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المؤلفون: William Pei, Radhakrishnan Mahadevan, Leo Zhu, Ines Thiele
المصدر: PLoS Computational Biology, Vol 17, Iss 8, p e1009110 (2021)
PLoS Computational Biologyمصطلحات موضوعية: Male, Enzyme Metabolism, Alcohol, Pharmacology, Biochemistry, chemistry.chemical_compound, 0302 clinical medicine, Drug Metabolism, Disulfiram, Medicine and Health Sciences, Metabolites, Tissue Distribution, Biology (General), Enzyme Chemistry, 0303 health sciences, Alcohol Consumption, Ecology, biology, Organic Compounds, Aldehyde Dehydrogenase, Mitochondrial, 3. Good health, Enzymes, Alcoholism, Chemistry, Computational Theory and Mathematics, Liver, Modeling and Simulation, Physical Sciences, medicine.drug, Research Article, Physiologically based pharmacokinetic modelling, QH301-705.5, Acetaldehyde Dehydrogenase Inhibitors, Acetaldehyde, Models, Biological, 03 medical and health sciences, Cellular and Molecular Neuroscience, Genetics, medicine, Humans, Computer Simulation, Pharmacokinetics, Ethanol metabolism, Molecular Biology, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Alcohol dehydrogenase, ALDH2, Nutrition, Ethanol, Organic Chemistry, Chemical Compounds, Computational Biology, Biology and Life Sciences, Proteins, Diet, Kinetics, Metabolism, chemistry, Intestinal Absorption, Alcohols, biology.protein, Enzymology, 030217 neurology & neurosurgery, Alcohol Deterrents
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المؤلفون: Anaar Siletz, Eugene Galdones, Ines Thiele, Beatriz Penalver Bernabe, Linda J. Broadbelt, Lonnie D. Shea, Sriram Chandrasekaran, Teresa K. Woodruff
المصدر: BMC Bioinformatics, Vol 20, Iss 1, Pp 1-16 (2019)
BMC Bioinformaticsمصطلحات موضوعية: Cell signaling, Somatic cell, Cellular differentiation, Cell Communication, Biology, lcsh:Computer applications to medicine. Medical informatics, Biochemistry, Models, Biological, Mural cell, 03 medical and health sciences, Follicle, Mice, 0302 clinical medicine, Ovarian Follicle, Structural Biology, medicine, Animals, Cell-type specific metabolic models, Ovarian follicle, Molecular Biology, Secreted metabolites, lcsh:QH301-705.5, 030304 developmental biology, Uncategorized, 0303 health sciences, Genome, Applied Mathematics, Cell Differentiation, Oocyte, Computer Science Applications, Cell biology, Metabolic communities, medicine.anatomical_structure, Metabolism, Genome-scale modeling, lcsh:Biology (General), 030220 oncology & carcinogenesis, lcsh:R858-859.7, Female, Ovarian follicle development, Germ cell, Metabolic Networks and Pathways, Research Article
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المؤلفون: Stefania Magnusdottir, Ines Thiele
المصدر: Current Opinion in Biotechnology. 51:90-96
مصطلحات موضوعية: 0301 basic medicine, Microbiota, Systems Biology, Systems biology, In silico, Gastrointestinal Microbiome, Biomedical Engineering, Bioengineering, Computational biology, Biology, Models, Biological, Gut microbiome, 03 medical and health sciences, Human health, 030104 developmental biology, Human gut, Host-Pathogen Interactions, Humans, Microbial Interactions, Metabolic modeling, Computer Simulation, Microbiome, Metabolic Networks and Pathways, Biotechnology
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المؤلفون: Santosh Vempala, Jennifer Modamio, Alejandro Maass, Costas D. Maranas, Sylvain Arreckx, Masoud Ahookhosh, Miguel A.P. Oliveira, Stefania Magnusdottir, Nathan E. Lewis, Chiam Yu Ng, Aarash Bordbar, Bernhard O. Palsson, Inna Kuperstein, Lemmer P. El Assal, Lin Wang, Benjamin Cousins, German Preciat, Sarah M. Keating, Egils Stalidzans, Iñigo Apaolaza, Nicolas Sompairac, William A. Bryant, Vanja Vlasov, Phan Tu Vuong, Siu Hung Joshua Chan, Andrejs Kostromins, Laurent Heirendt, Yuekai Sun, Sebastián N. Mendoza, Ronan M. T. Fleming, Francisco J. Aragón Artacho, Michael Hucka, Hulda S. Haraldsdóttir, Jacek Wachowiak, Susan Ghaderi, Marouen Ben Guebila, Almut Heinken, Ines Thiele, Hoai M. Le, Thomas Sauter, James T. Yurkovich, Alise Žagare, Diana C. El Assal, Maike K. Aurich, H. Scott Hinton, Alberto Noronha, Catherine M. Clancy, Thomas Pfau, Andrei Zinovyev, Michael A. Saunders, Luis Vitores Valcárcel, John T. Sauls, Anne Richelle, Ding Ma, Francisco J. Planes
