المؤلفون: Chan, Wayne W, Wise, Scott C, Kaufman, Michael D, Ahn, Yu Mi, Ensinger, Carol L, Haack, Torsten, Hood, Molly M, Jones, Jennifer, Lord, John W, Lu, Wei Ping, Miller, David, Patt, William C, Smith, Bryan D, Petillo, Peter A, Rutkoski, Thomas J, Telikepalli, Hanumaiah, Vogeti, Lakshminarayana, Yao, Tony, Chun, Lawrence, Clark, Robin, Evangelista, Peter, Gavrilescu, L Cristina, Lazarides, Katherine, Zaleskas, Virginia M, Stewart, Lance J, Van Etten, Richard A, Flynn, Daniel L

المصدر: Cancer cell. 19(4)

مصطلحات موضوعية: Animals, Cell Line, Tumor, Cell Proliferation: drug effects, Cell Survival: drug effects, Drug Design, Fusion Proteins, bcr-abl: antagonists & inhibitors, chemistry, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive: drug therapy, Male, Mice, Mice, Inbred BALB C, Mutation, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma: drug therapy, Protein Conformation, Protein Kinase Inhibitors: pharmacology, Protein-Tyrosine Kinases: antagonists & inhibitors, chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/6qk7857n

المؤلفون: Setlur, Sunita R., Mertz, Kirsten D., Hoshida, Yujin, Demichelis, Francesca, Lupien, Mathieu, Perner, Sven, Sboner, Andrea, Pawitan, Yudi, Andrén, Ove, Johnson, Laura A., Tang, Jeff, Adami, Hans-Olov, Calza, Stefano, Chinnaiyan, Arul M., Rhodes, Daniel, Tomlins, Scott, Fall, Katja, Mucci, Lorelei A., Kantoff, Philip W., Stampfer, Meir J., Andersson, Swen-Olof, Varenhorst, Eberhard, Johansson, Jan-Erik, Brown, Myles, Golub, Todd R., Rubin, Mark A.

المصدر: Journal of the National Cancer Institute. 100(11):815-825

مصطلحات موضوعية: Antineoplastic Agents, Hormonal/*pharmacology/therapeutic use, Area Under Curve, Blotting, Western, Cell Line, Tumor, Cell Survival/drug effects, Chromatin Immunoprecipitation, DNA, Complementary/metabolism, Estradiol/pharmacology, Estrogen Receptor alpha/*antagonists & inhibitors/metabolism, Estrogen Receptor beta/*agonists/metabolism, Estrogens/*metabolism, Gene Expression Profiling, Gene Expression Regulation, Neoplastic/drug effects, Health Surveys, Humans, Male, Neoplasms, Hormone-Dependent/drug therapy/*metabolism/pathology, Nitriles/pharmacology, Oncogene Proteins, Fusion/*metabolism, Physicians/statistics & numerical data, Polymerase Chain Reaction, Propionates/pharmacology, Prostatic Neoplasms/drug therapy/*metabolism/pathology, Pyrazoles/pharmacology, Serine Endopeptidases/metabolism, Signal Transduction/drug effects, Sweden/epidemiology, Transfection, MEDICINE, MEDICIN, Surgery, Oncology, Kirurgi, Onkologi, Surgical research, Urology and andrology, Kirurgisk forskning, Urologi och andrologi

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-3670
https://doi.org/10.1093/jnci/djn150

المؤلفون: Kimberly A. Mace, Edward A. McKenzie, Andrew J.M. Boulton, Tanja Torbica, Frank L. Bowling, Hadeel Al Sadoun, Salma Alrdahe

المصدر: Alrdahe, S, Al Sadoun, H, Torbica, T, McKenzie, E A, Bowling, F L, Boulton, A J M & Mace, K A 2019, ' Dysregulation of macrophage development and phenotype in diabetic human macrophages can be rescued by Hoxa3 protein transduction ', PLoS One., vol. 14, no. 10, pp. e0223980 . https://doi.org/10.1371/journal.pone.0223980, https://doi.org/10.1371/journal.pone.0223980
PLoS ONE, Vol 14, Iss 10, p e0223980 (2019)
PLoS ONE

مصطلحات موضوعية: Male, Cellular differentiation, Up-Regulation/drug effects, Pathology and Laboratory Medicine, Biochemistry, Monocytes, Endocrinology, 0302 clinical medicine, Tumor Necrosis Factors/analysis, Animal Cells, Immune Response, Cells, Cultured, Innate Immune System, Antigens, CD/genetics, Up-Regulation, 3. Good health, RUNX1, Cytokines, Medicine, Tumor necrosis factor alpha, Cellular Types, Endocrine Disorders, Immune Cells, Science, Immunology, 03 medical and health sciences, Signs and Symptoms, Antigens, CD, Manchester Institute of Biotechnology, DNA-binding proteins, Diabetes Mellitus, Genetics, Humans, Blood Cells, Macrophages, Core Binding Factor Alpha 2 Subunit/genetics, Antigens, Differentiation, Myelomonocytic/genetics, Biology and Life Sciences, Proteins, Molecular Development, Regulatory Proteins, 030104 developmental biology, Diabetes Mellitus, Type 2, chemistry, Culture Media, Conditioned, Case-Control Studies, Leukocytes, Mononuclear, Transcription Factors, Developmental Biology, 0301 basic medicine, Myeloid, Physiology, Gene Expression, Cell Maturation, White Blood Cells, chemistry.chemical_compound, Immune Physiology, Medicine and Health Sciences, Leukocytes, Mononuclear/cytology, Multidisciplinary, Cell Differentiation, Middle Aged, Recombinant Proteins, Interleukin-6/analysis, medicine.anatomical_structure, Phenotype, Core Binding Factor Alpha 2 Subunit, Tumor Necrosis Factors, Female, medicine.symptom, Research Article, Cell Survival/drug effects, Adult, Culture Media, Conditioned/chemistry, Cell Survival, Antigens, Differentiation, Myelomonocytic, Bone Marrow Cells, Inflammation, Biology, Downregulation and upregulation, Diagnostic Medicine, medicine, Gene Regulation, Recombinant Proteins/biosynthesis, Homeodomain Proteins, Interleukin-6, Macrophages/cytology, Cell Biology, ResearchInstitutes_Networks_Beacons/manchester_institute_of_biotechnology, Diabetes Mellitus, Type 2/metabolism, Metabolic Disorders, Immune System, Cancer research, Bone marrow, Homeodomain Proteins/genetics, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6ea39074a79895983e43418ef1be36
https://doi.org/10.1371/journal.pone.0223980

المؤلفون: Giuseppe Vassalli, Giovanni G. Camici, Sara Bolis, Elisabetta Cervio, Giuseppina Milano, Vanessa Biemmi, A. Ciullo, Tiziano Moccetti, Emanuel T. Fertig, Lucio Barile, Mihaela Gherghiceanu

المساهمون: University of Zurich, Barile, Lucio

المصدر: International Journal of Molecular Sciences, Vol 20, Iss 3, p 468 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 3
International journal of molecular sciences, vol. 20, no. 3

مصطلحات موضوعية: 0301 basic medicine, Male, Benzylamines, Myocardial Infarction, 1607 Spectroscopy, Fluorescent Antibody Technique, Pharmacology, Cyclams, Cell therapy, lcsh:Chemistry, 0302 clinical medicine, Heterocyclic Compounds, intravenous injection, Myocardial infarction, lcsh:QH301-705.5, Spectroscopy, Cells, Cultured, Ejection fraction, General Medicine, Flow Cytometry, 3. Good health, Computer Science Applications, 030220 oncology & carcinogenesis, 10209 Clinic for Cardiology, Systemic administration, 1606 Physical and Theoretical Chemistry, Cardiac function curve, Receptors, CXCR4, 1503 Catalysis, Cell Survival, Blotting, Western, Ischemia, cardiac progenitor cells, 610 Medicine & health, Enzyme-Linked Immunosorbent Assay, macromolecular substances, exosomes, 11171 Cardiocentro Ticino, Catalysis, Article, Inorganic Chemistry, 03 medical and health sciences, Animals, Cell Survival/drug effects, Cell Survival/genetics, Cell Survival/physiology, Chemokine CXCL12/genetics, Chemokine CXCL12/metabolism, Cryoelectron Microscopy, Exosomes/metabolism, Heterocyclic Compounds/therapeutic use, Humans, Myocardial Infarction/genetics, Myocardial Infarction/metabolism, Myocardial Infarction/therapy, RNA, Messenger/genetics, RNA, Messenger/metabolism, Rats, Rats, Wistar, Receptors, CXCR4/antagonists & inhibitors, Receptors, CXCR4/genetics, Receptors, CXCR4/metabolism, CXCR4, 1312 Molecular Biology, 1706 Computer Science Applications, medicine, RNA, Messenger, Physical and Theoretical Chemistry, Progenitor cell, Molecular Biology, 1604 Inorganic Chemistry, business.industry, Organic Chemistry, fungi, medicine.disease, Chemokine CXCL12, carbohydrates (lipids), enzymes and coenzymes (carbohydrates), 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, business, Reperfusion injury, 1605 Organic Chemistry

