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المؤلفون: Paul Declerck, Joana Torres
المصدر: Current Opinion in Pharmacology. 55:iii-vi
مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, medicine.diagnostic_test, Tumor Necrosis Factor-alpha, business.industry, Drug Resistance, MEDLINE, Drug resistance, Inflammatory Bowel Diseases, medicine.disease, Inflammatory bowel disease, Biological Factors, Gastrointestinal Agents, Therapeutic drug monitoring, Drug Discovery, medicine, Humans, Drug Monitoring, Intensive care medicine, business, Biomarkers, Introductory Journal Article
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المؤلفون: Russell A Settipane, Joseph A. Bellanti
المصدر: Allergy Asthma Proc
مصطلحات موضوعية: Pulmonary and Respiratory Medicine, medicine.medical_specialty, medicine.medical_treatment, MEDLINE, Anxiety, Electronic Nicotine Delivery Systems, Cigarette Smoking, Cigarette smoking, Internal medicine, medicine, Humans, Immunology and Allergy, Chronic Urticaria, Anti-Asthmatic Agents, Respiratory sounds, Chronic urticaria, Respiratory Sounds, Asthma, Tobacco Use Cessation, Biological Products, medicine.diagnostic_test, business.industry, Vaping, Angioedemas, Hereditary, Articles, General Medicine, medicine.disease, Smoking cessation, Smoking Cessation, business, Food Hypersensitivity, Stress, Psychological, Introductory Journal Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6eaf286c5f3ae3428a787a04fda6184
https://doi.org/10.2500/aap.2020.41.200020 -
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المؤلفون: A.M. Gijs van Leeuwen, Wouter B. Veldhuis, Jeanine E. Vasmel, Arjen J Witkamp, Marielle E.P. Philippens, Helena M. Verkooijen, Elsken van der Wall, Joost van Gorp, Thijs van Dalen, Anna M. Kirby, Paul J. van Diest, H.J.G. Desiree van den Bongard, Antonetta C. Houweling, Iris E. van Dam, Celien P.H. Vreuls, R. Koelemij, M. Sier, Bram van Asselen, Ramona K. Charaghvandi, A. Doeksen
المساهمون: Graduate School, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Personalized Medicine, APH - Quality of Care, ACS - Atherosclerosis & ischemic syndromes
المصدر: International Journal of Radiation Oncology, Biology, Physics, 106, 4, pp. 821-829
International Journal of Radiation Oncology Biology Physics, 106(4), 821. Elsevier Inc.
International Journal of Radiation Oncology, Biology, Physics, 106, 821-829
International Journal of Radiation Oncology Biology Physics, 106(4), 821-829. Elsevier Inc.مصطلحات موضوعية: Ablation Techniques, Cancer Research, medicine.medical_specialty, Breast Neoplasms, 030218 nuclear medicine & medical imaging, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Journal Article, medicine, Humans, Radiology, Nuclear Medicine and imaging, Radiation treatment planning, Radiation oncologist, Aged, Radiation, medicine.diagnostic_test, business.industry, Cosmesis, Partial Breast Irradiation, Magnetic resonance imaging, Common Terminology Criteria for Adverse Events, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Neoadjuvant Therapy, Confidence interval, Treatment Outcome, Oncology, Radiology Nuclear Medicine and imaging, 030220 oncology & carcinogenesis, Female, Radiology, business, Radiotherapy, Image-Guided
الوصف: Contains fulltext : 219916.pdf (Publisher’s version ) (Closed access) PURPOSE: To assess the pathologic and radiologic response in patients with low-risk breast cancer treated with magnetic resonance (MR) guided neoadjuvant partial breast irradiation (NA-PBI) and to evaluate toxicity and patient-reported outcomes (PROs). METHODS AND MATERIALS: For this single-arm prospective trial, women with unifocal, non-lobular tumors with a maximum diameter of 20 mm (age, 50-70 years) or 30 mm (age, >/=70 years) and tumor-negative sentinel node(s) were eligible. Patients were treated with a single ablative dose of NA-PBI followed by breast-conserving surgery after an interval of 6 to 8 months. Target volumes were defined on radiation therapy planning computed tomography scan and additional magnetic resonance imaging. Prescribed doses to gross tumor volume and clinical target volume (gross tumor volume plus 20 mm