المؤلفون: Bruna Pilan, Ana Claudia Latronico, Antonio Lerario, Anna Flavia Figueredo Benedetti, Victor Srougi, Luciano F. Drager, Leticia A P Vilela, Tatiana S Goldbaum, Luiz Aparecido Bortolotto, Berenice B. Mendonca, Marcela Rassi-Cruz, Maria Adelaide Albergaria Pereira, Fabio R. Faucz, Lucas Santos de Santana, Aline C B S Cavalcante, Fabio Y Tanno, Jose Luis Chambo, Andrea Gutierrez Maria, Maria Candida Barisson Villares Fragoso, Francisco Cesar Carnevale, Maria Claudia Nogueira Zerbini, Edra London, Madson Q. Almeida, Constantine A. Stratakis

المصدر: Endocr Relat Cancer

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Cancer Research, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Article, Germline, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Primary aldosteronism, Internal medicine, Hyperaldosteronism, medicine, Humans, Gene, Aged, Messenger RNA, business.industry, Phosphodiesterase, Transfection, Middle Aged, Hyperplasia, medicine.disease, Cyclic Nucleotide Phosphodiesterases, Type 2, Cyclic Nucleotide Phosphodiesterases, Type 3, 030104 developmental biology, medicine.anatomical_structure, Oncology, Zona glomerulosa, 030220 oncology & carcinogenesis, Female, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e5c3b64ea5d8c98d4e2f12830b6c5f
https://doi.org/10.1530/erc-20-0384

المؤلفون: Mark K. Crowder, Sheila Collins, Fubiao Shi, Sumita Mishra, Dianxin Liu, Ryan P. Ceddia, David A. Kass

المصدر: Diabetes. 70:2823-2836

مصطلحات موضوعية: Male, medicine.medical_specialty, Adipose Tissue, White, Endocrinology, Diabetes and Metabolism, Regulator, Mice, Obese, Diet, High-Fat, Mice, Adipose Tissue, Brown, In vivo, Internal medicine, Brown adipose tissue, Internal Medicine, medicine, Animals, Humans, Glucose homeostasis, Obesity, Receptor, Cells, Cultured, Mice, Knockout, Chemistry, Phosphodiesterase, Thermogenesis, medicine.disease, Up-Regulation, Mice, Inbred C57BL, medicine.anatomical_structure, Endocrinology, 3',5'-Cyclic-AMP Phosphodiesterases, Second messenger system, Steatosis, Energy Metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0efb58fac0e51d627e887b86f3f1026
https://doi.org/10.2337/db21-0100

المؤلفون: Pedro Everson Alexandre de Aquino, Rui Seabra Ferreira Junior, Aline Diogo Marinho, Helena Serra Azul Monteiro, Antônio Rafael Coelho Jorge, Ana Paula Negreiros Nunes Alves, Francisco Assis Nogueira Júnior, João Alison de Moraes Silveira, Roberta Jeane Bezerra Jorge

المساهمون: Federal University of Ceara, Universidade Estadual Paulista (UNESP)

المصدر: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP

مصطلحات موضوعية: Snake venom, animal structures, medicine.drug_mechanism_of_action, Sildenafil, Renal function, Pharmacology, Kidney, Toxicology, Sildenafil Citrate, Nephrotoxicity, chemistry.chemical_compound, medicine, Animals, Bothrops, Kidney perfusion, Rats, Wistar, Cyclic guanosine monophosphate, Cyclic Nucleotide Phosphodiesterases, Type 5, business.industry, Acute kidney injury, Phosphodiesterase 5 Inhibitors, medicine.disease, Malondialdehyde, Rats, medicine.anatomical_structure, chemistry, business, Phosphodiesterase 5 inhibitor, Snake Venoms

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd0f13fcb26b351191449d4f20a1783
https://doi.org/10.1016/j.toxicon.2021.08.024

المؤلفون: Qian Zhou, Xixin He, Yi-Jing Tian, Jiaqi Zhu, Jinhao Liang, Yue Huang, Ziran Zhu, Yi-You Huang, Jinhui Deng, Hai-Bin Luo, Xi Xie

