المؤلفون: Dunlap J; Department of Pathology, Oregon Health & Science University, Portland, USA., Kelemen K, Leeborg N, Braziel R, Olson S, Press R, Huang J, Gatter K, Loriaux M, Fan G

المصدر: American journal of clinical pathology [Am J Clin Pathol] 2011 May; Vol. 135 (5), pp. 709-19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0370470 Publication Model: Print Cited Medium: Internet ISSN: 1943-7722 (Electronic) Linking ISSN: 00029173 NLM ISO Abbreviation: Am J Clin Pathol Subsets: MEDLINE

مواضيع طبية MeSH: Chromosome Aberrations* , Mutation*, Janus Kinase 2/*genetics , Myelodysplastic-Myeloproliferative Diseases/*enzymology , Myelodysplastic-Myeloproliferative Diseases/*genetics , Myeloproliferative Disorders/*enzymology , Myeloproliferative Disorders/*genetics, Cell Transformation, Neoplastic ; Chromosomes, Human, Pair 13/genetics ; Chromosomes, Human, Pair 20/genetics ; Chromosomes, Human, Pair 21/genetics ; Chromosomes, Human, Pair 7/genetics ; Chromosomes, Human, Pair 9/genetics ; Disease Progression ; Humans ; Karyotyping ; Myelodysplastic-Myeloproliferative Diseases/pathology ; Myeloproliferative Disorders/pathology

المؤلفون: Fröhling S; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Scholl C, Levine RL, Loriaux M, Boggon TJ, Bernard OA, Berger R, Döhner H, Döhner K, Ebert BL, Teckie S, Golub TR, Jiang J, Schittenhelm MM, Lee BH, Griffin JD, Stone RM, Heinrich MC, Deininger MW, Druker BJ, Gilliland DG

المصدر: Cancer cell [Cancer Cell] 2007 Dec; Vol. 12 (6), pp. 501-13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print Cited Medium: Print ISSN: 1535-6108 (Print) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

مواضيع طبية MeSH: Alleles*, Mutation/*genetics , fms-Like Tyrosine Kinase 3/*genetics, Adult ; Animals ; Cell Proliferation/drug effects ; DNA Mutational Analysis ; Enzyme Activation/drug effects ; Humans ; Leukemia, Monocytic, Acute/enzymology ; Leukemia, Monocytic, Acute/genetics ; Leukemia, Monocytic, Acute/pathology ; Mice ; Mutant Proteins/metabolism ; Phosphorylation/drug effects ; Protein Kinase Inhibitors/pharmacology ; Protein Structure, Secondary ; Signal Transduction/drug effects ; Staurosporine/analogs & derivatives ; Staurosporine/pharmacology ; fms-Like Tyrosine Kinase 3/chemistry

المؤلفون: Jason D. MacManiman, Jason Gotlib, Emily A. Stevens, Peter L. Greenberg, Melissa L. Abel, Samuel B. Luty, Marc M. Loriaux, Jason C. Paik, Swaleh Bahamadi, Jeffrey W. Tyner, Julia E. Maxson, Christopher A. Eide, Samantha L. Savage

المصدر: Clinical Cancer Research. 22:757-764

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Glycosylation, DNA Mutational Analysis, Chronic neutrophilic leukemia, Mutant, Biology, Ligands, medicine.disease_cause, Article, Cell Line, Mice, 03 medical and health sciences, Bone Marrow, Receptors, Colony-Stimulating Factor, medicine, Animals, Humans, Codon, Protein Kinase Inhibitors, Bone Marrow Transplantation, Janus Kinases, Mutation, Leukemia, Point mutation, Middle Aged, medicine.disease, Molecular biology, Disease Models, Animal, Cell Transformation, Neoplastic, 030104 developmental biology, medicine.anatomical_structure, Amino Acid Substitution, Oncology, Atypical chronic myeloid leukemia, Female, Bone marrow, Janus kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0f2116441cfd4006dc1506ba5d3860
https://doi.org/10.1158/1078-0432.ccr-14-3100

المؤلفون: Elie Traer, Paul Tardi, Tibor Kovacsovics, Stephen E. Spurgeon, Marc M. Loriaux, Max J. Gordon, Lawrence D. Mayer, Jeffrey W. Tyner

المصدر: Leukemia research. 53

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Antimetabolites, Antineoplastic, Daunorubicin, Chronic lymphocytic leukemia, Pharmacology, Biology, 03 medical and health sciences, Inhibitory Concentration 50, 0302 clinical medicine, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, medicine, Tumor Cells, Cultured, Cytotoxic T cell, Humans, Antibiotics, Antineoplastic, Cytarabine, Hematology, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, Lymphoma, Leukemia, 030104 developmental biology, Oncology, fms-Like Tyrosine Kinase 3, 030220 oncology & carcinogenesis, Fms-Like Tyrosine Kinase 3, Liposomes, Mutation, Blast Crisis, Ex vivo, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220a999dbd3c01798882e67d1760dfb0
https://pubmed.ncbi.nlm.nih.gov/28013106

