المؤلفون: Cappellani D; Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Brancatella A; Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Morganti R; Statistic Analysis Unit, Department of Medicine and Oncology., Borsari S; Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Baldinotti F; Laboratory of Molecular Genetics, University Hospital of Pisa, Pisa, Italy., Caligo MA; Laboratory of Molecular Genetics, University Hospital of Pisa, Pisa, Italy., Kaufmann M; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada., Jones G; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada., Marcocci C; Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Cetani F; Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

المصدر: European journal of endocrinology [Eur J Endocrinol] 2021 Dec 10; Vol. 186 (2), pp. 137-149. Date of Electronic Publication: 2021 Dec 10.

نوع المنشور: Journal Article; Systematic Review

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 9423848 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-683X (Electronic) Linking ISSN: 08044643 NLM ISO Abbreviation: Eur J Endocrinol Subsets: MEDLINE

مواضيع طبية MeSH: Heterozygote*, Hypercalcemia/*genetics , Mutation/*genetics , Pregnancy Complications/*genetics , Vitamin D3 24-Hydroxylase/*genetics, Female ; Genetic Variation/genetics ; Humans ; Hypercalcemia/blood ; Hypercalcemia/physiopathology ; Pregnancy ; Pregnancy Complications/blood ; Pregnancy Complications/physiopathology

المؤلفون: Rocca MS; Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy., Piatti G; Unit of Bronchopneumology, Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, University of Milan, Milan, Italy., Michelucci A; Laboratory of Molecular Genetics, University Hospital of Pisa, Pisa, Italy., Guazzo R; Unit of Pathological Anatomy, Department of Medical Biotechnology, University of Siena, Siena, Italy., Bertini V; Laboratory of Cytogenetics, University Hospital of Pisa, Pisa, Italy., Vinanzi C; Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy., Caligo MA; Laboratory of Molecular Genetics, University Hospital of Pisa, Pisa, Italy., Valetto A; Laboratory of Cytogenetics, University Hospital of Pisa, Pisa, Italy., Foresta C; Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy. carlo.foresta@unipd.it.

المصدر: BMC medical genetics [BMC Med Genet] 2020 Nov 10; Vol. 21 (1), pp. 220. Date of Electronic Publication: 2020 Nov 10.

نوع المنشور: Case Reports; Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968552 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2350 (Electronic) Linking ISSN: 14712350 NLM ISO Abbreviation: BMC Med Genet Subsets: MEDLINE

مواضيع طبية MeSH: Mutation*, Ciliary Motility Disorders/*genetics , Dyneins/*genetics , Hydrocephalus, Normal Pressure/*genetics , Intracellular Signaling Peptides and Proteins/*genetics, Cilia/genetics ; Cilia/metabolism ; Cilia/pathology ; Ciliary Motility Disorders/diagnosis ; Ciliary Motility Disorders/pathology ; Dyneins/deficiency ; Female ; Gene Expression ; Humans ; Hydrocephalus, Normal Pressure/diagnosis ; Hydrocephalus, Normal Pressure/pathology ; Infant ; Intracellular Signaling Peptides and Proteins/deficiency ; Risk Factors

المؤلفون: Patel VL; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts., Busch EL; Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Friebel TM; Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; Dana-Farber Cancer Institute. Boston, Massachusetts., Cronin A; Dana-Farber Cancer Institute. Boston, Massachusetts., Leslie G; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., McGuffog L; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Adlard J; Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, United Kingdom., Agata S; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Agnarsson BA; Department of Pathology, Landspitali University Hospital, 101, Reykjavik, Iceland.; School of Medicine, University of Iceland, Reykjavik, Iceland., Ahmed M; North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom., Aittomäki K; Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Alducci E; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Andrulis IL; Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Arason A; Department of Pathology, Landspitali University Hospital, 101, Reykjavik, Iceland.; BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Arnold N; Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany., Artioli G; ULSS 3 Serenissima, U.O.C. Oncologia ed Ematologia Oncologica, Mirano, Venice, Italy., Arver B; Department of Oncology, Karolinska Institutet, Stockholm, Sweden., Auber B; Institute of Human Genetics, Hannover Medical School, Hannover, Germany., Azzollini J; Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori di Milano, Milan, Italy., Balmaña J; High Risk and Cancer Prevention Group, Vall d'Hebron Institute of Oncology, University Hospital Vall d'Hebron, Barcelona, Spain., Barkardottir RB; Department of Pathology, Landspitali University Hospital, 101, Reykjavik, Iceland.; BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Barnes DR; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Barroso A; Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Barrowdale D; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Belotti M; Service de Génétique, Institut Curie, Paris, France., Benitez J; Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain., Bertelsen B; Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Blok MJ; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands., Bodrogi I; Department of Chemotherapy, National Institute of Oncology, Budapest, Hungary., Bonadona V; Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France., Bonanni B; Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Milan, Italy., Bondavalli D; Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Milan, Italy., Boonen SE; Clinical Genetic Unit, Department of Paediatrics, Zealand University Hospital, Roskilde, Denmark., Borde J; Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany., Borg A; Department of Oncology, Lund University and Skåne University Hospital, Lund, Sweden., Bradbury AR; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Brady A; North West Thames Regional Genetics Service, Kennedy Galton Centre, The North West London Hospitals NHS Trust, Middlesex, United Kingdom., Brewer C; Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, United Kingdom., Brunet J; Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, CIBERONC, Girona, Spain., Buecher B; Service de Génétique, Institut Curie, Paris, France., Buys SS; Department of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah., Cabezas-Camarero S; Department of Oncology, Hospital Clinico San Carlos, IdISSC, Madrid, Spain., Caldés T; Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., Caliebe A; Institute of Human Genetics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany., Caligo MA; Section of Molecular Genetics, Department of Laboratory Medicine, University Hospital of Pisa, Pisa, Italy., Calvello M; Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Milan, Italy., Campbell IG; Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia., Carnevali I; UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Varese, Italy., Carrasco E; High Risk and Cancer Prevention Group, Vall d'Hebron Institute of Oncology, University Hospital Vall d'Hebron, Barcelona, Spain., Chan TL; Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, Happy Valley, Hong Kong.; Department of Pathology, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong., Chu ATW; Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, Happy Valley, Hong Kong., Chung WK; Departments of Pediatrics and Medicine, Columbia University, New York, New York., Claes KBM; Centre for Medical Genetics, Ghent University, Ghent, Belgium., Collaborators GS; Service de Génétique, Institut Curie, Paris, France., Collaborators E; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Cook J; Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, United Kingdom., Cortesi L; Department of Oncology and Haematology, University of Modena and Reggio Emilia, Modena, Italy., Couch FJ; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota., Daly MB; Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania., Damante G; Department of Medical and Biological Sciences, University of Udine, Udine, Italy., Darder E; Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, CIBERONC, Girona, Spain., Davidson R; Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, United Kingdom., de la Hoya M; Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., Puppa LD; Division of Functional Onco-genomics and Genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy., Dennis J; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Díez O; Oncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital, Barcelona, Spain., Ding YC; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California., Ditsch N; Department of Gynecology and Obstetrics, Ludwig Maximilian University of Munich, Munich, Germany., Domchek SM; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Donaldson A; Clinical Genetics Department, St Michael's Hospital, Bristol, United Kingdom., Dworniczak B; Institute of Human Genetics, University of Münster, Münster, Germany., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom., Eccles DM; Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Eeles RA; Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, United Kingdom., Ehrencrona H; Department of Clinical Genetics, Lund University Hospital, Lund, Sweden., Ejlertsen B; Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Engel C; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE - Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany., Evans DG; Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health and Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.; Manchester Centre for Genomic Medicine, St Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust and Manchester Academic Health Science Centre, Manchester, United Kingdom., Faivre L; Unité d'oncogénétique, Centre de Lutte Contre le Cancer, Centre Georges-François Leclerc, Dijon, France., Faust U; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany., Feliubadaló L; Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain., Foretova L; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic., Fostira F; Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece., Fountzilas G; Second Department of Medical Oncology, EUROMEDICA General Clinic of Thessaloniki, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece., Frost D; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., García-Barberán V; Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., Garre P; Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., Gauthier-Villars M; Service de Génétique, Institut Curie, Paris, France., Géczi L; Department of Chemotherapy, National Institute of Oncology, Budapest, Hungary., Gehrig A; Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University of Würzburg, Würzburg, Germany., Gerdes AM; Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark., Gesta P; Service Régional Oncogénétique Poitou-Charentes, CH Niort, Niort, France., Giannini G; Department of Molecular Medicine, University La Sapienza, Rome, Italy., Glendon G; Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada., Godwin AK; Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, Kansas., Goldgar DE; Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah., Greene MH; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland., Gutierrez-Barrera AM; Department of Breast Medical Oncology and Clinical Genetics Program, University of Texas MD Anderson Cancer Center, Houston, Texas., Hahnen E; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany., Hamann U; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hauke J; Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany., Herold N; Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany., Hogervorst FBL; Family Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands., Honisch E; Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany., Hopper JL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Hulick PJ; Center for Medical Genetics, NorthShore University HealthSystem, Evanston, Illinois.; The University of Chicago Pritzker School of Medicine, Chicago, Illinois., Investigators K; Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia., Investigators H; The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), Coordinating center: The Netherlands Cancer Institute, Amsterdam, the Netherlands., Izatt L; Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom., Jager A; Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., James P; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia.; Parkville Familial Cancer Centre, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia., Janavicius R; Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania., Jensen UB; Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark., Jensen TD; Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark., Johannsson OT; Department of Oncology, Landspitali University Hospital, Reykjavik, Iceland., John EM; Division of Oncology, Department of Medicine, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California., Joseph V; Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York., Kang E; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea., Kast K; Department of Gynecology and Obstetrics, Technical University of Dresden, Dresden, Germany., Kiiski JI; Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Kim SW; Department of Surgery, Daerim Saint Mary's Hospital, Seoul, Korea., Kim Z; Department of Surgery, Soonchunhyang University Bucheon Hospital, Bucheon, Korea., Ko KP; Department of Preventive Medicine, Gacheon University College of Medicine, Incheon, Republic of Korea., Konstantopoulou I; Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece., Kramer G; Department of Urology, Medical University of Vienna, Vienna, Austria., Krogh L; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Kruse TA; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Kwong A; Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, Happy Valley, Hong Kong.; Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong.; Department of Surgery, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong., Larsen M; Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany., Lasset C; Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France., Lautrup C; Department of Clinical Genetics, Aalborg University Hospital, Aalborg, Denmark., Lazaro C; Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain., Lee J; Department of Surgery, Soonchunhyang University College of Medicine and Soonchunhyang University Hospital, Seoul, Korea., Lee JW; Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Seoul, Korea., Lee MH; Department of Surgery, Soonchunhyang University College of Medicine and Soonchunhyang University Hospital, Seoul, Korea., Lemke J; Institute of Human Genetics, University Hospital Leipzig, Leipzig, Germany., Lesueur F; Service de Génétique, Institut Curie, Paris, France.; Genetic Epidemiology of Cancer Team, Inserm U900, Paris, France.; Institut Curie, Paris, France.; Mines ParisTech, Fontainebleau, France., Liljegren A; Department of Oncology, Karolinska Institutet, Stockholm, Sweden., Lindblom A; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden., Llovet P; Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., Lopez-Fernández A; High Risk and Cancer Prevention Group, Vall d'Hebron Institute of Oncology, University Hospital Vall d'Hebron, Barcelona, Spain., Lopez-Perolio I; Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., Lorca V; Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., Loud JT; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland., Ma ESK; Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, Happy Valley, Hong Kong.; Department of Pathology, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong., Mai PL; Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Manoukian S; Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori di Milano, Milan, Italy., Mari V; Département d'Hématologie-Oncologie Médicale, Centre Antoine Lacassagne, Nice, France., Martin L; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Matricardi L; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Mebirouk N; Service de Génétique, Institut Curie, Paris, France.; Genetic Epidemiology of Cancer Team, Inserm U900, Paris, France.; Institut Curie, Paris, France.; Mines ParisTech, Fontainebleau, France., Medici V; Department of Oncology and Haematology, University of Modena and Reggio Emilia, Modena, Italy., Meijers-Heijboer HEJ; Department of Clinical Genetics, VU University Medical Center, Amsterdam, the Netherlands., Meindl A; Department of Gynecology and Obstetrics, Ludwig Maximilian University of Munich, Munich, Germany., Mensenkamp AR; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., Miller C; Department of Clinical Genetics, Alder Hey Hospital, Liverpool, United Kingdom., Gomes DM; Service de Biologie de la Reproduction, Cytogénétique et Génétique Médicale, CHI Poissy - Saint Germain, Poissy, France., Montagna M; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Mooij TM; Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Moserle L; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Mouret-Fourme E; Service de Génétique, Institut Curie, Paris, France., Mulligan AM; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada., Nathanson KL; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Navratilova M; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic., Nevanlinna H; Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Niederacher D; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Nielsen FCC; Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Nikitina-Zake L; Latvian Biomedical Research and Study Centre, Riga, Latvia., Offit K; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.; Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York., Olah E; Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary., Olopade OI; Center for Clinical Cancer Genetics, The University of Chicago, Chicago, Illinois., Ong KR; West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Birmingham, United Kingdom., Osorio A; Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain., Ott CE; Institute for Medical Genetics and Human Genetics, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Palli D; Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy., Park SK; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.; Cancer Research Institute, Seoul National University, Seoul, Korea., Parsons MT; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Pedersen IS; Section of Molecular Diagnostics, Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark., Peissel B; Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori di Milano, Milan, Italy., Peixoto A; Department of Genetics, Portuguese Oncology Institute, Porto, Portugal., Pérez-Segura P; Department of Oncology, Hospital Clinico San Carlos, IdISSC, Madrid, Spain., Peterlongo P; Genome Diagnostics Program, IFOM - the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy., Petersen AH; Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark., Porteous ME; South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, United Kingdom., Pujana MA; Translational Research Laboratory, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain., Radice P; Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, in Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy., Ramser J; Division of Gynaecology and Obstetrics, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany., Rantala J; Clinical Genetics, Karolinska Institutet, Stockholm, Sweden., Rashid MU; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC), Lahore, Pakistan., Rhiem K; Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany., Rizzolo P; Department of Molecular Medicine, University La Sapienza, Rome, Italy., Robson ME; Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York., Rookus MA; Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Rossing CM; Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Ruddy KJ; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Santos C; Department of Genetics, Portuguese Oncology Institute, Porto, Portugal., Saule C; Service de Génétique, Institut Curie, Paris, France., Scarpitta R; Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy., Schmutzler RK; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany., Schuster H; Unité d'Oncogénétique, Centre de Lutte Contre le Cancer Paul Strauss, Strasbourg, France., Senter L; Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio., Seynaeve CM; Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., Shah PD; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Sharma P; Department of Internal Medicine, Division of Oncology, University of Kansas Medical Center, Westwood, Kansas., Shin VY; Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong., Silvestri V; Department of Molecular Medicine, University La Sapienza, Rome, Italy., Simard J; Genomics Center, Centre Hospitalier Universitaire de Québec - Université Laval, Research Centre, Québec City, Québec, Canada., Singer CF; Dept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Skytte AB; Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark., Snape K; Medical Genetics Unit, St George's, University of London, London, United Kingdom., Solano AR; INBIOMED, Faculty of Medicine/CONICET and CEMIC, Department of Clinical Chemistry, Medical Direction, University of Buenos Aires, Buenos Aires, Argentina., Soucy P; Department of Internal Medicine, Division of Oncology, University of Kansas Medical Center, Westwood, Kansas., Southey MC; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.; Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia., Spurdle AB; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Steele L; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California., Steinemann D; Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany., Stoppa-Lyonnet D; Service de Génétique, Institut Curie, Paris, France.; Department of Tumour Biology, INSERM U830, Paris, France.; Université Paris Descartes, Paris, France., Stradella A; Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain., Sunde L; Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark., Sutter C; Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany., Tan YY; Department of OB/GYN, Medical University of Vienna, Vienna, Austria., Teixeira MR; Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.; Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal., Teo SH; Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.; Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia., Thomassen M; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Tibiletti MG; UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Varese, Italy., Tischkowitz M; Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, Quebec, Canada.; Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom., Tognazzo S; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Toland AE; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio., Tommasi S; Istituto Nazionale Tumori 'Giovanni Paolo II, Bari, Italy., Torres D; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia., Toss A; Department of Oncology and Haematology, University of Modena and Reggio Emilia, Modena, Italy., Trainer AH; Parkville Familial Cancer Centre, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia., Tung N; Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts., van Asperen CJ; Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands., van der Baan FH; Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., van der Kolk LE; Family Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands., van der Luijt RB; Department of Medical Genetics, University Medical Center, Utrecht, the Netherlands., van Hest LP; Clinical Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Varesco L; Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) AOU San Martino, IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy., Varon-Mateeva R; Institute for Medical Genetics and Human Genetics, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Viel A; Division of Functional Onco-genomics and Genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy., Vierstraete J; Centre for Medical Genetics, Ghent University, Ghent, Belgium., Villa R; Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori di Milano, Milan, Italy., von Wachenfeldt A; Department of Oncology, Karolinska Institutet, Stockholm, Sweden., Wagner P; Department of Women's Health, Tubingen University Hospital, Tubingen, Germany., Wang-Gohrke S; Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany., Wappenschmidt B; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany., Weitzel JN; Clinical Cancer Genetics, City of Hope, Duarte, California., Wieme G; Centre for Medical Genetics, Ghent University, Ghent, Belgium., Yadav S; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Yannoukakos D; Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece., Yoon SY; Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Selangor, Malaysia., Zanzottera C; Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori di Milano, Milan, Italy., Zorn KK; Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., D'Amico AV; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts., Freedman ML; Dana-Farber Cancer Institute. Boston, Massachusetts., Pomerantz MM; Dana-Farber Cancer Institute. Boston, Massachusetts., Chenevix-Trench G; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Antoniou AC; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Neuhausen SL; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California., Ottini L; Department of Molecular Medicine, University La Sapienza, Rome, Italy., Nielsen HR; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Rebbeck TR; Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Timothy_Rebbeck@dfci.harvard.edu.; Dana-Farber Cancer Institute. Boston, Massachusetts.

