نتائج البحث - "ADENINE"

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 257-274 (2022)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: medicine.medical_treatment, Nonalcoholic Steatohepatitis, AST, aspartate aminotransferase, RC799-869, IL12, interleukin 12, Non-alcoholic Fatty Liver Disease, TBARS, thiobarbituric acid reactive substances, NK cell, natural killer cell, NF-κB, nuclear factor kappa B, Original Research, Activated Natural Killer Cell, JAK-STAT, Janus kinase-signal transducer and activator of transcription, Chemistry, Gastroenterology, JAK-STAT signaling pathway, ELISA, enzyme-linked immunosorbent assay, TG, triglycerides, Diseases of the digestive system. Gastroenterology, Killer Cells, Natural, medicine.anatomical_structure, Cytokine, Interleukin 12, LPS, lipopolysaccharide, FITC, fluorescein isothiocyanate, GM-CSF, granulocyte-macrophage colony-stimulating factor, NASH, nonalcoholic steatohepatitis, CDHF, choline-deficient high-fat diet, MFI, mean fluorescent intensity, CCL5, Natural killer cell, ROS, reactive oxygen species, ALT, alanine aminotransferase, medicine, KEGG, Kyoto encyclopedia of genes and genomes, Humans, MoMF, monocyte derived macrophage, MCD, methionine- and choline-deficient, IFN-γ, interferon gamma, Hepatology, nutritional and metabolic diseases, NADPH, nicotinamide adenine dinucleotide phosphate, medicine.disease, NKG2D, Ig, immunoglobulin, JAK/STAT, Cancer research, NAFLD, nonalcoholic fatty liver disease, Steatohepatitis, HCC, hepatocellular carcinoma, NKT cell, natural killer T cell, Natural Killer Cell

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c28da1742a020c4b72f0c4a997351c0
http://www.sciencedirect.com/science/article/pii/S2352345X21001867

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A novel mechanism of imeglimin‐mediated insulin secretion via the cADPR‐TRP channel pathway

المؤلفون: Masashi Yoshida, Masafumi Kakei, Shunsuke Funazaki, Kazuo Hara, Masanobu Kawakami, Katsuya Dezaki, Shuichi Nagashima, Hodaka Yamada

المصدر: Journal of Diabetes Investigation, Vol 13, Iss 1, Pp 34-41 (2022)
Journal of Diabetes Investigation

مصطلحات موضوعية: Blood Glucose, Male, Basic Science and Research, endocrine system, Imeglimin, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, TRPM Cation Channels, Nicotinamide adenine dinucleotide, Pharmacology, Cyclic ADP-ribose, Diseases of the endocrine glands. Clinical endocrinology, Islets of Langerhans, Mice, chemistry.chemical_compound, Transient receptor potential channel, Insulin Secretion, Internal Medicine, Animals, Hypoglycemic Agents, Medicine, TRPM2, ADP-ribosyl Cyclase, Triazines, business.industry, Pancreatic islets, Insulin, Articles, General Medicine, RC648-665, Transient receptor potential melastatin 2, medicine.anatomical_structure, chemistry, Cyclic ADP ribose, Original Article, NAD+ kinase, business, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429031974de2a9495267210088a29639
https://doaj.org/article/cdbd03d228fa4020bed2960ac6e58c2b

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6

Lack of Endothelial Nitric Oxide Synthase Accelerates Ectopic Calcification in Uremic Mice Fed an Adenine and High Phosphorus Diet

المؤلفون: Sadayoshi Ito, Mariko Miyazaki, Hiroshi Sato, Akiyo Sekimoto, Emiko Sato, Yuji Oe, Nobuyuki Takahashi, Shohei Mitsui, Naoko Shibata, Kiyomi Kisu

المصدر: The American Journal of Pathology. 191:283-293

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Nitric Oxide Synthase Type III, Exacerbation, 030204 cardiovascular system & hematology, medicine.disease_cause, Pathology and Forensic Medicine, Mice, 03 medical and health sciences, chemistry.chemical_compound, Ectopic calcification, 0302 clinical medicine, Enos, medicine.artery, Internal medicine, medicine, Animals, Renal Insufficiency, Chronic, Aorta, Uremia, Kidney, biology, business.industry, Adenine, Calcinosis, Phosphorus, biology.organism_classification, medicine.disease, Diet, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, chemistry, Mice, Inbred DBA, business, Nicotinamide adenine dinucleotide phosphate, Oxidative stress, Kidney disease

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c420c5fa0f9c31f74955569508f45824
https://doi.org/10.1016/j.ajpath.2020.10.012

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7

Neomenthol prevents the proliferation of skin cancer cells by restraining tubulin polymerization and hyaluronidase activity

المؤلفون: Kaneez Fatima, Abha Meena, Suaib Luqman, Nusrat Masood, Zahoor Ahmad Wani

