المؤلفون: Freeman WR; Jacobs Retina Center, University of California San Diego, La Jolla, California. Electronic address: wrfreeman@health.ucsd.edu., Bandello F; Department of Ophthalmology, University Vita-Salute Scientific Institute, Hospital San Raffaele, Milan, Italy., Souied E; Centre Hospitalier Creteil, Service Universitaire d'Ophthalmologie, Creteil, France., Guymer RH; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, and Department of Surgery (Ophthalmology), University of Melbourne, Melbourne, Australia., Garg SJ; Mid Atlantic Retina, the Retina Service of Wills Eye Hospital, Philadelphia, Pennsylvania., Chen FK; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, and Department of Surgery (Ophthalmology), University of Melbourne, Melbourne, Australia; Centre for Ophthalmology and Visual Science (incorporating Lions Eye Institute), the University of Western Australia, Nedlands, Western Australia, Australia., Rich R; Retina Consultants of Southern Colorado PC, Colorado Springs, Colorado., Holz FG; Department of Ophthalmology, University of Bonn, Bonn, Germany., Patel SS; West Texas Retina, Abilene, Texas., Kim K; Data and Statistical Sciences, Allergan, an AbbVie company, Irvine, California., López FJ; Eye Care Development, Allergan, an AbbVie company, Irvine, California.

مؤلفون مشاركون: BEACON Study Group

المصدر: Ophthalmology. Retina [Ophthalmol Retina] 2023 Jul; Vol. 7 (7), pp. 573-585. Date of Electronic Publication: 2023 Mar 10.

نوع المنشور: Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase II; Journal Article

بيانات الدورية: Publisher: Published by Elsevier Inc. on behalf of American Academy of Ophthalmology Country of Publication: United States NLM ID: 101695048 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-6530 (Electronic) Linking ISSN: 24686530 NLM ISO Abbreviation: Ophthalmol Retina Subsets: MEDLINE

مواضيع طبية MeSH: Geographic Atrophy*/diagnosis , Geographic Atrophy*/drug therapy , Geographic Atrophy*/etiology , Macular Degeneration*/complications , Macular Degeneration*/diagnosis , Macular Degeneration*/drug therapy, Humans ; Retina ; Drug Delivery Systems/adverse effects ; Intravitreal Injections

المؤلفون: Kuppermann BD; Gavin Herbert Eye Institute, University of California Irvine, Irvine, California., Patel SS; West Texas Retina, Abilene, Texas., Boyer DS; Retina-Vitreous Associates Medical Group, Los Angeles, California., Augustin AJ; Department of Ophthalmology, Staedtisches Klinikum Karlsruhe, Karlsruhe, Germany., Freeman WR; Jacobs Retina Center, University of California San Diego, San Diego, California; and., Kerr KJ; Allergan plc, Irvine, California., Guo Q; Allergan plc, Irvine, California., Schneider S; Allergan plc, Irvine, California., López FJ; Allergan plc, Irvine, California.

مؤلفون مشاركون: Brimo DDS Gen 1 Study Group

المصدر: Retina (Philadelphia, Pa.) [Retina] 2021 Jan 01; Vol. 41 (1), pp. 144-155.

نوع المنشور: Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8309919 Publication Model: Print Cited Medium: Internet ISSN: 1539-2864 (Electronic) Linking ISSN: 0275004X NLM ISO Abbreviation: Retina Subsets: MEDLINE

مواضيع طبية MeSH: Visual Acuity*, Brimonidine Tartrate/*administration & dosage , Geographic Atrophy/*drug therapy , Macular Degeneration/*drug therapy, Adrenergic alpha-2 Receptor Agonists/administration & dosage ; Aged ; Aged, 80 and over ; Double-Blind Method ; Drug Delivery Systems ; Female ; Fluorescein Angiography/methods ; Follow-Up Studies ; Fundus Oculi ; Geographic Atrophy/diagnosis ; Geographic Atrophy/etiology ; Humans ; Intravitreal Injections ; Macular Degeneration/complications ; Macular Degeneration/diagnosis ; Male ; Middle Aged ; Treatment Outcome

المؤلفون: Lashkari K; Schepens Eye Research Institute, Mass Eye & Ear, Harvard Medical School, Boston, Massachusetts, United States of America., Teague GC; Schepens Eye Research Institute, Mass Eye & Ear, Harvard Medical School, Boston, Massachusetts, United States of America., Beattie U; Schepens Eye Research Institute, Mass Eye & Ear, Harvard Medical School, Boston, Massachusetts, United States of America., Betts J; Alternative Discovery & Development, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America., Kumar S; Alternative Discovery & Development, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America., McLaughlin MM; Alternative Discovery & Development, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America., López FJ; Alternative Discovery & Development, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America.

المصدر: PloS one [PLoS One] 2020 Aug 07; Vol. 15 (8), pp. e0236283. Date of Electronic Publication: 2020 Aug 07 (Print Publication: 2020).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Amyloid beta-Peptides/*metabolism , Geographic Atrophy/*blood , Macular Degeneration/*complications , Retinal Pigment Epithelium/*pathology, Aged ; Aged, 80 and over ; Biomarkers/blood ; Biomarkers/metabolism ; Cohort Studies ; Computational Biology ; Female ; Fundus Oculi ; Geographic Atrophy/diagnosis ; Geographic Atrophy/etiology ; Geographic Atrophy/pathology ; Humans ; Macular Degeneration/blood ; Macular Degeneration/pathology ; Male ; Middle Aged ; Optical Imaging ; Signal Transduction ; Tissue Plasminogen Activator

المؤلفون: Callanan D; Texas Retina Associates, Arlington, Texas., Kunimoto D; Retinal Consultants of Arizona, Phoenix, Arizona., Maturi RK; Midwest Eye Institute, Indianapolis, Indiana.; Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana., Patel SS; West Texas Retina, Abilene, Texas., Staurenghi G; Department of Biomedical and Clinical Sciences, Eye Clinic, University of Milan, 'Luigi Sacco' Hospital, Milan, Italy., Wolf S; Department of Ophthalmology and Bern Photographic Reading Center, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Cheetham JK; Allergan plc, Irvine, California., Hohman TC; Allergan plc, Irvine, California., Kim K; Allergan plc, Irvine, California., López FJ; Allergan plc, Irvine, California., Schneider S; Allergan plc, Irvine, California.

المصدر: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics [J Ocul Pharmacol Ther] 2018 Dec; Vol. 34 (10), pp. 700-709. Date of Electronic Publication: 2018 Nov 09.

نوع المنشور: Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Association For Ocular Pharmacology And Therapeutics Country of Publication: United States NLM ID: 9511091 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7732 (Electronic) Linking ISSN: 10807683 NLM ISO Abbreviation: J Ocul Pharmacol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Choroidal Neovascularization*/diagnosis , Choroidal Neovascularization*/drug therapy , Macular Degeneration*/diagnosis , Macular Degeneration*/drug therapy , Ranibizumab*/administration & dosage , Ranibizumab*/adverse effects , Recombinant Fusion Proteins*/administration & dosage , Recombinant Fusion Proteins*/adverse effects , Retina*/diagnostic imaging , Retina*/pathology, Vascular Endothelial Growth Factor A/*antagonists & inhibitors, Aged ; Angiogenesis Inhibitors/administration & dosage ; Angiogenesis Inhibitors/adverse effects ; Double-Blind Method ; Female ; Humans ; Intravitreal Injections/methods ; Male ; Tomography, Optical Coherence/methods ; Treatment Outcome ; Visual Acuity

المؤلفون: Lashkari K; Schepens Eye Research Institute, Mass Eye & Ear, Harvard Medical School, Boston, Massachusetts, United States of America., Teague G; Schepens Eye Research Institute, Mass Eye & Ear, Harvard Medical School, Boston, Massachusetts, United States of America., Chen H; Alliance Pharma, Malvern, Pennsylvania, United States of America., Lin YQ; Alliance Pharma, Malvern, Pennsylvania, United States of America., Kumar S; Alternative Discovery & Development, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America., McLaughlin MM; Alternative Discovery & Development, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America., López FJ; Alternative Discovery & Development, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America.

المصدر: PloS one [PLoS One] 2018 May 21; Vol. 13 (5), pp. e0195751. Date of Electronic Publication: 2018 May 21 (Print Publication: 2018).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease/*drug therapy , Amyloid beta-Peptides/*antagonists & inhibitors , Antibodies, Monoclonal/*therapeutic use , Biomarkers/*blood , Complement Activation/*drug effects , Complement Factor I/*metabolism , Macular Degeneration/*drug therapy, Aged ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/immunology ; Case-Control Studies ; Female ; Humans ; Macular Degeneration/metabolism ; Macular Degeneration/pathology ; Male

المؤلفون: Doyle SL; Department of Clinical Medicine School of Medicine, Trinity College Dublin, Dublin 2, Ireland;, López FJ; Allergan Incorporated, Irvine, California, United States;, Humphries P; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland; and the., Adamson P; UCL, ORBIT, Institute of Ophthalmology, London, United Kingdom., Campbell M; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland; and the.

المصدر: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2015 Dec; Vol. 56 (13), pp. 8237-8.