وصف الملف: application/pdf; Exosomal_Expression_of_CXCR4.pdf - application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd80ce773ca01cb03b66b6207e52de7
https://www.mdpi.com/1422-0067/20/3/468

المؤلفون: Francisco-Javier Bermúdez-Silva, Reinhold Schirmbeck, Piero Marchetti, Livia López-Noriega, Paolo Meda, Nadia Cobo-Vuilleumier, Christian Claude Lachaud, Petra I. Lorenzo, Noelia García Rodríguez, Abdelkrim Hmadcha, Bernat Soria, Marco Bugliani, Esther Fuente-Martin, Katja Stifter, Peter de Haan, Alejandro Martin-Montalvo, Miguel G. Toscano, Luc St-Onge, Géraldine Parnaud, Vincenzo De Tata, Germán Perdomo, Silvana-Yanina Romero-Zerbo, Luis Sánchez Palazón, David Pozo, Benoit R. Gauthier, Kristina Schoonjans, Javier Florido, Irene de Gracia Herrera Gómez, José Manuel Mellado-Gil, Domenico Bosco, Mathurin Baquié

المساهمون: Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Juvenile Diabetes Research Foundation, Junta de Andalucía, Ministerio de Economía y Competitividad (España), European Commission, German Research Foundation, Instituto de Salud Carlos III, Amarna Therapeutics, Centro Andaluz de Investigaciones en Biología Molecular y Medina Regenerativa (CABIMER), [Cobo-Vuilleumier,N, Lorenzo,PI, García Rodríguez,N, Herrera Gómez,IG, Fuente-Martin,E, López-Noriega,L, Mellado-Gil,JM, Claude Lachaud,C, Hmadcha,A, Martín-Montalvo,A, Soria,B, Gauthier, BR] Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain. [Romero-Zerbo,SY, Bermúdez-Silva,FJ] Unidad de Gestión Clínica Intercentros de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, 29010, Spain. [Romero-Zerbo,SY, Bermúdez-Silva,FJ] Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, 28029, Spain. [Baquié,M] Neurix SA, Geneva, 1228, Switzerland. [Stifter,K, Schirmbeck,R] Ulm University Hospital, Ulm, 89081, Germany. [Perdomo,G] Facultad de Ciencias de la Salud, Universidad de Burgos, Burgos, 09001, Spain. [Bugliani,M, Marchetti,P] Department Clinical and Experimental Medicine, University of Pisa—AOUP University Hospital, Pisa, 56126, Italy. [De Tata,V] Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, 56126, Italy. [Bosco,D, Parnaud,G] Cell Isolation and Transplantation Centre, University Hospital, Geneva, 1211, Switzerland. [Pozo,D] Department of Cell Dynamics and Signalling, CABIMER-Andalusian Center for Molecular Biology and Regenerative Medicine, Seville, 41092, Spain. [Florido,JP] Clinical Bioinformatics Area, Fundación Progreso y Salud, Consejería de Salud, Seville, 41013, Spain. [Toscano,MG, de Haan,P] Amarna Therapeutics, Seville, 41092, Spain. [Schoonjans,K] Laboratory of Metabolic Signaling, EPFL, Lausanne, 1015, Switzerland. [Sánchez Palazón,L] Biological Resources, CABIMER-Andalusian Center for Molecular Biology and Regenerative Medicine, Seville, 41092, Spain. [Meda,P] Department of Cell Physiology and Metabolism, University of Geneva, Geneva, 1211, Switzerland. [St-Onge,L] Neuried Munich, 82061, Germany.

