المؤلفون: Milstein S; Alnylam Pharmaceuticals, 300 Third St, Cambridge, MA, 02155, USA., Qian K; Alnylam Pharmaceuticals, 300 Third St, Cambridge, MA, 02155, USA., Zhang L; Alnylam Pharmaceuticals, 300 Third St, Cambridge, MA, 02155, USA., Sehgal A; Alnylam Pharmaceuticals, 300 Third St, Cambridge, MA, 02155, USA. asehgal@alnylam.com.

المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2017; Vol. 1639, pp. 115-126.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: RNA Interference*, Molecular Biology/*methods , RNA, Small Interfering/*metabolism , alpha 1-Antitrypsin/*genetics, Animals ; Cell Line ; DNA, Complementary/genetics ; Female ; Gene Knockdown Techniques ; Humans ; Mice ; Rats ; Reproducibility of Results ; Transfection ; alpha 1-Antitrypsin/metabolism

المؤلفون: Krishnan B; G.N. Ramachandran Protein Centre, CSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh, 160 036, India. beena@imtech.res.in., Hedstrom L; Department of Biology, Brandeis University Waltham, Waltham, MA, USA.; Department of Chemistry, Brandeis University Waltham, Waltham, MA, USA., Hebert DN; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA, USA., Gierasch LM; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA, USA.; Department of Chemistry, University of Massachusetts Amherst, Amherst, MA, USA., Gershenson A; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA, USA.

المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2017; Vol. 1639, pp. 195-209.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Escherichia coli/*metabolism , Molecular Biology/*methods , Recombinant Proteins/*isolation & purification , Recombinant Proteins/*metabolism , alpha 1-Antitrypsin/*isolation & purification , alpha 1-Antitrypsin/*metabolism, Catalytic Domain ; Cell Extracts ; Chromatography, Ion Exchange ; Escherichia coli/growth & development ; Humans ; Spectrum Analysis ; Trypsin/metabolism

المؤلفون: Wang C; Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Bouchecareilh M; Institut de Biochimie et Génétique Cellulaires, CNRS UMR 5095, Université de Bordeaux, Bordeaux, France., Balch WE; Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA. webalch@scripps.edu.

المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2017; Vol. 1639, pp. 185-193.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Histone Deacetylase Inhibitors/*pharmacology , Molecular Biology/*methods , alpha 1-Antitrypsin/*metabolism, Blotting, Western ; HCT116 Cells ; Humans ; Hydroxamic Acids/pharmacology ; Solutions ; Vorinostat

المؤلفون: Dunstone MA; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia., Whisstock JC

المصدر: Methods in enzymology [Methods Enzymol] 2011; Vol. 501, pp. 63-87.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0212271 Publication Model: Print Cited Medium: Internet ISSN: 1557-7988 (Electronic) Linking ISSN: 00766879 NLM ISO Abbreviation: Methods Enzymol Subsets: MEDLINE

مواضيع طبية MeSH: Antithrombin III/*isolation & purification , Crystallization/*methods , Crystallography, X-Ray/*methods , Molecular Biology/*methods , Plasminogen Activator Inhibitor 1/*isolation & purification , Recombinant Fusion Proteins/*isolation & purification , alpha 1-Antitrypsin/*isolation & purification, Animals ; Antithrombin III/biosynthesis ; Antithrombin III/genetics ; CHO Cells ; Chickens ; Cricetinae ; Escherichia coli ; HEK293 Cells ; Humans ; Mice ; Models, Molecular ; Plasminogen Activator Inhibitor 1/biosynthesis ; Plasminogen Activator Inhibitor 1/genetics ; Polymerization ; Protein Folding ; Protein Structure, Secondary ; Recombinant Fusion Proteins/biosynthesis ; Recombinant Fusion Proteins/genetics ; alpha 1-Antitrypsin/biosynthesis ; alpha 1-Antitrypsin/genetics

المؤلفون: Read RJ; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom., Zhou A, Stein PE

المصدر: Methods in enzymology [Methods Enzymol] 2011; Vol. 501, pp. 49-61.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0212271 Publication Model: Print Cited Medium: Internet ISSN: 1557-7988 (Electronic) Linking ISSN: 00766879 NLM ISO Abbreviation: Methods Enzymol Subsets: MEDLINE

مواضيع طبية MeSH: Crystallization/*methods , Crystallography, X-Ray/*methods , Molecular Biology/*methods , Plasminogen Activator Inhibitor 1/*isolation & purification , Recombinant Fusion Proteins/*isolation & purification , Serpins/*isolation & purification , alpha 1-Antitrypsin/*isolation & purification, Animals ; CHO Cells ; Cricetinae ; Escherichia coli ; Glycosylation ; Humans ; Models, Molecular ; Plasminogen Activator Inhibitor 1/biosynthesis ; Plasminogen Activator Inhibitor 1/genetics ; Protein Folding ; Protein Structure, Secondary ; Recombinant Fusion Proteins/biosynthesis ; Recombinant Fusion Proteins/genetics ; Serpins/biosynthesis ; Serpins/genetics ; alpha 1-Antitrypsin/biosynthesis ; alpha 1-Antitrypsin/genetics

المؤلفون: Pearce MC; Department of Biochemistry, Monash University, Clayton, Australia., Cabrita LD

المصدر: Methods in enzymology [Methods Enzymol] 2011; Vol. 501, pp. 13-28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0212271 Publication Model: Print Cited Medium: Internet ISSN: 1557-7988 (Electronic) Linking ISSN: 00766879 NLM ISO Abbreviation: Methods Enzymol Subsets: MEDLINE

