المؤلفون: Ming Yan, Lu-Xia Wang, Ya-Juan Cheng, Jie Liang, Hua-Ju Liang, Niu-Niu Zhang, Bao-Qin Huang

المصدر: Archiv der Pharmazie. 353:1900294

مصطلحات موضوعية: Staphylococcus aureus, Gram-positive bacteria, Pharmaceutical Science, Microbial Sensitivity Tests, medicine.disease_cause, 01 natural sciences, Enterococcus faecalis, Bacterial cell structure, Microbiology, Structure-Activity Relationship, Minimum inhibitory concentration, Staphylococcus epidermidis, Drug Discovery, medicine, Molecular Structure, biology, 010405 organic chemistry, Chemistry, biology.organism_classification, Anti-Bacterial Agents, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Carbamates, Drug Screening Assays, Antitumor, Antibacterial activity, Bacteria

الوصف: A series of (3-benzyl-5-hydroxyphenyl)carbamates were evaluated as new antibacterial agents. Several compounds showed potent inhibitory activity against sensitive and drug-resistant Gram-positive bacteria. The compounds are ineffective against all tested Gram-negative bacteria. The structure of the ester group exerted a profound effect on antibacterial activity. 4,4-Dimethylcyclohexanyl carbamate 6h exhibited the most potent inhibitory activity against the standard and clinically isolated Staphylococcus aureus, Staphylococcus epidermidis, and Enterococcus faecalis (minimum inhibitory concentration = 4-8 µg/ml) strains. The preliminary experimental evidence indicated that these carbamates target the bacterial cell wall and share a similar mechanism of action with vancomycin.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203af362e18e6b43af6ff2e770feea5c
https://doi.org/10.1002/ardp.201900294