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المؤلفون: Pauline Chabosseau, Guy A. Rutter, Qifeng Zhang, Matthew C. Cane, Elizabeth Haythorne, Marie-Sophie Nguyen-Tu, Timothy J. Pullen, Aida Martinez-Sanchez, Sophie Sayers
المساهمون: The Royal Society, Medical Research Council (MRC), Wellcome Trust
المصدر: Martinez-Sanchez, A, Pullen, T J, Chabosseau, P, Zhang, Q, Haythorne, E, Cane, M C, Nguyen-Tu, M-S, Sayers, S R & Rutter, G A 2016, ' Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion ', Diabetes, vol. 65, no. 5, pp. 1268-82 . https://doi.org/10.2337/db15-1240
مصطلحات موضوعية: 0301 basic medicine, Male, Palmitoyl-CoA Hydrolase/genetics, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Fatty Acids, Nonesterified, Tissue Culture Techniques, Insulin-Secreting Cells/cytology, Insulin-Secreting Cells, Insulin Secretion, Insulin, Glucose/metabolism, Recombinant Proteins/metabolism, Sex Characteristics, Recombinant Proteins, Insulin oscillation, Up-Regulation, Islets of Langerhans/cytology, Palmitoyl-CoA Hydrolase, Organ Specificity, Fatty Acids, Nonesterified/metabolism, Female, Genetically modified mouse, medicine.medical_specialty, Down-Regulation, Mice, Transgenic, Carbohydrate metabolism, Biology, Article, Exocytosis, Gene Expression Regulation, Enzymologic, Glucose Intolerance/enzymology, Islets of Langerhans, 03 medical and health sciences, Downregulation and upregulation, Lipid biosynthesis, Internal medicine, Cell Line, Tumor, Glucose Intolerance, Internal Medicine, medicine, Animals, Secretion, Calcium Signaling, Insulin/secretion, Clone Cells, Rats, Mice, Inbred C57BL, Glucose, 030104 developmental biology, Endocrinology
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068b681fc8d623188e02db3bf12752c7
https://kclpure.kcl.ac.uk/en/publications/0740fa8c-8032-4d75-8dad-7e7af64dde80 -
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المؤلفون: Philippe A. Halban, Tetsuro Izumi, Shengli Zhao, Jie Wang, Toshiyuki Takeuchi, Hiromi Yokota-Hashimoto
المصدر: Diabetes, Vol. 52, No 2 (2003) pp. 409-416
مصطلحات موضوعية: Protein Denaturation, Protein Folding, endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Mutant, Prohormone, Golgi Apparatus, Endoplasmic Reticulum, Mice, Cricetinae, Multienzyme Complexes/metabolism, Cysteine Endopeptidases/metabolism, Endoplasmic Reticulum/metabolism, Genes, Dominant, Proinsulin, ddc:616, Recombinant Proteins/metabolism, Golgi Apparatus/metabolism, Diabetes Mellitus, Type 1/ genetics/pathology, Protease Inhibitors/pharmacology, Recombinant Proteins, Cell biology, Cysteine Endopeptidases, Protein Transport, symbols, hormones, hormone substitutes, and hormone antagonists, medicine.drug, Heterozygote, Proteasome Endopeptidase Complex, endocrine system, medicine.medical_specialty, CHO Cells, Biology, Transfection, Islets of Langerhans, symbols.namesake, Proinsulin/ genetics/metabolism/secretion, Multienzyme Complexes, Internal medicine, Organelle, Internal Medicine, medicine, Animals, Protease Inhibitors, Cysteine, Secretory pathway, DNA Primers, Base Sequence, Endoplasmic reticulum, Insulin, Golgi apparatus, Mice, Mutant Strains, Diabetes Mellitus, Type 1, Endocrinology, Amino Acid Substitution, Mutagenesis, Site-Directed, Islets of Langerhans/pathology/ physiology/ultrastructure
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المؤلفون: C.H. Lobo, A.D. Sales, R.M.P. Rocha, M. B. Wheeler, Johan Smitz, A.C.A. Ferreira, Laritza Ferreira de Lima, N. A. Ribeiro de Sá, José Ricardo de Figueiredo, G.M. Silva, H.H.V. Correia, Cláudio Cabral Campello, I.R. Brito
المساهمون: Follicle Biology
المصدر: Reproduction, Fertility and Development. 29:1144
