University Medicine Berlin, Berlin, Germany., Guerri L; Laboratory of Neurogenetics and., Feng D; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism (NIAAA), NIH, Bethesda, Maryland, USA., Kim SJ; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism (NIAAA), NIH, Bethesda, Maryland, USA., Ahmed YA; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism (NIAAA), NIH, Bethesda, Maryland, USA., Paloczi J; Laboratory of Cardiovascular Physiology and Tissue Injury, NIAAA, NIH, Bethesda, Maryland, USA., He Y; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism (NIAAA), NIH, Bethesda, Maryland, USA., Schuebel K; Laboratory of Neurogenetics and., Dai S; Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, USA., Liu F; Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, USA., Pacher P; Laboratory of Cardiovascular Physiology and Tissue Injury, NIAAA, NIH, Bethesda, Maryland, USA., Kisseleva T; Department of Surgery, UCSD, San Diego, California, USA., Qin X; Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, USA., Goldman D; Laboratory of Neurogenetics and., Tacke F; Department of Hepatology and Gastroenterology, Charité University Medicine Berlin, Berlin, Germany., Gao B; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism (NIAAA), NIH, Bethesda, Maryland, USA.

المصدر: The Journal of clinical investigation [J Clin Invest] 2021 May 03; Vol. 131 (9).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

مواضيع طبية MeSH: Cell Proliferation* , Macrophage Activation* , Up-Regulation*, Antigens, Neoplasm/*biosynthesis , Bile Acids and Salts/*metabolism , Biliary Tract/*metabolism , Epithelial Cells/*metabolism , Integrins/*biosynthesis , Macrophages/*metabolism, Animals ; Antigens, Neoplasm/genetics ; Bile Acids and Salts/genetics ; Female ; Humans ; Integrins/genetics ; Male ; Mice ; Mice, Transgenic ; RNA-Seq

المؤلفون: Liang S; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California., Ma HY; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California., Zhong Z; Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, California., Dhar D; Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, California., Liu X; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California., Xu J; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California., Koyama Y; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Nishio T; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Karin D; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California., Karin G; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California., Mccubbin R; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California., Zhang C; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California; School of Public Health, Shandong University, Jinan, China., Hu R; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California; Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China., Yang G; Guangdong Pharmaceutical University, Guangzhou, China., Chen L; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California., Ganguly S; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California., Lan T; Guangdong Pharmaceutical University, Guangzhou, China., Karin M; Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, California., Kisseleva T; Department of Surgery, School of Medicine, University of California San Diego, La Jolla, California. Electronic address: tkisseleva@mail.ucsd.edu., Brenner DA; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California. Electronic address: dbrenner@ucsd.edu.

المصدر: Gastroenterology [Gastroenterology] 2019 Mar; Vol. 156 (4), pp. 1156-1172.e6. Date of Electronic Publication: 2018 Nov 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Hepatocellular/*genetics , Carcinoma, Hepatocellular/*pathology , Cell Transformation, Neoplastic/*genetics , Hepatitis/*genetics , Hepatocytes/*pathology , Liver Neoplasms, Experimental/*genetics , Liver Neoplasms, Experimental/*pathology , Macrophages/*enzymology , NADPH Oxidase 1/*genetics , NADPH Oxidase 4/*genetics, Alarmins/metabolism ; Animals ; Carcinoma, Hepatocellular/chemically induced ; Cell Proliferation/physiology ; Cells, Cultured ; Culture Media, Conditioned/pharmacology ; Diethylnitrosamine ; Enzyme Inhibitors/pharmacology ; Hepatic Stellate Cells ; Hepatocytes/physiology ; Humans ; Interleukin-6/metabolism ; Liver/metabolism ; Liver/pathology ; Liver Neoplasms, Experimental/chemically induced ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; NADPH Oxidase 1/metabolism ; Necrosis ; STAT3 Transcription Factor/metabolism ; Tumor Burden ; Tumor Necrosis Factor-alpha/metabolism