نتائج البحث - "Lucio H. Freitas-Junior"

1

Human induced pluripotent stem cells as a tool for disease modeling and drug screening for COVID-19

المؤلفون: Carolina B. Moraes, Patricia Nolasco, Lygia da Veiga Pereira, Juliana Borsoi, Lucio H. Freitas-Junior

المصدر: Genetics and Molecular Biology
Genetics and Molecular Biology, Vol 44, Iss 1 suppl 1 (2020)
Genetics and Molecular Biology, Volume: 44, Issue: 1 Supplement 1, Article number: e20200198, Published: 16 NOV 2020
Genetics and Molecular Biology v.44 n.1 suppl.1 2021
Sociedade Brasileira de Genética (SBG)
instacron:SBG
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

وصف الملف: text/html

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be39dc697f9a03c3ddf96c77ba0d9da9
http://europepmc.org/articles/PMC7737100

2

Identification of Inhibitors to trypanosoma cruzi sirtuins based on compounds developed to human enzymes

المؤلفون: Nilmar Silvio Moretti, Laura M. Alcântara, Milena Botelho Pereira Soares, Sergio Schenkman, Rino Ragno, Carolina B. Moraes, Lucio H. Freitas-Junior, Nicola Mautone, Dante Rotili, Lorenzo Antonini, Manuela Sabatino, Antonello Mai, Caio Haddad Franco, Tanira Matutino Bastos

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 3659, p 3659 (2020)
Volume 21
Issue 10

مصطلحات موضوعية: 0301 basic medicine, deacetylation, sirtuins, Trypanosoma cruzi, sirtuin inhibitors, Pharmacology, 01 natural sciences, lcsh:Chemistry, lcsh:QH301-705.5, Spectroscopy, Phylogeny, media_common, chemistry.chemical_classification, biology, Group III Histone Deacetylases, Drug Synergism, General Medicine, Trypanocidal Agents, Recombinant Proteins, Computer Science Applications, Molecular Docking Simulation, Benznidazole, Nitroimidazoles, Sirtuin, medicine.drug, Chagas disease, Drug, media_common.quotation_subject, Catalysis, Article, Cell Line, Inorganic Chemistry, 03 medical and health sciences, Inhibitory Concentration 50, medicine, Animals, Chagas Disease, Physical and Theoretical Chemistry, Nifurtimox, Molecular Biology, 010405 organic chemistry, Organic Chemistry, Epithelial Cells, biology.organism_classification, medicine.disease, Macaca mulatta, 0104 chemical sciences, 030104 developmental biology, Enzyme, chemistry, lcsh:Biology (General), lcsh:QD1-999, biology.protein, NAD+ kinase

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be24b0eb23df1cb4b5d68310a7131e38
http://hdl.handle.net/11573/1401342

3

Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections

المؤلفون: Maria Kuzikov, Maria Laura Bolognesi, Federica Belluti, Andrea Mazzanti, Bernhard Ellinger, Chiara Borsari, Sheraz Gul, Elisa Uliassi, Maria Paola Costi, Lorna Piazzi, Lucio H. Freitas-Junior, Carolina B. Moraes, Reto Brun, Marcel Kaiser

المساهمون: Uliassi, Elisa, Piazzi, Lorna, Belluti, Federica, Mazzanti, Andrea, Kaiser, Marcel, Brun, Reto, Moraes, Carolina B., Freitas-Junior, Lucio H., Gul, Sheraz, Kuzikov, Maria, Ellinger, Bernhard, Borsari, Chiara, Costi, Maria Paola, Bolognesi, Maria Laura

المصدر: ChemMedChem. 13(7)

مصطلحات موضوعية: 0301 basic medicine, ERG1 Potassium Channel, protozoan parasitic infection, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Parasitic Sensitivity Tests, Drug Discovery, Cytochrome P-450 Enzyme Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, media_common, Leishmania, biology, Molecular Structure, Drug discovery, 3. Good health, Molecular Medicine, privileged scaffold, Drug, Trypanosoma, media_common.quotation_subject, hERG, Plasmodium falciparum, Triazole, Antiprotozoal Agents, Phenylpiperazine, phenotypic screening, privileged scaffolds, protozoan parasitic infections, Small Molecule Libraries, 03 medical and health sciences, Phenothiazine, Cell Line, Tumor, Potassium Channel Blockers, Animals, Humans, Pharmacology, 010405 organic chemistry, Organic Chemistry, Cytochrome P450, Triazoles, biology.organism_classification, 0104 chemical sciences, Rats, 030104 developmental biology, chemistry, Pharmacology, Toxicology and Pharmaceutics (all), biology.protein

وصف الملف: STAMPA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74178d7e85de8ea8ef92a162b1f6a825
https://pubmed.ncbi.nlm.nih.gov/29451361