المساهمون: Laboratoire de Génie Informatique, de Production et de Maintenance (LGIPM), Université de Lorraine (UL), AIMMS, Systems Bioinformatics, Universidad de Alicante. Departamento de Matemáticas, Laboratorio de Optimización (LOPT)
المصدر: Nature Protocols
Nature Protocols, Nature Publishing Group, 2019, 14 (3), pp.639-702. ⟨10.1038/s41596-018-0098-2⟩
Nature Protocols, 14(3), 639-702. Nature Publishing Group
RUA. Repositorio Institucional de la Universidad de Alicante
Universidad de Alicante (UA)
Nature protocols, vol 14, iss 3
Heirendt, L, Arreckx, S, Pfau, T, Mendoza, S N, Richelle, A, Heinken, A, Haraldsdóttir, H S, Wachowiak, J, Keating, S M, Vlasov, V, Magnusdóttir, S, Ng, C Y, Preciat, G, Žagare, A, Chan, S H J, Aurich, M K, Clancy, C M, Modamio, J, Sauls, J T, Noronha, A, Bordbar, A, Cousins, B, El Assal, D C, Valcarcel, L V, Apaolaza, I, Ghaderi, S, Ahookhosh, M, Ben Guebila, M, Kostromins, A, Sompairac, N, Le, H M, Ma, D, Sun, Y, Wang, L, Yurkovich, J T, Oliveira, M A P, Vuong, P T, El Assal, L P, Kuperstein, I, Zinovyev, A, Hinton, H S, Bryant, W A, Aragón Artacho, F J, Planes, F J, Stalidzans, E, Maass, A, Vempala, S, Hucka, M, Saunders, M A, Maranas, C D, Lewis, N E, Sauter, T, Palsson, B, Thiele, I & Fleming, R M T 2019, ' Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0 ', Nature Protocols, vol. 14, no. 3, pp. 639-702 . https://doi.org/10.1038/s41596-018-0098-2
Heirendt, L, Arreckx, S, Pfau, T, Mendoza, S N, Richelle, A, Heinken, A, Haraldsdottir, H S, Wachowiak, J, Keating, S M, Vlasov, V, Magnusdottir, S, Ng, C Y, Preciat, G, Zagare, A, Chan, S H J, Aurich, M K, Clancy, C M, Modamio, J, Sauls, J T, Noronha, A, Bordbar, A, Cousins, B, El Assal, D C, Valcarcel, L V, Apaolaza, I, Ghaderi, S, Ahookhosh, M, Ben Guebila, M, Kostromins, A, Sompairac, N, Le, H M, Ma, D, Sun, Y, Wang, L, Yurkovich, J T, Oliveira, M A P, Vuong, P T, El Assal, L P, Kuperstein, I, Zinovyev, A, Hinton, H S, Bryant, W A, Aragon Artacho, F J, Planes, F J, Stalidzans, E, Maass, A, Vempala, S, Hucka, M, Saunders, M A, Maranas, C D, Lewis, N E, Sauter, T, Palsson, B O, Thiele, I & Fleming, R M T 2019, ' Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0 ', Nature Protocols, vol. 14, no. 3, pp. 639-702 . https://doi.org/10.1038/s41596-018-0098-2مصطلحات موضوعية: Computer science, Bioinformatics, Systems biology, Interoperability, Cobra, Multidisciplinary, general & others [F99] [Life sciences], computer.software_genre, Models, Biological, Medical and Health Sciences, Article, General Biochemistry, Genetics and Molecular Biology, Multidisciplinaire, généralités & autres [F99] [Sciences du vivant], 03 medical and health sciences, 0302 clinical medicine, Software, [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], Models, Estadística e Investigación Operativa, Protocol (object-oriented programming), ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, computer.programming_language, 0303 health sciences, Computational model, Software suite, Genome, q-bio.QM, Biochemical constraint-based models, business.industry, Systems Biology, Biological Sciences, Biological, Toolbox, Chemical Sciences, Systems engineering, Data mining, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], business, computer, 030217 neurology & neurosurgery, Metabolic Networks and Pathways, Constraint-based reconstruction and analysis (COBRA), Biotechnology
وصف الملف: application/pdf; Print
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المؤلفون: Almut Heinken, Ines Thiele
المصدر: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
مصطلحات موضوعية: biology, Microbiota, Systems biology, Medicine (miscellaneous), Computational biology, Gut flora, biology.organism_classification, Bioinformatics, Models, Biological, Biochemistry, Genetics and Molecular Biology (miscellaneous), Body Fluids, Gastrointestinal Tract, Metabolism, Human gut, Metabolomics, Molecular level, Advanced Review, Host-Pathogen Interactions, Metabolome, Advanced Reviews, Animals, Humans, Mechanistic Models, Host (network)
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المصدر: PLoS Computational Biology. San Francisco, CA: Public Library of Science (2017).
PLoS Computational Biology
PLoS Computational Biology, Vol 13, Iss 5, p e1005544 (2017)مصطلحات موضوعية: 0301 basic medicine, Microbiologie [F11] [Sciences du vivant], simulation of microbial communities, Physiology, Microbial metabolism, flux balance analysis, Gut flora, Pathology and Laboratory Medicine, Biochemistry, biofilm, Multidisciplinaire, généralités & autres [F99] [Sciences du vivant], Glucose Metabolism, Metabolites, Medicine and Health Sciences, Microbiology [F11] [Life sciences], Biology (General), Ecology, Simulation and Modeling, Community structure, Pseudomonas Aeruginosa, Oxygen Metabolism, Microbial Physiology, Bacterial Pathogens, Body Fluids, Flux balance analysis, Cell metabolism, Computational Theory and Mathematics, Medical Microbiology, Modeling and Simulation, Carbohydrate Metabolism, Pathogens, Anatomy, microbial physiology, Research Article, Cell Physiology, QH301-705.5, Microbial Consortia, 030106 microbiology, Niche, Computational biology, Multidisciplinary, general & others [F99] [Life sciences], Biology, Research and Analysis Methods, Models, Biological, Microbiology, 03 medical and health sciences, Cellular and Molecular Neuroscience, Pseudomonas, Genetics, Humans, Microbial Pathogens, Molecular Biology, cross-feeding, Ecology, Evolution, Behavior and Systematics, Bacteria, gut microbiota, Organisms, Biofilm, Biology and Life Sciences, Bacteriology, agent-based modeling, Cell Biology, biology.organism_classification, Metabolic Flux Analysis, Gastrointestinal Microbiome, Cell Metabolism, Mucus, Metabolism, 030104 developmental biology, Biofilms, Microbial Interactions, Bacterial Biofilms
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5fc8c32dff35011c5d6603c5953685
http://orbilu.uni.lu/handle/10993/30995 -
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المؤلفون: Ines Thiele, Laurent Heirendt, Ronan M. T. Fleming
المساهمون: National Centre of Excellence in Research (NCER) on Parkinson’s disease [sponsor], Luxembourg National Research Fund (FNR) ATTRACT program grant (FNR/A12/01) [sponsor], U.S. Department of Energy, Offices of Advanced Scientific Computing Research and the Biological and Environmental Research as part of the Scientific Discovery Through Advanced Computing program, grant no. DE-SC0010429 [sponsor], Luxembourg Centre for Systems Biomedicine (LCSB): Systems Biochemistry (Fleming Group) [research center], Luxembourg Centre for Systems Biomedicine (LCSB): Molecular Systems Physiology (Thiele Group) [research center]
المصدر: Bioinformatics, 33(9), 1421-1423. Oxford University Press
Bioinformatics
Bioinformatics. Oxford University Press (2017).مصطلحات موضوعية: Parallel computing, 0301 basic medicine, Statistics and Probability, Computer science, Distributed computing, 0206 medical engineering, Metabolic networks, 02 engineering and technology, Biochemistry, biophysics & molecular biology [F05] [Life sciences], Quantitative Biology - Quantitative Methods, Biochemistry, Models, Biological, Computational science, Multidisciplinaire, généralités & autres [C99] [Ingénierie, informatique & technologie], 03 medical and health sciences, Flux variability analysis, Code (cryptography), Biochimie, biophysique & biologie moléculaire [F05] [Sciences du vivant], Molecular Biology, Quantitative Methods (q-bio.QM), Systems Biology, Multidisciplinary, general & others [C99] [Engineering, computing & technology], Computational Biology, Computational modeling, Applications Notes, Computer Science Applications, Flux balance analysis, Computational Mathematics, 030104 developmental biology, Computational Theory and Mathematics, FOS: Biological sciences, Flux (metabolism), 020602 bioinformatics, Metabolic Networks and Pathways, Software
