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1
المؤلفون: John Maclean, Lesley-Anne Nisbet, Helen Feilden, Olaf Nimz, Duncan McArthur, Ronnie Palin, Lynn Abernethy, Hazel McLuskey, Thomas R. Clarkson, Darren Edwards, Deborah McGregor, Anna-Marie Easson, Katy Everett, Paul Ratcliffe, Heather Tracey, Maureen Dempster, Littlewood Peter Thomas Albert, Glenn Walker
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2559-2563
مصطلحات موضوعية: Clinical Biochemistry, Analgesic, TRPV1, Administration, Oral, Pain, TRPV Cation Channels, Pharmaceutical Science, Biochemistry, Pharmacokinetics, In vivo, Oral administration, Drug Discovery, Animals, Humans, Potency, Molecular Biology, Chemistry, Organic Chemistry, Antagonist, Isoxazoles, Amides, In vitro, Rats, Disease Models, Animal, Molecular Medicine
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2
المؤلفون: Ronald Palin, Hardy Sundaram, Philip S. Jones, David Vrolijk, Louise Evans, Mark A. Weston, David R. Barn, Grove Simon James Anthony, Helen Feilden, John K. Clark, J. Cottney, Marc Crockatt, Alasdair R.C. Smith, Grant Wishart, Paul Wren, Phillip M. Cowley, Richard Morphy, Frank Griekspoor, Richard R. Goodwin, Andrea K. Houghton
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:589-593
مصطلحات موضوعية: Male, Agonist, Stereochemistry, medicine.drug_class, Clinical Biochemistry, NOP, Pharmaceutical Science, CHO Cells, Transfection, Biochemistry, Chemical synthesis, Nociceptin Receptor, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Vas Deferens, Piperidines, Cricetinae, Drug Discovery, Cyclic AMP, medicine, Animals, Humans, Receptor, Molecular Biology, Organic Chemistry, In vitro, Nociceptin receptor, chemistry, Drug Design, Receptors, Opioid, Molecular Medicine, Piperidine, Hydrophobic and Hydrophilic Interactions, ORL1 receptor
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3
المؤلفون: Jean E. Cottney, Paul Ratcliffe, James Baker, Ruth Fields, John K. Clark, Helen Feilden, Darren Edwards, Grant Wishart, Fiona Jeremiah, Maureen Deehan, Angus John Morrison, Stuart Francis, Louise Evans, Alan Prosser, Robert A. Campbell, Ola Epemolu, Jurgen Schulz, Keneth Davies, Takao Kiyoi, Duncan McArthur, Julia M. Adam, Anna-Marie Easson
المصدر: Bioorganicmedicinal chemistry letters. 21(6)
مصطلحات موضوعية: Agonist, Cannabinoid receptor, medicine.drug_class, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Oxadiazole, Administration, Oral, Biological Availability, Pharmacology, Biochemistry, chemistry.chemical_compound, Thiadiazoles, Receptor, Cannabinoid, CB1, Heterocyclic Compounds, Drug Discovery, medicine, Animals, Molecular Biology, Indole test, Organic Chemistry, Cannabinoid Receptor Agonists, Biological activity, Rats, chemistry, Molecular Medicine, lipids (amino acids, peptides, and proteins), Cannabinoid
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4
المؤلفون: Lynn Abernethy, Quynhchi Pham, Helen Feilden, Olaf Nimz, Yajing Rong, Michael Ohlmeyer, Anna-Marie Easson, David A. Dunn, Heather Tracey, Littlewood Peter Thomas Albert, Steve Kultgen, Lesley-Anne Nisbet, John Maclean, Maureen Dempster, Duncan McArthur, Robert Swanson, Melanie Sammons, Ronnie Palin, Andrew Laird Roughton, Darren Edwards, Kenneth S. Cameron, Deborah McGregor, Paul Ratcliffe, Irina Neagu, Hazel McLuskey, Koc-Kan Ho, Katy Everett, Thomas R. Clarkson, Glenn Walker, Nasrin Ansari