المؤلفون: Marc M. Loriaux, Michael W. Deininger, Stephanie G. Willis, Michael Rutenberg-Schoenberg, Thomas O'Hare, Heidi Erickson, B. J. Druker, Jeffrey W. Tyner

المصدر: Leukemia. 23:1345-1348

مصطلحات موضوعية: Cancer Research, biology, JAK-STAT signaling pathway, Myeloid leukemia, Hematology, Protein tyrosine phosphatase, Receptor, TIE-2, Receptor tyrosine kinase, Leukemia, Myeloid, Acute, Oncology, hemic and lymphatic diseases, Mutation, ROR1, Cancer research, biology.protein, Humans, Tyrosine kinase, Platelet-derived growth factor receptor, Proto-oncogene tyrosine-protein kinase Src

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35cf2d61fff8af56e53e4a55f949cc1
https://doi.org/10.1038/leu.2009.66

المؤلفون: Michael W. Deininger, Olivier Bernard, James D. Griffin, Sewit Teckie, Jingrui Jiang, Benjamin H. Lee, Brian J. Druker, Titus J. Boggon, Benjamin L. Ebert, Todd R. Golub, Marcus M Schittenhelm, Richard Stone, D. Gary Gilliland, Roland Berger, Marc M. Loriaux, Ross L. Levine, Claudia Scholl, Konstanze Döhner, Michael Heinrich, Hartmut Döhner, Stefan Fröhling

المصدر: Cancer Cell. 12(6):501-513

مصطلحات موضوعية: Adult, Cancer Research, Sequence analysis, DNA Mutational Analysis, CELLCYCLE, Biology, medicine.disease_cause, Protein Structure, Secondary, Leukemogenic, Malignant transformation, Mice, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, medicine, Animals, Humans, Coding region, Phosphorylation, Allele, Protein Kinase Inhibitors, Alleles, Cell Proliferation, 030304 developmental biology, Genetics, 0303 health sciences, Point mutation, Cell Biology, Cell cycle, Staurosporine, Enzyme Activation, fms-Like Tyrosine Kinase 3, Oncology, 030220 oncology & carcinogenesis, Leukemia, Monocytic, Acute, Mutation, Mutant Proteins, Carcinogenesis, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5376ce999eb6f2b28db31c5235bd31bf

المؤلفون: Jason Gotlib, Shannon K. McWeeney, Christopher A. Eide, Stephen T. Oh, Jeffrey W. Tyner, Robert H. Collins, Basem S. Goueli, Julia E. Maxson, Daniel Bottomly, Cristina E. Tognon, Michael W. Deininger, J. Blake Pond, Anupriya Agarwal, Beth Wilmot, Brian J. Druker, Marc M. Loriaux, Angela G. Fleischman, Daniel A. Pollyea, Bill H. Chang

المصدر: The New England journal of medicine. 368(19)

مصطلحات موضوعية: Biology, medicine.disease_cause, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Mice, Receptors, Colony-Stimulating Factor, medicine, Animals, Humans, RNA, Small Interfering, Protein Kinase Inhibitors, Leukemia, Neutrophilic, Chronic, Janus Kinases, Mutation, General Medicine, Protein-Tyrosine Kinases, medicine.disease, Leukemia, Lymphoid, Leukemia, Immunology, Cancer research, Atypical chronic myeloid leukemia, Carcinogenesis, Janus kinase, Tyrosine kinase, Proto-oncogene tyrosine-protein kinase Src, Chronic myelogenous leukemia, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5e59a21bae8ee6ff04e1c5da2699ce
https://pubmed.ncbi.nlm.nih.gov/23656651

المؤلفون: Katalin Kelemen, Richard D. Press, Ken Gatter, James Huang, Rita M. Braziel, Guang Fan, Marc M. Loriaux, Nicky Leeborg, Susan B. Olson, Jennifer Dunlap

المصدر: American journal of clinical pathology. 135(5)

مصطلحات موضوعية: medicine.medical_specialty, Pathology, Down syndrome, Chromosomes, Human, Pair 21, Chromosomes, Human, Pair 20, Chromosome 9, hemic and lymphatic diseases, medicine, Humans, Chromosome 7 (human), Chromosome Aberrations, Myeloproliferative Disorders, Chromosomes, Human, Pair 13, business.industry, Cytogenetics, food and beverages, Karyotype, General Medicine, Janus Kinase 2, medicine.disease, Myelodysplastic-Myeloproliferative Diseases, Cell Transformation, Neoplastic, Karyotyping, Mutation (genetic algorithm), Mutation, Chromosome abnormality, Disease Progression, business, Trisomy, Chromosomes, Human, Pair 9, hormones, hormone substitutes, and hormone antagonists, Chromosomes, Human, Pair 7

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3112ebddaad42b9d98fa2ad3a63e6a87
https://pubmed.ncbi.nlm.nih.gov/22431549

المