المؤلفون: Ulla Kampmann, Janne R. Hingst, Niels Jessen, Jørgen F. P. Wojtaszewski, Mads Svart, Niels Møller, Thomas Schmidt Voss, Mikkel H. Vendelbo

المصدر: Voss, T S, Vendelbo, M, Opstrup, U K, Hingst, J R, Wojtaszewski, J F P, Svart, M, Møller, N & Jessen, N 2017, ' Acute Hypoglycemia in Healthy Humans Impairs Insulin Stimulated Glucose Uptake and Glycogen Synthase in Skeletal Muscle; a Randomized Clinical Study ', Diabetes, vol. 66, no. 9, pp. 2483-2494 . https://doi.org/10.2337/db16-1559

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Adolescent, endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Glucose uptake, Glycogen Synthase/genetics, Gene Expression Regulation, Enzymologic/drug effects, Hypoglycemia, medicine.disease_cause, Gene Expression Regulation, Enzymologic, Young Adult, 03 medical and health sciences, Glucose Transporter Type 4/genetics, Muscle, Skeletal/enzymology, Internal medicine, Internal Medicine, medicine, Insulin, Glucose/metabolism, Humans, Amino Acid Sequence, Phosphorylation, Muscle, Skeletal, Hyperinsulinemic hypoglycemia, Glycogen synthase, Glucose Transporter Type 4, Cross-Over Studies, biology, business.industry, Glucose transporter, nutritional and metabolic diseases, Skeletal muscle, Hypoglycemia/etiology, medicine.disease, Insulin/adverse effects, Insulin receptor, Glucose, Glycogen Synthase, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, biology.protein, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b27ddeca9d3fd63a619eb4e9fe63b84
https://doi.org/10.2337/db16-1559

المؤلفون: Camille Hallez, Cristina M. Dorobantu, Mohamed S Bouzidi, Valérie Thiers, Vincent Lucansky, Jean-Pierre Vartanian, Xiongxiong Li, Simon Wain-Hobson, Raphael Gaudin, Rodolphe Suspène

المساهمون: Rétrovirologie moléculaire - Molecular Retrovirology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Collège Doctoral, Sorbonne Université (SU), China National Biotec Group (CNBG), Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Viroclinics Biosciences B. V. [Rotterdam, Netherlands], Biomedical Center Martin [Slovaquie], Jessenius Medical Faculty [Commenius University, Slovaquie] (JFMED), Commenius University in Bratislava - Univerzita Komenského-Commenius University in Bratislava - Univerzita Komenského, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), This work was supported by grants from the Institut Pasteur and Centre National de la Recherche Scientifique. C.H. and M.S.B. were supported by the Allocation de Recherche du Ministère de la Recherche and Ligue contre le Cancer, respectively. X.L. was supported by a stipend from the Lanzhou Institute of Biological Products Co., Ltd, subsidiary company of China National Biotec Group Company Limited and by a stipend from the Pasteur-Paris University International PhD program. V.L. was supported by the Fondation pour la Recherche Medicale (project no. ING20160435328). C.D. was supported by an EMBO Long Term Fellowship (EMBO ALTF 1428–2016). The study of patients was sponsored by the French National Agency for research on AIDS and hepatitis (ANRS). This work has been published within the framework of IdEx Université de Strasbourg and has received funding from the French State via the French National Research Agency (ANR) as part of the program ‘Investissements d’avenir’ to R.G. This work was supported by an ATIP-AVENIR starting grant to R.G., We would like to thank S. Urban for providing HepG2-NTCP cells, P. Pineau and A. Marchio for the cirrhotic liver samples, M.-L. Michel and S. Pol for serum samples, C. Neuveut, P. Moreau, P. Maillard and B. Quioc for HBV infection, Y. Jacob for the HIF-1α and HIF-1β plasmids, J. Krijnse-Locker and C. Schmitt for electron microscopy immunolabelling and V. Caval, N. Frampton and J. McKeating for helpful discussions., Rétrovirologie moléculaire, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Collège doctoral [Sorbonne universités], Vartanian, Jean-Pierre, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)

المصدر: Nature Microbiology
Nature Microbiology, 2019, 4 (7), pp.1196-1207. ⟨10.1038/s41564-019-0405-x⟩
Nature Microbiology, Nature Publishing Group, 2019, 4 (7), pp.1196-1207. ⟨10.1038/s41564-019-0405-x⟩