المصدر: Bioorganicmedicinal chemistry letters. 21(15)
مصطلحات موضوعية: Clinical Biochemistry, TRPV1, Drug Evaluation, Preclinical, Pharmaceutical Science, Administration, Oral, TRPV Cation Channels, Pharmacology, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Oral administration, Drug Discovery, Potency, Animals, Humans, Solubility, Molecular Biology, Organic Chemistry, Isoxazoles, Cyclohexanols, Amides, Rats, Disease Models, Animal, Orally active, chemistry, Capsaicin, Hyperalgesia, Microsomes, Liver, Molecular Medicine
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5
المؤلفون: Michael Ohlmeyer, Yajing Rong, Katy Everett, Robert Swanson, Nasrin Ansari, Duncan McArthur, Kenneth S. Cameron, Quynhchi Pham, Irina Neagu, Heather Tracey, Darren Edwards, John Maclean, Maureen Dempster, Thomas R. Clarkson, Hazel McLuskey, Koc-Kan Ho, Helen Feilden, Paul Ratcliffe, David A. Dunn, Andrew Laird Roughton, S.A. Neale, Steve Kultgen, Glenn Walker, Littlewood Peter Thomas Albert, Melanie Sammons, Ronald Palin, Lynn Abernethy, Anna-Marie Easson, Deborah McGregor, Lesley-Anne Nisbet
المصدر: Bioorganicmedicinal chemistry letters. 21(3)
مصطلحات موضوعية: Stereochemistry, medicine.drug_class, Clinical Biochemistry, TRPV1, Pharmaceutical Science, Mechanism based, TRPV Cation Channels, Carboxamide, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Potency, Animals, Isoxazole, Solubility, Rats, Wistar, Molecular Biology, Antihypertensive Agents, Organic Chemistry, Hyperthermia, Induced, Isoxazoles, Cyclohexanols, Amides, Rats, chemistry, Molecular Medicine
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6
المؤلفون: Duncan McArthur, Alasdair R.C. Smith, Niall M. Hamilton, Louise Evans, Ronald Palin, Helen Feilden, Dan Fletcher, Grant Wishart, Aaron Sutherland, Philip S. Jones, Mark A. Weston, Paul Ratcliffe, John K. Clark, Brian Montgomery, Andrea K. Houghton
المصدر: Bioorganicmedicinal chemistry letters. 19(22)
مصطلحات موضوعية: Agonist, medicine.drug_class, Stereochemistry, Narcotic Antagonists, Clinical Biochemistry, NOP, hERG, Pharmaceutical Science, Biochemistry, Nociceptin Receptor, chemistry.chemical_compound, Structure-Activity Relationship, Piperidines, Cricetinae, Drug Discovery, Rapid access, medicine, Moiety, Animals, Receptor, Molecular Biology, biology, Organic Chemistry, chemistry, Receptors, Opioid, biology.protein, Molecular Medicine, Benzimidazoles, Piperidine, Pharmacophore
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7
المؤلفون: Grant Wishart, Brian Montgomery, Anton Bom, Ronald Palin, Mark A. Weston, Andrea K. Houghton, Philip S. Jones, Helen Feilden, John K. Clark, Louise Evans
المصدر: Bioorganicmedicinal chemistry. 15(4)
مصطلحات موضوعية: Agonist, medicine.drug_class, Stereochemistry, Clinical Biochemistry, NOP, Pharmaceutical Science, Rodentia, Biochemistry, Chemical synthesis, Nociceptin Receptor, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Animals, Hypnotics and Sedatives, Molecular Biology, Analgesics, Organic Chemistry, Nociceptin receptor, chemistry, Receptors, Opioid, Molecular Medicine, Benzimidazoles, Piperidine, Enantiomer, Acetamide