مصطلحات موضوعية: Anti-Mullerian Hormone, 0301 basic medicine, endocrine system diseases, Oogenesis/drug effects, Reproductive technology, Oogenesis, Cell Proliferation/drug effects, Tissue Culture Techniques, Follicle-stimulating hormone, Endocrinology, Ovarian Follicle, Follicular phase, Testosterone, Progesterone, Cell Size/drug effects, Recombinant Proteins/metabolism, Estradiol, Goats, Gene Expression Regulation, Developmental, Anti-Müllerian hormone, Recombinant Proteins, female genital diseases and pregnancy complications, medicine.anatomical_structure, Hormone receptor, Receptors, Transforming Growth Factor beta/agonists, Testosterone/metabolism, Receptors, FSH, Female, Progesterone/metabolism, Folliculogenesis, Abattoirs, Brazil, hormones, hormone substitutes, and hormone antagonists, Cell Survival/drug effects, Biotechnology, endocrine system, medicine.medical_specialty, Anti-Mullerian Hormone/genetics, Estradiol/metabolism, Ovarian Follicle/cytology, Receptors, Peptide, Cell Survival, Biology, 03 medical and health sciences, Internal medicine, Genetics, medicine, Animals, Humans, Ovarian follicle, Molecular Biology, Crosses, Genetic, Cell Proliferation, Cell Size, Gene Expression Regulation, Developmental/drug effects, urogenital system, Follicle Stimulating Hormone/genetics, Receptors, FSH/agonists, 030104 developmental biology, Reproductive Medicine, biology.protein, Cattle, Animal Science and Zoology, Follicle Stimulating Hormone, Receptors, Transforming Growth Factor beta, Receptors, Peptide/agonists, Developmental Biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a0269548ce1f7265875aea026c904a1
https://doi.org/10.1071/rd15290 -
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المؤلفون: Domenico Bosco, Carmen Gonelle-Gispert, Dominique G. Rouiller, Claes B. Wollheim, Philippe A. Halban
المصدر: Diabetes, Vol. 50, No 5 (2001) pp. 1039-1046
مصطلحات موضوعية: Calcium Channel Blockers/pharmacology, Male, Botulinum Toxins, Time Factors, Endocrinology, Diabetes and Metabolism, Botulinum Toxins/metabolism, Cell Degranulation, Calcium in biology, Potassium Chloride, Rats, Sprague-Dawley, chemistry.chemical_compound, Cell Movement, Calcium Channels, L-Type/drug effects/physiology, Potassium Chloride/pharmacology, Diphosphonates/pharmacology, Insulin Secretion, Insulin, Enzyme Inhibitors, Cell Degranulation/drug effects, Cells, Cultured, Cell Size/drug effects, ddc:616, Enzyme Inhibitors/pharmacology, Recombinant Proteins/metabolism, geography.geographical_feature_category, Diphosphonates, Tetradecanoylphorbol Acetate/pharmacology, Calcium Channel Blockers, Islet, Glucose/pharmacology, Calcium/ physiology, Recombinant Proteins, Extracellular Matrix, Cell biology, Tetradecanoylphorbol Acetate, Thapsigargin, Glucagon/pharmacology, Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors, Cell Adhesion/drug effects/physiology, Insulin/ secretion, Intracellular, Signal Transduction, medicine.drug, medicine.medical_specialty, Calcium Channels, L-Type, Islets of Langerhans/cytology/drug effects/ physiology, chemistry.chemical_element, Biology, Calcium, Transfection, Exocytosis, Islets of Langerhans, Cell Movement/drug effects/physiology, Internal medicine, Cell Adhesion, Internal Medicine, Diazoxide, medicine, Animals, Thapsigargin/pharmacology, Cell Size, Extracellular Matrix/ physiology, geography, Signal Transduction/physiology, Endoplasmic reticulum, Diazoxide/pharmacology, Glucagon, Cyclic AMP-Dependent Protein Kinases, Rats, Kinetics, Glucose, Endocrinology, chemistry
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المؤلفون: Matthias Kamber, Pierre-Edouard Sottas, Séverine Lamon, Patrice Mangin, Hugues Henry, Neil Robinson, Martial Saugy
المصدر: Clinica Chimica Acta, Vol. 385, No 1-2 (2007) pp. 61-6
مصطلحات موضوعية: Male, medicine.medical_specialty, Clinical Biochemistry, Physiology, Urine, Trypsin/metabolism, Biochemistry, medicine, Albuminuria, Humans, Trypsin, Recombinant erythropoietin, Practical implications, Erythropoietin, Recombinant Proteins/metabolism, Adulterant, Sex Characteristics, Urine specific gravity, business.industry, ddc:614.1, Biochemistry (medical), Albumin, General Medicine, Recombinant Proteins, Surgery, Urine/chemistry, Female, Erythropoietin/classification/urine, medicine.symptom, Isoelectric Focusing, business, Urine collection
