المؤلفون: Zhuang Miao, Kaifei Han, Desu Luo, Mingxing Liu, Lei Li, Peilai Liu, Qunshan Lu, Xiangshuai Zhang, Songlin Li, Wenwei Qian, Yang Yu

المصدر: International Orthopaedics. 46:823-829

مصطلحات موضوعية: medicine.medical_specialty, Tourniquet, business.industry, Visual analogue scale, equipment and supplies, law.invention, body regions, surgical procedures, operative, High tibial osteotomy, Randomized controlled trial, Blood loss, law, Anesthesia, Orthopedic surgery, Medicine, Orthopedics and Sports Medicine, Surgery, business, Prospective cohort study, Tranexamic acid, medicine.drug

الوصف: Purpose Tourniquets are routinely used in high tibial osteotomy (HTO). However, research on the necessity of tourniquets during HTO is lacking. This study was designed to investigate the necessity of tourniquets in HTO. Methods This was a prospective study that included patients who underwent HTO at the same hospital. The patients were randomised into Group A (non-tourniquet, n = 45) and Group B (tourniquet, n = 45). Same surgical techniques and haemostatic methods were used in the two groups. Results All patients were followed up for more than three months. There was no difference in operation time, and no intra-operative vascular or nerve damage occurred in either group. The hospital stay was shorter in group A than in group B (p 0.05). The post-operative visual analogue scale (VAS) pain scores and calf swelling were lower in group A (p 0.05). Conclusion Tourniquet use during HTO does not reduce post-operative blood loss, operation time or intra-operative complications, but not using a tourniquet shortens the hospital stay and reduces the post-operative usage of morphine and tourniquet-related complications, which promotes early recovery of knee function.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f818de187f4ce99d7a962f9e1cdc4283
https://doi.org/10.1007/s00264-021-05246-4

المؤلفون: Zhuang Miao, Qunshan Lu, Xingzhi Guo, Songlin Li, Peilai Liu, Meng Zhang, Desu Luo

المصدر: Orthopaedic Surgery, Vol 12, Iss 2, Pp 515-523 (2020)
Orthopaedic Surgery

مصطلحات موضوعية: Male, Tranexamic acid, Blood transfusion, Administration, Topical, medicine.medical_treatment, Osteoarthritis, Postoperative Hemorrhage, Disability Evaluation, 03 medical and health sciences, 0302 clinical medicine, High tibial osteotomy, lcsh:Orthopedic surgery, medicine, Humans, Orthopedics and Sports Medicine, Saline, Aged, Pain Measurement, Retrospective Studies, Prothrombin time, 030222 orthopedics, Tourniquet, Clinical Article, Tibia, medicine.diagnostic_test, business.industry, Blood loss, Middle Aged, Osteoarthritis, Knee, medicine.disease, Antifibrinolytic Agents, Osteotomy, lcsh:RD701-811, Case-Control Studies, Anesthesia, Clinical Articles, Administration, Intravenous, Female, Surgery, Knee osteoarthritis, business, 030217 neurology & neurosurgery, Partial thromboplastin time, medicine.drug

الوصف: Objective To investigate whether intravenous combined with topical administration of tranexamic acid (TXA) is superior to intravenous administration alone in terms of blood loss, incision complications, functional recovery, and pain relief in high tibial osteotomy (HTO). Methods Clinical data of patients with knee osteoarthritis (OA) treated with unilateral HTO were retrospectively reviewed. The patients were grouped according to the TXA administration method, with 24 patients in the combined group and 21 in the solo group. In the combined group, 100 mL saline containing 1 g TXA was intravenously administered before application of a tourniquet, and 20 mL saline containing 2 g TXA was injected through a drainage tube after closure of the incision. Alternatively, 100 mL of saline containing 1 g TXA was intravenously administered before application of a tourniquet in the solo group. The blood loss and adverse events were compared between the two groups. Results All patients were followed for more than half a year. The drainage volume on the first day and total blood loss on the second day after surgery in the combined and single treatment groups were 130.06 ± 29.22 and 165.35 ± 43.08 mL (P

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d54ad6711b04539d969ff09845fa5e2
https://doaj.org/article/793842820596475f951d0ae6dbc1a6d2

المؤلفون: Qunshan Lu, Christiaan Watson, Jianling Yang, Zhuang Miao, Peilai Liu, Songlin Li, Meng Zhang, Desu Luo