المصدر: Cancer research [Cancer Res] 2020 Feb 01; Vol. 80 (3), pp. 624-638. Date of Electronic Publication: 2019 Nov 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Predisposition to Disease* , Mutation*, BRCA1 Protein/*genetics , BRCA2 Protein/*genetics , Genomics/*methods , Prostatic Neoplasms/*genetics , Prostatic Neoplasms/*pathology, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Genetic Association Studies ; Heterozygote ; Humans ; Male ; Middle Aged ; Prognosis ; Risk Factors ; Young Adult

المؤلفون: Qian F; Department of Medicine, University of Chicago, Chicago, IL, USA., Rookus MA; Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Leslie G; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Risch HA; Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA., Greene MH; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Aalfs CM; Department of Clinical Genetics, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., Adank MA; Family Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands., Adlard J; Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK., Agnarsson BA; Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland.; School of Medicine, University of Iceland, Reykjavik, Iceland., Ahmed M; North East Thames Regional Genetics Service, Great Ormond Street Hospital, London, UK., Aittomäki K; Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Andrulis IL; Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Arnold N; Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany.; Institute of Clinical Molecular Biology, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany., Arun BK; Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ausems MGEM; Division Laboratories, Pharmacy and Biomedical Genetics, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands., Azzollini J; Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Barrowdale D; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Barwell J; Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, UK., Benitez J; Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain., Białkowska K; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Bonadona V; Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France., Borde J; Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany., Borg A; Department of Oncology, Lund University and Skåne University Hospital, Lund, Sweden., Bradbury AR; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Brunet J; Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, CIBERONC, Girona, Spain., Buys SS; Department of Medicine, Huntsman Cancer Institute, Salt Lake City, UT, USA., Caldés T; Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., Caligo MA; Section of Molecular Genetics, Dept. of Laboratory Medicine, University Hospital of Pisa, Pisa, Italy., Campbell I; Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia., Carter J; Department of Gynaecological Oncology, Chris O'Brien Lifehouse and The University of Sydney, Camperdown, NSW, Australia., Chiquette J; CRCHU de Québec- oncologie, Centre des maladies du sein Deschênes-Fabia, Hôpital du Saint-Sacrement, Québec, QC, Canada., Chung WK; Departments of Pediatrics and Medicine, Columbia University, New York, NY, USA., Claes KBM; Centre for Medical Genetics, Ghent University, Gent, Belgium., Collée JM; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands., Collonge-Rame MA; Service de Génétique, CHU de Besançon, Besançon, France., Couch FJ; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Daly MB; Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA., Delnatte C; Unité d'Oncogénétique, ICO-Centre René Gauducheau, Saint Herblain, France., Diez O; Oncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital Vall d'Hebron, Barcelona, Spain., Domchek SM; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Dorfling CM; Department of Genetics, University of Pretoria, Arcadia, South Africa., Eason J; Nottingham Clinical Genetics Service, Nottingham University Hospitals NHS Trust, Nottingham, UK., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Eeles R; Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK., Engel C; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany., Evans DG; Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.; Manchester Centre for Genomic Medicine, St Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK., Faivre L; Unité d'oncogénétique, Centre de Lutte Contre le Cancer, Centre Georges-François Leclerc, Dijon, France.; Centre de Génétique, CHU Dijon, Dijon, France., Feliubadaló L; Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Bellvitge Biomedical Research Institute, Catalan Institute of Oncology), CIBERONC, Barcelona, Spain., Foretova L; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic., Friedman E; The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel., Frost D; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Ganz PA; Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Centre, UCLA, Los Angeles, CA, USA., Garber J; Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA, USA., Garcia-Barberan V; Department of Medicine, Huntsman Cancer Institute, Salt Lake City, UT, USA., Gehrig A; Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany., Glendon G; Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada., Godwin AK; Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS, USA., Gómez Garcia EB; Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands., Hamann U; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hauke J; Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France.; Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Hopper JL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia., Hulick PJ; Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL, USA.; The University of Chicago Pritzker School of Medicine, Chicago, IL, USA., Imyanitov EN; N.N. Petrov Institute of Oncology, St. Petersburg, Russia., Isaacs C; Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA., Izatt L; Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK., Jakubowska A; Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.; Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland., Janavicius R; Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania.; State Research Institute, Innovative Medicine Center, Vilnius, CA, Lithuania., John EM; Department of Medicine, Division of Oncology, and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Karlan BY; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Kets CM; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Laitman Y; The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel., Lázaro C; Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Bellvitge Biomedical Research Institute, Catalan Institute of Oncology), CIBERONC, Barcelona, Spain., Leroux D; Département de Génétique, CHU de Grenoble, Grenoble, France., Lester J; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Lesueur F; Genetic Epidemiology of Cancer team, Inserm U900, Paris, France.; Institut Curie, Paris, France., Loud JT; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Lubiński J; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Łukomska A; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., McGuffog L; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Mebirouk N; Genetic Epidemiology of Cancer team, Inserm U900, Paris, France.; Institut Curie, Paris, France.; Mines ParisTech, Fontainebleau, France., Meijers-Heijboer HEJ; Department of Clinical Genetics, Amsterdam UMC, Location VU University Medical Center, Amsterdam, The Netherlands., Meindl A; Department of Gynecology and Obstetrics, Ludwig Maximilian University of Munich, Munich, Germany., Miller A; NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, NY, USA., Montagna M; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Mooij TM; Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Mouret-Fourme E; Service de Génétique, Institut Curie, Paris, France., Nathanson KL; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Nehoray B; Clinical Cancer Genomics, City of Hope, Duarte, CA, USA., Neuhausen SL; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA., Nevanlinna H; Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Nielsen FC; Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Offit K; Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.; Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA., Olah E; Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary., Ong KR; West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Birmingham, UK., Oosterwijk JC; Department of Genetics, University Medical Center Groningen, University Groningen, Groningen, The Netherlands., Ottini L; Department of Molecular Medicine, University La Sapienza, Rome, Italy., Parsons MT; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Peterlongo P; Genome Diagnostics Program, IFOM - the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy., Pfeiler G; Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Pradhan N; Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA., Radice P; Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy., Ramus SJ; School of Women's and Children's Health, Faculty of Medicine, University of NSW Sydney, Sydney, NSW, Australia.; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW, Australia., Rantala J; Clinical Genetics, Karolinska Institutet, Stockholm, Sweden., Rennert G; Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel., Robson M; Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA., Rodriguez GC; Division of Gynecologic Oncology, NorthShore University HealthSystem, University of Chicago, Evanston, IL, USA., Salani R; Wexner Medical Center, The Ohio State University, Columbus, OH, USA., Scheuner MT; Cancer Genetics and Prevention Program, University of California San Francisco, San Francisco, CA, USA., Schmutzler RK; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany., Shah PD; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Side LE; Wessex Clinical Genetics Service, University Hospitals Southampton NHS Trust, Southampton, UK., Simard J; Genomics Center, Centre Hospitalier Universitaire de Québec - Université Laval, Research Center, Québec City, QC, Canada., Singer CF; Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Steinemann D; Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany., Stoppa-Lyonnet D; Service de Génétique, Institut Curie, Paris, France.; Department of Tumour Biology, INSERM U830, Paris, France.; Université Paris Descartes, Paris, France., Tan YY; Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Teixeira MR; Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.; Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal., Terry MB; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA., Thomassen M; Department of Clinical Genetics, Odense University Hospital, Odence C, Denmark., Tischkowitz M; Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, QC, Canada.; Department of Medical Genetics, University of Cambridge, Cambridge, UK., Tognazzo S; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Toland AE; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA., Tung N; Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA., van Asperen CJ; Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands., van Engelen K; Department of Clinical Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., van Rensburg EJ; Department of Genetics, University of Pretoria, Arcadia, South Africa., Venat-Bouvet L; Department of Medical Oncology, CHU Dupuytren, Limoges, France., Vierstraete J; Centre for Medical Genetics, Ghent University, Gent, Belgium., Wagner G; Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Walker L; Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK., Weitzel JN; Clinical Cancer Genomics, City of Hope, Duarte, CA, USA., Yannoukakos D; Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece., Antoniou AC; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Goldgar DE; Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Olopade OI; Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, USA., Chenevix-Trench G; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Rebbeck TR; Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Huo D; Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, USA. dhuo@health.bsd.uchicago.edu.; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA. dhuo@health.bsd.uchicago.edu.

