نتائج البحث - "Lucio H. Freitas-Junior"

1

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform

المؤلفون: Flavio Di Pisa, Elisa Uliassi, Lucio H. Freitas-Junior, Maria Laura Bolognesi, Antonio Quotadamo, Maria Paola Costi, Claudia Danielli Pereira Bertolacini, Joachim Clos, Joanna Panecka-Hofman, Chiara Borsari, María Jesús Corral, G. Landi, Maria Kuzikov, Deepa Karunakaran, Pasquale Linciano, Wolfgang Müller, Birte Behrens, Kyriakos C. Prousis, Carolina B. Moraes, Lucia Dello Iacono, Markus Wolf, Oliver Keminer, Cecilia Pozzi, Rebecca C. Wade, Bruno dos Santos Pascoalino, José María Alunda, Stefania Ferrari, Martina Fenske, Alberto Venturelli, Sheraz Gul, Jeanette Reinshagen, Nuno Santarém, Matteo Santucci, Jennifer Leu, Stephen Wrigley, Ina Pöhner, Bethlehem Kebede, Theodora Calogeropoulou, Bernhard Ellinger, Stefano Mangani, Anabela Cordeiro-da-Silva, Gesa Witt

المساهمون: Carolina B. Moraes, Gesa Witt, Maria Kuzikov, Bernhard Ellinger, Theodora Calogeropoulou, Kyriakos C. Prousis, Stefano Mangani, Flavio Di Pisa, Giacomo Landi, Lucia Dello Iacono, Cecilia Pozzi, Lucio H. Freitas-Junior, Bruno dos Santos Pascoalino, Claudia P. Bertolacini, Birte Behrens, Oliver Keminer, Jennifer Leu, Markus Wolf, Jeanette Reinshagen, Anabela Cordeiro-da-Silva, Nuno Santarem, Alberto Venturelli, Stephen Wrigley, Deepa Karunakaran, Bethlehem Kebede, Ina Pöhner, Wolfgang Müller, Joanna Panecka-Hofman, Rebecca C. Wade, Martina Fenske, Joachim Clos, José María Alunda, María Jesús Corral, Elisa Uliassi, Maria Laura Bolognesi, Pasquale Linciano, Antonio Quotadamo, Stefania Ferrari, Matteo Santucci, Chiara Borsari, Maria Paola Costi, Sheraz Gul, Publica

المصدر: Slas Discovery

مصطلحات موضوعية: Chagas disease, cell-based assays, Antiparasitic, medicine.drug_class, cell-based assay, Computational biology, liquid handling, Trypanosoma brucei, 01 natural sciences, Biochemistry, Article, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Trypanosomiasis, anti-infective drugs, Drug Discovery, parasitic diseases, medicine, Humans, compound repositories, enzyme assays or enzyme kinetics, Biotechnology, Molecular Medicine, 030304 developmental biology, 0303 health sciences, Biological Products, Natural product, biology, Drug discovery, Leishmaniasis, biology.organism_classification, medicine.disease, Trypanocidal Agents, anti-infective drug, 0104 chemical sciences, 3. Good health, 010404 medicinal & biomolecular chemistry, chemistry, compound repositorie, Neglected tropical diseases, enzyme assays or enzyme kinetic

وصف الملف: ELETTRONICO

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5b64ff9e20812ab96c4f3ad8331d20
https://hdl.handle.net/11380/1175165

2

A Multi-Species Phenotypic Screening Assay for Leishmaniasis Drug Discovery Shows That Active Compounds Display a High Degree of Species-Specificity

المؤلفون: Thalita Camêlo da Silva Ferreira, Vanessa Fontana, Laura M. Alcântara, Carolina B. Moraes, Lucio H. Freitas-Junior, Eric Chatelain

المصدر: Molecules
Volume 25
Issue 11
Molecules, Vol 25, Iss 2551, p 2551 (2020)

مصطلحات موضوعية: THP-1 Cells, Phenotypic screening, 030231 tropical medicine, Antiprotozoal Agents, Drug Evaluation, Preclinical, Pharmaceutical Science, Biology, Article, Leishmania, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, Mice, 0302 clinical medicine, lcsh:Organic chemistry, Species Specificity, Leishmania species, Drug Discovery, Multi species, medicine, leishmaniasis drug discovery, Animals, Humans, Physical and Theoretical Chemistry, Protriptyline, Leishmaniasis, 030304 developmental biology, 0303 health sciences, Drug discovery, Organic Chemistry, phenotypic screening, medicine.disease, biology.organism_classification, Phenotype, Small molecule, Biochemistry, Maprotiline, Chemistry (miscellaneous), Molecular Medicine, Leishmaniasis, Visceral

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40958fcafa258e8a1a7f3c6e4e965aa3
http://europepmc.org/articles/PMC7321149

Find this article in full text from ProQuest

3

Identification of Inhibitors to trypanosoma cruzi sirtuins based on compounds developed to human enzymes

المؤلفون: Nilmar Silvio Moretti, Laura M. Alcântara, Milena Botelho Pereira Soares, Sergio Schenkman, Rino Ragno, Carolina B. Moraes, Lucio H. Freitas-Junior, Nicola Mautone, Dante Rotili, Lorenzo Antonini, Manuela Sabatino, Antonello Mai, Caio Haddad Franco, Tanira Matutino Bastos

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 3659, p 3659 (2020)
Volume 21
Issue 10