مصطلحات موضوعية: Liver Cirrhosis, viruses, [SDV]Life Sciences [q-bio], MESH: Virus Replication*/drug effects, Gene Expression, medicine.disease_cause, Virus Replication, Applied Microbiology and Biotechnology, chemistry.chemical_compound, Hypoxia, ComputingMilieux_MISCELLANEOUS, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, 0303 health sciences, MESH: Liver Cirrhosis/enzymology, Cytidine, Transfection, Cobalt, Hepatitis B, MESH: Cobalt/pharmacology, MESH: Deoxyribonuclease I/metabolism, Hepatitis B Core Antigens, 3. Good health, [SDV] Life Sciences [q-bio], Capsid, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Hypoxia-Inducible Factor 1, MESH: Deoxyribonuclease I/genetics, Microbiology (medical), Hepatitis B virus, MESH: Mutation, MESH: Gene Expression, MESH: Hepatitis B/enzymology, MESH: Hypoxia-Inducible Factor 1/metabolism, Immunology, Biology, Microbiology, Gene Expression Regulation, Enzymologic, Cell Line, 03 medical and health sciences, Genetics, medicine, Deoxyribonuclease I, Humans, MESH: Gene Expression Regulation, Enzymologic/drug effects, 030304 developmental biology, MESH: Hypoxia*/chemically induced, MESH: Humans, 030306 microbiology, Virion, MESH: Virion/metabolism, MESH: Hepatitis B Core Antigens/metabolism, Cell Biology, medicine.disease, Molecular biology, In vitro, MESH: Cell Line, MESH: DNA, Viral/metabolism, chemistry, DNA, Viral, Mutation, DNA, MESH: Hepatitis B virus/physiology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5b9df1192a8473ace5d62d1f522f99
https://hal-pasteur.archives-ouvertes.fr/pasteur-02424852

المؤلفون: Susanna M.O. Hourani, Sapna Thakur, Catherine Ledent, Jian-Mei Li, Junjie Du

المصدر: The Journal of biological chemistry, 285 (51
The Journal of Biological Chemistry

مصطلحات موضوعية: Adenosine A2A receptor, Signal Transduction -- drug effects -- physiology, 030204 cardiovascular system & hematology, medicine.disease_cause, Biochemistry, p38 Mitogen-Activated Protein Kinases, Mice, 0302 clinical medicine, Adenosine deaminase, Enzyme Activation -- drug effects -- genetics, Endothelial dysfunction, Phosphorylation, Receptor, Cells, Cultured, chemistry.chemical_classification, Mice, Knockout, 0303 health sciences, Membrane Glycoproteins, Mitogen-Activated Protein Kinase 3, biology, Pyrimidines -- pharmacology, Angiotensin II, Cell Surface Receptor, Membrane Glycoproteins -- genetics -- metabolism, Mitogen-Activated Protein Kinase 3 -- genetics -- metabolism, Adenosine A2 Receptor Antagonists, p38 Mitogen-Activated Protein Kinases -- genetics -- metabolism, medicine.anatomical_structure, Phosphorylation -- drug effects -- genetics, NADPH Oxidase 2, cardiovascular system, MAP Kinases (MAPKs), hormones, hormone substitutes, and hormone antagonists, Signal Transduction, circulatory and respiratory physiology, Endothelium, Receptor, Adenosine A2A, Angiotensin II -- metabolism -- pharmacology, Adenosine A2 Receptor Antagonists -- pharmacology, Gene Expression Regulation, Enzymologic, Reactive Oxygen Species -- metabolism, Gene Knockout, 03 medical and health sciences, Nox2, medicine, Animals, Gene Expression Regulation, Enzymologic -- drug effects -- genetics, Molecular Biology, Proto-Oncogene Proteins c-akt -- genetics -- metabolism, 030304 developmental biology, Reactive oxygen species, Endothelial Cells, NADPH Oxidases, Cell Biology, Triazoles, medicine.disease, Molecular biology, Receptor, Adenosine A2A -- genetics -- metabolism, Sciences biomédicales, Enzyme Activation, Pyrimidines, chemistry, Reactive Oxygen Species (ROS), biology.protein, Triazoles -- pharmacology, Reactive Oxygen Species, Proto-Oncogene Proteins c-akt, NADPH Oxidase -- biosynthesis -- genetics -- metabolism, Oxidative stress, Endothelial Cells -- metabolism

وصف الملف: 1 full-text file(s): application/pdf; text

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7f2468fb8e9c9f71e6f0fc5a55bcee
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/124818