مؤلفون مشاركون: KConFab Investigators, HEBON Investigators, GEMO Study Collaborators, EMBRACE Collaborators, CIMBA

المصدر: British journal of cancer [Br J Cancer] 2019 Jul; Vol. 121 (2), pp. 180-192. Date of Electronic Publication: 2019 Jun 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Body Height* , Body Mass Index* , Genes, BRCA1* , Genes, BRCA2* , Heterozygote* , Mendelian Randomization Analysis* , Mutation*, Ovarian Neoplasms/*etiology, Adult ; Aged ; Female ; Humans ; Menopause ; Middle Aged ; Ovarian Neoplasms/genetics ; Proportional Hazards Models

المؤلفون: Qian F; Department of Medicine, The University of Chicago, Chicago, IL., Wang S; Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL.; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China., Mitchell J; Division of Gastroenterology, Department of Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA., McGuffog L; Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK., Barrowdale D; Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK., Leslie G; Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK., Oosterwijk JC; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Chung WK; Departments of Pediatrics and Medicine, Columbia University, New York, NY., Evans DG; Division of Evolution and Genomic Sciences, Genomic Medicine, Manchester Academic Health Sciences Centre, University of Manchester, Central Manchester University Hospitals, NHS Foundation Trust, Manchester, UK., Engel C; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE - Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany., Kast K; Department of Gynecology and Obstetrics, Technical University of Dresden, Dresden, Germany.; Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands., Aalfs CM; Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands.; Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL.; The University of Chicago Pritzker School of Medicine, Chicago, IL., Adank MA; Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands., Adlard J; Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK.; Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands., Agnarsson BA; Department of Pathology, National Institute of Oncology, Budapest, Hungary.; School of Medicine, University of Iceland, Reykjavik, Iceland., Aittomäki K; Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Alducci E; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.; Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands., Andrulis IL; Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Arun BK; Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX., Ausems MGEM; Department of Medical Genetics, University Medical Center, Utrecht, the Netherlands., Azzollini J; Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy., Barouk-Simonet E; Oncogénétique, Institut Bergonié, Bordeaux, France.; Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS., Barwell J; Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, UK.; Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, CIBERONC, Girona, Spain., Belotti M; Service de Génétique, Institut Curie, Paris, France., Benitez J; Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, University of California Los Angeles, CA., Berger A; Department of Oncology, Lund University and Skåne University Hospital, Lund, Sweden., Borg A; Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA.; Institute of Genetic Medicine, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK., Bradbury AR; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Brunet J; Service de Génétique, Institut Curie, Paris, France.; Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain.; Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain, Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria., Buys SS; Department of Medicine, Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT., Caldes T; Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, CIBERONC, Madrid, Spain., Caligo MA; Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy., Campbell I; Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia., Caputo SM; Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, UK.; Service de Génétique, Institut Curie, Paris, France., Chiquette J; Unité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Hôpital du Saint-Sacrement, Québec, QC, Canada., Claes KBM; Centre for Medical Genetics, Ghent University, Ghent, Belgium., Margriet Collée J; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands., Couch FJ; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Coupier I; Unité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France., Daly MB; Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA., Davidson R; Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, UK., Diez O; N.N. Petrov Institute of Oncology, St. Petersburg, Russia., Domchek SM; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Donaldson A; Oncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital, Vall d'Hebron, Barcelona, Spain (OD); Clinical Genetics Department, St Michael's Hospital, Bristol, UK., Dorfling CM; Department of Genetics, University of Pretoria, Arcadia, South Africa.; City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA., Eeles R; Ocogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK., Feliubadaló L; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Foretova L; Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Catalan Institute of Oncology, Bellvitge Biomedical Research Institute), CIBERONC, Barcelona, Spain.; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic., Fowler J; The Ohio State University, Columbus Cancer Council, Columbus, OH., Friedman E; The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel., Frost D; Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK., Ganz PA; Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, University of California Los Angeles, CA., Garber J; Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA., Garcia-Barberan V; Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, CIBERONC, Madrid, Spain., Glendon G; Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada., Godwin AK; Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS., Gómez Garcia EB; Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands., Gronwald J; Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands., Hahnen E; Centers for Hereditary Breast and Ovarian Cancer, Integrated Oncology and Molecular Medicine, University Hospital of Cologne, Cologne, Germany Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hamann U, Henderson A; Institute of Genetic Medicine, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK., Hendricks CB; City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA., Hopper JL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Hulick PJ; Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL.; The University of Chicago Pritzker School of Medicine, Chicago, IL., Imyanitov EN; N.N. Petrov Institute of Oncology, St. Petersburg, Russia., Isaacs C; Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC (CI)., Izatt L; Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK., Izquierdo Á; Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, CIBERONC, Girona, Spain., Jakubowska A; Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands., Kaczmarek K; Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands., Kang E; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea., Karlan BY; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA., Kets CM; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., Kim SW; Department of Surgery, Daerim Saint Mary's Hospital, Seoul, Korea., Kim Z; Department of Surgery, Soonchunhyang University Hospital Bucheon, Bucheon, Korea., Kwong A; Hong Kong Hereditary Breast Cancer Family Registry, Happy Valley, Hong Kong.; Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong.; Department of Surgery, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong., Laitman Y; The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel., Lasset C; Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France., Hyuk Lee M; Department of Surgery, Soonchunhyang University College of Medicine and Soonchunhyang University Hospital, Seoul, Korea., Won Lee J; Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Seoul, Korea., Lee J; Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA.; Department of Surgery, Soonchunhyang University College of Medicine and Soonchunhyang University Hospital, Seoul, Korea., Lester J; Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands., Lesueur F; Genetic Epidemiology of Cancer team, Institut Curie, Paris, France.; U900, INSERM, Paris, France.; PSL University, Paris, France.; Mines ParisTech, Fontainebleau, France., Loud JT; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD., Lubinski J; Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands., Mebirouk N; Genetic Epidemiology of Cancer team, Institut Curie, Paris, France.; U900, INSERM, Paris, France.; PSL University, Paris, France.; Mines ParisTech, Fontainebleau, France., Meijers-Heijboer HEJ; Department of Clinical Genetics, VU University Medical Center, Amsterdam, the Netherlands., Meindl A; Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany.; NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, NY., Miller A; Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany., Montagna M; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Mooij TM; Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Morrison PJ; Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, UK., Mouret-Fourme E; Service de Génétique, Institut Curie, Paris, France., Nathanson KL, Neuhausen SL; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA., Nevanlinna H; Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Niederacher D; Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany., Nielsen FC; Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Nussbaum RL; Cancer Genetics and Prevention Program, University of California San Francisco, San Francisco, CA., Offit K; Clinical Genetics Research Laboratory, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY.; Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY., Olah E; Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary., Ong KR; West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Birmingham, UK., Ottini L; Department of Molecular Medicine, University La Sapienza, Rome, Italy., Park SK; Departments of Preventive Medicine and Biomedical Sciences, and Cancer Research Institute, Seoul National University, Seoul, Korea., Peterlongo P; IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy., Pfeiler G; Department of Urology, Medical University of Vienna, Vienna, Austria., Phelan CM; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL., Poppe B; Centre for Medical Genetics, Ghent University, Ghent, Belgium., Pradhan N; Clinical Genetics Research Laboratory, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY., Radice P; Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy., Ramus SJ; School of Women's and Children's Health, University of New South Wales Sydney, New South Wales, Australia.; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales, Australia., Rantala J; Clinical Genetics, Karolinska Institutet, Stockholm, Sweden., Robson M; Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY., Rodriguez GC; Division of Gynecologic Oncology, NorthShore University HealthSystem, University of Chicago, Evanston, IL., Schmutzler RK; Centers for Hereditary Breast and Ovarian Cancer, Integrated Oncology and Molecular Medicine, University Hospital of Cologne, Cologne, Germany Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hutten Selkirk CG; Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL., Shah PD; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Simard J; Laboratoire de génétique médicale, Nancy Université, Centre Hospitalier Régional et Universitaire, Vandoeuvre-les-Nancy, France., Singer CF; Department of Obstetrics and Gynecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Sokolowska J; Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, QC, Canada., Stoppa-Lyonnet D; Department of Tumour Biology, Institut Curie, INSERM U830, Paris, France.; Université Paris Descartes, Paris, France., Sutter C; Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany., Yen Tan Y; Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain, Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria., Teixeira RM; Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.; Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal., Teo SH; Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.; Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia., Terry MB; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY., Thomassen M; Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark., Tischkowitz M; Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, QC, Canada.; Department of Medical Genetics, Addenbrooke's Hospital, Cambridge, UK., Toland AE; Department of Cancer Biology and Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH., Tucker KM; School of Medicine, University of New South Wales, Sydney, New South Wales, Australia.; Hereditary Cancer Centre, Prince of Wales Hospital, Sydney, New South Wales, Australia., Tung N; Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA., van Asperen CJ; Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands., van Engelen K; Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands., van Rensburg EJ; Department of Genetics, University of Pretoria, Arcadia, South Africa., Wang-Gohrke S; Department of Gynaecology and Obstetrics, University of Ulm, Ulm, Germany., Wappenschmidt B; Centers for Hereditary Breast and Ovarian Cancer, Integrated Oncology and Molecular Medicine, University Hospital of Cologne, Cologne, Germany Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Weitzel JN; Clinical Cancer Genetics, City of Hope, Duarte, CA., Yannoukakos D; Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece., Greene MH; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD., Rookus MA; Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Easton DF; Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Chenevix-Trench G; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Antoniou AC; Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK., Goldgar DE; Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT., Olopade OI; Department of Medicine, The University of Chicago, Chicago, IL., Rebbeck TR; Harvard T.H. Chan School of Public Health, Boston, MA.; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA., Huo D; Department of Medicine, The University of Chicago, Chicago, IL.; Department of Public Health Sciences, The University of Chicago, Chicago, IL (DH).

مؤلفون مشاركون: GEMO Study Collaborators, HEBON, EMBRACE

المصدر: Journal of the National Cancer Institute [J Natl Cancer Inst] 2019 Apr 01; Vol. 111 (4), pp. 350-364.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 7503089 Publication Model: Print Cited Medium: Internet ISSN: 1460-2105 (Electronic) Linking ISSN: 00278874 NLM ISO Abbreviation: J Natl Cancer Inst Subsets: MEDLINE

مواضيع طبية MeSH: Body Height* , Body Mass Index* , Mendelian Randomization Analysis* , Mutation*, BRCA1 Protein/*genetics , BRCA2 Protein/*genetics , Breast Neoplasms/*etiology, Adult ; Breast Neoplasms/pathology ; Female ; Genetic Predisposition to Disease ; Humans ; Polymorphism, Single Nucleotide ; Prognosis ; Risk Factors

المؤلفون: Rebbeck TR; Harvard TH Chan School of Public Health and Dana Farber Cancer Institute, Boston, USA., Friebel TM; Harvard TH Chan School of Public Health and Dana Farber Cancer Institute, Boston, USA., Friedman E; The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan 52621, and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Hamann U; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Huo D; Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, USA., Kwong A; The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong, China., Olah E; Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary., Olopade OI; Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, USA., Solano AR; INBIOMED, Faculty of Medicine, University of Buenos Aires/CONICET and CEMIC, Department of Clinical Chemistry, Medical Direction, Buenos Aires, Argentina., Teo SH; Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia., Thomassen M; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Weitzel JN; Division of Clinical Cancer Genomics, City of Hope Cancer Center, California, USA., Chan TL; Division of Molecular Pathology, Department of Pathology, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong., Couch FJ; Department of Laboratory Medicine and Pathology, and Health Sciences Research, Rochester, USA., Goldgar DE; Department of Dermatology, University of Utah School of Medicine, Salt Lake City, USA., Kruse TA; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Palmero EI; Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, Brazil., Park SK; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.; Department of Biomedical Science, Seoul National University Graduate School, Seoul, Korea.; Cancer Research Center, Seoul National University, Seoul, Korea., Torres D; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institute of Human Genetics, Pontificia Universidad Javeriana, Colombia., van Rensburg EJ; Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, South Africa., McGuffog L; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Parsons MT; Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Leslie G; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Aalfs CM; Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands., Abugattas J; City of Hope Clinical Cancer Genomics Community Research Network, Duarte, USA., Adlard J; Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK., Agata S; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Aittomäki K; Department of Clinical Genetics, Helsinki University Hospital, Helsinki, Finland., Andrews L; Hereditary Cancer Clinic, Prince of Wales Hospital, Randwick, Australia., Andrulis IL; Lunenfeld-Tanenbaum Research Institute, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Arason A; Laboratory of Cell Biology, Department of Pathology, hus 9, Landspitali-LSH v/Hringbraut, 101 Reykjavik, Iceland and BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Arnold N; Department of Gynaecology & Oncology, Medical University of Vienna, Austria., Arun BK; Department of Breast Medical Oncology and Clinical Cancer Genetics Program, University Of Texas MD Anderson Cancer Center, Houston, USA., Asseryanis E; Dept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Auerbach L; Dept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Azzollini J; Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Instituto Nazionale Tumori (INT), Milan, Italy., Balmaña J; Department of Medical Oncology, Vall d'Hebron University Hospital, Barcelona, Spain., Barile M; Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy., Barkardottir RB; Laboratory of Cell Biology, Department of Pathology, hus 9, Landspitali-LSH v/Hringbraut, 101 Reykjavik, Iceland and BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Barrowdale D; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Benitez J; Human Genetics Group and Genotyping Unit (CEGEN), Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain., Berger A; Dept of OB/GYN, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Berger R; The Institute of Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel., Blanco AM; UCSF Cancer Genetics and Prevention Program, San Francisco, USA., Blazer KR; Division of Clinical Cancer Genomics, City of Hope Cancer Center, California, USA., Blok MJ; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands., Bonadona V; Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, 28 rue Laënnec, Lyon, France., Bonanni B; Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy., Bradbury AR; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA., Brewer C; Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, UK., Buecher B; Service de Génétique, Institut Curie, 26 rue d'Ulm, Paris, France., Buys SS; Department of Medicine, Huntsman Cancer Institute, Salt Lake City, USA., Caldes T; Molecular Oncology Laboratory, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., Caliebe A; Institute of Human Genetics, University Hospital of Schleswig-Holstein, Kiel, Germany., Caligo MA; Section of Molecular Genetics, Dept. of Laboratory Medicine, University Hospital of Pisa, Pisa, Italy., Campbell I; Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia., Caputo SM; Service de Génétique, Institut Curie, 26 rue d'Ulm, Paris, France., Chiquette J; CRCHU de Quebec-oncologie, Centre des maladies du sein Deschênes-Fabia, Hôpital du Saint-Sacrement, Sainte-Foy, Canada., Chung WK; Departments of Pediatrics and Medicine, Columbia University, New York, USA., Claes KBM; Center for Medical Genetics, Ghent University, Gent, Belgium., Collée JM; Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands., Cook J; Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, UK., Davidson R; Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, UK., de la Hoya M; Molecular Oncology Laboratory, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., De Leeneer K; Center for Medical Genetics, Ghent University, Gent, Belgium., de Pauw A; Service de Génétique, Institut Curie, 26 rue d'Ulm, Paris, France., Delnatte C; Unité d'oncogénétique, ICO-Centre René Gauducheau, Saint Herblain, France., Diez O; Oncogenetics Group, Vall d'Hebron Institute of Oncology (VHIO), Clinical and Molecular Genetics Area, Vall d'Hebron University Hospital, Barcelona, Spain., Ding YC; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, USA., Ditsch N; Department of Gynaecology and Obstetrics, Ludwig-Maximilian University, Munich, Germany., Domchek SM; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA., Dorfling CM; Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, South Africa., Velazquez C; Cáncer Hereditario, Instituto de Biología y Genética Molecular, IBGM, Universidad de Valladolid, Valladolid, Spain., Dworniczak B; Institute of Human Genetics, University of Münster, Münster, Germany., Eason J; Nottingham Clinical Genetics Service, Nottingham University Hospitals NHS Trust, Nottingham, UK., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Eeles R; Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK., Ehrencrona H; Department of Clinical Genetics, Lund University Hospital, Lund, Sweden., Ejlertsen B; Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Engel C; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany., Engert S; Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University, Munich, Germany., Evans DG; Genomic Medicine, Manchester Academic Health Sciences Centre, Division of Evolution and Genomic Sciences, University of Manchester, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK., Faivre L; Centre de Lutte Contre le Cancer Georges François Leclerc, France and Genomic and Immunotherapy Medical Institute, Dijon University Hospital, Dijon, France., Feliubadaló L; Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Catalan Institute of Oncology-Bellvitge Biomedical Research Institute), Barcelona, Spain., Ferrer SF; Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France., Foretova L; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic., Fowler J; Columbus Cancer Council, Ohio State University, Columbus, USA., Frost D; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Galvão HCR; Oncogenetics Department, Barretos Cancer Hospital, Barretos, Brazil., Ganz PA; UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, Los Angeles, USA., Garber J; 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مؤلفون مشاركون: EMBRACE; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., GEMO Study Collaborators; Department of Tumour Biology, Institut Curie, Paris, France.; Institut Curie, Paris, France., HEBON; The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), Netherlands Cancer Institute, Amsterdam, The Netherlands.

