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المؤلفون: E. Lawes, A. Lambert, S L Gupta, L.A. Cochrane, J. Fleming, Lesley Cavalli, C.G. Jephson, Kate Stephenson
المصدر: International Journal of Pediatric Otorhinolaryngology. 100:86-90
مصطلحات موضوعية: Male, medicine.medical_specialty, Adolescent, Voice Quality, Vocal Cords, Ambulatory Care Facilities, Hospital experience, Injections, Laryngoplasty, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Humans, Medicine, Vocal cord paralysis, Voice Handicap Index, Child, 030223 otorhinolaryngology, Retrospective Studies, Paresis, business.industry, Retrospective cohort study, General Medicine, medicine.disease, Surgery, Treatment Outcome, Otorhinolaryngology, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, Female, medicine.symptom, Calcium hydroxylapatite, business, Vocal Cord Paralysis
الوصف: Introduction Unilateral vocal fold paresis may significantly impair the vocal quality and laryngeal competence of a child. Relatively little literature relates to injection medialisation laryngoplasty (IML) in children and previous reports have involved small numbers of heterogenous cases. Methods A retrospective review was conducted of paediatric patients managed by our multidisciplinary specialist voice clinic undergoing IML for unilateral vocal fold paresis. Cases of bilateral paresis, those characterised by vocal fold fixation, and patients without formal pre and post-operative voice evaluation were excluded. Results Eighteen IML procedures were performed in 12 children eligible for inclusion between 2005 and 2015. The average age at time of procedure was 12 years (range 9–15 years). Autologous fat was used in 5 procedures, succeeded by calcium hydroxylapatite (Radiesse ® Voice) from 2011 (n = 13). A significant improvement in median GRBAS score components was observed after calcium hydroxylapatite injection in terms of grade (p = 0.008), breathiness (p = 0.002) and aesthenia (p = 0.016). A pre- and post-procedural Voice Handicap Index was self-completed by 6 patients receiving calcium hydroxylapatite injection; the median change in score was an improvement of 19 points (interquartile range 36.5). Conclusion We describe the outcomes of a comparatively large paediatric series and have found IML using calcium hydroxylapatite to be a reliable technique associated with improved subjective outcome measures. Management of UVCP in the child is a challenge with particular investigative and interventional considerations. Further study supported by high quality subjective and, where possible, objective outcome measures, is required to better inform patient selection, timing of intervention and choice of injection material.
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المؤلفون: S D Sharma, S L Gupta, David M. Albert, Benjamin Hartley, Michelle Wyatt
المصدر: The Journal of Laryngology & Otology. 131:268-272
مصطلحات موضوعية: Male, medicine.medical_specialty, medicine.medical_treatment, Subglottic stenosis, Laryngoscopy, Balloon, Catheterization, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Child, 030223 otorhinolaryngology, Subglottis, Retrospective Studies, medicine.diagnostic_test, business.industry, Laryngostenosis, Endoscopic dilatation, General Medicine, medicine.disease, Dilatation, Surgery, Tracheal Stenosis, Stenosis, Otorhinolaryngology, Child, Preschool, 030220 oncology & carcinogenesis, Female, Airway management, business
الوصف: Objectives:To describe our experience and provide guidelines for maximum safe balloon sizes according to age in children undergoing balloon dilatation.Method:A retrospective review was conducted of children undergoing balloon dilatation for subglottic stenosis in a paediatric tertiary unit between May 2006 and February 2016.Results:A total of 166 patients underwent balloon dilatation. Mean ( ± standard deviation) patient age was 4.5 ± 3.99 years. The median balloon size was 8 mm, the median balloon inflation pressure was 10 atm, and the mean balloon inflation time was 65.1 ± 18.6 seconds. No significant unexpected events occurred. The Pearson correlation co-efficient for the relationship between patient age and balloon size was 0.85 (p = 0.001), suggesting a strongly positive correlation.Conclusion:This study demonstrated that balloon dilatation is a safe procedure for airway stenosis. The results suggest using a balloon diameter that is equal to the outer diameter of the age-appropriate endotracheal tube +1 mm for the larynx and subglottis and +2 mm for the trachea.
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المؤلفون: D J Tweedie, Kate Stephenson, L.A. Cochrane, Michelle Wyatt, C M Pepper, J Cooke, S L Gupta, M D Elloy
المصدر: The Journal of laryngology and otology. 132(11)
مصطلحات موضوعية: Design modification, Male, medicine.medical_specialty, business.industry, General Medicine, Equipment Design, Speech Therapy, Infant newborn, Tracheostomy tubes, 03 medical and health sciences, 0302 clinical medicine, Tracheostomy, Otorhinolaryngology, Chart, Current practice, 030225 pediatrics, Small range, medicine, Humans, Female, 030223 otorhinolaryngology, Intensive care medicine, business, Child, Tracheostomy tube
الوصف: ObjectiveA variety of paediatric tracheostomy tubes are available. This article reviews the tubes in current use at Great Ormond Street Hospital for Children and Evelina London Children's Hospital.MethodsThis paper outlines our current preferences, and the particular indications for different tracheostomy tubes, speaking valves and other attachments.ResultsOur preferred types of tubes have undergone significant design changes. This paper also reports further experience with certain tubes that may be useful in particular circumstances. An updated sizing chart is included for reference purposes.ConclusionThe choice of a paediatric tracheostomy tube remains largely determined by individual clinical requirements. Although we still favour a small range of tubes for use in the majority of our patients, there are circumstances in which other varieties are indicated.
