المؤلفون: Bhabha, Gira, Ekiert, Damian C, Jennewein, Madeleine, Zmasek, Christian M, Tuttle, Lisa M, Kroon, Gerard, Dyson, H Jane, Godzik, Adam, Wilson, Ian A, Wright, Peter E

المصدر: Nature Structural & Molecular Biology. 20(11)

مصطلحات موضوعية: Genetics, Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance, Amino Acid Sequence, Crystallography, X-Ray, Escherichia coli, Evolution, Molecular, Genetic Complementation Test, Genetic Drift, Humans, Models, Molecular, Molecular Dynamics Simulation, Molecular Sequence Data, Mutation, Protein Conformation, Selection, Genetic, Sequence Alignment, Tetrahydrofolate Dehydrogenase, Chemical Sciences, Biological Sciences, Medical and Health Sciences, Biophysics, Developmental Biology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/00t2j60d

المؤلفون: Too, Priscilla, Erales, Jenny, Simen, Joana, Marjanovic, Antonija, Coffino, Philip

المصدر: Journal of Biological Chemistry. 288(19)

مصطلحات موضوعية: ATP, ATP-dependent Protease, ATPases, Protease, Proteasome, Protein Degradation, Protein Turnover, Translocation, Unfolding, ATPases Associated with Diverse Cellular Activities, Adenosine Triphosphatases, Amino Acid Sequence, Amino Acid Substitution, Connectin, Endopeptidase Clp, Escherichia coli, Escherichia coli Proteins, Humans, Hydrophobic and Hydrophilic Interactions, Kinetics, Models, Molecular, Molecular Chaperones, Molecular Sequence Data, Muscle Proteins, Peptide Fragments, Protein Kinases, Protein Stability, Protein Structure, Tertiary, Protein Transport, Protein Unfolding, Proteolysis, Repetitive Sequences, Amino Acid, Tetrahydrofolate Dehydrogenase

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/44g151fc
https://escholarship.org/content/qt44g151fc/qt44g151fc.pdf

المؤلفون: Machado, Carlos A, Ayala, Francisco J

المصدر: Molecular and biochemical parasitology. 121(1)

مصطلحات موضوعية: Animals, Humans, Trypanosoma cruzi, Multienzyme Complexes, Tetrahydrofolate Dehydrogenase, NADH, NADPH Oxidoreductases, Thymidylate Synthase, Sequence Alignment, Sequence Analysis, DNA, Evolution, Molecular, Phylogeny, Amino Acid Sequence, Base Sequence, Polymorphism, Genetic, Molecular Sequence Data, Genetic Variation, DHFR-TS, TR, polymorphism, evolution, Mycology & Parasitology, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/7tr49750

المؤلفون: Hao, Hong, Tyshenko, Michael G., Walker, Virginia K.

مصطلحات موضوعية: Models, Molecular, Molecular Sequence Data, Drug Resistance, DNA, Sequence Analysis, DNA, Mini-Review, Polymerase Chain Reaction, Trimethoprim, Cell Line, Kinetics, Tetrahydrofolate Dehydrogenase, Methotrexate, Mutation, Animals, Folic Acid Antagonists, heterocyclic compounds, Drosophila

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::89fd74d3651945d60ae71ba8247ec115
https://europepmc.org/articles/PMC6148270/

المؤلفون: Shyam Prakash Dumre, Effie Espino, Jiraporn Kuesap, Pimwan Thongdee, Kesara Na-Bangchang, Kanchana Rungsihirunrat, Harald Noedl

المصدر: The Korean Journal of Parasitology

مصطلحات موضوعية: sulfadoxine-pyrimethamine (SP), Philippines, Molecular Sequence Data, Plasmodium vivax, malaria, Brief Communication, PCR-RFLP, Nepal, Genotype, Genetic variation, Malaria, Vivax, Humans, Amino Acid Sequence, Allele, Plasmodium vivax dihydrofolate reductase (pvdhfr), Genetics, Bangladesh, Dihydropteroate Synthase, Polymorphism, Genetic, Base Sequence, biology, Haplotype, biology.organism_classification, Virology, Tetrahydrofolate Dehydrogenase, Plasmodium vivax dihydropteroate synthase (pvdhps), Infectious Diseases, Genetic marker, Parasitology, Restriction fragment length polymorphism, Dihydropteroate synthase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab91210fd3a35d99fce7bafc35c8c1ac
https://doi.org/10.3347/kjp.2015.53.2.227

المؤلفون: Kaoru Nakasone, Eiji Ohmae, Katsuo Katayanagi, Yurina Miyashita

المصدر: Extremophiles. 19:479-493

مصطلحات موضوعية: Protein Denaturation, Circular dichroism, Archaeal Proteins, Molecular Sequence Data, Sodium Chloride, medicine.disease_cause, Microbiology, Cofactor, Fluorescence spectroscopy, Enzyme Stability, Dihydrofolate reductase, medicine, Urea, Amino Acid Sequence, Escherichia coli, chemistry.chemical_classification, Haloarcula, biology, Strain (chemistry), Chemistry, General Medicine, Halophile, Tetrahydrofolate Dehydrogenase, Crystallography, Enzyme, biology.protein, Biophysics, Molecular Medicine, NADP