المصدر: Human mutation [Hum Mutat] 2018 May; Vol. 39 (5), pp. 593-620. Date of Electronic Publication: 2018 Mar 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 9215429 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-1004 (Electronic) Linking ISSN: 10597794 NLM ISO Abbreviation: Hum Mutat Subsets: MEDLINE

مواضيع طبية MeSH: Internationality*, BRCA1 Protein/*genetics , BRCA2 Protein/*genetics , Mutation/*genetics, Databases, Genetic ; Family ; Geography ; Humans

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Chan School of Public Health, Boston, Massachusetts, USA., Hui S; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada., Lemaçon A; Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Québec, Canada., Soucy P; Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Québec, Canada., Dennis J; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Jiang X; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Rostamianfar A; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada., Finucane H; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Bolla MK; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., McGuffog L; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Wang Q; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Aalfs CM; Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands., Adams M; Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Adlard J; Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK., Agata S; Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS, Padua, Italy., Ahmed S; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Ahsan H; Center for Cancer Epidemiology and Prevention, University of Chicago, Chicago, Illinois, USA., Aittomäki K; Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Al-Ejeh F; Personalised Medicine Team, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Allen J; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Ambrosone CB; Roswell Park Cancer Institute, Buffalo, New York, USA., Amos CI; Center for Genomic Medicine, Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA., Andrulis IL; Fred A. 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Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus.; Department of Radiation Oncology, Hannover Medical School, Hannover, Germany.; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Bojesen A; Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark., Bojesen SE; Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bonanni B; Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy., Børresen-Dale AL; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway., Bozsik A; Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary., Bradbury AR; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA., Brand JS; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Brauch H; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tübingen, Tübingen, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany., Bressac-de Paillerets B; Gustave Roussy, Biopathology Department, Villejuif, France., Brewer C; Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, UK., Brinton L; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA., Broberg P; Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden., Brooks-Wilson A; Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada., Brunet J; Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona, Spain., Brüning T; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany., Burwinkel B; Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.; Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Buys SS; Department of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA., Byun J; Center for Genomic Medicine, Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA., Cai Q; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Caldés T; Medical Oncology Department, CIBERONC, Hospital Clínico San Carlos, Madrid, Spain., Caligo MA; Section of Molecular Genetics, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa, Italy., Campbell I; Research Department, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Canzian F; Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Caron O; Gustave Roussy, Biopathology Department, Villejuif, France., Carracedo A; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servizo Galego de Saúde SERGAS, Santiago de Compostela, Spain.; Centro de Investigación en Red de Enfermedades Raras (CIBERER) and Centro Nacional de Genotipado (CEGEN-PRB2), Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Carter BD; Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA., Castelao JE; Oncology and Genetics Unit, Instituto de Investigación Biomédica (IBI) de Orense-Pontevedra-Vigo, Xerencia de Xestión Integrada de Vigo, Servizo Galego de Saúde SERGAS, Vigo, Spain., Castera L; Centre François Baclesse, Caen, France., Caux-Moncoutier V; Service de Génétique Oncologique and INSERM U830, Institut Curie, Paris, France - Université Paris Descartes, Sorbonne Paris Cité., Chan SB, Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA., Chen X; Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Cheng TD; Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, New York, USA., Chiquette J; Unité de Recherche en Santé des Populations, Centre des Maladies du Sein Deschênes-Fabia, Hôpital du Saint-Sacrement, Québec City, Québec, Canada., Christiansen H; Department of Radiation Oncology, Hannover Medical School, Hannover, Germany., Claes KBM; Center for Medical Genetics, Ghent University, Ghent, Belgium., Clarke CL; Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia., Conner T; Huntsman Cancer Institute, Salt Lake City, Utah, USA., Conroy DM; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Cook J; Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, UK., Cordina-Duverger E; Cancer and Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France., Cornelissen S; Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands., Coupier I; Unité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France., Cox A; Academic Unit of Molecular Oncology, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK., Cox DG; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; INSERM U1052, Cancer Research Center of Lyon, Lyon, France., Cross SS; Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK., Cuk K; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Cunningham JM; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Czene K; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Daly MB; Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA., Damiola F; Bâtiment Cheney D, Centre Léon Bérard, Lyon, France., Darabi H; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Davidson R; Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, UK., De Leeneer K; Center for Medical Genetics, Ghent University, Ghent, Belgium., Devilee P; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Dicks E; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Diez O; Oncogenetics Group, Vall d'Hebron Institute of Oncology (VHIO), Clinical and Molecular Genetics Area, Vall d'Hebron University Hospital, Barcelona, Spain., Ding YC; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA., Ditsch N; Department of Gynecology and Obstetrics, Ludwig Maximilians University of Munich, Munich, Germany., Doheny KF; Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Domchek SM; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA., Dorfling CM; Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Arcadia, South Africa., Dörk T; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Dos-Santos-Silva I; Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK., Dubois S; Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Québec, Canada., Dugué PA; Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia., Dumont M; Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Québec, Canada., Dunning AM; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Durcan L; Southampton Clinical Trials Unit, Faculty of Medicine, University of Southampton, Southampton, UK.; Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK., Dwek M; Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, UK., Dworniczak B; Institute of Human Genetics, University of Münster, Münster, Germany., Eccles D; Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK., Eeles R; Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK., Ehrencrona H; Department of Clinical Genetics, Lund University Hospital, Lund, Sweden., Eilber U; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Ejlertsen B; Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Ekici AB; Institute of Human Genetics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany., Eliassen AH; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Engel C; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE-Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany., Eriksson M; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Fachal L; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Faivre L; Genetics Department, Dijon University Hospital, Dijon, France.; Oncogenetics, Centre Georges-François Leclerc, Dijon, France., Fasching PA; Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.; Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA., Faust U; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany., Figueroa J; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.; Usher Institute of Population Health Sciences and Informatics, CRUK Edinburgh Centre, University of Edinburgh Medical School, Edinburgh, UK., Flesch-Janys D; Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Fletcher O; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Flyger H; Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark., Foulkes WD; Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, Québec, Canada., Friedman E; Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel., Fritschi L; School of Public Health, Curtin University, Perth, Western Australia, Australia., Frost D; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Gabrielson M; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Gaddam P; Clinical Cancer Genetics Laboratory, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Gammon MD; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Ganz PA; Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, Schools of Medicine and Public Health, University of California, Los Angeles, Los Angeles, California, USA., Gapstur SM; Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA., Garber J; Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Garcia-Barberan V; Medical Oncology Department, CIBERONC, Hospital Clínico San Carlos, Madrid, Spain., García-Sáenz JA; Medical Oncology Department, CIBERONC, Hospital Clínico San Carlos, Madrid, Spain., Gaudet MM; Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA., Gauthier-Villars M; Service de Génétique Oncologique and INSERM U830, Institut Curie, Paris, France - Université Paris Descartes, Sorbonne Paris Cité., Gehrig A; Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany., Georgoulias V; Department of Medical Oncology, University Hospital of Heraklion, Heraklion, Greece., Gerdes AM; Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark., Giles GG; Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia., Glendon G; Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada., Godwin AK; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA., Goldberg MS; Department of Medicine, McGill University, Montréal, Québec, Canada.; Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montréal, Québec, Canada., Goldgar DE; Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA., González-Neira A; Human Genotyping Unit -Centro Nacional de Genotipado (CEGEN), Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Goodfellow P; Department of Obstetrics and Gynecology, Ohio State University James Comprehensive Cancer Center, Columbus, Ohio, USA., Greene MH; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA., Alnæs GIG; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway., Grip M; Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland., Gronwald J; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Grundy A; Centre de Recherche du Centre Hospitalier de Université de Montréal (CHUM), Montréal, Québec, Canada., Gschwantler-Kaulich D; Department of Obstetrics and Gynaecology and Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria., Guénel P; Cancer and Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France., Guo Q; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Haeberle L; Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany., Hahnen E; Center for Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany.; Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Haiman CA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Håkansson N; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Hallberg E; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA., Hamann U; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hamel N; McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada., Hankinson S; Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, Amherst, Massachusetts, USA., Hansen TVO; Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Harrington P; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Hart SN; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA., Hartikainen JM; Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland.; Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland., Healey CS; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Hein A; Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany., Helbig S; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Henderson A; Institute of Genetic Medicine, Centre for Life, Newcastle-upon-Tyne Hospitals NHS Trust, Newcastle-upon-Tyne, UK., Heyworth J; School of Population Health, University of Western Australia, Perth, Western Australia, Australia., Hicks B; Cancer Genomics Research Laboratory (CGR), Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA., Hillemanns P; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Hodgson S; Medical Genetics Unit, St George's, University of London, London, UK., Hogervorst FB; Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands., Hollestelle A; Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., Hooning MJ; Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., Hoover B; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA., Hopper JL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia., Hu C; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Huang G; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hulick PJ; Center for Medical Genetics, NorthShore University HealthSystem, Evanston, Illinois, USA.; Pritzker School of Medicine, University of Chicago, Evanston, Illinois, USA., Humphreys K; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Hunter DJ; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Imyanitov EN; N.N. Petrov Institute of Oncology, St. Petersburg, Russian Federation., Isaacs C; Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA., Iwasaki M; Division of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan., Izatt L; Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK., Jakubowska A; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., James P; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.; Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Janavicius R; State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania., Janni W; Department of Gynaecology and Obstetrics, University of Ulm, Ulm, Germany., Jensen UB; Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark., John EM; Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, USA.; Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA., Johnson N; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Jones K; Cancer Genomics Research Laboratory (CGR), Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA., Jones M; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK., Jukkola-Vuorinen A; Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland., Kaaks R; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Kabisch M; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Kaczmarek K; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Kang D; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea., Kast K; Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Keeman R; Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands., Kerin MJ; School of Medicine, National University of Ireland, Galway, Ireland., Kets CM; Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands., Keupers M; Leuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium., Khan S; Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Khusnutdinova E; Institute of Biochemistry and Genetics, Ufa Scientific Center of the Russian Academy of Sciences, Ufa, Russian Federation.; Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russian Federation., Kiiski JI; Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Kim SW; Department of Obstetrics and Gynaecology and Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria., Knight JA; Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Konstantopoulou I; Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece., Kosma VM; Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland.; Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland., Kristensen VN; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway., Kruse TA; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Kwong A; Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong.; Department of Surgery, University of Hong Kong, Hong Kong.; Department of Surgery, Hong Kong Sanatorium and Hospital, Hong Kong., Lænkholm AV; Department of Pathology, University Hospital of Region Zealand, Division Slagelse, Slagelse, Denmark., Laitman Y; Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, Israel., Lalloo F; Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK., Lambrechts D; Vesalius Research Center, VIB, Leuven, Belgium.; Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium., Landsman K; Clalit National Cancer Control Center, Haifa, Israel., Lasset C; Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France., Lazaro C; Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain., Le Marchand L; University of Hawaii Cancer Center, Honolulu, Hawaii, USA., Lecarpentier J; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Lee A; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Lee E; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Lee JW; Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea., Lee MH; Department of Surgery, Soonchunhyang University and Hospital, Seoul, Republic of Korea., Lejbkowicz F; Clalit National Cancer Control Center, Haifa, Israel., Lesueur F; Institut Curie, Paris, France.; PSL Research University, Paris, France.; INSERM U900, Paris, France.; Mines Paris Tech, Fontainebleau, France., Li J; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Lilyquist J; Department of Health Sciences Research, Mayo Clinic, Scottsdale, Arizona, USA., Lincoln A; Clinical Genetics Research Laboratory, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Lindblom A; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Lissowska J; Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland., Lo WY; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tübingen, Tübingen, Germany., Loibl S; German Breast Group, Neu Isenburg, Germany., Long J; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Loud JT; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA., Lubinski J; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Luccarini C; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Lush M; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., MacInnis RJ; Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia., Maishman T; Southampton Clinical Trials Unit, Faculty of Medicine, University of Southampton, Southampton, UK.; Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK., Makalic E; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia., Kostovska IM; Research Centre for Genetic Engineering and Biotechnology 'Georgi D. Efremov', Macedonian Academy of Sciences and Arts, Skopje, Macedonia., Malone KE; Division of Public Health Sciences, Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Manoukian S; Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori (INT), Milan, Italy., Manson JE; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Margolin S; Department of Oncology, Pathology, Karolinska Institutet, Stockholm, Sweden., Martens JWM; Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., Martinez ME; Moores Cancer Center, University of California, San Diego, La Jolla, California, USA.; Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, California, USA., Matsuo K; Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan.; Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Mavroudis D; Department of Medical Oncology, University Hospital of Heraklion, Heraklion, Greece., Mazoyer S; Lyon Neuroscience Research Center-CRNL, INSERM U1028, CNRS UMR 5292, University of Lyon, Lyon, France., McLean C; Anatomical Pathology, Alfred Hospital, Melbourne, Victoria, Australia., Meijers-Heijboer H; Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands.; Department of Clinical Genetics, VU University Medical Centre, Amsterdam, the Netherlands., Menéndez P; Servicio de Anatomía Patológica, Hospital Monte Naranco, Oviedo, Spain., Meyer J; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Miao H; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Miller A; NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, New York, USA., Miller N; School of Medicine, National University of Ireland, Galway, Ireland., Mitchell G; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.; Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Montagna M; Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS, Padua, Italy., Muir K; Institute of Population Health, University of Manchester, Manchester, UK.; Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK., Mulligan AM; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada., Mulot C; Université Paris Sorbonne Cité, INSERM UMRS 1147, Paris, France., Nadesan S; City of Hope Clinical Cancer Genomics Community Research Network, Duarte, California, USA., Nathanson KL; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA., Neuhausen SL; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA., Nevanlinna H; Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Nevelsteen I; Leuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium., Niederacher D; Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Nielsen SF; Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark., Nordestgaard BG; Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Norman A; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA., Nussbaum RL; Department of Medicine, University of California, San Francisco,San Francisco, California, USA., Olah E; Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary., Olopade OI; Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, Illinois, USA., Olson JE; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA., Olswold C; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA., Ong KR; West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK., Oosterwijk JC; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Orr N; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Osorio A; 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مؤلفون مشاركون: ABCTB Investigators, EMBRACE, GEMO Study Collaborators, HEBON, kConFab/AOCS Investigators, NBSC Collaborators