مواضيع طبية MeSH: Escherichia coli*/classification , Escherichia coli*/genetics , Escherichia coli*/metabolism , Gene Expression*, Chromatography, Affinity/*methods , Cloning, Molecular/*methods , Molecular Biology/*methods , Recombinant Proteins/*isolation & purification , Staining and Labeling/*methods , alpha 1-Antitrypsin/*isolation & purification, Carbon Radioisotopes/metabolism ; Culture Media ; Electrophoresis, Polyacrylamide Gel ; Humans ; Inclusion Bodies/chemistry ; Inclusion Bodies/metabolism ; Plasmids/chemistry ; Plasmids/genetics ; Promoter Regions, Genetic ; Protein Folding ; Protein Refolding ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/genetics ; Solubility ; Transformation, Bacterial ; alpha 1-Antitrypsin/biosynthesis ; alpha 1-Antitrypsin/genetics

المؤلفون: Rein CM; Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Desai UR, Church FC

المصدر: Methods in enzymology [Methods Enzymol] 2011; Vol. 501, pp. 105-37.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0212271 Publication Model: Print Cited Medium: Internet ISSN: 1557-7988 (Electronic) Linking ISSN: 00766879 NLM ISO Abbreviation: Methods Enzymol Subsets: MEDLINE

مواضيع طبية MeSH: Chemistry Techniques, Analytical*, Antithrombin III/*metabolism , Heparin Cofactor II/*metabolism , Molecular Biology/*methods , Plasminogen Activator Inhibitor 1/*metabolism , Protein C Inhibitor/*metabolism , alpha 1-Antitrypsin/*metabolism, Animals ; Antithrombin III/chemistry ; Binding Sites ; Blood Coagulation ; Dermatan Sulfate/chemistry ; Dermatan Sulfate/metabolism ; Heparin/chemistry ; Heparin/metabolism ; Heparin Cofactor II/chemistry ; Humans ; Kinetics ; Mice ; Mice, Knockout ; Models, Molecular ; Plasminogen Activator Inhibitor 1/chemistry ; Protein Binding ; Protein C Inhibitor/chemistry ; Protein Structure, Secondary ; Species Specificity ; Thrombin/chemistry ; Thrombin/metabolism ; alpha 1-Antitrypsin/chemistry

عنوان ترانسليتريتد: Hereditäre Lebererkrankungen. Neue molekulargenetische Aspekte.

المؤلفون: Möhler M; Abteilung Innere Medizin IV, Universität Heidelberg., Wagner V, Stremmel W

المصدر: Deutsche medizinische Wochenschrift (1946) [Dtsch Med Wochenschr] 1998 Apr 09; Vol. 123 (15), pp. 466-71.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: G. Thieme Country of Publication: Germany NLM ID: 0006723 Publication Model: Print Cited Medium: Print ISSN: 0012-0472 (Print) Linking ISSN: 00120472 NLM ISO Abbreviation: Dtsch Med Wochenschr Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Biology*, Liver Diseases/*genetics , Metabolism, Inborn Errors/*genetics, Animals ; Bilirubin/metabolism ; Cholestasis, Intrahepatic/complications ; Cholestasis, Intrahepatic/genetics ; Cholestasis, Intrahepatic/therapy ; Cystic Fibrosis/complications ; Cystic Fibrosis/genetics ; Cystic Fibrosis/therapy ; Disease Models, Animal ; Genetic Therapy ; Hepatolenticular Degeneration/complications ; Hepatolenticular Degeneration/genetics ; Hepatolenticular Degeneration/therapy ; Humans ; Jaundice, Chronic Idiopathic/complications ; Jaundice, Chronic Idiopathic/genetics ; Jaundice, Chronic Idiopathic/therapy ; Liver Diseases/therapy ; Metabolism, Inborn Errors/therapy ; Tyrosine/blood ; alpha 1-Antitrypsin/metabolism

المؤلفون: Cohen AB, Woo S, Kelley R, Rosenbloom J, Crystal RG, Sifers R, Perlmutter D

المصدر: The American review of respiratory disease [Am Rev Respir Dis] 1988 Oct; Vol. 138 (4), pp. 1041-3.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Lung Association Country of Publication: United States NLM ID: 0370523 Publication Model: Print Cited Medium: Print ISSN: 0003-0805 (Print) Linking ISSN: 00030805 NLM ISO Abbreviation: Am Rev Respir Dis Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Biology*, Pulmonary Emphysema/*genetics, Gene Expression Regulation ; Genes ; Humans ; Mutation ; Osmolar Concentration ; alpha 1-Antitrypsin/blood ; alpha 1-Antitrypsin/genetics ; alpha 1-Antitrypsin Deficiency

المؤلفون: Aiello, Marina, Marchi, Laura, Ferrarotti, Ilaria, Frizzelli, Annalisa, Pisi, Roberta, Calzetta, Luigino, Manari, Gaia, Pelà, Giovanna, Russo, Annalisa, Minerba, Roberta, Aloe, Rosalia, Ranzieri, Silvia, Corradi, Massimo, Chetta, Alfredo

المصدر: Respiration; Sep2022, Vol. 101 Issue 9, p851-858, 8p

مصطلحات موضوعية: ASTHMA risk factors, RESPIRATORY diseases, GENETIC mutation, ANTHROPOMETRY, GENETIC testing, MOLECULAR biology, GENE expression, HEALTH literacy, ALPHA 1-antitrypsin deficiency, SYMPTOMS, GENOTYPES, DESCRIPTIVE statistics, ALPHA 1-antitrypsin, SMOKING, PULMONARY emphysema, DISEASE risk factors

مصطلحات جغرافية: ITALY