المؤلفون: Martina Nesti, Fabiana Luca, Luca Panchetti, Silvia Garibaldi, Umberto Startari, Gianluca Mirizzi, Federico Landra, Alberto Giannoni, Marcello Piacenti, Andrea Rossi

المصدر: Journal of Clinical Medicine, Vol 12, Iss 21, p 6916 (2023)

مصطلحات موضوعية: catheter ablation (CA), persistent atrial fibrillation (PeAF), vein of Marshall (VOM), VOM ethanol infusion (EI), pulmonary vein isolation (PVI), left atrial (LA) roofline, Medicine

الوصف: Background: The best ablation treatment for persistent atrial fibrillation (PeAF) patients is still debated. The vein of Marshall (VOM) seems to be a promising target for ablation and could be combined with a linear set of ablation lesions. The aim of our study is to evaluate the incidence of AF recurrences in a PeAF population treated with a comprehensive ablation approach consisting of VOM ethanol infusion (EI), pulmonary vein isolation (PVI), a left atrial (LA) roofline, a mitral line (guided by the newly formed lesion after alcohol infusion into the VOM and validated by pacing), and a cavotricuspid isthmus line. Methods: Consecutive patients undergoing the first ablation procedure of catheter ablation (CA) for PeAF were enrolled. All patients underwent VOM-EI, PVI, and ablation lines along the roof of the LA, mitral, and cavotricuspid isthmus. LA voltage mapping before and after VOM-EI was also performed. An implantable loop recorder (ILR) was implanted at the end of the ablation in each patient. Results: Thirty-one consecutive patients (66 ± 8 years and 71% male) affected by PeAF were included in this study. The VOM-EI procedural phase lasted 21.4 ± 10.1 min. PV isolation and lines were validated in all subjects. The ML block was achieved within 10.8 ± 8.7 min. At a mean follow-up of 12 ± 7 months, 27 out of 31 (87%) patients remained free from AT/AF recurrences. Among the patients with recurrences, two (50%) had incomplete ablation lesions and three (75%) had “suboptimal” VOM-EI. In 23/31 patients (74%), antiarrhythmic drugs (AADs) were discontinued after 1 month of follow-up. No significant complications were reported during the follow-up. Conclusions: this single-center experience demonstrates that VOM-EI systematically combined with an anatomical ablation set in patients with PeAF resulted in feasible, safe, and effective freedom from AF/AT recurrences in 87% of the population after a 1-year follow-up period according to an ILR.

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2077-0383/12/21/6916; https://doaj.org/toc/2077-0383

URL الوصول: https://doaj.org/article/b9f45e2837324e4a985d24324083b792

المؤلفون: Chung Hyeon Lee, Min Sung Ko, Ye Seul Kim, Ju Eon Ham, Jee Yeon Choi, Kwang Woo Hwang, So-Young Park

المصدر: Pharmaceuticals, Vol 16, Iss 11, p 1606 (2023)

مصطلحات موضوعية: ethanol extract of D. mariesii roots, Aβ production, Aβ aggregation, scopolamine-induced memory impairment, flavonoids, Medicine, Pharmacy and materia medica, RS1-441

الوصف: Beta-amyloid (Aβ) proteins, major contributors to Alzheimer’s disease (AD), are overproduced and accumulate as oligomers and fibrils. These protein accumulations lead to significant changes in neuronal structure and function, ultimately resulting in the neuronal cell death observed in AD. Consequently, substances that can inhibit Aβ production and/or accumulation are of great interest for AD prevention and treatment. In the course of an ongoing search for natural products, the roots of Davallia mariesii T. Moore ex Baker were selected as a promising candidate with anti-amyloidogenic effects. The ethanol extract of D. mariesii roots, along with its active constituents, not only markedly reduced Aβ production by decreasing β-secretase expression in APP–CHO cells (Chinese hamster ovary cells which stably express amyloid precursor proteins), but also exhibited the ability to diminish Aβ aggregation while enhancing the disaggregation of Aβ aggregates, as determined through the Thioflavin T (Th T) assay. Furthermore, in an in vivo study, the extract of D. mariesii roots showed potential (a tendency) for mitigating scopolamine-induced memory impairment, as evidenced by results from the Morris water maze test and the passive avoidance test, which correlated with reduced Aβ deposition. Additionally, the levels of acetylcholine were significantly elevated, and acetylcholinesterase levels significantly decreased in the brains of mice (whole brains). The treatment with the extract of D. mariesii roots also led to upregulated brain-derived neurotrophic factor (BDNF) and phospho-cAMP response element-binding protein (p-CREB) in the hippocampal region. These findings suggest that the extract of D. mariesii roots, along with its active constituents, may offer neuroprotective effects against AD. Consequently, there is potential for the development of the extract of D. mariesii roots and its active constituents as effective therapeutic or preventative agents for AD.