المصدر: Journal of Medicinal Chemistry. 64:13736-13751

مصطلحات موضوعية: Male, Epithelial-Mesenchymal Transition, Nausea, Pharmacology, Heterocyclic Compounds, 4 or More Rings, Rats, Sprague-Dawley, Structure-Activity Relationship, Idiopathic pulmonary fibrosis, Dogs, Fibrosis, Oral administration, Drug Discovery, medicine, Animals, Humans, Lung, IC50, Roflumilast, Rolipram, Molecular Structure, Chemistry, Pirfenidone, medicine.disease, Idiopathic Pulmonary Fibrosis, Cyclic Nucleotide Phosphodiesterases, Type 4, A549 Cells, Molecular Medicine, Phosphodiesterase 4 Inhibitors, medicine.symptom, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97dab0b55195d8e8e88da2d44d2ced00
https://doi.org/10.1021/acs.jmedchem.1c01085

المؤلفون: Arjang Ruhparwar, Aiste-Monika Jakstaite, Peter Luedike, Maria Papathanasiou, Bastian Schmack, Nikolaus Pizanis, Alexander Weymann, Matthias Riebisch, Markus Kamler, Tienush Rassaf

المصدر: ESC Heart Failure, Vol 8, Iss 4, Pp 2419-2427 (2021)
ESC Heart Failure

مصطلحات موضوعية: Male, Gastrointestinal bleeding, medicine.medical_specialty, Sildenafil, Ventricular Dysfunction, Right, medicine.medical_treatment, Medizin, 030204 cardiovascular system & hematology, Tadalafil, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Original Research Articles, medicine, Clinical endpoint, Humans, Diseases of the circulatory (Cardiovascular) system, Cumulative incidence, Prospective Studies, Original Research Article, 030212 general & internal medicine, Prospective cohort study, Retrospective Studies, Cyclic Nucleotide Phosphodiesterases, Type 5, Heart Failure, business.industry, Incidence (epidemiology), Phosphodiesterase‐5 inhibitors, Middle Aged, Phosphodiesterase 5 Inhibitors, medicine.disease, Surgery, Editorial, chemistry, Ventricular assist device, Heart failure, RC666-701, Left ventricular assist devices, Heart-Assist Devices, Cardiology and Cardiovascular Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb29f696a03eb92191c49dbea1f17a8
https://doaj.org/article/0b84ac4f6974497584c2bd2465219e34

المؤلفون: Na Li, Yang Wang, Lei Ying, Jiantong Chen, Zhengju Chen, Yan Nan, Zhenlang Lin, Dezhong Wang, Zhiyi Jin, Xueqin Zeng

المصدر: Journal of Cellular and Molecular Medicine

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, coronary artery, Swine, PDE1, Nitric Oxide, Constriction, 03 medical and health sciences, 0302 clinical medicine, Tandem Mass Spectrometry, Internal medicine, medicine, Animals, Metabolomics, Hypoxia, Inosine, Cyclic GMP, neoplasms, Chromatography, High Pressure Liquid, Cyclic IMP, Cyclic Nucleotide Phosphodiesterases, Type 5, Chemistry, Phosphodiesterase, Original Articles, Cell Biology, hypoxic constriction, Phosphodiesterase 5 Inhibitors, inosine 3′,5′‐cyclic monophosphate, Cyclic Nucleotide Phosphodiesterases, Type 1, medicine.disease, Coronary Vessels, digestive system diseases, Coronary arteries, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Vasoconstriction, 030220 oncology & carcinogenesis, Coronary vasospasm, Molecular Medicine, Original Article, Endothelium, Vascular, medicine.symptom, phosphodiesterase, Artery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838078f6c82c0c2dc9675e2fc262e1ec
https://doi.org/10.1111/jcmm.16078

المؤلفون: Fumi Shimizu, Mitsugi Ookawara, Guido Hanauer, Kimio Tohyama, Masatoshi Hazama, Tomoya Sano, Yasunori Nio, Takanori Matsuo, Hisashi Anayama, Sachio Shibata, Midori Yamasaki

المصدر: The FASEB Journal. 34:14997-15014

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Angiotensin receptor, Tyramine, Cardiomegaly, Acetates, Sodium Chloride, urologic and male genital diseases, Biochemistry, Sildenafil Citrate, Diabetic nephropathy, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Irbesartan, Mineralocorticoids, Internal medicine, Genetics, medicine, Animals, Renal Insufficiency, Desoxycorticosterone, Molecular Biology, Cyclic Nucleotide Phosphodiesterases, Type 5, Mice, Knockout, Creatinine, Kidney, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Glomerulosclerosis, Phosphodiesterase 5 Inhibitors, medicine.disease, Cyclic Nucleotide Phosphodiesterases, Type 4, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, chemistry, Hyperglycemia, cGMP-specific phosphodiesterase type 5, Hypertension, Female, business, 030217 neurology & neurosurgery, Nephrosclerosis, Biotechnology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005f970e38618f971a9ead3d067aaa16
https://doi.org/10.1096/fj.202001084r