margin) were 20 Gy and 15 Gy, respectively. Primary outcome was pathologic complete response (pCR). Secondary outcomes were radiologic response (on magnetic resonance imaging), toxicity (Common Terminology Criteria for Adverse Events), PROs (European Organisation for Research and Treatment of Cancer QLQ-BR23, Hospital Anxiety and Depression Scale), and cosmesis (assessed by patient, radiation oncologist, and BCCT.core software). RESULTS: Thirty-six patients were treated with NA-PBI, and pCR was reported in 15 patients (42%; 95% confidence interval, 26%-59%). Radiologic complete response was observed in 15 patients, 10 of whom had pCR (positive predictive value, 67%; 95% confidence interval, 39%-87%). After a median follow-up of 21 months (range, 12-41), all patients experienced grade 1 fibrosis in the treated breast volume. Transient grade 2 and 3 toxicity was observed in 31% and 3% of patients, respectively. Local recurrences were absent. No deterioration in PROs or cosmetic results was observed. CONCLUSIONS: NA-PBI has the potential to induce pCR in a substantial proportion of patients, with acceptable toxicity. This treatment seems a feasible alternative to standard postoperative irradiation and could even result in postponement or omission of surgery if pCR can be accurately predicted in selected low-risk patients.
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المؤلفون: Maarten J. Cramer, Frans H. Rutten, Karel G.M. Moons, Aisha Gohar, Johannes B. Reitsma, Yvonne van Mourik, Arno W. Hoes, Jan-Willem J. Lammers, Loes C.M. Bertens
المصدر: American Heart Journal, 220, 73. Mosby Inc.
مصطلحات موضوعية: Male, Spirometry, medicine.medical_specialty, Health Status, General Practice, Physical examination, 030204 cardiovascular system & hematology, law.invention, Electrocardiography, Pulmonary Disease, Chronic Obstructive, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), Randomized controlled trial, law, Health care, Journal Article, medicine, Humans, Medical history, 030212 general & internal medicine, Medical History Taking, Physical Examination, Aged, Netherlands, Heart Failure, Health Services Needs and Demand, COPD, Exercise Tolerance, medicine.diagnostic_test, business.industry, Incidence, Multimorbidity, medicine.disease, Dyspnea, Echocardiography, Heart failure, Quality of Life, Physical therapy, Female, Cardiology and Cardiovascular Medicine, business
الوصف: Background Heart failure (HF) and chronic obstructive pulmonary disease (COPD) often remain undiagnosed in older individuals, although both disorders inhibit functionality and impair health. The aim of the study was to assess the effectiveness of a case-finding strategy of these disorders. Methods This is a clustered randomized trial; 18 general practices from the vicinity of Utrecht, the Netherlands, were randomly allocated to a case-finding strategy or usual care. Multimorbid community subjects (≥65 years) with dyspnea or reduced exercise tolerance were eligible for inclusion. The case-finding strategy consisted of history taking, physical examination, blood tests, electrocardiography, spirometry, and echocardiography. Subsequent treatment decisions were at the discretion of the general practitioner. Questionnaires regarding health status and functionality were filled out at baseline and after 6 months of follow-up. Information regarding changes in medication and health care use during the 6 months follow-up was extracted. Results A total of 829 participants were randomized: 389 in the case-finding strategy group and 440 in the usual care group. More patients in the case-finding group received a new diagnosis of HF or COPD than the usual care group (cumulative incidence 34% vs 2% and 17% vs. 2%, respectively). Scores for health status, functionality, and health care use were similar between the 2 strategies after 6 months of follow-up. Conclusions A case-finding strategy applied in primary care to multimorbid older people with dyspnea or reduced exercise tolerance resulted in a number of new diagnoses of HF and COPD but did not result in short-term improvement of health status compared to usual care.
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المصدر: Pediatric Radiology, 50(4), 534. Springer Verlag
Pediatric Radiologyمصطلحات موضوعية: Male, Adolescent, Contrast Media, Lymphadenopathy, Computed tomography, Pediatrics, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Cervical spine, Normal values, Journal Article, medicine, Humans, Radiology, Nuclear Medicine and imaging, Pediatrics, Perinatology, and Child Health, Child, Lymph nodes, Lymph node, Retrospective Studies, Neuroradiology, medicine.diagnostic_test, business.industry, Ultrasound, Infant, Perinatology, and Child Health, Transverse plane, medicine.anatomical_structure, Radiology Nuclear Medicine and imaging, Cervical lymph nodes, Child, Preschool, 030220 oncology & carcinogenesis, Coronal plane, Pediatrics, Perinatology and Child Health, Diagnostic imaging, Original Article, Female, Lymph, Tomography, X-Ray Computed, business, Nuclear medicine, Neck
الوصف: Background No normal measurements or specific size criteria have been described for cervical lymph nodes in children. Objective To determine the normal measurements of cervical lymph nodes in children on CT. Materials and methods We included 142 children (ages 1–17 years) who underwent cervical CT examination after high-energy trauma. We evaluated axial and coronal 2-mm reconstructions for lymph nodes at six cervical levels. For the largest lymph node at each level, we measured diameters in both the long and short axial axes and the long coronal axis. Results A total of 733 lymph nodes were measured in 142 children (62% boys, 38% girls). The greatest measured diameters were 14 mm for the short axis in the axial plane, 24 mm for the long axis in the axial plane and 28 mm for the long axis in the coronal plane. The Pearson correlation coefficient for age and lymph node size at Levels IV–VI was in the range of 0.19–0.47. Conclusion Lymph nodes with an axial short-axis diameter exceeding 15 mm for Level II and 10 mm for all other cervical levels are uncommon in otherwise healthy children.
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المؤلفون: Dylan W. de Lange, Erik M. van Maarseveen, Maaike A. Sikma, Alwin D. R. Huitema, Claudine C. Hunault
المصدر: Clinical Pharmacokinetics
Clinical Pharmacokinetics, 59(4), 403. Adis International Ltdمصطلحات موضوعية: medicine.medical_treatment, Calcineurin Inhibitors, Biological Availability, chemical and pharmacologic phenomena, Pharmacology, Hematocrit, Tacrolimus, Pharmacokinetics, Journal Article, medicine, Humans, Lung transplantation, Pharmacology (medical), Dosing, medicine.diagnostic_test, business.industry, Bioavailability, Calcineurin, surgical procedures, operative, Biological Variation, Population, Current Opinion, Toxicity, Heart Transplantation, Drug Monitoring, business, Immunosuppressive Agents, Lung Transplantation
الوصف: The calcineurin inhibitor tacrolimus is an effective immunosuppressant and is extensively used in solid organ transplantation. In the first week after heart and lung transplantation, tacrolimus dosing is difficult due to considerable physiological changes because of clinical instability, and toxicity often occurs, even when tacrolimus concentrations are within the therapeutic range. The physiological and pharmacokinetic changes are outlined. Excessive variability in bioavailability may lead to higher interoccasion (dose-to-dose) variability than interindividual variability of pharmacokinetic parameters. Intravenous tacrolimus dosing may circumvent this high variability in bioavailability. Moreover, the interpretation of whole-blood concentrations is discussed. The unbound concentration is related to hematocrit, and changes in hematocrit may increase toxicity, even within the therapeutic range of whole-blood concentrations. Therefore, in clinically unstable patients with varying hematocrit, aiming at the lower therapeutic level is recommended and tacrolimus personalized dosing based on hematocrit-corrected whole-blood concentrations may be used to control the unbound tacrolimus plasma concentrations and subsequently reduce toxicity.