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79909fe900248ca0a830f5121b6baf42
https://doi.org/10.1007/s00792-015-0732-7

المؤلفون: Nicole Webb, William W. Barrow, Nancy Wakeham, Christina R. Bourne, K. Darrell Berlin, Baskar Nammalwar, Richard A. Bunce

المصدر: Biochemistry

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Molecular Sequence Data, Coenzymes, Leucovorin, Biochemistry, Cofactor, Enterococcus faecalis, Article, Substrate Specificity, 03 medical and health sciences, Enzyme activator, chemistry.chemical_compound, Structure-Activity Relationship, Dihydrofolate reductase, Structure–activity relationship, Amino Acid Sequence, Enzyme Inhibitors, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, Dose-Response Relationship, Drug, Molecular Structure, 030306 microbiology, biology.organism_classification, Enzyme Activation, Molecular Docking Simulation, Tetrahydrofolate Dehydrogenase, Enzyme, chemistry, Docking (molecular), biology.protein, Folic Acid Antagonists, Phthalazines, Sequence Alignment, Nicotinamide adenine dinucleotide phosphate, NADP

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6b872f260f06c9e800efb33b8e0699
http://europepmc.org/articles/PMC3985486

المؤلفون: Janine T, Bossé, Yanwen, Li, Stephanie, Walker, Tom, Atherton, Roberto, Fernandez Crespo, Susanna M, Williamson, Jon, Rogers, Roy R, Chaudhuri, Lucy A, Weinert, Olusegun, Oshota, Matt T G, Holden, Duncan J, Maskell, Alexander W, Tucker, Brendan W, Wren, Andrew N, Rycroft, Paul R, Langford

المساهمون: University of St Andrews. School of Medicine, University of St Andrews. Infection Group, University of St Andrews. Biomedical Sciences Research Complex

المصدر: Journal of Antimicrobial Chemotherapy

مصطلحات موضوعية: Microbiology (medical), antibiotic resistance, Antibiotic resistance, Swine, Molecular Sequence Data, NDAS, Respiratory tract, Microbial Sensitivity Tests, R Medicine, Trimethoprim, Microbiology, 03 medical and health sciences, Plasmid, Actinobacillus Infections, Anti-Infective Agents, animal infections, Animals, Pharmacology (medical), Actinobacillus pleuropneumoniae, Biological sciences, 030304 developmental biology, Original Research, Pharmacology, Swine Diseases, 0303 health sciences, biology, Animal health, 030306 microbiology, Trimethoprim Resistance, Animal infections, QR Microbiology, Sequence Analysis, DNA, biology.organism_classification, bacterial infections and mycoses, respiratory tract, Virology, QR, Tetrahydrofolate Dehydrogenase, Infectious Diseases, England, Research council, Tetrahydrofolate dehydrogenase, Sulfisoxazole, Genome, Bacterial, Plasmids

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9305f94fe191d2e2630bc83b8177ad76
https://pubmed.ncbi.nlm.nih.gov/25957382

المؤلفون: Thomas H. Pringle, Stephen J. Benkovic, C. Tony Liu, Jarrod B. French, Sharon Hammes-Schiffer, Philip Hanoian

المصدر: Proceedings of the National Academy of Sciences. 110:10159-10164

مصطلحات موضوعية: Molecular Sequence Data, Plasma protein binding, medicine.disease_cause, Evolution, Molecular, Structure-Activity Relationship, Enzyme activator, Protein sequencing, Species Specificity, Dihydrofolate reductase, Escherichia coli, medicine, Animals, Humans, Amino Acid Sequence, Urochordata, Peptide sequence, Phylogeny, Mammals, Genetics, chemistry.chemical_classification, Multidisciplinary, biology, Escherichia coli Proteins, Fishes, Active site, Biological Sciences, Protein Structure, Tertiary, Enzyme Activation, Tetrahydrofolate Dehydrogenase, Enzyme, Biochemistry, chemistry, Mutagenesis, Sea Urchins, biology.protein, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c6e1406d12628149dac65ad9c733de
https://doi.org/10.1073/pnas.1307130110

المؤلفون: Dan T. Nguyen, Rumit Maini, Larisa M. Dedkova, Sandipan Roy Chowdhury, Sidney M. Hecht, Rafael Alcala-Torano, Shengxi Chen

المصدر: Bioorganic & Medicinal Chemistry. 21:1088-1096

مصطلحات موضوعية: Molecular Sequence Data, Clinical Biochemistry, Pharmaceutical Science, Peptide, Biochemistry, Ribosome, Drug Discovery, Dihydrofolate reductase, Escherichia coli, Protein biosynthesis, Amino Acid Sequence, Amino Acids, Molecular Biology, Peptide sequence, Alanine, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Proteolytic enzymes, Amino acid, RNA, Ribosomal, 23S, Tetrahydrofolate Dehydrogenase, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, beta-Alanine, biology.protein, Molecular Medicine, Peptides, Ribosomes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ed759e4198e92f711e8752c09f071c
https://doi.org/10.1016/j.bmc.2013.01.002