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المصدر: Case Reports in Oncology
Case Reports in Oncology, Vol 13, Iss 3, Pp 1091-1096 (2020)مصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, Cutaneous adnexal carcinoma, medicine.medical_treatment, Case Report, Next-generation sequencing test, medicine.disease_cause, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Everolimus, Chemotherapy, business.industry, Bone metastasis, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Chemotherapy regimen, 030104 developmental biology, 030220 oncology & carcinogenesis, Adenocarcinoma, KRAS, business, PI3KCA mutation, Adnexal Carcinoma, Rare disease, medicine.drug
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المؤلفون: Andrea Bertotti, Davide Ciardiello, Nunzia Matrone, Valentina Belli, Floriana Morgillo, Vincenzo De Falco, Erika Martinelli, Emilio Francesco Giunta, Fortunato Ciardiello, Livio Trusolino, Stefania Napolitano, Umberto Bracale, Giorgia Migliardi, Francesca Cottino, Teresa Troiani
المساهمون: Belli, V., Matrone, N., Napolitano, S., Migliardi, G., Cottino, F., Bertotti, A., Trusolino, L., Martinelli, E., Morgillo, F., Ciardiello, D., De Falco, V., Giunta, E. F., Bracale, U., Ciardiello, F., Troiani, T.
المصدر: Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Journal of Experimental & Clinical Cancer Research : CR
Journal of experimental & clinical cancer research (Online) 38 (2019). doi:10.1186/s13046-019-1230-z
info:cnr-pdr/source/autori:Belli V.; Matrone N.; Napolitano S.; Migliardi G.; Cottino F.; Bertotti A.; Trusolino L.; Martinelli E.; Morgillo F.; Ciardiello D.; De Falco V.; Giunta E.F.; Bracale U.; Ciardiello F.; Troiani T./titolo:Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models/doi:10.1186%2Fs13046-019-1230-z/rivista:Journal of experimental & clinical cancer research (Online)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:38مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Neuroblastoma RAS viral oncogene homolog, MAP Kinase Kinase Kinase, Cancer Research, Transcription Factor, Receptor, ErbB-2, Colorectal cancer, Colorectal Neoplasm, medicine.disease_cause, Antineoplastic Agent, Mice, 0302 clinical medicine, Epidermal growth factor receptor, skin and connective tissue diseases, Nuclear Protein, Cetuximab, biology, Nuclear Proteins, MAP Kinase Kinase Kinases, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, HER2-amplified cancer, MEK and PI3KCA inhibitors, xenografts, patient-derived xenografts, Oncology, 030220 oncology & carcinogenesis, Female, Pertuzumab, KRAS, Colorectal Neoplasms, Human, medicine.drug, patient-derived xenograft, Xenograft Model Antitumor Assay, MEK and PI3KCA inhibitor, Protein Kinase Inhibitor, Antineoplastic Agents, Lapatinib, lcsh:RC254-282, 03 medical and health sciences, Cell Line, Tumor, Biomarkers, Tumor, medicine, Animals, Humans, xenograft, Protein Kinase Inhibitors, neoplasms, Dose-Response Relationship, Drug, Animal, business.industry, Research, Gene Amplification, medicine.disease, Xenograft Model Antitumor Assays, Disease Models, Animal, 030104 developmental biology, Drug Resistance, Neoplasm, Cancer research, biology.protein, business, Transcription Factors
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المؤلفون: Giulia Hardoin, Julie Vasseur, Aldrick Ruiz, Marc-Antoine Allard, Jean-François Morère, Jocelyne Hamelin, Mylène Sebagh, Nelly Bosselut, René Adam, Antoinette Lemoine, Raphaël Saffroy
المساهمون: Department of Surgery [Utrecht, Pays-Bas], University Medical Center [Utrecht], Centre hépato-biliaire (CHB), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Pathologie [Villejuif], Hôpital Paul Brousse, Physiopathogenèse et Traitement des Maladies du Foie [Villejuif], Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département d'Oncogénétique [Villejuif], Université Paris-Sud - Paris 11 (UP11), Département de Cancérologie [Villejuif], The Netherlands Organization for Scientific Research (NOW). Grant number: 017.009.053., Physiopathogénèse et Traitement des Maladies du Foie, Hôpital Paul Brousse-Université Paris-Saclay, Bodescot, Myriam
المصدر: BMC Cancer
BMC Cancer, BioMed Central, 2019, 19 (1), pp.169. ⟨10.1186/s12885-019-5365-2⟩