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المؤلفون: Jacques C. Giltay, Michael E. Talkowski, Sjors Middelkamp, Ellen van Binsbergen, Wigard P. Kloosterman, Markus J. van Roosmalen, Roel Janssen, Sander Boymans, Lisanne de la Fonteijne, Daniela Giachino, Nicolle Besselink, Jerome Korzelius, Ron Hochstenbach, Judith M. Vlaar, Edwin Cuppen
المصدر: Genome Medicine, Vol 11, Iss 1, Pp 1-15 (2019)
Genome Medicine
Genome Medicine, 11(1). BioMed Centralمصطلحات موضوعية: Microarray, Intellectual disability, lcsh:Medicine, 0302 clinical medicine, Genetics(clinical), Copy-number variation, Transcriptome sequencing, Non-U.S. Gov't, Genetics (clinical), 0303 health sciences, medicine.diagnostic_test, Topologically associating domains, Research Support, Non-U.S. Gov't, Neurodevelopmental disorders, Copy number variants, Driver genes, Multiple congenital anomalies, Position effects, Structural variation, Whole-genome sequencing, Phenotype, 3. Good health, Chromatin, Molecular Medicine, Prioritization, DNA Copy Number Variations, lcsh:QH426-470, Computational biology, Biology, Research Support, N.I.H, 03 medical and health sciences, Research Support, N.I.H., Extramural, medicine, Genetics, Journal Article, Humans, Genetic Predisposition to Disease, Gene, Molecular Biology, Genetic Association Studies, 030304 developmental biology, Genetic testing, Whole genome sequencing, Whole Genome Sequencing, Genome, Human, Research, lcsh:R, Genetic Diseases, Inborn, Computational Biology, Genetic Variation, Extramural, Molecular Sequence Annotation, Human genetics, lcsh:Genetics, Genomic Structural Variation, 030217 neurology & neurosurgery
الوصف: Background Genomic structural variants (SVs) can affect many genes and regulatory elements. Therefore, the molecular mechanisms driving the phenotypes of patients carrying de novo SVs are frequently unknown. Methods We applied a combination of systematic experimental and bioinformatic methods to improve the molecular diagnosis of 39 patients with multiple congenital abnormalities and/or intellectual disability harboring apparent de novo SVs, most with an inconclusive diagnosis after regular genetic testing. Results In 7 of these cases (18%), whole-genome sequencing analysis revealed disease-relevant complexities of the SVs missed in routine microarray-based analyses. We developed a computational tool to predict the effects on genes directly affected by SVs and on genes indirectly affected likely due to the changes in chromatin organization and impact on regulatory mechanisms. By combining these functional predictions with extensive phenotype information, candidate driver genes were identified in 16/39 (41%) patients. In 8 cases, evidence was found for the involvement of multiple candidate drivers contributing to different parts of the phenotypes. Subsequently, we applied this computational method to two cohorts containing a total of 379 patients with previously detected and classified de novo SVs and identified candidate driver genes in 189 cases (50%), including 40 cases whose SVs were previously not classified as pathogenic. Pathogenic position effects were predicted in 28% of all studied cases with balanced SVs and in 11% of the cases with copy number variants. Conclusions These results demonstrate an integrated computational and experimental approach to predict driver genes based on analyses of WGS data with phenotype association and chromatin organization datasets. These analyses nominate new pathogenic loci and have strong potential to improve the molecular diagnosis of patients with de novo SVs.
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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a3de66330b22156e98c0ce67e4d4ac
https://doaj.org/article /341d24bce7eb47ffb1b6902c15a0ce41 -
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المؤلفون: L. Jaap Kappelle, Michiel L. Bots, Robert J. van Oostenbrugge, Astrid M. Hooghiemstra, Wiesje M. van der Flier, Hans-Peter Brunner-La Rocca, Anne Suzannne Bertens, Jacoba P. Greving, Albert C. van Rossum, Anna E. Leeuwis, Geert Jan Biessels