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/11/1606; https://doaj.org/toc/1424-8247

URL الوصول: https://doaj.org/article/1d0fcfdd40ef474481e944bae655a193

المؤلفون: Lihui Du, Liping Xiao, Chenglin Zou, Jinrong Huang

المصدر: Folia Neuropathologica, Vol 60, Iss 3, Pp 316-323 (2022)

مصطلحات موضوعية: vanillin, ethanol, anxiety, corticosterone, behaviour., Medicine

الوصف: Ethanol abuse is a major public issue globally and withdrawal of ethanol after chronic exposure contributes to the development of behavioural changes. The present study evaluates vanillin effect against the ethanol withdrawal syndrome (EWS) and the associated anxiety. Rats were exposed to ethanol for 21 days at 7.2% concentration maximum with drinking water in a modified liquid diet. Vanillin at doses of 100 and 200 mg/kg were administered 30 min prior to ethanol withdrawal, and behavioural changes were observed at 1st, 2nd, 4th, 6th and 12th h of ethanol withdrawal. Moreover, the locomotor activity was assessed using the astrophotometer and level of anxiety by the elevated plus maze. The level of neurotransmitters and mRNA expression of corticotropin-releasing factor (CRF) and corticotropin releasing factor receptor 1 (CRFR1) were estimated in brain tissue of vanillin treated EWS rats. There was a significant improvement in the ethanol withdrawal behaviour in the vanillin treated group compared to EWS rats. The locomotor activity and level of anxiety was observed to be reduced significantly (p < 0.01) in the vanillin treated group compared to EWS rats. Treatment with vanillin ameliorates the altered level of g-aminobutyric acid (GABA), dopamine and glutamate and level of corticosterone in ethanol withdrawal rats. mRNA expression of CRF and CRFR1 was reduced significantly (p < 0.01) in brain tissue of the vanillin treated group compared to the EWS group of rats. In conclusion, data reveal that treatment with vanillin shows a beneficial effect against EWS and ethanol withdrawal associated anxiety by regulating CRF/CRFR1 expression.

وصف الملف: electronic resource

Relation: https://www.termedia.pl/Vanillin-attenuates-the-ethanol-withdrawal-syndrome-and-ethanol-withdrawal-induced-anxiety-by-regulating-the-neurochemical-balance,20,47595,1,1.html; https://doaj.org/toc/1641-4640; https://doaj.org/toc/1509-572X

URL الوصول: https://doaj.org/article/58974b16606442c98fb0e56c78a80618

المؤلفون: Weni Puspita, Heny Puspasari

المصدر: Majalah Obat Tradisional, Vol 27, Iss 2, Pp 93-100 (2022)

مصطلحات موضوعية: peel-off gel mask, ethanol extract of premna serratifolia l. leaves, physical stability, antioxidant activity, Medicine

الوصف: This study aims to determine the physical stability and antioxidant activity of peel-off gel mask ethanol extract of buas-buas leaf (Premna serratifolia L.). The ethanol extract of buas-buas leaves was obtained by maceration using 70% ethanol solvent, then concentrated using a rotary evaporator to get a thick extract. Formulation EEDB into a peel-off gel mask with a concentration of each EEDB (FI: 1%, FII: 2%, FIII : 3%). The EEDB peel-off gel mask formula was tested for physical stability by cycling test method using a climatic chamber at a temperature of 40°C ± 2°C and 4°C ± 2°C for six cycles. The tests included organoleptic, homogeneity, viscosity, pH, spreadability, and drying time. An antioxidant test was carried out using the DPPH method. The results of the physical stability test on the three EEDB peel-off gel mask formulas (FI: 1%, FII: 2%, FIII: 3%) showed good physical stability because there was no significant difference during six storage cycles (P>0.05) with the results of the preparation have a characteristic aroma of oleum citri, brownish-green in color, have a thick, homogeneous texture, meet the requirements of pH, viscosity, spreadability, and drying time. The stability test results of the antioxidant activity of the peel-off gel mask EEDB in the three formulas showed no significant change (P>0.05). The antioxidant activity during six storage cycles with the highest average percent inhibition before and after the cycling test, namely in Formula III, was 77.20 ± 0.28%.