مصطلحات موضوعية: 0301 basic medicine, deacetylation, sirtuins, Trypanosoma cruzi, sirtuin inhibitors, Pharmacology, 01 natural sciences, lcsh:Chemistry, lcsh:QH301-705.5, Spectroscopy, Phylogeny, media_common, chemistry.chemical_classification, biology, Group III Histone Deacetylases, Drug Synergism, General Medicine, Trypanocidal Agents, Recombinant Proteins, Computer Science Applications, Molecular Docking Simulation, Benznidazole, Nitroimidazoles, Sirtuin, medicine.drug, Chagas disease, Drug, media_common.quotation_subject, Catalysis, Article, Cell Line, Inorganic Chemistry, 03 medical and health sciences, Inhibitory Concentration 50, medicine, Animals, Chagas Disease, Physical and Theoretical Chemistry, Nifurtimox, Molecular Biology, 010405 organic chemistry, Organic Chemistry, Epithelial Cells, biology.organism_classification, medicine.disease, Macaca mulatta, 0104 chemical sciences, 030104 developmental biology, Enzyme, chemistry, lcsh:Biology (General), lcsh:QD1-999, biology.protein, NAD+ kinase

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be24b0eb23df1cb4b5d68310a7131e38
http://hdl.handle.net/11573/1401342

4

Aryl thiosemicarbazones for the treatment of trypanosomatidic infections

المؤلفون: Maria Kuzikov, Gesa Witt, Bruno dos Santos Pascoalino, Caio Haddad Franco, Luca Costantino, Rosaria Luciani, Laura M. Alcantara, Nuno Santarém, Sara Macedo, Antonio Quotadamo, Lucio H. Freitas-Junior, Bernhard Ellinger, Carolina B. Moraes, Stefania Ferrari, Maria Paola Costi, Sheraz Gul, Anabela Cordeiro-da-Silva, Pasquale Linciano

المساهمون: Publica

المصدر: European Journal of Medicinal Chemistry. 146:423-434

مصطلحات موضوعية: Thiosemicarbazones, 0301 basic medicine, Trypanosoma, Stereochemistry, hERG, Antiprotozoal Agents, Trypanosoma brucei, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Parasitic Sensitivity Tests, Thiadiazoles, Early-toxicity, Leishmania infantum, pan-anti-trypanosomatidic activity, Thiosemicarbazone, Trypanosoma cruzi, Pharmacology, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, parasitic diseases, Drug Discovery, medicine, Humans, Chagas Disease, Amastigote, Semicarbazone, Dose-Response Relationship, Drug, Molecular Structure, biology, Macrophages, General Medicine, biology.organism_classification, medicine.disease, 0104 chemical sciences, 3. Good health, 010404 medicinal & biomolecular chemistry, Mitochondrial toxicity, 030104 developmental biology, chemistry, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bebcff45eb81d168c200819955e00630
https://doi.org/10.1016/j.ejmech.2018.01.043

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5

Design, synthesis and antitrypanosomal activity of some nitrofurazone 1,2,4-triazolic bioisosteric analogues

المؤلفون: Caio Haddad Franco, Lucio H. Freitas-Junior, Denize C. Favaro, Fredson Torres Silva, Elizabeth Igne Ferreira, Carolina B. Moraes

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c52ca13b182cc48528df23eeb4f888
https://doi.org/10.1016/j.ejmech.2016.04.065

View record from ScienceDirect

6

Drug Discovery for Chagas Disease: Impact of Different Host Cell Lines on Assay Performance and Hit Compound Selection

المؤلفون: Lucio H. Freitas-Junior, Eric Chatelain, Carolina B. Moraes, Caio Haddad Franco, Laura M. Alcântara

المصدر: Tropical Medicine and Infectious Disease; Volume 4; Issue 2; Pages: 82
Tropical Medicine and Infectious Disease
Tropical Medicine and Infectious Disease, Vol 4, Iss 2, p 82 (2019)

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6a0e1644904b7564f4337743ad5a36

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Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity

المؤلفون: Lavínia Maria Dal'Mas Romera, Caio Haddad Franco, Ana Claudia Torrecilhas, Ho Y.A. Au, Carolina B. Moraes, Hai Le, Bruno dos Santos Pascoalino, Tapan Bhattacharyya, Miriam A. Giardini, Rafael Pedro Madeira, Sergio Schenkman, Lucio H. Freitas-Junior, Eric Chatelain, David C. Warhurst, Michael A. Miles

المصدر: International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 13, Iss, Pp 107-120 (2020)

مصطلحات موضوعية: 0301 basic medicine, Chagas disease, Trypanosoma cruzi, 030231 tropical medicine, Genes, Protozoan, Clone (cell biology), Drug resistance, CYP51, Biology, Ravuconazole, Article, Microbiology, lcsh:Infectious and parasitic diseases, Cell Line, 03 medical and health sciences, Sterol 14-Demethylase, 0302 clinical medicine, medicine, Animals, Pharmacology (medical), lcsh:RC109-216, Chagas Disease, Nifurtimox, Pharmacology, Triazoles, biology.organism_classification, medicine.disease, Trypanocidal Agents, Drug Resistance, Multiple, Multiple drug resistance, Thiazoles, 030104 developmental biology, Infectious Diseases, Benznidazole, 14-alpha Demethylase Inhibitors, Nitroimidazoles, Mutation, Parasitology, medicine.drug