المصدر: Nature Communications, Vol. 9, No 1 (2018) P. 1488
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Repositorio Institucional de la Universidad de Burgos (RIUBU)
Digital.CSIC. Repositorio Institucional del CSIC
Cell Stress

مصطلحات موضوعية: Genetics and Molecular Biology (all), Male, endocrine system diseases, Trans-Differentiation, Cell Communication/drug effects, Islets of Langerhans Transplantation, Receptors, Cytoplasmic and Nuclear, Apoptosis, Cell Communication, T-Lymphocytes, Regulatory, Biochemistry, Mice, Endocrinology, Islet Regeneration, Organisms::Eukaryota::Animals [Medical Subject Headings], Insulin, Macrophages/drug effects/immunology/pathology, lcsh:Science, geography.geographical_feature_category, Islets of Langerhans/drug effects/immunology/pathology, ddc:617, Type 1 diabetes, Phenalenes/pharmacology, Pancreas, Regulatory/drug effects/immunology/pathology, Islotes Pancreáticos, Science, General Biochemistry, Genetics and Molecular Biology, Streptozocin, 03 medical and health sciences, Physics and Astronomy (all), Islets of Langerhans, Cytoplasmic and Nuclear/agonists/genetics/immunology, Diabetes Mellitus, Humans, Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 1 [Medical Subject Headings], Macrophages, Apoptosis/drug effects, Immunity, Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2 [Medical Subject Headings], nutritional and metabolic diseases, Insulin-Secreting Cells/drug effects/immunology/pathology, medicine.disease, Immunity, Innate, Lrh-1, Mice, Inbred C57BL, 030104 developmental biology, Diabetes Mellitus, Type 2, Nr5a2, lcsh:Q, Chemistry (all), Biochemistry, Genetics and Molecular Biology (all), 0301 basic medicine, T-Lymphocytes, General Physics and Astronomy, Diabetes Mellitus Tipo 2, Type 2 diabetes, Diabetes Mellitus Tipo 1, Inbred C57BL, Insulin-Secreting Cells, Receptors, Endocrinología, Innate, Heterologous, Multidisciplinary, Diabetes, Type 2/genetics/immunology/pathology, Phenalenes, Islet, medicine.anatomical_structure, Female, medicine.symptom, Beta cell, Cell Survival/drug effects, Insulin/metabolism, Cell Survival, Transplantation, Heterologous, Inflammation, Diabetes Mellitus, Experimental, Hypoglycemic Agents/pharmacology, Immune system, Anatomy::Endocrine System::Endocrine Glands::Islets of Langerhans [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae [Medical Subject Headings], Immune Tolerance, medicine, Hypoglycemic Agents, Animals, ddc:612, geography, Transplantation, Diseases::Endocrine System Diseases::Diabetes Mellitus [Medical Subject Headings], business.industry, Pancreatic islets, General Chemistry, Microreview, Experimental/chemically induced/genetics/immunology/therapy, Gene Expression Regulation, Cancer research, Therapy, business

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342a63365fbd42840ce799e55f5e722d
https://archive-ouverte.unige.ch/unige:119421

المؤلفون: Claudine Seeliger, Elizabeth R. Balmayor, Martijn van Griensven, Alexander T. Haug, Markus Prause, Marina Unger

المصدر: Mediators of Inflammation, Vol 2015 (2015)
Mediators of Inflammation, 2015. Hindawi Publishing Corporation
Mediators of Inflammation

مصطلحات موضوعية: Male, Pathology, Osteoclasts, Pharmacology, 2-Pyridinylmethylsulfinylbenzimidazoles, 2-Pyridinylmethylsulfinylbenzimidazoles/pharmacology, Isoenzymes/metabolism, Pantoprazole, Cells, Cultured, Cultured, biology, Stomach, NF-kappa B/genetics, NF-kappa B, Middle Aged, ddc, Isoenzymes, medicine.anatomical_structure, Acid Phosphatase/metabolism, Female, Research Article, lcsh:RB1-214, Cell Survival/drug effects, medicine.drug, medicine.medical_specialty, Article Subject, Cell Survival, medicine.drug_class, Cells, Acid Phosphatase, Immunology, Proton-pump inhibitor, lcsh:Pathology, medicine, Humans, Viability assay, Adverse effect, Aged, Tartrate-Resistant Acid Phosphatase, business.industry, Acid phosphatase, Proton Pump Inhibitors, Cell Biology, NFKB1, In vitro, Proton Pump Inhibitors/pharmacology, biology.protein, Osteoclasts/drug effects, business

وصف الملف: application/pdf; text/xhtml

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fe14b4ab1e7d39f330b9959bd2e109
https://doi.org/10.1155/2015/413097

المؤلفون: Claudine Seeliger, Martijn van Griensven, Alexander T. Haug, Marina Unger, Markus Prause

المصدر: Injury-International Journal of the Care of the Injured, 45(8), 1156-64. ELSEVIER SCI LTD

مصطلحات موضوعية: Male, Time Factors, Gene Expression Regulation/drug effects, Cell Count, Stimulation, 2-Pyridinylmethylsulfinylbenzimidazoles, Proton Pump Inhibitors/adverse effects, Cell Proliferation/drug effects, Fractures, Bone, Risk Factors, Gene expression, 80 and over, 2-Pyridinylmethylsulfinylbenzimidazoles/adverse effects, Pantoprazole, Cells, Cultured, General Environmental Science, Aged, 80 and over, Cultured, Osteoblast, Mitochondria/drug effects, Mitochondria, medicine.anatomical_structure, Alkaline phosphatase, Female, Drug, Cell Survival/drug effects, medicine.drug, medicine.medical_specialty, Bone/chemically induced, Cell Survival, Fractures, Bone/chemically induced, Cells, Gene Expression Regulation, Enzymologic/drug effects, Gene Expression Regulation, Enzymologic, Dose-Response Relationship, Osteoblasts/drug effects, Internal medicine, medicine, Humans, Viability assay, Cell Proliferation, Aged, Osteoblasts, Dose-Response Relationship, Drug, Cell growth, business.industry, Proton Pump Inhibitors, Enzymologic/drug effects, Alkaline Phosphatase, In vitro, Endocrinology, Gene Expression Regulation, General Earth and Planetary Sciences, business, Alkaline Phosphatase/genetics, Fractures

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb885ed791c07fc2502c83abc34e48d
https://doi.org/10.1016/j.injury.2014.05.005

المؤلفون: Edgardo E. Guibert, María Dolores Pizarro, Luciana L. Almada, Joaquín V. Rodríguez, María E. Mamprin, Cristina Bellarosa, Claudio Tiribelli

المساهمون: Guibert, Ee, Almada, Ll, Mamprin, Me, Bellarosa, Cristina, Pizarro, Md, Tiribelli, Claudio, Rodriguez, J. v.

المصدر: Annals of Hepatology, Vol 8, Iss 2, Pp 129-133 (2009)

مصطلحات موضوعية: Male, Adenosine, Time Factors, Specialties of internal medicine, Carbamyl Phosphate, law.invention, chemistry.chemical_compound, Cryoprotective Agents, law, Insulin, Urea, Butylene Glycols, chemistry.chemical_classification, General Medicine, Adenosine/pharmacology Allopurinol/pharmacology Animals Butylene Glycols/pharmacology* Carbamoyl-Phosphate Synthase (Ammonia)/genetics Carbamoyl-Phosphate Synthase (Ammonia)/metabolism Cell Survival/drug effects Cryopreservation/methods* Cryoprotective Agents/pharmacology* Gene Expression Regulation, Glutathione, Enzymologic/drug effects Glutathione/pharmacology Hepatocytes/drug effects* Hepatocytes/enzymology Insulin/pharmacology L-Lactate Dehydrogenase/metabolism Male Organ Preservation Solutions/pharmacology* Ornithine Carbamoyltransferase/genetics Ornithine Carbamoyltransferase/metabolism Propidium/metabolism Quaternary Ammonium Compounds/metabolism RNA, Biochemistry, RC581-951, Urea cycle, Propidium, Cell Survival, Allopurinol, Organ Preservation Solutions, Ornithine transcarbamylase, Carbamoyl-Phosphate Synthase (Ammonia), Biology, Gene Expression Regulation, Enzymologic, Raffinose, Subzero cold storage, Animals, Ammonium, Viaspan, RNA, Messenger, Adenosine/pharmacology Allopurinol/pharmacology Animals Butylene Glycols/pharmacology* Carbamoyl-Phosphate Synthase (Ammonia)/genetics Carbamoyl-Phosphate Synthase (Ammonia)/metabolism Cell Survival/drug effects Cryopreservation/methods* Cryoprotective Agents/pharmacology* Gene Expression Regulation, Enzymologic/drug effects Glutathione/pharmacology Hepatocytes/drug effects* Hepatocytes/enzymology Insulin/pharmacology L-Lactate Dehydrogenase/metabolism Male Organ Preservation Solutions/pharmacology* Ornithine Carbamoyltransferase/genetics Ornithine Carbamoyltransferase/metabolism Propidium/metabolism Quaternary Ammonium Compounds/metabolism RNA, Messenger/metabolism Raffinose/pharmacology Rats Rats, Wistar Time Factors Urea/metabolism, Rats, Wistar, Ornithine Carbamoyltransferase, Cryopreservation, Hepatology, L-Lactate Dehydrogenase, Messenger/metabolism Raffinose/pharmacology Rats Rats, Bioartificial liver device, Wistar Time Factors Urea/metabolism, Rats, Quaternary Ammonium Compounds, Enzyme, chemistry, Hepatic stellate cell, Hepatocytes, gene expression, urea cycle enzymes