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المؤلفون: W, Dai, H, Pan, H, Hassanain, S L, Gupta, M J, Murphy
المصدر: Oncogene. 9(3)
مصطلحات موضوعية: Male, DNA, Complementary, Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, Ovary, Testis, Humans, Receptor Protein-Tyrosine Kinases, Female, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular
الوصف: Using a combination of polymerase chain reaction and conventional cDNA library screening approaches, we have cloned and characterized a putative receptor tyrosine kinase termed tif. The extracellular domain of tif has an immunoglobulin-like loop and a fibronectin type III structure. The intracellular domain contains a tyrosine kinase domain. Compared with ryk, a ubiquitously expressed receptor tyrosine kinase, tif expression is tissue-specific with human ovary and testis containing the highest amount of tif mRNA. Many other tested human tissues such as heart, liver, pancreas and thymus do not contain detectable levels of tif mRNA. The molecular cloning and characterization of tif cDNA will facilitate the identification of a potential ligand(s) for the putative receptor and the study of its biological role.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::e3dd9da0ee16eb7a80cc1398d8feab5c
https://pubmed.ncbi.nlm.nih.gov/8108143 -
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المؤلفون: S.K. Mahajan, S L Gupta, O P Gautam, M B Chhabra
المصدر: Veterinary parasitology. 11(4)
مصطلحات موضوعية: Male, Veterinary medicine, Buffaloes, Fever, Anorexia, Serology, parasitic diseases, medicine, Animals, General Veterinary, biology, Inoculation, Toxoplasma gondii, General Medicine, medicine.disease, biology.organism_classification, Conjunctivitis, Toxoplasmosis, Dyspnea, Toxoplasmosis, Animal, Antibody Formation, biology.protein, Parasitology, Lymph, Lymph Nodes, Antibody, medicine.symptom, Toxoplasma
الوصف: Eight buffalo calves were inoculated with infectious oocysts of a virulent strain of Toxoplasma gondii, five with 1 x 10(5), and the other three with 5 x 10(5) oocytes each while two more were kept as non-inoculated controls. Infected animals developed pyrexia, anorexia, conjunctivitis and dyspnoea. The clinical symptoms, haematological changes and serological response were of a low order. The appearance of haemagglutinating antibodies at significant levels (greater than or equal to 1:64) was first observed at 21 days after inoculation (DAI), peaked at 42 DAI and rapidly declined after 63 DAI. The inoculated calves were killed (or died) at intervals from 11 DAI to 110 DAI. The organism could be recovered from several tissues of a calf that died 11 DAI, but was rapidly removed subsequently. Only the lymph nodes were infective till 32 DAI. Parasitism of the retina was demonstrated in one calf. The significance of these findings is discussed.
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المؤلفون: S L, Gupta, O P, Gautam, M B, Chhabra
المصدر: The Indian journal of medical research. 74
مصطلحات موضوعية: Male, Mice, Toxoplasmosis, Animal, Animals, Sulfadiazine, Mice, Inbred Strains, Toxoplasma
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::0ea90b4c21bfc17ebe0051ef1bfcab76
https://pubmed.ncbi.nlm.nih.gov/7341454 -
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المؤلفون: S L, Gupta, O P, Gautam, R M, Bhardwaj
المصدر: The Indian journal of medical research. 71
مصطلحات موضوعية: Male, Sheep, Testis, Animals, Humans, Toxoplasma, Cells, Cultured, Culture Media
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::a01195bbe4724b5c5c60af50cc149f5f
https://pubmed.ncbi.nlm.nih.gov/7380496 -
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المؤلفون: M B, Chhabra, S L, Gupta, O P, Gautam
المصدر: International journal of zoonoses. 12(2)
مصطلحات موضوعية: Male, Sheep, Buffaloes, Swine, Climate, Goats, Age Factors, India, Hemagglutination Tests, Antibodies, Muridae, Dogs, Toxoplasmosis, Animal, Cats, Animals, Humans, Cattle, Female, Horses, Toxoplasma
الوصف: In a serological survey of latent Toxoplasma prevalence on 3761 animals in northern India by the microtitre indirect haemagglutination test, 23.7 per cent were found to have antibody titres ranging from 1:4 to 1:1024. Seropositivity was recorded in 25.3 per cent of 1227 sheep, 30.3 per cent of 961 goats, 11.8 per cent of 603 horses, 19.3 per cent of 243 cattle, 15.7 per cent of 108 water buffaloes, 31.5 per cent of 178 pigs, 30.9 per cent of 175 dogs, 33.7 per cent of 80 cats and in 9.7 per cent of 186 bandicoot rats. Relevant epidemiological data has been furnished. High seropositivity in food animals and frequent isolations of Toxoplasma highlight the likely public health implications of the findings.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::63805155d768964353bffc1834b81dd3
https://pubmed.ncbi.nlm.nih.gov/4077411 -
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المؤلفون: S. L. Gupta, Bhoop Singh, Archana Srivastava
المصدر: Tropical Animal Health and Production. 15:207-208
مصطلحات موضوعية: Male, Sheep, biology, Goats, India, Toxoplasma gondii, Hemagglutination Tests, biology.organism_classification, medicine.disease, Virology, Antibodies, Toxoplasmosis, Sex Factors, Food Animals, Sex factors, Immunology, biology.protein, medicine, Animals, Female, Animal Science and Zoology, Antibody, Toxoplasma
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56cd31dec76ed51df93667aee49c4e56
https://doi.org/10.1007/bf02242057
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