وصف الملف: electronic resource

Relation: https://jurnal.ugm.ac.id/TradMedJ/article/view/71033; https://doaj.org/toc/1410-5918; https://doaj.org/toc/2406-9086

URL الوصول: https://doaj.org/article/792c34f7050b4f5dab543f062f34a642

المؤلفون: Kramer, Axel, Benkhai, Hicham, Jäkel, Christian, Zwicker, Paula

المصدر: GMS Hygiene and Infection Control, Vol 18, p Doc02 (2023)

مصطلحات موضوعية: biocidal product regulation, 1-propanol, 2-propanol, ethanol, ethanol based hand rubs, benefit-risk-assessment, virucidal efficacy, dermal absorption, worker safety, patient safety, Medicine, Public aspects of medicine, RA1-1270, Microbiology, QR1-502

الوصف: The approval of ethanol by the Biocidal Products Regulation has been under evaluation since 2007 due to controversial opinions on the risk assessment. Because of this critical situation, 2022 a memorandum was published to verify whether the use of ethanol for hand antisepsis poses any hazard. On the basis of the memorandum a toxicological evaluation of ethanol-based hand rubs is given.

وصف الملف: electronic resource

Relation: http://www.egms.de/static/en/journals/dgkh/2023-18/dgkh000428.shtml; https://doaj.org/toc/2196-5226

URL الوصول: https://doaj.org/article/a6b9d26fb8fd4eebb45c676d218d23e3

المؤلفون: Yen-Chu Chen, Hou-Chuan Lai, Yi-Hsuan Huang

المصدر: Journal of Medical Sciences, Vol 43, Iss 2, Pp 90-92 (2023)

مصطلحات موضوعية: ethanol sclerotherapy, acute cardiopulmonary decompensation, general anesthesia, Medicine, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

الوصف: Ethanol sclerotherapy is a therapeutic method commonly applied to address low-flow vascular malformations. However, numerous complications, including hemodynamic instability, may develop after ethanol injection. We present a case who experienced cardiopulmonary instability during intraoperative percutaneous ethanol injection under general anesthesia and spontaneously recovered 5 min after ethanol injection. The toxic effects of the treatment were associated with the injection volume and may be related to ethanol-induced pulmonary vasoconstriction and transient right ventricular dysfunction. Prompt and proper management, including providing supportive treatment, decreasing pulmonary vascular resistance with pulmonary vasodilators, and improving right ventricular function, should be carefully prepared to minimize the progression of cardiovascular collapse.

وصف الملف: electronic resource

Relation: http://www.jmedscindmc.com/article.asp?issn=1011-4564;year=2023;volume=43;issue=2;spage=90;epage=92;aulast=Chen; https://doaj.org/toc/1011-4564

URL الوصول: https://doaj.org/article/d6239f7f647844e3b357e8a80a92e90f

المؤلفون: Jin Ho Choi, Sang Hyub Lee

المصدر: International Journal of Gastrointestinal Intervention, Vol 11, Iss 3, Pp 119-125 (2022)

مصطلحات موضوعية: antineoplastic agents, endosonography, ethanol, pancreatic cyst, radiofrequency ablation, Medicine, Internal medicine, RC31-1245, Specialties of internal medicine, RC581-951, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Endoscopic ultrasound (EUS)-guided ablation procedures are emerging as minimally invasive therapeutic methods that address unmet needs in treatment methods for pancreatic cystic lesions (PCLs). Several studies have been published on the feasibility and efficacy of EUS-guided chemical ablation for PCLs, but further research on the actual treatment effects and real clinical benefits is needed. EUS-guided radiofrequency ablation for PCLs has recently been introduced. This review aimed to describe the broad framework of EUS-guided ablation treatments for PCLs and to present a blueprint for the future of these treatment methods.

وصف الملف: electronic resource

Relation: http://journaleditor.inforang.com/journal/view.html?doi=10.18528/ijgii220027; https://doaj.org/toc/2636-0004

URL الوصول: https://doaj.org/article/fe59a5fa7c854ceb8cbe13734e382dcf

المؤلفون: Nina Dwi Putri, Hindra Irawan Satari, Mulya Rahma Karyanti, Ari Prayitno, Pratama Wicaksana, Anis Karuniawati, Delly Chipta Lestari, Nabila Maudy Salma, Shindy Claudya Aprianti, Amalia Almira, Andi Annisa Rusyda Khafiyani

المصدر: Paediatrica Indonesiana, Vol 62, Iss 4, Pp 232-6 (2022)

مصطلحات موضوعية: hand hygiene, ethanol-based, hand rub, homemade, who, Medicine, Pediatrics, RJ1-570