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233eccb6c93c0a341f4f21a29ef5f5fb
http://hdl.handle.net/1887/71470 -
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المصدر: Bioinformatics
Bioinformatics, 33(11), 1741-1743. Oxford University Pressمصطلحات موضوعية: 0301 basic medicine, Statistics and Probability, Mathematical optimization, Computer science, Convex set, MathematicsofComputing_NUMERICALANALYSIS, Models, Biological, Biochemistry, Set (abstract data type), 03 medical and health sciences, 0302 clinical medicine, Humans, Molecular Biology, Systems Biology, Rounding, Quantitative Biology::Molecular Networks, Computational Biology, Sampling (statistics), Random walk, Applications Notes, Computer Science Applications, Constraint (information theory), Computational Mathematics, 030104 developmental biology, ComputingMethodologies_PATTERNRECOGNITION, Computational Theory and Mathematics, Sampling distribution, Algorithms, Metabolic Networks and Pathways, Software, 030217 neurology & neurosurgery, Curse of dimensionality
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1751636869fdf2b56dc1c851df9a18e7
https://hdl.handle.net/1887/76708 -
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المؤلفون: Almut Heinken, Ines Thiele, Swagatika Sahoo, Ronan M. T. Fleming
المصدر: Gut Microbes
مصطلحات موضوعية: computational modeling, Microbiology (medical), Systems Biology/methods, Metabolite, Systems biology, In silico, Multidisciplinary, general & others [F99] [Life sciences], Biology, Bacterial Physiological Phenomena, Models, Biological, Microbiology, host-microbe interactions, Multidisciplinaire, généralités & autres [F99] [Sciences du vivant], Mice, chemistry.chemical_compound, Gastrointestinal Tract/microbiology, Bacteroidesthetaiotaomicron, Metabolome, Animals, Bacteroides, Mus musculus, Symbiosis, Gene, Metabolic Networks and Pathways/genetics, Systems Biology, Gastroenterology, systems biology, Metabolism, Phenotype, Diet, Gastrointestinal Tract, Bacteroides thetaiotaomicron, Infectious Diseases, chemistry, Biochemistry, Genes, Bacterial, constraint-based modeling, Bacteroides/genetics/metabolism, Models, Animal, metabolism, Metabolic Networks and Pathways, Research Paper
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المؤلفون: Ines Thiele, Ronan M. T. Fleming
المساهمون: [ 1 ] Univ Iceland, Ctr Syst Biol, IS-101 Reykjavik, Iceland [ 2 ] Univ Iceland, Fac Med, Dept Biochem & Mol Biol, IS-101 Reykjavik, Iceland [ 3 ] Univ Iceland, Fac Ind Engn Mech Engn & Comp Sci, IS-101 Reykjavik, Iceland
المصدر: Journal of Theoretical Biology. 314:173-181
مصطلحات موضوعية: Statistics and Probability, Thermodynamic equilibrium, Molecular Networks (q-bio.MN), Trypanosoma brucei brucei, Thermodynamics, Kinetic energy, Models, Biological, 01 natural sciences, General Biochemistry, Genetics and Molecular Biology, Reaction rate, 03 medical and health sciences, 0103 physical sciences, Quantitative Biology - Molecular Networks, Anaerobiosis, Statistical physics, Time complexity, 030304 developmental biology, Physics, 0303 health sciences, Forcing (recursion theory), 010304 chemical physics, General Immunology and Microbiology, Applied Mathematics, General Medicine, State (functional analysis), Enzymes, Living systems, Molecular Weight, Kinetics, FOS: Biological sciences, Modeling and Simulation, Steady state (chemistry), General Agricultural and Biological Sciences, Glycolysis
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