نوع المنشور: Letter; Comment

بيانات الدورية: Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE

مواضيع طبية MeSH: Endothelial Cells/*pathology , Immunotherapy/*methods , Interleukin-18/*administration & dosage , Macular Degeneration/*drug therapy , Retinal Neovascularization/*drug therapy, Animals ; Female ; Humans

المؤلفون: Doyle SL; Department of Clinical Medicine School of Medicine, Trinity College Dublin, Dublin, Ireland., López FJ; Ophthalmology Discovery Performance Unit, GlaxoSmithKline, King of Prussia, Pennsylvania, United States., Celkova L; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Brennan K; Department of Clinical Medicine School of Medicine, Trinity College Dublin, Dublin, Ireland., Mulfaul K; Department of Clinical Medicine School of Medicine, Trinity College Dublin, Dublin, Ireland., Ozaki E; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Kenna PF; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland 4The Research Foundation, Royal Victoria Eye and Ear Hospital, Adelaide Road, Dublin, Ireland., Kurali E; Statistics Consulting Group, Quantitative Science, PTS, GlaxoSmithKline, King of Prussia, Pennsylvania, United States., Hudson N; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Doggett T; Department of Ophthalmology and Visual Science, Washington University School of Medicine, St. Louis, Missouri, United States., Ferguson TA; Department of Ophthalmology and Visual Science, Washington University School of Medicine, St. Louis, Missouri, United States., Humphries P; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Adamson P; Ophthalmology Discovery Performance Unit, GlaxoSmithKline, Stevenage, United Kingdom 8Ocular Biology and Therapeutics, Institute of Ophthalmology, University College London, London, United Kingdom., Campbell M; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.

المصدر: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2015 Aug; Vol. 56 (9), pp. 5424-30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE

مواضيع طبية MeSH: Endothelial Cells/*pathology , Immunotherapy/*methods , Interleukin-18/*administration & dosage , Macular Degeneration/*drug therapy , Retinal Neovascularization/*drug therapy, Animals ; Blotting, Western ; Disease Models, Animal ; Electroretinography ; Endothelial Cells/metabolism ; Female ; Fluorescein Angiography ; Fundus Oculi ; Gene Expression Regulation/drug effects ; Humans ; Intravitreal Injections ; Macaca fascicularis ; Macular Degeneration/diagnosis ; Macular Degeneration/etiology ; Mice ; Mice, Mutant Strains ; Polymerase Chain Reaction ; Primates ; RNA/genetics ; Retina/metabolism ; Retina/pathology ; Retina/physiopathology ; Retinal Neovascularization/complications ; Retinal Neovascularization/diagnosis ; Treatment Outcome ; Vascular Endothelial Growth Factor A/biosynthesis ; Vascular Endothelial Growth Factor A/genetics

المؤلفون: Doyle SL; Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland;, Adamson P; Ophthalmology, Discovery Performance Unit, GlaxoSmithKline, Stevenage, United Kingdom;, López FJ; Ophthalmology Discovery Performance Unit, GlaxoSmithKline, King of Prussia, Pennsylvania, United States; and., Humphries P; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland., Campbell M; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.

المصدر: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2014 Dec 23; Vol. 55 (12), pp. 8349-50. Date of Electronic Publication: 2014 Dec 23.

نوع المنشور: Letter; Comment

بيانات الدورية: Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Electronic Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE

مواضيع طبية MeSH: Interleukin-18/*metabolism , Macular Degeneration/*pathology , Retinal Pigment Epithelium/*pathology, Animals ; Female ; Humans ; Male

المؤلفون: Doyle SL; Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland., Adamson P; Ophthiris Discovery Performance Unit, GSK, Stevenage, UK., López FJ; Ophthalmology IPE US, RD Alternative Discovery and Development, GSK, King of Prussia, Pennsylvania, USA., Humphries P; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Campbell M; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.

المصدر: Nature medicine [Nat Med] 2014 Dec; Vol. 20 (12), pp. 1376-7.

نوع المنشور: Letter; Comment

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Choroidal Neovascularization/*drug therapy , Choroidal Neovascularization/*prevention & control , Interleukin-18/*therapeutic use , Macular Degeneration/*drug therapy, Animals ; Humans

المؤلفون: Catchpole I; Topical BioPharm Discovery Research and Development Unit, King of Prussia, Philadelphia, Pennsylvania, United States of America. ian.r.catchpole@gsk.com, Germaschewski V, Hoh Kam J, Lundh von Leithner P, Ford S, Gough G, Adamson P, Overend P, Hilpert J, López FJ, Ng YS, Coffey P, Jeffery G

المصدر: PloS one [PLoS One] 2013 Jun 14; Vol. 8 (6), pp. e65518. Date of Electronic Publication: 2013 Jun 14 (Print Publication: 2013).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Amyloid beta-Peptides/*metabolism , Antibodies, Monoclonal, Murine-Derived/*administration & dosage , Complement C3/*metabolism , Macular Degeneration/*drug therapy , Peptide Fragments/*metabolism , Retina/*metabolism, Amyloid beta-Peptides/immunology ; Animals ; Disease Models, Animal ; Humans ; Hybridomas ; Macular Degeneration/immunology ; Macular Degeneration/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Peptide Fragments/immunology ; Retina/pathology