المصدر: Nature genetics [Nat Genet] 2017 Dec; Vol. 49 (12), pp. 1767-1778. Date of Electronic Publication: 2017 Oct 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Mutation* , Polymorphism, Single Nucleotide*, BRCA1 Protein/*genetics , Breast Neoplasms/*genetics , Genetic Predisposition to Disease/*genetics, Breast Neoplasms/ethnology ; Breast Neoplasms/metabolism ; Female ; Genetic Predisposition to Disease/ethnology ; Genome-Wide Association Study/methods ; Heterozygote ; Humans ; Receptors, Estrogen/metabolism ; Risk Factors ; White People/genetics

المؤلفون: Hamdi Y; Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec, QC, G1V 4G2, Canada., Soucy P; Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec, QC, G1V 4G2, Canada., Kuchenbaeker KB; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK.; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus Hinxton, Cambridge, CB10 1HH, UK., Pastinen T; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.; McGill University and Genome Quebec Innovation Centre, Montreal, QC, H3A 0G1, Canada., Droit A; Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec, QC, G1V 4G2, Canada., Lemaçon A; Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec, QC, G1V 4G2, Canada., Adlard J; Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, LS7 4SA, UK., Aittomäki K; Department of Clinical Genetics, Helsinki University Hospital, HUS, Meilahdentie 2, P.O. BOX 160, 00029, Helsinki, Finland., Andrulis IL; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.; Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Arason A; Department of Pathology hus 9, Landspitali-LSH v/Hringbraut, 101, Reykjavík, Iceland.; BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Vatnsmyrarvegi 16, 101, Reykjavík, Iceland., Arnold N; Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Christian-Albrechts University Kiel, Campus Kiel, 24105, Kiel, Germany., Arun BK; Department of Breast Medical Oncology and Clinical Cancer Genetics Program, University of Texas MD Anderson Cancer Center, 1515 Pressler Street CBP 5, Houston, TX, 77030, USA., Azzollini J; Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133, Milan, Italy., Bane A; Department of Pathology & Molecular Medicine, Juravinski Hospital and Cancer Centre, McMaster University, 711 Concession Street, Hamilton, ON, L8V 1C3, Canada., Barjhoux L; Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, 69373, Lyon, France., Barrowdale D; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK., Benitez J; Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain.; Biomedical Network on Rare Diseases (CIBERER), 28029, Madrid, Spain.; Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Berthet P; Centre François Baclesse, 3 avenue Général Harris, 14076, Caen, France., Blok MJ; Department of Clinical Genetics, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands., Bobolis K; City of Hope Clinical Cancer Genomics Community Research Network, 1500 East Duarte Road, Duarte, CA, 91010, USA., Bonadona V; Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, 28 rue Laënnec, 69373, Lyon, France., Bonanni B; Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Via Ripamonti 435, 20141, Milan, Italy., Bradbury AR; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA., Brewer C; Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, EX1 2ED, UK., Buecher B; Service de Génétique Oncologique, Institut Curie, 26 rue d'Ulm, 75248, Paris Cedex 05, France., Buys SS; Department of Medicine, Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT, 84112, USA., Caligo MA; Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy., Chiquette J; Unité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Hôpital du Saint-Sacrement, 1050 chemin Sainte-Foy, Quebec, QC, G1S 4L8, Canada., Chung WK; Departments of Pediatrics and Medicine, Columbia University, 1150 St. Nicholas Avenue, New York, NY, 10032, USA., Claes KB; Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000, Ghent, Belgium., Daly MB; Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA., Damiola F; Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, 69373, Lyon, France., Davidson R; Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, G51 4TF, UK., De la Hoya M; Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Martin Lagos s/n, Madrid, Spain., De Leeneer K; Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000, Ghent, Belgium., Diez O; Oncogenetics Group, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, Clinical and Molecular Genetics Area, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain., Ding YC; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA., Dolcetti R; Cancer Bioimmunotherapy Unit, Department of Medical Oncology, Centro di Riferimento Oncologico, IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) National Cancer Institute, Via Franco Gallini 2, 33081, Aviano, PN, Italy.; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD, Australia., Domchek SM; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA., Dorfling CM; Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Private Bag X323, Arcadia, 0007, South Africa., Eccles D; Faculty of Medicine, University of Southampton, Southampton University Hospitals NHS Trust, Southampton, UK., Eeles R; Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, SM2 5NG, UK., Einbeigi Z; Department of Oncology, Sahlgrenska University Hospital, 41345, Göteborg, Sweden., Ejlertsen B; Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark., Engel C; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107, Leipzig, Germany.; LIFE, Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany., Gareth Evans D; Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals, NHS Foundation Trust, Manchester, M13 9WL, UK., Feliubadalo L; Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Gran Via de l'Hospitalet, 199-203, L'Hospitalet, 08908, Barcelona, Spain., Foretova L; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Zluty kopec 7, 65653, Brno, Czech Republic., Fostira F; Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research 'Demokritos', Patriarchou Gregoriou & Neapoleos str., Aghia Paraskevi Attikis, Athens, Greece., Foulkes WD; Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, QC, Canada., Fountzilas G; Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloníki, Greece., Friedman E; The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, 52621, Ramat Gan, Israel.; Sackler Faculty of Medicine, Tel Aviv University, 69978, Ramat Aviv, Israel., Frost D; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK., Ganschow P; Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA., Ganz PA; UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, 650 Charles Young Drive South, Room A2-125 HS, Los Angeles, CA, 90095-6900, USA., Garber J; Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA., Gayther SA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA., Gerdes AM; Department of Clincial Genetics, Rigshospitalet, Blegdamsvej 9, 4062, Copenhagen, Denmark., Glendon G; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada., Godwin AK; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, 4019 Wahl Hall East, MS 3040, Kansas City, Kansas, USA., Goldgar DE; Department of Dermatology, University of Utah School of Medicine, 30 North 1900 East, SOM 4B454, Salt Lake City, UT, 84132, USA., Greene MH; Clinical Genetics Branch, DCEG, NCI NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, USA., Gronwald J; Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, 70-115, Szczecin, Poland., Hahnen E; Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, 50931, Cologne, Germany., Hamann U; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany., Hansen TV; Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark., Hart S; Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Hays JL; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH, 43210, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University, Columbus, OH, 43210, USA.; Comprehensive Cancer Center Arthur C. James Cancer Hospital and Richard J. Solove Research Institute Biomedical Research Tower, Room 588, 460 West 12th Avenue, Columbus, OH, 43210, USA., Hogervorst FB; Family Cancer Clinic, Netherlands Cancer Institute, P.O. Box 90203, 1006 BE, Amsterdam, The Netherlands., Hulick PJ; Center for Medical Genetics, NorthShore University HealthSystem, University of Chicago Pritzker School of Medicine, 1000 Central Street, Suite 620, Evanston, IL, 60201, USA., Imyanitov EN; N.N. Petrov Institute of Oncology, St. Petersburg, Russia, 197758., Isaacs C; Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC, 20007, USA., Izatt L; Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, SE1 9RT, UK., Jakubowska A; Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, 70-115, Szczecin, Poland., James P; Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, 3010, Australia., Janavicius R; Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Santariskiu st. 2, 08661, Vilnius, Lithuania.; State Research Institute Centre for Innovative Medicine, Zygymantu st. 9, Vilnius, Lithuania., Jensen UB; Department of Clinical Genetics, Aarhus University Hospital, Brendstrupgaardsvej 21C, Århus N, Denmark., John EM; Department of Epidemiology, Cancer Prevention Institute of California, 2201 Walnut Avenue Suite 300, Fremont, CA, 94538, USA.; Department of Health Research and Policy (Epidemiology) and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Joseph V; Clinical Genetics Research Laboratory, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10044, USA., Just W; Institute of Human Genetics, University of Ulm, 89091, Ulm, Germany., Kaczmarek K; Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, 70-115, Szczecin, Poland., Karlan BY; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA, 90048, USA., Kets CM; Department of Human Genetics, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands., Kirk J; Westmead Hospital, Familial Cancer Service, Hawkebury Road, P.O. Box 533, Wentworthville, NSW, 2145, Australia., Kriege M; Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, P.O. Box 5201, 3008 AE, Rotterdam, The Netherlands., Laitman Y; The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, 52621, Ramat Gan, Israel., Laurent M; Service de Génétique Oncologique, Institut Curie, 26 rue d'Ulm, 75248, Paris Cedex 05, France., Lazaro C; Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Gran Via de l'Hospitalet, 199-203, L'Hospitalet, 08908, Barcelona, Spain., Leslie G; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK., Lester J; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA, 90048, USA., Lesueur F; Genetic Epidemiology of Cancer Team, INSERM U900, Institut Curie Mines ParisTech, PSL University, 26 rue d'Ulm, 75248, Paris Cedex 05, France., Liljegren A; Department of Oncology, Karolinska University Hospital, 17176, Stockholm, Sweden., Loman N; Department of Oncology, Lund University Hospital, 22185, Lund, Sweden., Loud JT; Clinical Genetics Branch, DCEG, NCI NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, USA., Manoukian S; Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133, Milan, Italy., Mariani M; Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133, Milan, Italy., Mazoyer S; Lyon Neuroscience Research Center-CRNL, INSERM U1028, CNRS UMR5292, University of Lyon, Lyon, France., McGuffog L; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK., Meijers-Heijboer HE; Department of Clinical Genetics, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands., Meindl A; Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Christian-Albrechts University Kiel, Campus Kiel, 24105, Kiel, Germany., Miller A; NRG Oncology Statistics and Data Management Center, Roswell Park Cancer Institute, Elm St & Carlton St, Buffalo, NY, 14263, USA., Montagna M; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35128, Padua, Italy., Mulligan AM; Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada., Nathanson KL; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA., Neuhausen SL; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA., Nevanlinna H; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki, Haartmaninkatu 8, HUS, P.O. BOX 700, 00029, Helsinki, Finland., Nussbaum RL; Department of Medicine and Genetics, University of California, 513 Parnassus Ave., HSE 901E, San Francisco, CA, 94143-0794, USA., Olah E; Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary., Olopade OI; Department of Medicine, University of Chicago, 5841 South Maryland Avenue, MC 2115, Chicago, IL, USA., Ong KR; West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK., Oosterwijk JC; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB, Groningen, The Netherlands., Osorio A; Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain.; Biomedical Network on Rare Diseases (CIBERER), 28029, Madrid, Spain., Papi L; Unit of Medical Genetics, Department of Biomedical Experimental and Clinical Sciences, University of Florence, Viale Morgagni 50, 50134, Florence, Italy., Park SK; Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 110-799, Korea., Pedersen IS; Section of Molecular Diagnostics, Department of Biochemistry, Aalborg University Hospital, Reberbansgade 15, Ålborg, Denmark., Peissel B; Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133, Milan, Italy., Segura PP; Department of Oncology, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Martin Lagos s/n, Madrid, Spain., Peterlongo P; IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, c/o IFOM-IEO Campus, Via Adamello 16, 20139, Milan, Italy., Phelan CM; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, 33612, USA., Radice P; Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), c/o Amaedeolab via GA Amadeo 42, 20133, Milan, Italy., Rantala J; Department of Clinical Genetics, Karolinska University Hospital, L5:03, 171 76, Stockholm, Sweden., Rappaport-Fuerhauser C; Department of OB/GYN, Medical University of Vienna, Waehringer Guertel 18-20, A, 1090, Vienna, Austria., Rennert G; Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, 7 Michal St., 34362, Haifa, Israel., Richardson A; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Robson M; Clinical Genetics, Services Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA., Rodriguez GC; Division of Gynecologic Oncology, NorthShore University HealthSystem, University of Chicago, 2650 Ridge Avenue, Suite 1507, Walgreens, Evanston, IL, 60201, USA., Rookus MA; Department of Epidemiology, Netherlands Cancer Institute, P.O. Box 90203, 1006 BE, Amsterdam, The Netherlands., Schmutzler RK; Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, 50931, Cologne, Germany.; Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, 50931, Cologne, Germany.; Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany., Sevenet N; Oncogénétique, Institut Bergonié, 229 cours de l'Argonne, 33076, Bordeaux, France., Shah PD; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA., Singer CF; Department of OB/GYN, Medical University of Vienna, Waehringer Guertel 18-20, A, 1090, Vienna, Austria., Slavin TP; Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA., Snape K; Medical Genetics Unit, St George's, University of London, London, SW17 0RE, UK., Sokolowska J; Laboratoire de génétique médicale Nancy Université, Centre Hospitalier Régional et Universitaire, Rue du Morvan cedex 1, 54511, Vandoeuvre-les-Nancy, France., Sønderstrup IM; Department of Pathology Region Zealand Section Slagelse, Slagelse Hospital, Ingemannsvej 18 Slagelse, Cpoenhagen, Denmark., Southey M; Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, VIC, 3010, Australia., Spurdle AB; Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, QLD, 4006, Australia., Stadler Z; Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA., Stoppa-Lyonnet D; Service de Génétique Oncologique, Institut Curie, 26 rue d'Ulm, 75248, Paris Cedex 05, France., Sukiennicki G; Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, 70-115, Szczecin, Poland., Sutter C; Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany., Tan Y; Department of OB/GYN, Medical University of Vienna, Waehringer Guertel 18-20, A, 1090, Vienna, Austria., Tea MK; Department of OB/GYN, Medical University of Vienna, Waehringer Guertel 18-20, A, 1090, Vienna, Austria., Teixeira MR; Department of Genetics, Portuguese Oncology Institute, Rua Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal.; Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal., Teulé A; Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Gran Via de l'Hospitalet, 199-203, L'Hospitalet, 08908, Barcelona, Spain., Teo SH; Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 1 Jalan SS12/1A, 47500, Subang Jaya, Malaysia.; University Malaya Cancer Research Institute, University Malaya, 1 Jalan SS12/1A, 50603, Kuala Lumpur, Malaysia., Terry MB; Department of Epidemiology, Columbia University, New York, NY, USA., Thomassen M; Department of Clinical Genetics, Odense University Hospital, Sonder Boulevard 29, Odense C, Denmark., Tihomirova L; Latvian Biomedical Research and Study Centre, Ratsupites str 1, Riga, Latvia., Tischkowitz M; Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, QC, Canada.; Department of Medical Genetics Level 6 Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Hills Road, Box 134, Cambridge, CB2 0QQ, UK., Tognazzo S; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35128, Padua, Italy., Toland AE; Division of Human Genetics, Departments of Internal Medicine and Cancer Biology and Genetics Comprehensive Cancer Center, The Ohio State University, 998 Biomedical Research Tower, Columbus, OH, 43210, USA., Tung N; Department of Medical Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215, USA., van den Ouweland AM; Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, 330 Brookline Avenue, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands., van der Luijt RB; Department of Medical Genetics, University Medical Center Utrecht, 3584 EA, Utrecht, The Netherlands., van Engelen K; Department of Clinical Genetics, Academic Medical Center, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands., van Rensburg EJ; Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Private Bag X323, Arcadia, 0007, South Africa., Varon-Mateeva R; Institute of Human Genetics, Charite Berlin, Campus Virchov Klinikum, 13353, Berlin, Germany., Wappenschmidt B; Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, 50931, Cologne, Germany., Wijnen JT; Department of Human Genetics & Department of Clinical Genetics, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands., Rebbeck T; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Chenevix-Trench G; Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, QLD, 4006, Australia., Offit K; Clinical Genetics Research Laboratory, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10044, USA., Couch FJ; Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.; Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Nord S; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0372, Oslo, Norway., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK., Antoniou AC; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK., Simard J; Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec, QC, G1V 4G2, Canada. Jacques.Simard@crchudequebec.ulaval.ca.