المؤلفون: David Hutchings, David A. Eisner, George W.P. Madders, Andrew W. Trafford, Katharine M. Dibb, Charles M. Pearman, Lori Woods

المصدر: Circulation Research
Hutchings, D, Pearman, C, Madders, G, Woods, L, Eisner, D, Dibb, K & Trafford, A 2021, ' PDE5 inhibition suppresses ventricular arrhythmias by reducing SR Ca2+ content ', Circulation research . https://doi.org/10.1161/CIRCRESAHA.121.318473

مصطلحات موضوعية: Physiology, Long QT syndrome, Carbazoles, chemistry.chemical_element, Dofetilide, sildenafil citrate, 030204 cardiovascular system & hematology, Calcium, Pharmacology, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, In vivo, Phenethylamines, medicine, Potassium Channel Blockers, Repolarization, Animals, Humans, Calcium Signaling, Protein Kinase Inhibitors, Original Research, Cyclic Nucleotide Phosphodiesterases, Type 5, Sulfonamides, Sheep, calcium, Endoplasmic reticulum, Sodium, Depolarization, Phosphodiesterase 5 Inhibitors, medicine.disease, Sarcoplasmic Reticulum, Long QT Syndrome, chemistry, cardiovascular system, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Female, Cardiology and Cardiovascular Medicine, cGMP-dependent protein kinase, Protein Kinases, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810e2998d6815c59de9628f6750c1691
http://europepmc.org/articles/PMC8409902

المؤلفون: Shimin Dong, Xinliang Zhang

المصدر: Bioscience, Biotechnology, and Biochemistry. 85:1962-1970

مصطلحات موضوعية: Lipopolysaccharides, Lipopolysaccharide, Regulator, Inflammation, Applied Microbiology and Biotechnology, Biochemistry, Cell Line, Analytical Chemistry, Sepsis, chemistry.chemical_compound, Circular RNA, medicine, Humans, Gene silencing, Viability assay, Molecular Biology, Cyclic Nucleotide Phosphodiesterases, Type 7, business.industry, Organic Chemistry, Computational Biology, RNA, Circular, General Medicine, medicine.disease, MicroRNAs, chemistry, Apoptosis, Gene Knockdown Techniques, Cancer research, lipids (amino acids, peptides, and proteins), medicine.symptom, business, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e421bd9021f2803065bb4320c3e322
https://doi.org/10.1093/bbb/zbab100

المؤلفون: Sean E. Sissons, Cody J. Buckman, Mary S. Zuniga, Shweta Urva, Karen Cox, Yanfei Ma, Stephen Ho, Diane Philips, Jean Lim, Dipak R. Patel, Daniel J. Dairaghi

المصدر: Clinical and Translational Science, Vol 14, Iss 3, Pp 1037-1048 (2021)
Clinical and Translational Science

مصطلحات موضوعية: Adult, Male, 030213 general clinical medicine, Drug Evaluation, Preclinical, Administration, Oral, RM1-950, Pharmacology, 030226 pharmacology & pharmacy, General Biochemistry, Genetics and Molecular Biology, Article, law.invention, 03 medical and health sciences, Mice, 0302 clinical medicine, Pharmacokinetics, law, Psoriasis, medicine, Animals, Humans, General Pharmacology, Toxicology and Pharmaceutics, Adverse effect, Enzyme Assays, Clinical pharmacology, Cross-Over Studies, business.industry, General Neuroscience, Research, General Medicine, Articles, Drugs, Investigational, Middle Aged, medicine.disease, Macaca mulatta, Healthy Volunteers, Cyclic Nucleotide Phosphodiesterases, Type 4, Thalidomide, Tolerability, Pharmacodynamics, Female, Apremilast, Phosphodiesterase 4 Inhibitors, Therapeutics. Pharmacology, Public aspects of medicine, RA1-1270, business, Ex vivo, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065a98f367138609cf7eaff098736997
https://doaj.org/article/26338cb3724a46be895644ae7734a730