المساهمون: Cardiologie, MUMC+: MA Med Staf Spec Cardiologie (9), RS: Carim - H02 Cardiomyopathy, RS: CARIM - R2.02 - Cardiomyopathy, MUMC+: MA Neurologie (3), Klinische Neurowetenschappen, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: Carim - B05 Cerebral small vessel disease, RS: CARIM - R3.03 - Cerebral small vessel disease, Neurology, Cardiology, ACS - Heart failure & arrhythmias, Amsterdam Neuroscience - Neurodegeneration, APH - Personalized Medicine, APH - Methodology, Epidemiology and Data Science
المصدر: Stroke, 50(12), 3369-3375. LIPPINCOTT WILLIAMS & WILKINS
Stroke, 50(12), 3369-3375. Lippincott Williams and Wilkins
Stroke, 50(12), 3369. Lippincott Williams and Wilkins
Hooghiemstra, A M, Leeuwis, A E, Bertens, A S, Biessels, G J, Bots, M L, Brunner-la Rocca, H-P, Greving, J P, Kappelle, L J, van Oostenbrugge, R J, van Rossum, A C & van der Flier, W M 2019, ' Frequent Cognitive Impairment in Patients With Disorders Along the Heart-Brain Axis ', Stroke, vol. 50, no. 12, pp. 3369-3375 . https://doi.org/10.1161/STROKEAHA.119.026031مصطلحات موضوعية: Male, PARTICIPANTS AGED 24-81, medicine.medical_specialty, NORMATIVE DATA, media_common.quotation_subject, brain, heart failure, Audiology, PRESSURE, ARTERY OCCLUSION, medicine, Journal Article, Dementia, Humans, Carotid Stenosis, Cognitive Dysfunction, Cognitive skill, Cognitive decline, ASYMPTOMATIC CAROTID STENOSIS, media_common, Aged, cognitive impairment, Advanced and Specialized Nursing, Psychomotor learning, DECLINE, medicine.diagnostic_test, business.industry, Dementia, Vascular, DEMENTIA, Magnetic resonance imaging, Cognition, EDUCATION, Middle Aged, PERFORMANCE, medicine.disease, PULSE-WAVE VELOCITY, Heart failure, Female, Neurology (clinical), cerebral small vessel diseases, Cardiology and Cardiovascular Medicine, business, Vigilance (psychology)
الوصف: Background and Purpose— Patients with cardiovascular disease are at increased risk for cognitive decline. We studied the occurrence and profile of cognitive impairment in 3 patient groups as exemplar conditions of hemodynamic disturbances at different levels of the heart-brain axis, including patients with heart failure (HF), carotid occlusive disease (COD), and patients with cognitive complaints and vascular brain injury on magnetic resonance imaging (possible vascular cognitive impairment [VCI]). Methods— In 555 participants (160 HF, 107 COD, 160 possible VCI, 128 reference participants; 68±9 years; 36% F; Mini-Mental State Examination 28±2), we assessed cognitive functioning with a comprehensive test battery. Test scores were transformed into z -scores. Compound z -scores were constructed for: memory, language, attention/psychomotor speed, executive functioning, and global cognitive functioning. We rated cognitive domains as impaired when z -score≤−1.5. Based on the number of impaired domains, patients were classified as cognitively normal, minor, or major cognitive impairment. We used general linear models and χ 2 tests to compare cognitive functioning between patient groups and the reference group. Results— Age, sex, and education adjusted global cognitive functioning z-score was lower in patients with COD (β [SE]=−0.46 [0.10], P P z -scores were lower in patients with COD and possible VCI compared with reference participants. Patients with HF had lower z-scores on attention/speed and language compared with reference participants. Cognitive impairment was observed in 18% of HF, 36% of COD, and 45% possible VCI. There was no difference in profile of impaired cognitive domains between patient groups. Memory and attention-psychomotor speed were most commonly affected, followed by executive functioning and language. Conclusions— A substantial part of patients with HF and COD had cognitive impairment, which warrants vigilance for the occurrence of cognitive impairment. These results underline the importance of an integrative approach in medicine in patients presenting with disorders in the heart-brain axis.