المصدر: Journal of Advanced Research

مصطلحات موضوعية: TRIG, Triglyceraldehyde, Skin Neoplasms, Cell, DOXO, Doxorubicin, Hyaluronidase, Pharmacology, NaOH, Sodium hydroxide, Polymerization, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, Mice, 0302 clinical medicine, BIL, Bilirubin total & direct, Neomenthol, PEP A, pepstatin A, Cancer biomarker, MEF, Mean erythrocyte fragility, HYAL, Hyaluronidase, PBS, Phosphate buffer saline, CM-H2DCFDA, Chloromethyl derivative of dichloro fluorescin diacetate, HA, Hyaluronic acid, Epidermoid carcinoma, Human epidermoid carcinoma, 030220 oncology & carcinogenesis, RBC, Red blood cell, DMEM, Dulbecco’s minimal essential media, SRB, Sulphorhodamine B, BUN, Blood urea nitrogen, FACS, Fluorescence-Activated Cell Sorting, AKLP, Alkaline phosphatase, Hyaluronoglucosaminidase, NADPH, Nicotinamide adenine dinucleotide phosphate hydrogen, TMPD, N,N,N′,N′-tetramethyl-p-phenylenediamine, Article, 03 medical and health sciences, In vivo, Ehrlich Ascites Carcinoma, BE, Binding energy, Humans, CATD, Cathepsin D, LDH, Lactate dehydrogenase, COX-2, Cyclooxygenase 2, FOX, Ferrous oxidation-xylenol orange, DMSO, Dimethyl sulfoxide, mTOR, Mammalian target of rapamycin, In vitro, Ab/Am, Antibiotic/antimycotic, NRU, Neutral red uptake, EC50, Half maximal effective concentration, 030104 developmental biology, IC50, Half maximal inhibitory concentration, EAC, Ehlrich Ascites Carcinoma, RPMI, Roswell park memorial institute, ROS, Reactive oxygen species, 0301 basic medicine, HDL, High density lipoprotein, TNBS, Trinitrobenzenesulphonic acid, PI3K, Phosphotidyl inositol-3 kinase, URIC, Uric acid, DNA, Deoxyribonucleic acid, GAPDH, Glyceraldehyde 3-phosphate dehydrogenase, HEPES, N-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid, Tubulin, OECD, Organization for Economic Co-operation and Development, SGPT, Alanine aminotransferase, LOX-5, Lipoxygenase-5, DFMO, α-difluoro methyl ornithine, Multidisciplinary, WBC, White blood cell, Chemistry, ELISA, enzyme-linked immunosorbent assay, PKB/Akt, Protein kinase B, AA, Arachidonic acid, RNase A, Ribonuclease A, TPR, Total protein, Molecular Docking Simulation, medicine.anatomical_structure, TCA, Tricarboxylic acid, CHOL, Cholesterol, Ki, Inhibitory constant, medicine.drug, ODC, Ornithine decarboxylase, DHFR, Dihydrofolatereductase, BSA, Bovine serum albumin, PDB, Protein Data Bank, medicine, Animals, MMP, Mitochondrial membrane potential, DCFDA, 2′,7′ dichloro fluorescin diacetate, RNA, Ribonucleic acid, RIPA, Radio immune precipitation assay buffer, EDTA, Ethylene diamine tetra acetic acid, IC50, TPA, 12-O-Tetradecanoylphorbol-13-acetate, ComputingMethodologies_COMPUTERGRAPHICS, TRPM8, Transient receptor potential member 8, Cell Proliferation, HDAC, Histone deacetylase, MTX, Methotrexate, OF, Osmotic fragility, PI, Propidium iodide, FDA, Food and Drug Administration, HEK293 Cells, PDT, Podophyllotoxin, Cell culture, NAC, N-acetyl cysteine, SGOT, Aspartate aminotransferase, CRTN, Creatinine, FBS, Fetal bovine serum, PCR, Polymerase chain reaction, Rh123, Rhodamine 123, Ex vivo, IDT, Integrated DNA Technologies

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7618e7dc6e2d535e1930d5f8c2bf7d7e
https://doi.org/10.1016/j.jare.2021.06.003

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8

Huangjinsan ameliorates adenine‐induced chronic kidney disease by regulating metabolic profiling

المؤلفون: Fang Liu, Yuejiao Guo, Chenggang Huang, Xiaoting Tian, Qiang Xiong, Qiang Tian, Mingcang Chen

المصدر: Journal of Separation Science. 44:4384-4394

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da18a89f0d5fa6b68e55673f4fc45b4
https://doi.org/10.1002/jssc.202100542

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Sult2b1 deficiency exacerbates ischemic stroke by promoting pro-inflammatory macrophage polarization in mice

المؤلفون: Yu Nie, Haojie Jin, Baohui Xu, Jihong Meng, Lixiang Xue, Feng Wang, Yafang Wang, Yan Wang, Xiaomu Tan, Heng Zhao, Yang Yao, Cuixia Yang

المصدر: Theranostics

مصطلحات موضوعية: Male, medicine.medical_specialty, Macrophage, Macrophage polarization, Medicine (miscellaneous), Sult2b1, Cholesterol Sulfate, Monocytes, Brain Ischemia, chemistry.chemical_compound, Mice, Immune system, Neuroinflammation, Internal medicine, SULT2B1, Medicine, Animals, Humans, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Stroke, Ischemic Stroke, Inflammation, Mice, Knockout, business.industry, Cholesterol, Monocyte, Macrophages, Infarction, Middle Cerebral Artery, Recovery of Function, Macrophage Activation, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, medicine.anatomical_structure, Endocrinology, chemistry, Neuroinflammatory Diseases, Cholesterol Esters, Microglia, Sulfotransferases, business, Nicotinamide adenine dinucleotide phosphate, Research Paper, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d0eabaee6e0a60db5302e7b4a5623d
http://europepmc.org/articles/PMC8581421

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10

Adenine base editing reduces misfolded protein accumulation and toxicity in alpha-1 antitrypsin deficient patient iPSC-hepatocytes

المؤلفون: Joseph E. Kaserman, Lauren Young, Andrew A. Wilson, Yvonne Aratyn-Schaus, Packer Michael, Carlos Villacorta-Martin, Gregoire Francine, Jonathan Lindstrom-Vautrin, Rhiannon B Werder

المصدر: Molecular Therapy. 29:3219-3229

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a607aaccda9c5ddc82338a01c7fef4
https://doi.org/10.1016/j.ymthe.2021.06.021

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