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المؤلفون: Martyn J. James, Pascal Schneider, Johanna Laurikkala, Risto Jaatinen, Marja Pummila, Marja L. Mikkola, Ingrid Fliniaux, Irma Thesleff
المصدر: Development, vol. 134, no. 1, pp. 117-125
مصطلحات موضوعية: Male, Follistatin, medicine.medical_treatment, Organogenesis, Bone Morphogenetic Protein 4, Mice, 0302 clinical medicine, Sonic hedgehog, Animals, Bone Morphogenetic Proteins/antagonists & inhibitors, Connective Tissue Growth Factor, Crosses, Genetic, Ectoderm/metabolism, Ectodysplasins/genetics, Ectodysplasins/metabolism, Edar Receptor/metabolism, Embryo, Mammalian/cytology, Embryo, Mammalian/embryology, Female, Follistatin/metabolism, Gene Expression Regulation, Developmental, Hedgehog Proteins/genetics, Hedgehog Proteins/metabolism, Immediate-Early Proteins/metabolism, In Situ Hybridization, Intercellular Signaling Peptides and Proteins/metabolism, Mice, Inbred Strains, Mice, Knockout, Organ Culture Techniques, Recombinant Proteins/metabolism, Reverse Transcriptase Polymerase Chain Reaction, 0303 health sciences, biology, integumentary system, Edar Receptor, Ectodysplasins, Recombinant Proteins, Cell biology, embryonic structures, Bone Morphogenetic Proteins, Intercellular Signaling Peptides and Proteins, medicine.medical_specialty, animal structures, Bone morphogenetic protein, Immediate-Early Proteins, 03 medical and health sciences, Internal medicine, Ectoderm, medicine, Hedgehog Proteins, Noggin, Molecular Biology, Transcription factor, 030304 developmental biology, Growth factor, Embryo, Mammalian, CTGF, Endocrinology, biology.protein, 030217 neurology & neurosurgery, Developmental Biology
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b6ffb14840abdee5d2acc1c3fdb08c
https://pubmed.ncbi.nlm.nih.gov/17164417 -
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المؤلفون: Adriano Fontana, Marc Y. Donath, Christian Toso, Philippe A. Halban, Pavel Sergeev, Giatgen A. Spinas, Jose Oberholzer, Felix Bachmann, Kathrin Maedler, Andrea Tasinato, Roger Lehmann, Frédéric Ris
المصدر: Proceedings of the National Academy of Sciences, Vol. 99, No 12 (2002) pp. 8236-8241
مصطلحات موضوعية: Cell, CASP8 and FADD-Like Apoptosis Regulating Protein, 0302 clinical medicine, Diabetes Mellitus, Type 2/ physiopathology, Transforming Growth Factor beta, Glucose/ pharmacology, Carrier Proteins/ metabolism, Cells, Cultured, ddc:616, Recombinant Proteins/metabolism, Aged, 80 and over, 0303 health sciences, Multidisciplinary, biology, Intracellular Signaling Peptides and Proteins, Cell cycle, Middle Aged, Biological Sciences, Fas receptor, Caspase Inhibitors, Recombinant Proteins, Cell biology, medicine.anatomical_structure, Caspases/antagonists & inhibitors, Cell Division/ physiology, Signal transduction, Transforming Growth Factor beta/pharmacology, Cell Division, Signal Transduction, medicine.medical_specialty, Islets of Langerhans/cytology/drug effects/ physiology, 030209 endocrinology & metabolism, Transfection, 03 medical and health sciences, Islets of Langerhans, Internal medicine, medicine, Humans, fas Receptor, 030304 developmental biology, Aged, Cell growth, Antigens, CD95/ physiology, Transforming growth factor beta, Endocrinology, Glucose, Diabetes Mellitus, Type 2, Apoptosis, Flip, Liposomes, biology.protein, Carrier Proteins
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2088228eecbe17e09e677b60b4705b2b
https://pubmed.ncbi.nlm.nih.gov/12060768 -
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المؤلفون: Jean-Louis Carpentier, P De Meyts, M. Cordier-Bussat, R. Emkey, C R Kahn, Isabelle Hamer, J. Philippe, Michelangelo Foti, Christine Maeder
المصدر: Diabetologia, Vol. 45, No 5 (2002) pp. 657-667