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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d0909a1109f21c9ef557f467feb522
https://doi.org/10.1161/strokeaha.119.026031 -
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المؤلفون: Yassine Bouatou, Frederike J. Bemelman, Laura A. Michielsen, Joris J. T. H. Roelofs, Tri Q. Nguyen, Jesper Kers, Roel Goldschmeding, Sandrine Florquin
المساهمون: Graduate School, Pathology, ACS - Diabetes & metabolism, ACS - Pulmonary hypertension & thrombosis, AII - Inflammatory diseases, Nephrology, APH - Digital Health, APH - Global Health, APH - Aging & Later Life
المصدر: Transplantation, 103(12), 2692-2700. Lippincott Williams and Wilkins
Transplantation, 103(12), 2692. Lippincott Williams and Wilkinsمصطلحات موضوعية: Adult, Graft Rejection, Male, medicine.medical_specialty, Biopsy, Renal function, 030230 surgery, Kidney, medicine.disease_cause, Nephropathy, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Journal Article, medicine, Humans, Kidney transplantation, Retrospective Studies, Polyomavirus Infections, Transplantation, medicine.diagnostic_test, business.industry, Graft Survival, Retrospective cohort study, Middle Aged, medicine.disease, Kidney Transplantation, Transplant Recipients, BK virus, Tumor Virus Infections, BK Virus, Cohort, Nephritis, Interstitial, Female, 030211 gastroenterology & hepatology, business, Follow-Up Studies, Glomerular Filtration Rate
الوصف: BACKGROUND: With current immunosuppressive regimens, BK polyomavirus-associated nephropathy (BKPyVAN) is still a matter of concern. Stratification of patients at risk for allograft loss is of uttermost importance to guide treatment choice and assess prognosis. In 2018, the Banff working group proposed a classification scheme for the prognosis of BKPyVAN, but external application on independent cohorts is yet to be performed. We investigated how the 2018 Banff classification would perform in a multicenter cohort comprising 50 cases of biopsy-proven BKPyVAN compared to previously published classification systems. METHODS: We analyzed consecutive BKPyVAN cases from two Dutch university hospitals between 2002 and 2013, retrieved clinical data, and scored all biopsies according to the Banff 2018 classification, and as a comparison, 4 previously proposed BKPyVAN classification systems. We used estimated glomerular filtration rate trajectories and death-censored graft survival as primary endpoints. RESULTS: The 2018 Banff classification did not associate with estimated glomerular filtration rate decline or graft failure and performed only slightly better than the 4 previously proposed classifiers. Anti-human leukocyte antigen donor-specific antibodies (DSAs), especially in combination with ongoing biopsy-proven BKPyVAN on follow-up, did correlate with graft function and survival. Patients who were DSA+/BKPyVAN+ on follow-up had more inflammation at the baseline biopsy, which by itself was not associated with graft outcomes. CONCLUSIONS: Neither the 2018 Banff BKPyVAN classification nor previously published stratification systems could be applied to our multicenter patient cohort. Our data suggest that there might be a prognostic value for follow-up biopsies and DSA measurements to improve risk stratification after BKPyVAN, although prospective multicenter efforts with protocol measurements are needed to confirm this.
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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8868148313de1139ebf285558ee3156
https://doi.org/10.1097/tp.0000000000002712 -
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المؤلفون: Niek E. van der Aa, Corine Koopman, Floris Groenendaal, Cornelia H. Verhage, Linda S. de Vries, Bram P L van Gasselt, Manon J.N.L. Benders, Alexander Leemans, Nienke Wagenaar
المصدر: Pediatric Research, 87(5), 932. Lippincott Williams and Wilkins
مصطلحات موضوعية: medicine.medical_specialty, Pediatrics, Cerebral palsy, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Fractional anisotropy, Early prediction, Journal Article, medicine, Pediatrics, Perinatology, and Child Health, medicine.diagnostic_test, Term equivalent age, business.industry, Area under the curve, Magnetic resonance imaging, medicine.disease, Perinatology, and Child Health, Pediatrics, Perinatology and Child Health, Radiology, business, 030217 neurology & neurosurgery, Tractography, Diffusion MRI
الوصف: Background: Neonates with unilateral perinatal brain injury (UPBI) are at risk for developing unilateral spastic cerebral palsy (USCP). This study compares several predictors for USCP later in life. Methods: Twenty-one preterm and 24 term born infants with UPBI were included, with an MRI scan including diffusion tensor imaging (DTI) performed at term equivalent age or around 3 months after birth, respectively. T2-weighted images and DTI-based tractography were used to measure the surface area, diameter, and fractional anisotropy (FA) of both corticospinal tracts (CSTs). The hand assessment for infants (HAI) was performed before 5, between 5 and 8 and between 8 and 12 months of (corrected) age. Asymmetry indices were derived from all techniques and related to USCP at ≥2 years of age. Results: MRI measures and HAI scores were significantly lower for the affected compared to the unaffected side. Before 5 months of age, FA asymmetry on DTI yielded the highest area under the curve compared to conventional MRI and HAI. Conclusions: Prediction of USCP after UPBI is reliable using asymmetry of the CST on MRI, as well as clinical hand assessment. Before 5 months of age, DTI tractography provides strongest predictive information, while HAI specifically aids to prognosis of USCP at later age points.
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