مؤلفون مشاركون: EMBRACE, GEMO Study Collaborators, HEBON, KConFab Investigators

المصدر: Breast cancer research and treatment [Breast Cancer Res Treat] 2017 Jan; Vol. 161 (1), pp. 117-134. Date of Electronic Publication: 2016 Oct 28.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 8111104 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7217 (Electronic) Linking ISSN: 01676806 NLM ISO Abbreviation: Breast Cancer Res Treat Subsets: MEDLINE

مواضيع طبية MeSH: Alleles* , Genes, BRCA1* , Genes, BRCA2* , Heterozygote* , Mutation*, Breast Neoplasms/*epidemiology , Breast Neoplasms/*etiology, Biomarkers, Tumor ; Chromosomes, Human, Pair 11 ; Female ; Gene Expression ; Genetic Predisposition to Disease ; Genetic Variation ; Humans ; Quantitative Trait Loci ; Risk

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Latvian Biomedical Research and Study Centre, Rātsupītes iela 1, Rīga, LV-1067, Latvia. laima@biomed.lu.lv., Tung N; Division of Hematology Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Shapiro 9, Boston, MA, 02215-5400, USA. ntung@bidmc.harvard.edu., Dorfling CM; Department of Genetics, University of Pretoria, Private Bag X20, Hatfield, 0028, Pretoria, South Africa. celmari.dorfling@up.ac.za., van Rensburg EJ; Department of Genetics, University of Pretoria, Private Bag X20, Hatfield, 0028, Pretoria, South Africa. lizette.vanrensburg@up.ac.za., Neuhausen SL; Department of Population Sciences, Beckman Research Institute, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA. sneuhausen@coh.org., Ding YC; Department of Population Sciences, Beckman Research Institute, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA. ycding@coh.org., Gerdes AM; Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. anne-marie.gerdes@regionh.dk., Ejlertsen B; Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. bent.ejlertsen@regionh.dk., Nielsen FC; Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. fcn@rh.dk., Hansen TV; Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. tvoh@rh.dk., Osorio A; Human Genetics Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain. aosorio@cnio.es.; Center for Biomedical Network Research on Rare Diseases (CIBERER), Madrid, Spain. aosorio@cnio.es., Benitez J; Human Genetics Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain. jbenitez@cnio.es.; Center for Biomedical Network Research on Rare Diseases (CIBERER), Madrid, Spain. jbenitez@cnio.es., Conejero RA; Medical Oncology Service, Hospital Clínico Universitario Lozano Blesa, Avenida San Juan Bosco, 15, 50009, Zaragoza, Spain. andresraquel@hotmail.com., Segota E; Holy Cross Hospital, Michael and Dianne Bienes Comprehensive Cancer Center, Fort Lauderdale, FL, USA. zdenka.segota@holy-cross.com.; Clinical Cancer Genetics Community Research Network, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA. zdenka.segota@holy-cross.com., Weitzel JN; Division of Clinical Cancer Genetics, City of Hope (for the Clinical Cancer Genetics Community Research Network), City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA. jweitzel@coh.org., Thelander M; John Muir Medical Center, Walnut Creek, CA, USA; c/o Clinical Cancer Genetics Community Research Network, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA. margo.thelander@johnmuirhealth.com., Peterlongo P; Istituto FIRC di Oncologia Molecolare (IFOM), Via Adamello 16, 20139, Milan, Italy. paolo.peterlongo@ifom.eu., Radice P; Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale dei Tumori (INT), Via Venezian 1, 20133, Milan, Italy. paolo.radice@istitutotumori.mi.it., Pensotti V; Division of Clinical Cancer Genetics, City of Hope (for the Clinical Cancer Genetics Community Research Network), City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA. valeria.pensotti@ifom.eu.; Cogentech Cancer Genetic Test Laboratory, Via Adamello 16, 20139, Milan, Italy. valeria.pensotti@ifom.eu., Dolcetti R; Cancer Bioimmunotherapy Unit, Centro di Riferimento Oncologico (CRO), Via Franco Gallini 2, 33081, Aviano, Italy. rdolcetti@cro.it., Bonanni B; Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Via Ripamonti 435, 20141, Milan, Italy. bernardo.bonanni@ieo.it., Peissel B; Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale dei Tumori (INT), Via Venezian 1, 20133, Milan, Italy. bernard.peissel@istitutotumori.mi.it., Zaffaroni D; Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale dei Tumori (INT), Via Venezian 1, 20133, Milan, Italy. daniela.zaffaroni@istitutotumori.mi.it., Scuvera G; Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale dei Tumori (INT), Via Venezian 1, 20133, Milan, Italy. giulietta.scuvera@istitutotumori.m.it., Manoukian S; Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale dei Tumori (INT), Via Venezian 1, 20133, Milan, Italy. siranoush.manoukian@istitutotumori.mi.it., Varesco L; Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Azienda Ospedaliera Universitaria 'San Martino' di Genova, IST Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi, 10, 16132, Genoa, Italy. liliana.varesco@hsanmartino.it., Capone GL; FiorGen Foundation for Pharmacogenomics, Via Luigi Sacconi 6, 50019, Sesto Fiorentino, Italy. gabrycapo86@gmail.com.; Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy. gabrycapo86@gmail.com., Papi L; Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy. l.papi@dfc.unifi.it., Ottini L; Department of Molecular Medicine, Sapienza University, Rome, Italy. laura.ottini@uniroma1.it., Yannoukakos D; Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece. yannouka@rrp.demokritos.gr., Konstantopoulou I; Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens, Greece. reena@rrp.demokritos.gr., Garber J; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA. judy_garber@dfci.harvard.edu., Hamann U; Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany. u.hamann@dkfz-heidelberg.de., Donaldson A; Clinical Genetics Department, St Michael's Hospital, Southwell Street, Bristol, BS2 8EG, UK. alan.donaldson@uhbristol.nhs.uk., Brady A; North West Thames Regional Genetics Service, Kennedy-Galton Centre, Harrow, UK. a.brady@imperial.ac.uk., Brewer C; Department of Clinical Genetics, Royal Devon & Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK. carole.brewer1@nhs.net., Foo C; Merseyside and Cheshire Clinical Genetics Service, Liverpool Women's NHS Foundation Trust, Crown Street, Liverpool, Merseyside, L8 7SS, UK. claire.foo@lwh.nhs.uk., Evans DG; Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK. gareth.evans@cmft.nhs.uk., Frost D; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Worts Causeway, Cambridge, CB1 8RN, UK. djsf2@medschl.cam.ac.uk., Eccles D; Faculty of Medicine, University of Southampton, Southampton University Hospitals NHS Trust, Mailpoint 801, South Academic Block, PAH/G/MP105, Tremona Road, Southampton, SO16 6YD, UK. d.m.eccles@soton.ac.uk., Douglas F; Institute of Human Genetics, Northern Genetic Service, International Centre for Life, Newcastle upon Tyne Hospitals NHS Trust, Central Parkway, Newcastle upon Tyne, NE1 4EP, UK. fiona.douglas@nuth.nhs.uk., Cook J; Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, UK. jackie.cook@sch.nhs.uk., Adlard J; Yorkshire Regional Genetics Service, Leeds Teaching Hospitals NHS Trust, Old Medical School, Leeds General Infirmary, Leeds, LS1 3EX, UK. julian.adlard@leedsth.nhs.uk., Barwell J; Leicestershire Clinical Genetics Service, Department of Clinical Genetics, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, LE1 5WW, UK. julian.barwell@uhl-tr.nhs.uk., Walker L; Oxford Regional Genetics Service, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LE, UK. lisa.walker@ouh.nhs.uk., Izatt L; Clinical Genetics Service, Guy's and St Thomas' NHS Foundation Trust, 7th floor, Borough Wing, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK. louise.izatt@gstt.nhs.uk., Side LE; North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, Barclay House, 37, Queen Square, London, WC1N 3BH, UK. sidel@gosh.nhs.uk., Kennedy MJ; North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, Barclay House, 37, Queen Square, London, WC1N 3BH, UK. jkennedy@stjames.ie.; Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin, College Green, Dublin 2, Ireland. jkennedy@stjames.ie.; Medical Oncology Service, St James's Hospital, James's Street, Dublin 8, Ireland. jkennedy@stjames.ie., Tischkowitz M; Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrooke's Hospital, Level 6, Addenbrooke's Treatment Centre, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, CB2 0QQ, UK. mdt33@cam.ac.uk., Rogers MT; All Wales Medical Genetics Services, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK. mark.rogers@wales.nhs.uk., Porteous ME; South East Scotland Regional Genetic Service, Western General Hospital, David Brock Building, Crewe Road South, Edinburgh, EH4 2XU, UK. mary.porteous@ed.ac.uk., Morrison PJ; Centre for Cancer Research & Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, UK. patrick.morrison@belfasttrust.hscni.net.; Department of Medical Genetics, Belfast Health and Social Care Trust, Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, UK. patrick.morrison@belfasttrust.hscni.net., Platte R; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Worts Causeway, Cambridge, CB1 8RN, UK. rp356@medschl.cam.ac.uk., Eeles R; Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, 123 Old Brompton Road, London, SW7 3RP, UK. rosalind.eeles@icr.ac.uk., Davidson R; Ferguson-Smith Centre for Clinical Genetics, Yorkhill Hospitals, Block 4, Glasgow, G3 8SJ, UK. rosemarie.davidson@ggc.scot.nhs.uk., Hodgson S; South West Thames Regional Genetics Service, Department of Medical Genetics, St George's University of London, Cranmer Terrace, London, SW17 0RE, UK. shodgson@sgul.ac.uk., Cole T; West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Mindelsohn Way, Edgbaston, Birmingham, B15 2TG, UK. trevor.cole@bwhct.nhs.uk., Godwin AK; Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA. agodwin@kumc.edu., Isaacs C; Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC, 20057, USA. isaacsc@georgetown.edu., Claes K; Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium. kathleen.claes@ugent.be., De Leeneer K; Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium. kim.deleeneer@ugent.be., Meindl A; Division of Tumor Genetics, Department of Gynaecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675, Munich, Germany. alfons.meindl@lrz.tu-muenchen.de., Gehrig A; Center of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institut für Humangenetik, Biozentrum, Universität Würzburg, Am Hubland, 97074, Würzburg, Germany. gehrig@biozentrum.uni-wuerzburg.de., Wappenschmidt B; Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, Center for Integrated Oncology (CIO) Cancer Center Cologne, University Hospital Cologne, Cologne, Germany. barbara.wappenschmidt@uk-koeln.de.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Strasse 21, 50931, Cologne, Germany. barbara.wappenschmidt@uk-koeln.de., Sutter C; Department of Human Genetics, Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany. c.sutter@med.uni-heidelberg.de., Engel C; Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany. christoph.engel@imise.uni-leipzig.de., Niederacher D; Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, 40225, Düsseldorf, Germany. niederac@med.uni-duesseldorf.de., Steinemann D; Institute of Cell and Molecular Pathology, Centre for Pathology and Forensic and Genetic Medicine, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany. steinemann.doris@mh-hannover.de., Plendl H; Institute of Human Genetics, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3, D-24105, Kiel, Germany. plendl@medgen.uni-kiel.de., Kast K; Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus of Dresden, Technical University Dresden, Dresden, Germany. karin.kast@uniklinikum-dresden.de., Rhiem K; Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, Center for Integrated Oncology (CIO) Cancer Center Cologne, University Hospital Cologne, Cologne, Germany. kerstin.rhiem@uk-koeln.de.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Strasse 21, 50931, Cologne, Germany. kerstin.rhiem@uk-koeln.de., Ditsch N; Division of Tumor Genetics, Department of Gynaecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675, Munich, Germany. nina.ditsch@med.uni-muenchen.de., Arnold N; Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3, D-24105, Kiel, Germany. norbert.arnold@uksh.de., Varon-Mateeva R; Institute of Medical Genetics and Human Genetics, Campus Virchow-Klinikum, Charité Berlin - Universtitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. raymonda.varon-mateeva@charite.de., Schmutzler RK; Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, Center for Integrated Oncology (CIO) Cancer Center Cologne, University Hospital Cologne, Cologne, Germany. rita.schmutzler@uk-koeln.de.