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4

Discovery of Carbohybrid-Based 2-Aminopyrimidine Analogues As a New Class of Rapid-Acting Antimalarial Agents Using Image-Based Cytological Profiling Assay

المؤلفون: Jin Sook Song, Hong-Gun Lee, Nakyung Lee, Donghyun Lim, Myung Ae Bae, Lucio H. Freitas-Junior, Sukjun Lee, Eunyoung Lee, Michel Liuzzi, Seung Bum Park, Lawrence Ayong, Sangmi Oh, Jonathan Cechetto

المصدر: Journal of Medicinal Chemistry. 57:7425-7434

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24cc61c851d5c6b2871d6d64e0e5b5e3
https://doi.org/10.1021/jm5009693

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5

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity

المساهمون: Publica

المصدر: MOLECULES
Molecules; Volume 22; Issue 3; Pages: 426
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

مصطلحات موضوعية: 0301 basic medicine, Anti parasitic, Molecular Conformation, Pharmaceutical Science, Leishmania spp, Analytical Chemistry, pteridine reductase 1, Drug Discovery, Trypanosoma brucei, Leishmania major, media_common, chemistry.chemical_classification, chromen-4-one, Antiparasitic Agents, Molecular Structure, biology, chroman-4-one, 3. Good health, Molecular Docking Simulation, Biochemistry, Chemistry (miscellaneous), Molecular Medicine, Leishmania infantum, Oxidoreductases, Protein Binding, Drug, crystallographic studies, Stereochemistry, media_common.quotation_subject, Trypanosoma brucei brucei, Molecular Dynamics Simulation, Article, Inhibitory Concentration 50, 03 medical and health sciences, parasitic diseases, Chromans, Physical and Theoretical Chemistry, Binding Sites, Organic Chemistry, biology.organism_classification, Leishmania, Antiparasitic agent, Enzyme Activation, Chroman-4-one, Chromen-4-one, Crystallographic studies, Pteridine reductase 1, 030104 developmental biology, Enzyme, chemistry

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::465b0d0594164ef59a549b16d64bf327
http://livrepository.liverpool.ac.uk/3019074/1/molecules_2017.pdf

6

Evaluation of broad-spectrum antiviral compounds against chikungunya infection using a phenotypic screening strategy

المؤلفون: Luiz Tadeu Moraes Figueiredo, Rafaela Milan Bonotto, Soraya Jabur Badra, Carolina B. Moraes, Glaucia Souza-Almeida, Lucio H. Freitas-Junior

المصدر: F1000Research. 7:1730

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::76a363a802db007f0bf0785e2e1f394a
https://doi.org/10.12688/f1000research.16498.1

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7

In vitro and in vivo experimental models for drug screening and development for Chagas disease

المصدر: Scopus-Elsevier
Repositório Institucional da UFOP
Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
Memórias do Instituto Oswaldo Cruz., Vol 105, Iss 2, Pp 233-238 (2010)
Memórias do Instituto Oswaldo Cruz, Volume: 105, Issue: 2, Pages: 233-238, Published: MAR 2010

مصطلحات موضوعية: Male, Microbiology (medical), Drug, Chagas disease, medicine.medical_specialty, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, Trypanosoma cruzi, media_common.quotation_subject, Drug Evaluation, Preclinical, lcsh:QR1-502, Parasitemia, lcsh:Microbiology, Mice, medicine, Animals, Chagas Disease, drug screening, Intensive care medicine, Nifurtimox, media_common, benznidazole, business.industry, Transmission (medicine), Chagas disease treatment, medicine.disease, Trypanocidal Agents, Clinical trial, Disease Models, Animal, Drug screening, Drug development, Benznidazole, Acute Disease, Chronic Disease, Immunology, Neglected tropical diseases, Female, business, medicine.drug

وصف الملف: text/html

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c4e5a64768d44f58aeb2178105a226
https://doi.org/10.1590/s0074-02762010000200022

8

Quantum dots: a new tool for anti-malarial drug assays

المؤلفون: Min-Je Ku, Youngseon Choi, Fernando de M. Dossin, Carolina B. Moraes, Jiyoung Ryu, Lucio H. Freitas-Junior, Rita Song

المصدر: Malaria Journal, Vol 10, Iss 1, p 118 (2011)
Malaria Journal

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a767fd91e1d5150fe667ba9ba0a480
http://www.malariajournal.com/content/10/1/118

Find this article in full text from Springer Verlag.