وصف الملف: STAMPA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe91d865492ca8ecdb28a770084c6b5
http://www.sciencedirect.com/science/article/pii/S1665268119317910

المؤلفون: Ralph Fritsch, Miguel M. Murillo, Sareena Rana, David C. Hancock, Christopher I. Moore, Ian Rosewell, Eleanor Herbert, Dinis Pedro Calado, Joana Carvalho, Bradley Spencer-Dene, Philip East, Richard R. Neubig, Gordon Stamp, Djamil Damry, Daniël A. Lionarons, Miriam Molina-Arcas, Julian Downward

المساهمون: Oncology, CCA - Cancer biology and immunology, CCA - Treatment and quality of life, University of Zurich, Molina-Arcas, Miriam

المصدر: Cancer Cell
Cancer cell, 36(1), 68-83.e9. Cell Press

مصطلحات موضوعية: 0301 basic medicine, Neuroblastoma RAS viral oncogene homolog, p53, rac1 GTP-Binding Protein, Male, Cancer Research, PTEN, Serum Response Factor, Drug Resistance, Gene Expression, medicine.disease_cause, Cell Transformation, Transgenic, 1307 Cell Biology, Mice, 0302 clinical medicine, Models, 1306 Cancer Research, Tumor, biology, Melanocytes/metabolism, Melanoma, Melanoma/etiology, Cell Transformation, Neoplastic/genetics, EMT, Neoplastic/genetics, Prognosis, 3. Good health, Cell Transformation, Neoplastic, Oncology, 030220 oncology & carcinogenesis, Melanocytes, 2730 Oncology, Female, SRF, RAC1, Cell Survival/drug effects, Proto-Oncogene Proteins B-raf, Epithelial-Mesenchymal Transition, rac1 GTP-Binding Protein/genetics, Cell Survival, 610 Medicine & health, Drug Resistance, Neoplasm/genetics, Mice, Transgenic, Models, Biological, Article, BRAF, Cell Line, 03 medical and health sciences, Epithelial-Mesenchymal Transition/genetics, Cell Line, Tumor, Serum response factor, MRTF, Proto-Oncogene Proteins B-raf/genetics, medicine, melanoma, Animals, Humans, Protein kinase B, Protein Kinase Inhibitors, neoplasms, Alleles, Neoplasm/genetics, Animal, medicine.disease, Biological, Xenograft Model Antitumor Assays, Disease Models, Animal, 030104 developmental biology, Amino Acid Substitution, NF1, Drug Resistance, Neoplasm, Protein Kinase Inhibitors/pharmacology, Cutaneous melanoma, 10032 Clinic for Oncology and Hematology, Disease Models, Mutation, Cancer research, biology.protein, Carcinogenesis

وصف الملف: application/pdf; main.pdf - application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c66c04112d457e7f5d2d275d4630be
https://doi.org/10.1016/j.ccell.2019.05.015