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Strasse 21, 50931, Cologne, Germany. rita.schmutzler@uk-koeln.de.; German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC), Cologne, Germany. rita.schmutzler@uk-koeln.de., Preisler-Adams S; Institute of Human Genetics, University Hospital Münster, Vesaliusweg 12-14, 48149, Münster, Germany., Markov NB; Institute of Human Genetics, University Hospital Münster, Vesaliusweg 12-14, 48149, Münster, Germany. nadja.bogdanova-markov@ukmuenster.de., Wang-Gohrke S; Department of Gynecology and Obstetrics, University Hospital Ulm, Ulm, Germany. shan.wang-gohrke@uniklinik.ulm.de., de Pauw A; Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05, France. antoine.depauw@curie.net., Lefol C; Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05, France. cedrick.lefol@curie.net., Lasset C; UMR CNRS 5558, Laboratoire de Biométrie et Biologie Évolutive (LBBE), 'Biométrie et Biologie Évolutive', Université Claude Bernard Lyon 1, Bâtiment Grégor Mendel, 43 boulevard du 11 novembre 1918, 69622, Villeurbanne, cedex, France. christine.lasset@lyon.unicancer.fr.; Unité de Prévention et d'Épidémiologie Génétique, Centre Léon Bérard, 28 rue Laenned, 69008, Lyon, France. christine.lasset@lyon.unicancer.fr., Leroux D; Génétique Clinique, Centre Hospitalier Universitaire de Grenoble, CS 10217, 38043, Grenoble, cedex 9, France. dleroux@chu-grenoble.fr.; Institut Albert Bonniot - Inserm U823, Université Joseph Fourier, Rond-point de la Chantourne, 38706, La Tronche, France. dleroux@chu-grenoble.fr., Rouleau E; Laboratoire d'Oncogénétique, Hôpital René Huguenin, Institut Curie, 35 rue Dailly, 92210, Saint-Cloud, France. etienne.rouleau@curie.net., Damiola F; INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France. francesca.damiola@lyon.unicancer.fr., Dreyfus H; Génétique Clinique, Centre Hospitalier Universitaire de Grenoble, CS 10217, 38043, Grenoble, cedex 9, France. h.dreyfus@isc84.org.; Institut Albert Bonniot - Inserm U823, Université Joseph Fourier, Rond-point de la Chantourne, 38706, La Tronche, France. h.dreyfus@isc84.org., Barjhoux L; INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France. laure.barjhoux@lyon.unicancer.fr., Golmard L; Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05, France. lisa.golmard@curie.net., Uhrhammer N; Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, 58 rue Montalembert, BP 392, 63011, Clermont-Ferrand, France. nancy.uhrammer@cjp.fr., Bonadona V; UMR CNRS 5558, Laboratoire de Biométrie et Biologie Évolutive (LBBE), 'Biométrie et Biologie Évolutive', Université Claude Bernard Lyon 1, Bâtiment Grégor Mendel, 43 boulevard du 11 novembre 1918, 69622, Villeurbanne, cedex, France. valerie.bonadona@lyon.unicancer.fr.; Unité de Prévention et d'Épidémiologie Génétique, Centre Léon Bérard, 28 rue Laenned, 69008, Lyon, France. valerie.bonadona@lyon.unicancer.fr., Sornin V; INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France. valerie.sornin@lyon.unicancer.fr., Bignon YJ; Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, 58 rue Montalembert, BP 392, 63011, Clermont-Ferrand, France. yves-jean.bignon@cjp.fr., Carter J; Gynaecological Oncology, Sydney Cancer Centre, Royal Prince Alfred Hospital and University of Sydney, Missenden Road, Camperdown, NSW, 2050, Australia. j.carter@sydney.edu.au., Van Le L; Gynecologic Oncology Group, Department of OB-GYN, University of North Carolina at Chapel Hill, 103B Physicians' Office Building, CB# 7572, Chapel Hill, NC, 27599-7572, USA. linda_van_le@med.unc.edu., Piedmonte M; Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263-0001, USA. mpiedmon@gogstats.org., DiSilvestro PA; Women & Infants Hospital, 1 Blackstone Place, Providence, RI, 02905, USA. pdisilvestro@wihri.org., de la Hoya M; Molecular Oncology Laboratory, Health Research Institute of the San Carlos Clinical Hospital (IdISSC), 28040, Madrid, Spain. mdhoya@hotmail.com., Caldes T; Molecular Oncology Laboratory, Health Research Institute of the San Carlos Clinical Hospital (IdISSC), 28040, Madrid, Spain. trinidad.caldes@salud.madrid.org., Nevanlinna H; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Biomedicum Helsinki, PO Box 700, 00029, Helsinki, Finland. heli.nevanlinna@hus.fi., Aittomäki K; Department of Clinical Genetics, Helsinki University Central Hospital, Biomedicum Helsinki 1, Haartmaninkatu 8, 00290, Helsinki, Finland. kristiina.aittomaki@hus.fi., Jager A; Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, PO Box 2040, 3000, CA, Rotterdam, the Netherlands. a.jager@erasmusmc.nl., van den Ouweland AM; Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands. a.vandenouweland@erasmusmc.nl., Kets CM; Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands. marleen.kets@radboudumc.nl., Aalfs CM; Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands. c.m.aalfs@amc.uva.nl., van Leeuwen FE; Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands. f.v.leeuwen@nki.nl., Hogervorst FB; Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands. f.hogervorst@nki.nl., Meijers-Heijboer HE; Department of Clinical Genetics, VU University Medical Center Amsterdam, De Boelelaan 1118, 1081 HV, Amsterdam, the Netherlands. h.meijers@vumc.nl., Oosterwijk JC; Department of Genetics, University Medical Center, Groningen University, Groningen, the Netherlands. j.c.oosterwijk@umcg.nl., van Roozendaal KE; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands. kees.vanroozendaal@mumc.nl., Rookus MA; Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands. m.rookus@nki.nl., Devilee P; Department of Human Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, S4-P PO Box 9600, 2300, RC, Leiden, the Netherlands. p.devilee@lumc.nl.; Department of Pathology, Leiden University Medical Center, PO Box 9600, 2300 RC L1Q, Leiden, the Netherlands. p.devilee@lumc.nl., van der Luijt RB; Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands. r.b.vanderluijt@umcutrecht.nl., Olah E; Department of Molecular Genetics, National Institute of Oncology, Ráth György u 7-9, PO Box 1525 Budapest PF 21, 1122, Budapest, Hungary. e.olah@oncol.hu., Diez O; Oncogenetics Group, Vall d'Hebron Institute of Oncology (VHIO), University Hospital Vall d'Hebron, Vall d'Hebron Research Institute (VHIR) and Universitat Autònoma de Barcelona, Passeig de la Vall d'Hebron 119, 08035, Barcelona, Spain. odiez@vhebron.net., Teulé A; Genetic Counseling Unit, Hereditary Cancer Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)-Catalan Institute of Oncology, Hospital Duran i Reynals, 3a planta - Gran Via de l'Hospitalet, 199, 08908, Hospitalet de Llobregat, Barcelona, Spain. ateule@iconcologia.net., Lazaro C; Molecular Diagnostic Unit, Hereditary Cancer Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)-Catalan Institute of Oncology, Hospital Duran i Reynals, 3a planta - Gran Via de l'Hospitalet, 199, 08908, Hospitalet de Llobregat, Barcelona, Spain. clazaro@iconcologia.net., Blanco I; Genetic Counseling Unit, Hereditary Cancer Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)-Catalan Institute of Oncology, Hospital Duran i Reynals, 3a planta - Gran Via de l'Hospitalet, 199, 08908, Hospitalet de Llobregat, Barcelona, Spain. iblanco@iconcologia.net., Del Valle J; Molecular Diagnostic Unit, Hereditary Cancer Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)-Catalan Institute of Oncology, Hospital Duran i Reynals, 3a planta - Gran Via de l'Hospitalet, 199, 08908, Hospitalet de Llobregat, Barcelona, Spain. jdelvalle@iconcologia.net., Jakubowska A; Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111, Szczecin, Poland. aniaj@pum.edu.pl., Sukiennicki G; Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111, Szczecin, Poland. starosta84@wp.pl., Gronwald J; Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111, Szczecin, Poland. jgron@pum.edu.pl., Lubinski J; Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111, Szczecin, Poland. lubinski@pum.edu.pl., Durda K; Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111, Szczecin, Poland. k.durda@onet.pl., Jaworska-Bieniek K; Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111, Szczecin, Poland. ka_jaworska@wp.pl., Agnarsson BA; Landspítali National University Hospital of Iceland and Faculty of Medicine, School of Health Sciences, University of Iceland School of Medicine, Sæmundargötu 2, 101, Reykjavik, Iceland. bjarniaa@lsh.is., Maugard C; Laboratoire de diagnostic génétique et Service d'Onco-hématologie, Les Hopitaux Universitaire de Strasbourg, Nouvel Hôpital Civil, 1 place de l'Hôpital, BP 426, 67091, Strasbourg, France. christinemaugard@gmail.com., Amadori A; Department of Surgical Sciences, Oncology and Gastroenterology, Padua University, Clinical Surgery II, via Giustiniani 2, 35124, Padua, Italy. albido@unipd.it.; Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), via Gattamelata 64, 35128, Padua, Italy. albido@unipd.it., Montagna M; Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), via Gattamelata 64, 35128, Padua, Italy. montagna@unipd.it., Teixeira MR; Department of Genetics, Portuguese Oncology Institute (IPO-PORTO), Edifício dos Laboratórios, piso 6, 4200-072, Porto, Portugal. manuel.teixeira@ipoporto.min-saude.pt.; Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal. manuel.teixeira@ipoporto.min-saude.pt., Spurdle AB; Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia. amanda.spurdle@qimrberghofer.edu.au., Foulkes W; Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, 546 Pine Avenue West, Montreal, QC, J2W 1S6, Canada. william.foulkes@mcgill.ca., Olswold C; Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. olswold.curtis@mayo.edu., Lindor NM; Department of Health Sciences Research, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, USA. lindor.noralane@mayo.edu., Pankratz VS; Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. pankratz.vernon@mayo.edu., Szabo CI; National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, 31 Center Drive, MSC 2152, 9000 Rockville Pike, Bethesda, MD, 20892-2152, USA. szaboc@mail.nih.gov., Lincoln A; Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. lincolna@mskcc.org., Jacobs L; Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. jacobsl@mskcc.org., Corines M; Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. corinesm@mskcc.org., Robson M; Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. robsonm@mskcc.org., Vijai J; Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. josephv@mskcc.org., Berger A; 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Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090, Vienna, Austria. daphne.gschwantler-kaulich@meduniwien.ac.at., Pfeiler G; Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090, Vienna, Austria. george.pfeiler@meduniwien.ac.at., Tea MK; Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090, Vienna, Austria. muy-kheng.tea@meduniwien.ac.at., Greene MH; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. greenem@mail.nih.gov., Mai PL; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. maip@mail.nih.gov., Rennert G; Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Via Ripamonti 435, 20141, Milan, Italy. rennert@tx.technion.ac.il.; National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Clalit Health Services Carmel Medical Center, 34361, Haifa, Israel. rennert@tx.technion.ac.il.; Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, 2 Horev Street, 34362, Haifa, Israel. rennert@tx.technion.ac.il., Imyanitov EN; NN Petrov Institute of Oncology, 68 Leningradskaya Street, Pesochny, 197758, St Petersburg, Russia. evgeny@imyanitov.spb.ru., Mulligan AM; Department of Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Building, 6th Floor, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. annamarie.mulligan@uhn.ca.; Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, 209 Victoria Street, Toronto, ON, M5B 1T8, Canada. annamarie.mulligan@uhn.ca., Glendon G; Ontario Cancer Genetics Network, Cancer Care Ontario, 620 University Avenue, Toronto, ON, M5G 2L7, Canada. gord.glendon@cancercare.on.ca.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON, M5G 1X5, Canada. gord.glendon@cancercare.on.ca., Andrulis IL; Department of Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Building, 6th Floor, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. andrulis@lunenfeld.ca.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON, M5G 1X5, Canada. andrulis@lunenfeld.ca.; Department of Molecular Genetics, University of Toronto, Medical Science Building, Room 4386, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. andrulis@lunenfeld.ca., Tchatchou S; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON, M5G 1X5, Canada. tchatchou@lunenfeld.ca., Toland AE; Department of Human Cancer Genetics, 1093 Biomedical Research Tower, 460 West 12th Avenue, Columbus, OH, 43210, USA. amanda.toland@osumc.edu.; Department of Internal Medicine, The Ohio State University Wexner Medical Center, North Doan Tower, 395 West 12th Avenue, Columbus, OH, 43210, USA. amanda.toland@osumc.edu.; Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, 1093 Biomedical Research Tower, 460 West 12th Avenue, Columbus, OH, 43210, USA. amanda.toland@osumc.edu.; The Ohio State University Comprehensive Cancer Center - Arthur G James Cancer Hospital and Richard J Solove Research Institute (OSUCCC - James), 460 West 10th Avenue, Columbus, OH, 43210, USA. amanda.toland@osumc.edu., Pedersen IS; Section of Molecular Diagnostics, Department of Biochemistry, Aalborg University Hospital, Hobrovej 18, 9000, Aalborg, Denmark. isp@rn.dk., Thomassen M; Department of Clinical Genetics, Odense University Hospital, Soenderboulevard 29, 5000, Odense C, Denmark. mads.thomassen@ouh.rsyd.dk., Kruse TA; Department of Clinical Genetics, Odense University Hospital, Soenderboulevard 29, 5000, Odense C, Denmark. torben.kruse@ouh.rsyd.dk., Jensen UB; Department of Clinical Genetics, Aarhus University Hospital, Brendstrupgårdsvej 21 C, 8200, Aarhus N, Denmark. uffejens@rm.dk., Caligo MA; Laboratorio di Genetica Oncologica, Divisione di Anatomia Patologica e di Diagnostica Molecolare ed Ultrastrutturale, Azienda Ospedaliero Universitaria Pisana - Ospedale S Chiara, via Roma 67, 56126, Pisa, Italy. adelaide.caligo@do.unipi.it., Friedman E; Sheba Laboratory of Molecular Genetics, The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621, Tel Aviv, Israel. eitan.friedman@sheba.health.gov.il., Zidan J; Institute of Oncology, Rivka Ziv Medical Center, Maimonides, 13100, Safed, Israel. jamal.zidan@ziv.health.gov.il., Laitman Y; Sheba Laboratory of Molecular Genetics, The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621, Tel Aviv, Israel. yael.laitman@sheba.health.gov.il., Lindblom A; Department of Cancer Genetics, Karolinska University Hospital, Solna L8:02, SE-171 76, Stockholm, Sweden. annika.lindblom@karolinska.se., Melin B; Oncology, Department of Radiation Sciences, Umeå University, SE-901 87, Umeå, Sweden. beatrice.melin@onkologi.umu.se., Arver B; Department of Oncology-Pathology, Karolinska University Hospital, K7, Ärftlighetsmottagningen, Radiumhemmet, 171 76, Stockholm, Sweden. brita.wasteson-arver@karolinska.se., Loman N; Division of Oncology and Pathology, Department of Clinical Sciences, Lund University Hospital, Barngatan 2B, SE-221 85, Lund, Sweden. niklas.loman@med.lu.se., Rosenquist R; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85, Uppsala, Sweden. richard.rosenquist@igp.uu.se., Olopade OI; Center for Clinical Cancer Genetics and Global Health, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL, 60637, USA. folopade@medicine.bsd.uchicago.edu., Nussbaum RL; Department of Medicine and Genetics, University of California, San Francisco, CA, USA. nussbaumr@humgen.ucsf.edu., Ramus SJ; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Norris Comprehensive Cancer Center, NOR-4435, Los Angeles, CA, 90089-9175, USA. sramus@usc.edu., Nathanson KL; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA, 19104-3309, USA. knathans@exchange.upenn.edu., Domchek SM; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA, 19104-3309, USA. susan.domchek@uphs.upenn.edu., Rebbeck TR; Department of Epidemiology and Biostatistics, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA, 19104-3309, USA. rebbeck@exchange.upenn.edu., Arun BK; Division of Cancer Medicine, Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Unit 1354, PO Box 301439, Houston, TX, 77230-1439, USA. barun@mdanderson.org., Mitchell G; Sir Peter MacCallum Department of Oncology, Familial Cancer Centre, Peter MacCallum Cancer Centre, level 3, 10 St Andrews Place, East Melbourne, VIC, 3002, Australia. gillian.mitchell@petermac.org.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Level 5, 161 Barry Street, Parkville, 3010, VIC, Australia. gillian.mitchell@petermac.org., Karlan BY; Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA, 90048, USA. beth.karlan@cshs.org., Lester J; Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA, 90048, USA. jenny.lester@cshs.org., Orsulic S; Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA, 90048, USA. sandra.orsulic@cshs.org., Stoppa-Lyonnet D; Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05, France. dominique.stoppa-lyonnet@curie.net.; 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مؤلفون مشاركون: Breast Cancer Family Registry, EMBRACE, GEMO Study Collaborators, HEBON