المصدر: International Orthopaedics. 44:1037-1043

مصطلحات موضوعية: Male, medicine.medical_specialty, Knee Joint, Visual analogue scale, Blood Loss, Surgical, Postoperative Hemorrhage, Group B, law.invention, 03 medical and health sciences, 0302 clinical medicine, High tibial osteotomy, Randomized controlled trial, law, medicine, Humans, Orthopedics and Sports Medicine, Postoperative Period, Prospective Studies, Range of Motion, Articular, Drainage, 030203 arthritis & rheumatology, Pain, Postoperative, 030222 orthopedics, Tibia, business.industry, Incidence (epidemiology), Recovery of Function, Middle Aged, Osteotomy, Surgery, Treatment Outcome, Orthopedic surgery, Female, business, Tranexamic acid, medicine.drug

الوصف: Drainage is a common procedure in high tibial osteotomy (HTO), but the benefits of drainage during HTO remain poorly investigated. This study was designed to investigate the effect of drainage on blood loss and early functional recovery in HTO.Altogether, 80 patients undergoing HTO were analyzed from August 2018 to September 2019. Patients were randomized into two groups: group A (drainage, n = 40) and group B (no drainage, n = 40). There were no intergroup differences in baseline parameters between the two groups, and the same surgical techniques and haemostatic methods were used. The mean follow-up time was 3.2 months. Blood loss and early functional recovery of the knee were examined post-operatively in both groups.The total post-operative blood loss was 253.34 ± 104.18 ml in group A and 222.51 ± 106.89 ml in group B. This difference was non-significant (p 0.05). The post-operative haemoglobin and haematocrit differences between groups were also non-significant (p 0.05). Post-operative visual analogue scale (VAS) pain scores and lower leg swelling were lower in group A than those in group B (p 0.05), and the early range of motion of the knee joint was higher in group A than that in group B (p 0.05). Group A had lower incidence rates of dressing seepage and incision complications than group B (p 0.05). The differences in three month post-operative VAS and knee function scores were non-significant (p 0.05).Drainage in HTO does not increase patients' total blood loss, but it can promote early knee function recovery by reducing post-operative pain, lower leg swelling, and the incidence of incision complications.NCT-03954860.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990ca4fd61130ad2b831dc6a80da40cc
https://doi.org/10.1007/s00264-020-04530-z

المؤلفون: Qunshan Lu, Xianbo Peng, Zhiyuan Lou, Wei Guo, Tingting Ren, Yifeng Sun, Guangjun Jiao, Xinchang Lu, Shuai Zhang

المصدر: The Journal of international medical research. 41(5)

مصطلحات موضوعية: MAPK/ERK pathway, Time Factors, p38 mitogen-activated protein kinases, Antineoplastic Agents, Apoptosis, Biochemistry, Osteocytes, p38 Mitogen-Activated Protein Kinases, Bortezomib, Annexin, Cell Line, Tumor, Autophagy, Medicine, Humans, Protein kinase A, Cell Proliferation, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, biology, Dose-Response Relationship, Drug, business.industry, Kinase, Biochemistry (medical), Cell Cycle, JNK Mitogen-Activated Protein Kinases, Cell Biology, General Medicine, Boronic Acids, Cell biology, Gene Expression Regulation, Neoplastic, Mitogen-activated protein kinase, Pyrazines, Cancer research, biology.protein, business, medicine.drug, Signal Transduction

الوصف: Objective To investigate the effects of bortezomib on human osteosarcoma cells from the HOS cell line, and the underlying associated mechanisms. Methods Viability of HOS cells treated with bortezomib (5–20 nM) for different time periods was measured and changes in the cell cycle were assessed. Apoptosis and autophagy in HOS cells treated with bortezomib were analysed using annexin V-fluorescein isothiocyanate assay, transmission electron microscopy and Western blotting. Surges in mitogen-activated protein kinase (MAPK) pathways including MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK1/2), ERK1/2, c-Jun N-terminal kinase (JNK) and p38 MAPK were analysed using Western blotting. Results Bortezomib induced growth inhibition in a time- and dose-dependent manner, and autophagy and apoptosis in a dose-dependent manner, in HOS cells. HOS cell autophagy and apoptosis in response to bortezomib, corresponded with changing levels of intracellular MAPK signalling molecules. Conclusions This study provided new insights into the mechanisms underlying bortezomib-induced apoptosis in human osteosarcoma HOS cells, and suggests that bortezomib could be a potent chemotherapeutic agent in the treatment of osteosarcoma.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76f0181c29ac51adc95f1f0857e67b4
https://pubmed.ncbi.nlm.nih.gov/23975859