BMC Cancer, Vol 19, Iss 1, Pp 1-7 (2019)مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Time Factors, medicine.medical_treatment, Metastases, medicine.disease_cause, Gastroenterology, 0302 clinical medicine, Circulating tumor cell, Surgical oncology, Recurrence, Prevalence, Medicine, Breast, Cancer, Aged, 80 and over, Mutation, Liver Neoplasms, Nuclear Proteins, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, Oncology, Liver, 030220 oncology & carcinogenesis, Biomarker (medicine), Female, France, Research Article, Adult, Reoperation, medicine.medical_specialty, Lineage (genetic), Evolution, Breast Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, lcsh:RC254-282, 03 medical and health sciences, Breast cancer, [SDV.CAN] Life Sciences [q-bio]/Cancer, Lineage, Internal medicine, Genetics, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Hepatectomy, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Aged, PI3KCA, business.industry, medicine.disease, 030104 developmental biology, business, Transcription Factors
وصف الملف: application/pdf
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المؤلفون: Mirian G. Cardoso, Ilda S. Kunii, Rosana Delcelo, Susan C. Lindsey, Flávia O. F. Valente, Magnus R. Dias-da-Silva, Fabrício P Nascimento, Cleber P. Camacho, Rui M. B. Maciel, Marina M. L. Kizys
المصدر: Repositório Institucional da UNIFESP
Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESPمصطلحات موضوعية: Male, Proto-Oncogene Proteins B-raf, 0301 basic medicine, Neuroblastoma RAS viral oncogene homolog, Cancer Research, endocrine system diseases, Biology, medicine.disease_cause, medullary thyroid cancer, Biochemistry, BRAF, Thyroid carcinoma, CDKN2A, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, Genetics, medicine, Humans, somatic mutation, Thyroid Neoplasms, HRAS, neoplasms, Molecular Biology, Cyclin-Dependent Kinase Inhibitor p16, PI3KCA, Base Sequence, Point mutation, Thyroid, Nuclear Proteins, Exons, Middle Aged, digestive system diseases, Carcinoma, Neuroendocrine, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Mutation, Cancer research, Molecular Medicine, Female, KRAS, RET, Carcinogenesis, Transcription Factors, RAS
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المؤلفون: Thomas Herold, Sabine Kasimir‑Bauer, Bahriye Aktas, Rainer Kimmig, Siegfried Hauch, Hans Christian Kolberg, Agnes Bankfalvi, S. Synoracki, Maren Bredemeier, Philippos Edimiris, Mitra Tewes
المصدر: Molecular Medicine Reports
مصطلحات موضوعية: 0301 basic medicine, CA15-3, Cancer Research, Medizin, Tumor M2-PK, medicine.disease_cause, Biochemistry, 0302 clinical medicine, Circulating tumor cell, biology, Nuclear Proteins, DNA, Neoplasm, Articles, Middle Aged, Neoplastic Cells, Circulating, Immunohistochemistry, Primary tumor, Isoenzymes, Survival Rate, Oncology, 030220 oncology & carcinogenesis, Neoplastic Stem Cells, Molecular Medicine, Female, phosphatidylinositol 3-kinase-AKT signaling pathway, phosphatase and tensin homolog loss, metastatic breast cancer, PI3KCA mutation, Signal Transduction, Adult, Epithelial-Mesenchymal Transition, CA 15-3, Breast Neoplasms, circulating tumor cells, Aldehyde Dehydrogenase 1 Family, 03 medical and health sciences, Biomarkers, Tumor, Genetics, medicine, Humans, PTEN, Molecular Biology, Aged, liquid biopsy, Akt/PKB signaling pathway, business.industry, Twist-Related Protein 1, PTEN Phosphohydrolase, Retinal Dehydrogenase, Sequence Analysis, DNA, medicine.disease, 030104 developmental biology, Mutation, Cancer research, biology.protein, Carcinogenesis, business, Proto-Oncogene Proteins c-akt, Transcription Factors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f9cdf9fd8264f12d5fc30015d12764
https://www.ncbi.nlm.nih.gov/pubmed/28358430 -
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المؤلفون: Eduardo Cortes Gomez, Sudha Ramaiah, Mitsuko Murakami, Eric Ciamporcero, Anna Woloszynska-Read, Song Liu, Swathi Ramakrishnan, Roberto Pili, Kiersten Marie Miles, Carl Morrison, Sean T. Glenn, Sreenivasulu Chintala, Lei Wei, Candace S. Johnson, Yuchen Sun, Jeffrey M. Conroy, May Elbanna, Jacob Conroy, Anand Anbarasu, Lu Liu, Kullappan Malathi, Qiang Hu, Jianmin Wang
المصدر: Oncotarget