المصدر: Breast cancer research : BCR [Breast Cancer Res] 2015 Apr 25; Vol. 17, pp. 61. Date of Electronic Publication: 2015 Apr 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100927353 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-542X (Electronic) Linking ISSN: 14655411 NLM ISO Abbreviation: Breast Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Genes, BRCA2* , Genes, Mitochondrial* , Heterozygote* , Mutation*, Breast Neoplasms/*genetics, BRCA1 Protein/genetics ; Female ; Genetic Predisposition to Disease ; Haplotypes ; Humans ; Phylogeny ; Risk

المؤلفون: Rebbeck TR; Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia2Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia., Mitra N; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia., Wan F; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia., Sinilnikova OM; Centre de Recherche en Cancérologie de Lyon, UMR Inserm, Centre Léon Bérard, Lyon, France., Healey S; Department of Genetics and Computational Biology, Queensland Institute of Medical Research, Brisbane, Australia., McGuffog L; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Mazoyer S; Centre de Recherche en Cancérologie de Lyon, UMR Inserm, Centre Léon Bérard, Lyon, France., Chenevix-Trench G; Department of Genetics and Computational Biology, Queensland Institute of Medical Research, Brisbane, Australia., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Antoniou AC; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Nathanson KL; Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia6Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia., Laitman Y; Sheba Medical Center, Tel Aviv, Israel., Kushnir A; Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel Hashomer, Israel., Paluch-Shimon S; Sheba Medical Center, Tel Aviv, Israel., Berger R; Oncology Institute, Sheba Medical Center, Tel Hashomer, Israel., Zidan J; Oncology Institute, Rivkah Ziv Medical Center Zefat, Israel., Friedman E; Sheba Medical Center, Tel Aviv, Israel., Ehrencrona H; Department of Oncology, Lund University, Lund, Sweden12Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Stenmark-Askmalm M; Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden., Einbeigi Z; Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden., Loman N; Department of Oncology, Lund University, Lund, Sweden., Harbst K; Department of Oncology, Lund University, Lund, Sweden., Rantala J; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden., Melin B; Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden., Huo D; Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois., Olopade OI; Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois., Seldon J; UCLA Schools of Medicine and Public Health, Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, Los Angeles, California., Ganz PA; UCLA Schools of Medicine and Public Health, Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, Los Angeles, California., Nussbaum RL; Department of Medicine and Genetics, University of California, San Francisco., Chan SB; Cancer Risk Program, Helen Diller Family Cancer Center, University of California, San Francisco., Odunsi K; Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York., Gayther SA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles., Domchek SM; Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia6Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia., Arun BK; University of Texas MD Anderson Cancer Center, Houston., Lu KH; University of Texas MD Anderson Cancer Center, Houston., Mitchell G; Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia 25Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia., Karlan BY; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California., Walsh C; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California., Lester J; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California., Godwin AK; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City., Pathak H; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City., Ross E; Fox Chase Cancer Center, Philadelphia, Pennsylvania., Daly MB; Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California., Whittemore AS; Cancer Risk Program, Helen Diller Family Cancer Center, University of California, San Francisco., John EM; Department of Epidemiology, Cancer Prevention Institute of California, Fremont., Miron A; Dana-Farber Cancer Institute, Boston, Massachusetts., Terry MB; Department of Epidemiology, Columbia University, New York, New York., Chung WK; Departments of Pediatrics and Medicine, Columbia University, New York, New York., Goldgar DE; Department of Dermatology, University of Utah School of Medicine, Salt Lake City., Buys SS; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City., Janavicius R; Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology, and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, State Research Institute Innovative Medicine Center, Vilnius, Lithuania., Tihomirova L; Latvian Biomedical Research and Study Centre, Riga, Latvia., Tung N; Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Dorfling CM; Department of Genetics, University of Pretoria, Pretoria, South Africa., van Rensburg EJ; Department of Genetics, University of Pretoria, Pretoria, South Africa., Steele L; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California., Neuhausen SL; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California., Ding YC; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California., Ejlertsen B; Departments of Oncology or Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Gerdes AM; Departments of Oncology or Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Hansen Tv; Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Ramón y Cajal T; Oncology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Osorio A; Human Genetics Group, Spanish National Cancer Centre (CNIO), and Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain., Benitez J; Human Genetics Group and Genotyping Unit, Spanish National Cancer Centre (CNIO), and Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain., Godino J; Hospital clinico Universitario 'Lozano Blesa,' Instituto de investigación sanitaria de Aragón (IIS), Zaragoza, Spain., Tejada MI; Molecular Genetics Laboratory (Department of Genetics), Cruces University Hospital Barakaldo, Bizkaia, Spain., Duran M; Institute of Biology and Molecular Genetics. Universidad de Valladolid (IBGM-UVA), Valladolid, Spain., Weitzel JN; Clinical Cancer Genetics, City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California., Bobolis KA; Clinical Cancer Genetics, City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California., Sand SR; Clinical Cancer Genetics, City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California., Fontaine A; Clinical Cancer Genetics, City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California., Savarese A; Unit of Genetic Counselling, Medical Oncology Department, Istituto Nazionale Tumori Regina Elena, Rome, Italy., Pasini B; Department of Medical Science, University of Turin, and AO Città della Salute e della Scienza, Turin, Italy., Peissel B; Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy., Bonanni B; Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy., Zaffaroni D; Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy., Vignolo-Lutati F; AO Città della Salute e della Scienza, Turin, Italy., Scuvera G; Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy., Giannini G; Department of Molecular Medicine, University La Sapienza, Rome, Italy., Bernard L; Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy57Cogentech Cancer Genetic Test Laboratory, Milan, Italy., Genuardi M; Institute of Medical Genetics, Catholic University, 'A. Gemelli' Hospital, Rome, Italy., Radice P; Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy60IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy., Dolcetti R; Cancer Bioimmunotherapy Unit, Centro di Riferimento Oncologico, IRCCSCRO Aviano National Cancer Institute, Aviano (PN), Italy., Manoukian S; Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy., Pensotti V; Cogentech Cancer Genetic Test Laboratory, Milan, Italy60IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy., Gismondi V; Unit of Hereditary Cancer, IRCCS AOU San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy., Yannoukakos D; Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research 'Demokritos' Aghia Paraskevi Attikis, Athens, Greece., Fostira F; 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مؤلفون مشاركون: CIMBA Consortium

المصدر: JAMA [JAMA] 2015 Apr 07; Vol. 313 (13), pp. 1347-61.

نوع المنشور: Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE

مواضيع طبية MeSH: Genes, BRCA1* , Genes, BRCA2* , Genetic Predisposition to Disease* , Mutation*, Breast Neoplasms/*genetics , Ovarian Neoplasms/*genetics, Adult ; Age of Onset ; Female ; Heterozygote ; Humans ; Middle Aged ; Nucleotides ; Risk Factors