مصطلحات موضوعية: Male, Arginine, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Insulin Resistance/genetics, Insulin/genetics/metabolism/physiology, Insulin receptor substrate, Cricetinae, Insulin, Acanthosis Nigricans, Phosphorylation, Receptor, Acanthosis nigricans, ddc:616, Recombinant Proteins/metabolism, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, biology, Thymidine/metabolism, Recombinant Proteins, Protein Transport, Signal transduction, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinases/metabolism, Signal Transduction, Adult, medicine.medical_specialty, Insulin/metabolism, DNA/biosynthesis, CHO Cells, Transfection, Insulin resistance, Mitogen-Activated Protein Kinase 1/metabolism, Internal medicine, Internal Medicine, medicine, Animals, Humans, Cysteine, ddc:612, Signal Transduction/physiology, DNA, Acanthosis Nigricans/genetics, medicine.disease, Receptor, Insulin, Insulin receptor, Protein Subunits, Endocrinology, Amino Acid Substitution, Mutation, biology.protein, Insulin Resistance, Thymidine
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المصدر: Journal of Biological Chemistry, Vol. 276, No 39 (2001) pp. 36391-6
مصطلحات موضوعية: Cytosol/metabolism, Time Factors, Adenosine Triphosphate/metabolism, medicine.medical_treatment, Glutamate decarboxylase, Biochemistry, Membrane Potentials, 0302 clinical medicine, Adenosine Triphosphate, Cytosol, Glutamates, Transduction, Genetic, Insulin Secretion, Tumor Cells, Cultured, Glucose/metabolism, Insulin, Isoenzymes/metabolism, Cells, Cultured, Islets of Langerhans/cytology/metabolism, ddc:616, Recombinant Proteins/metabolism, 0303 health sciences, Glutamate Decarboxylase, Glutamates/metabolism, Glutamate receptor, Recombinant Proteins, 3. Good health, Insulin oscillation, Mitochondria, Isoenzymes, medicine.anatomical_structure, Insulin/metabolism/secretion, Glutamate dehydrogenase 1, Glutamic Acid/metabolism, Beta cell, Protein Binding, medicine.medical_specialty, Calcium/metabolism, Immunoblotting, Glutamic Acid, 030209 endocrinology & metabolism, Biology, Exocytosis, Adenoviridae, 03 medical and health sciences, Islets of Langerhans, Internal medicine, Mitochondria/metabolism, medicine, Animals, Humans, Adenoviridae/genetics, ddc:612, Molecular Biology, 030304 developmental biology, Pancreatic islets, Cell Biology, Metabolism, Glutamate Decarboxylase/metabolism, Rats, Endocrinology, Glucose, Microscopy, Fluorescence, biology.protein, Calcium
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf27507092b3e7205889a9a0ae74521f
https://pubmed.ncbi.nlm.nih.gov/11473118 -
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المؤلفون: Sarah Ferber, C. Ronald Kahn, David J Gross, Katharina Meyer, Frank Danehy, Philippe A. Halban, Mary R. Loeken, F. Vollenweider, Lydia Villa-Komaroff
المصدر: Molecular Endocrinology, Vol. 5, No 3 (1991) pp. 319-326
Scopus-Elsevierمصطلحات موضوعية: medicine.medical_specialty, endocrine system, Drug Resistance, Microbial/genetics, Pituitary Gland, Anterior/drug effects/ secretion, medicine.medical_treatment, Transgene, Mutant, Molecular Sequence Data, Gene Expression, Biology, Transfection, Gene dosage, Insulin/ analogs & derivatives/biosynthesis/genetics/ secretion, Mice, Endocrinology, Pituitary Gland, Anterior, Internal medicine, Gene expression, Insulin Secretion, medicine, Insulin, Animals, ddc:576.5, RNA, Messenger, Molecular Biology, Insulinoma, Cells, Cultured, Chromatography, High Pressure Liquid, Proinsulin, Recombinant Proteins/metabolism, Base Sequence, fungi, Drug Resistance, Microbial, Neomycin, General Medicine, RNA, Messenger/chemistry/metabolism, medicine.disease, Neomycin/pharmacology, Recombinant Proteins, Rats, Mutation, Plasmids
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424f148d825d95135739407c12bc021e
https://archive-ouverte.unige.ch/unige:9172
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