الوصف: Background Hand hygiene is essential in reducing healthcare-associated infections. Alcohol-based hand rub solutions have been reported to have superior antimicrobial efficacy on both bacteria and lipophilic viruses compared to washing with hand soap. In low- and middle-income countries, the cost of infection control poses a challenge. Our hospital produced an ethanol-based hand rub based on a WHO formulation to reduce the infection prevention costs. Objectives To identify the antimicrobial activity of a WHO ethanol-based hand rub solution against bacterial contamination on the hands of healthcare workers at the Department of Child Health, Dr. Cipto Mangunkusumo National Referral Hospital. Methods This cross-sectional study was performed on the hands of healthcare workers (physicians and nurses) working in the Department of Child Health, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta. A total of 225 specimens from 75 subjects were obtained by collecting swabs on both hands before and after participants worked in the Department of Child Health, Dr. Cipto Mangunkusumo General Hospital. Bacterial culture tests were performed to identify gram-positive and gram-negative bacteria. Bacteria were grouped into no-growth/Bacillus sp, Enterobacteriaceae, cocci, and non-fermenter groups. Results The use of our WHO ethanol-based hand rub solution, generally resulted in a statistically significant decrease in bacterial growth from 84 to 54.6%, before compared to after the hand rub was performed. In more detail, there was a 72.7% decrease in Enterobacteriaceae, a 71.4% decrease in non-fermenters, an 8.6% decrease in cocci and a 44.1% increase in the number of specimens showing no growth bacteria/Bacillus sp. Conclusion Our WHO ethanol-based hand rub has significant antimicrobial activity for common nosocomial pathogens (e.g., Staphylococcus aureus, P. aeruginosa, and K. pneumoniae).

وصف الملف: electronic resource

Relation: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2818; https://doaj.org/toc/0030-9311; https://doaj.org/toc/2338-476X

URL الوصول: https://doaj.org/article/879a65eb585345269278fa8ea291fee1

المؤلفون: Zahra Iranpour, Ali Hosseini-Sharifabad, Mohammad Rabbani, Mohammad Seyedabadi

المصدر: مجله دانشکده پزشکی اصفهان, Vol 40, Iss 667, Pp 223-230 (2022)

مصطلحات موضوعية: carnitine, memory disorders, ethanol, pregnancy, Medicine, Medicine (General), R5-920

الوصف: Background: Neuroprotective effects of L-carnitine on damage caused by fetal exposure to ethanol have been demonstrated. The purpose of this study was to evaluate the effects of different doses of L-carnitine at different stages of pregnancy on the memory of two month old offsprings whose mothers consumed alcohol during pregnancy.Methods: For the purpose of this study, 55 pregnant female rats were randomly divided into 11 groups of 5, including control group, which received drinking water, and the ethanol group which received drinking water containing 10 % (w/v) ethanol. L-Carnitine treated group received L-carnitine in doses of 50, 100, or 150 mg/kg in addition to the ethanol, in the first 10 days or the second 10 days of pregnancy. For modeling the third trimester of pregnancy, doses of L-carnitine were gavaged to the rat neonates for 10 days. After two months of birth, the memories of offsprings were evaluated using Passive Avoidance Task (PAT) and Novel Object Recognition Test (ORT).Findings: Administration of L-carnitine significantly increased discrimination of the ORT index and the escape latency of entry to dark compartment in PAT by two month old offspring compared to the ethanol group. The mentioned indices were significantly increased at a dose of 150 mg/kg compared to the dose of 50 mg/kg throughout all pregnancy periods. These indices were significantly different when l-carnitine was administered in the second 10 days of pregnancy compared to any other periods.Conclusion: The administration of L-carnitine during pregnancy can prevent alcohol-induced memory impairment in rat offsprings. This effect was more significant at higher doses of L-carnitine. The best response was seen when L-carnitine was administered to mothers in the second 10 days of pregnancy.

وصف الملف: electronic resource

Relation: https://jims.mui.ac.ir/article_24267_43333764e833917c2b556985b7747111.pdf; https://doaj.org/toc/1027-7595; https://doaj.org/toc/1735-854X

URL الوصول: https://doaj.org/article/761b66849cf34a0eaca2a1bcfbca7f80

المؤلفون: Shanmiao Ke

المصدر: Journal of Interventional Medicine, Vol 5, Iss 2, Pp 51-56 (2022)

مصطلحات موضوعية: Liver neoplasms, Transcatheter arterial chemoembolization, Radiofrequency ablation, Microwave ablation, Percutaneous ethanol injection, Efficacy, Medicine

الوصف: Hepatocellular carcinoma originating from the caudate lobe, also known as segment I hepatocellular carcinoma, is difficult to treat because of its special location, complex vascular supply, and the proximity of important vessels, bile ducts, and organs. This research is conducted to examine the efficacy and safety of interventional therapy for hepatocellular carcinoma in the caudate lobe. Conclusion: Superselective chemoembolization and ablation techniques for the treatment of caudate lobe hepatocellular carcinoma still need to be improved. The combination of multiple interventional methods and the application of multiple imaging techniques can improve the effectiveness and safety of interventional therapy for hepatocellular carcinoma in the caudate lobe. Multidisciplinary treatment is also essential to improve the prognosis of patients with caudate lobe hepatocellular carcinoma.

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2096360222000138; https://doaj.org/toc/2096-3602

URL الوصول: https://doaj.org/article/638906f734ca4cc2850d7b6ee6192a36