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9

Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds

المؤلفون: Jiyeon Jang, Seunghyun Moon, Hyunrim Oh, Ok-Ryul Song, Auguste Genovesio, Gyongseon Yang, Jeong-Hun Sohn, Chang Bok Lee, Jonathan Cechetto, Thierry Christophe, Jair L. Siqueira-Neto, Lucio H. Freitas-Junior, Eric Chatelain, Jiyoun Nam

المساهمون: Institut Pasteur Korea - Institut Pasteur de Corée, Réseau International des Instituts Pasteur (RIIP), Drugs for Neglected Diseases Initiative, This work has been funded by the Ministry of Education, Science and Technology (MEST) of South Korea, the Gyeonggi government, and KISTI.

المصدر: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2010, 4 (5), pp.e675. ⟨10.1371/journal.pntd.0000675⟩
PLoS Neglected Tropical Diseases, Vol 4, Iss 5, p e675 (2010)

مصطلحات موضوعية: MESH: Microsomes, Liver, Drug Evaluation, Preclinical, Pharmacology, MESH: Monocytes, Monocytes, Cytochrome P-450 Enzyme System, Drug Stability, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Cytotoxicity, media_common, MESH: Microbial Viability, Leishmania, 0303 health sciences, Drug discovery, lcsh:Public aspects of medicine, 3. Good health, Infectious Diseases, Drug development, MESH: Cytochrome P-450 Enzyme System, Microsomes, Liver, MESH: Drug Evaluation, Preclinical, Research Article, Drug, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, media_common.quotation_subject, MESH: Leishmania, Antiprotozoal Agents, Leishmania donovani, Biology, Cell Line, 03 medical and health sciences, MESH: Drug Stability, medicine, Humans, MESH: Antiprotozoal Agents, Amastigote, 030304 developmental biology, Microbial Viability, MESH: Humans, 030306 microbiology, Macrophages, Public Health, Environmental and Occupational Health, MESH: Macrophages, lcsh:RA1-1270, Leishmaniasis, biology.organism_classification, medicine.disease, MESH: Cell Line, Infectious Diseases/Neglected Tropical Diseases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8385f6cd474343252a12d02fdfa5590
https://hal-riip.archives-ouvertes.fr/pasteur-00696809/document

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10

An Image-Based Drug Susceptibility Assay Targeting the Placental Sequestration of Plasmodium falciparum-Infected Erythrocytes

المؤلفون: Fernando de M. Dossin, Lawrence Ayong, Lucio H. Freitas-Junior, Auguste Genovesio, Min-Je Ku, Michael Adsetts Edberg Hansen

المساهمون: Institut Pasteur Korea - Institut Pasteur de Corée, Réseau International des Instituts Pasteur (RIIP), This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST)(No. 2012-00011), Gyeonggi-do and KISTI.

المصدر: PLoS ONE, Vol 7, Iss 8, p e41765 (2012)
PLoS ONE
PLoS ONE, Public Library of Science, 2012, 7 (8), pp.e41765. ⟨10.1371/journal.pone.0041765⟩
PLOS ONE(7): 8

مصطلحات موضوعية: CD36 Antigens, Erythrocytes, MESH: Chondroitin Sulfates, Placenta, Applied Microbiology, Drug Evaluation, Preclinical, lcsh:Medicine, Protozoology, Pharmacology, Automation, MESH: Pregnancy, 0302 clinical medicine, Pregnancy, MESH: Automation, Drug Discovery, Image Processing, Computer-Assisted, MESH: Animals, Malaria, Falciparum, Artemisinin, lcsh:Science, MESH: Plasmodium falciparum, media_common, 0303 health sciences, Multidisciplinary, biology, MESH: Erythrocytes, MESH: Malaria, Falciparum, Chondroitin Sulfates, MESH: Placenta, MESH: Image Processing, Computer-Assisted, Artemisinins, 3. Good health, Infectious Diseases, medicine.anatomical_structure, MESH: Cell Survival, Medicine, MESH: Drug Evaluation, Preclinical, Female, Antibody, Algorithms, Research Article, Biotechnology, medicine.drug, Drug, Cell Survival, media_common.quotation_subject, Plasmodium falciparum, 030231 tropical medicine, [SCCO.COMP]Cognitive science/Computer science, MESH: Algorithms, Microbiology, Cell Line, MESH: Cell Adhesion, Antimalarials, 03 medical and health sciences, MESH: Artemisinins, parasitic diseases, Cell Adhesion, Parasitic Diseases, medicine, Animals, Humans, Glycophorin, Biology, 030304 developmental biology, Brefeldin A, MESH: Humans, MESH: Brefeldin A, MESH: Antigens, CD36, lcsh:R, Tropical Diseases (Non-Neglected), biology.organism_classification, MESH: Antimalarials, In vitro, Malaria, MESH: Cell Line, Red blood cell, biology.protein, Parastic Protozoans, lcsh:Q, MESH: Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0fe40479811c2fc98b30cb5138e83d
https://doi.org/10.1371/journal.pone.0041765

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