المؤلفون: Michael R. Stratton, Eric Padron, Tingting Qin, Kenichi Yoshida, Eric Solary, Seishi Ogawa, Stéphanie Solier, Eric Jourdan, Serge Koscielny, Margot Morabito, William Vainchenker, Emilie Chautard, Dorothée Selimoglu-Buet, Jean-François Deleuze, Thérèse Commes, Kristen Meldi, Stéphane de Botton, Olivier Bernard, Claude Preudhomme, Pierre Fenaux, Marcel E. Dinger, Thorsten Braun, Mark J. Cowley, Bruno Quesnel, Vincent Meyer, Didier Auboeuf, François Artiguenave, Nathalie Droin, Maria E. Figueroa, Noémie Pata-Merci, Raphael Itzykson, Velimir Gayevskiy, Ludmil B. Alexandrov, Jane Merlevede

المساهمون: Hématopoïèse normale et pathologique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Gustave Roussy (IGR)-Université Paris-Sud - Paris 11 (UP11), Dynamique moléculaire de la transformation hématopoïétique (Dynamo), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse (AMMICa), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), University of Michigan Medical School [Ann Arbor], University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, School of Information, University of Michigan, Department of Molecular Diagnosis, Hamamatsu University School of Medicine, Kyoto University [Kyoto], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Avicenne [AP-HP], Département d'hématologie [Gustave Roussy], Institut Gustave Roussy (IGR), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Cellules souches normales et cancéreuses, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Hématopoïèse normale et pathologique (U1170 Inserm), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Garvan Institute of Medical Research [Darlinghurst, Australia], Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service d'Hématologie Cellulaire [Lille], The Wellcome Trust Sanger Institute [Cambridge], Los Alamos National Laboratory (LANL), H. Lee Moffitt Cancer Center and Research Institute, Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), This programme was supported by grants from Ligue Nationale Contre le Cancer (équipe labellisée), Institut National du Cancer (INCa PLBIO, SIRIC SOCRATE), Institut National du Cancer and Direction Générale de l’Offre de Soins (PHRC-K 2011-182),Agence Nationale de la Recherche (Molecular Medicine in Oncology, Paris Alliance Cancer Research Institute: France Génomique National programs funded by ‘Investissements d’avenir’). J.M. was supported by the Fondation pour la Recherche Médicale (FDT20140931007)., Kyoto University, Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Garvan Institute of medical research

المصدر: Nature Communications
Nature Communications, Nature Publishing Group, 2016, 7 (1), ⟨10.1038/ncomms10767⟩
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications, 2016, 7 (1), ⟨10.1038/ncomms10767⟩

مصطلحات موضوعية: 0301 basic medicine, Male, [SDV]Life Sciences [q-bio], General Physics and Astronomy, medicine.disease_cause, Epigenesis, Genetic, chemistry.chemical_compound, Cancer, Genetics, Aged, 80 and over, Mutation, Multidisciplinary, High-Throughput Nucleotide Sequencing, Cytidine, Leukemia, Myelomonocytic, Chronic, Middle Aged, 3. Good health, Gene Expression Regulation, Neoplastic, Biological sciences, DNA methylation, Azacitidine, Female, medicine.drug, Antimetabolites, Antineoplastic, Cell Survival, Science, Decitabine, Biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, medicine, Humans, Epigenetics, Allele, Alleles, Aged, Sequence Analysis, RNA, Myelodysplastic syndromes, General Chemistry, Sequence Analysis, DNA, MESH: Aged, 80 and over Alleles Antimetabolites, Antineoplastic / pharmacology* Antimetabolites, Antineoplastic / therapeutic use Azacitidine / analogs & derivatives* Azacitidine / pharmacology* Azacitidine / therapeutic use Cell Survival / drug effects* DNA Methylation / drug effects* Decitabine Epigenesis, Genetic / drug effects* Female Gene Expression Regulation, Neoplastic / drug effects* HEK293 Cells High-Throughput Nucleotide Sequencing Humans Leukemia, Myelomonocytic, Chronic / drug therapy Leukemia, Myelomonocytic, Chronic / genetics* Male Middle Aged Mutation, DNA Methylation, medicine.disease, 030104 developmental biology, HEK293 Cells, chemistry, Cancer research

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c49d85c0bfff4c676a3aec15934499b
https://hal.archives-ouvertes.fr/hal-03130526/document