مصطلحات موضوعية: 0301 basic medicine, Oncology, DNA Mutational Analysis, medicine.disease_cause, Mice, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, urothelial carcinoma, Phosphoinositide-3 Kinase Inhibitors, Mutation, TOR Serine-Threonine Kinases, Genomics, Immunohistochemistry, 3. Good health, Phenotype, 030220 oncology & carcinogenesis, medicine.drug, medicine.medical_specialty, patient-derived xenograft, Antineoplastic Agents, MLH1, 03 medical and health sciences, Internal medicine, Cell Line, Tumor, medicine, Animals, Humans, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cisplatin, PI3KCA, Bladder cancer, Roswell Park Cancer Institute, Whole Genome Sequencing, business.industry, Gene Expression Profiling, Cancer, Reproducibility of Results, medicine.disease, Xenograft Model Antitumor Assays, Disease Models, Animal, 030104 developmental biology, Urinary Bladder Neoplasms, Drug Resistance, Neoplasm, Immunology, Personalized medicine, business, Priority Research Paper
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70acb0b7ff994af563e7f6871148073c
https://pubmed.ncbi.nlm.nih.gov/27823983 -
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المؤلفون: Vincenzo Minotti, Renato Colella, Annamaria Siggillino, A. Flacco, Antonio Cavaliere, Fortunato Bianconi, Rita Chiari, Francesca Romana Tofanetti, Dario Giuffrida, Vienna Ludovini, Maria Grazia Mameli, Lucio Crinò, Elisa Baldelli, Daniela Iacono, Lorenza Pistola
المصدر: Journal of Thoracic Oncology. 6(4):707-715
مصطلحات موضوعية: Male, Lung Neoplasms, Survival, Gene mutation, NSCLC, medicine.disease_cause, Polymerase Chain Reaction, Phosphatidylinositol 3-Kinases, Carcinoma, Non-Small-Cell Lung, Epidermal growth factor receptor, EGFR inhibitors, Aged, 80 and over, Mutation, biology, DNA, Neoplasm, Middle Aged, Prognosis, Response to EGFR TKIs, ErbB Receptors, Survival Rate, Oncology, Carcinoma, Squamous Cell, Female, KRAS, Tyrosine kinase, Adult, Pulmonary and Respiratory Medicine, KRAS mutations, Class I Phosphatidylinositol 3-Kinases, EGFR, Adenocarcinoma, Proto-Oncogene Proteins p21(ras), Proto-Oncogene Proteins, medicine, Humans, PTEN, Protein Kinase Inhibitors, neoplasms, Protein kinase B, Aged, Retrospective Studies, PI3KCA, business.industry, PTEN Phosphohydrolase, Adenocarcinoma, Bronchiolo-Alveolar, respiratory tract diseases, Drug Resistance, Neoplasm, ras Proteins, biology.protein, Cancer research, Carcinoma, Large Cell, business, Follow-Up Studies
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المؤلفون: ALEX MARTINEZ-MARTI, Judith Balmaña, ENRIQUETA FELIP
المصدر: Frontiers in Oncology, Vol 1 (2012)
Frontiers in Oncologyمصطلحات موضوعية: Cancer Research, gene amplification, Mini Review, p110α, P110α, Biology, exon 9, medicine.disease_cause, NSCLC, lcsh:RC254-282, chemistry.chemical_compound, Germline mutation, copy number, medicine, exon 20, Phosphatidylinositol, PI3K/AKT/mTOR pathway, Genetics, PI3KCA, Mutation, Cell growth, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, mutations, chemistry, Oncology, Cancer research, Signal transduction, Intracellular
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef5bdce28b5b6c1b6a972dc0004a4bd
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المؤلفون: Francesco Perrone, M. Di Bartolomeo, Andrea Lampis, Milo Frattini, Marco A. Pierotti, Salvatore Andreola, Marta Orsenigo, C Riva, Arpine Gevorgyan, Marco Losa, Lucio Bertario, Emilio Bajetta, Silvana Pilotti, Ermanno Leo
المساهمون: Perrone, F., Lampis, A., Orsenigo, M., Di Bartolomeo, M., Gevorgyan, A., Losa, M., Frattini, M., Riva, C., Andreola, S., Bajetta, E., Bertario, L., Leo, E., Pierotti, M. A., Pilotti, Silvana
مصطلحات موضوعية: Male, PTEN, Colorectal cancer, Transcription Factor, DNA Mutational Analysis, Cetuximab, Colorectal Neoplasm, medicine.disease_cause, Antineoplastic Agent, Epidermal growth factor receptor, Neoplasm Metastasis, Nuclear Protein, biology, Metastatic colorectal cancer, Nuclear Proteins, Antibodies, Monoclonal, Hematology, Middle Aged, Gene Expression Regulation, Neoplastic, Neoplasm Metastasi, Oncology, Female, KRAS, Colorectal Neoplasms, medicine.drug, Human, Signal Transduction, Adult, Tumor suppressor gene, Antineoplastic Agents, Antibodies, Monoclonal, Humanized, Disease-Free Survival, DNA Mutational Analysi, medicine, Humans, neoplasms, PI3K/AKT/mTOR pathway, Aged, PI3KCA, business.industry, PTEN Phosphohydrolase, Cancer, Genes, erbB-1, medicine.disease, Genes, ra, digestive system diseases, Genes, ras, Drug Resistance, Neoplasm, Mutation, Cancer research, biology.protein, business, Transcription Factors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eccfbace46e81a9555c947a4b38bb650
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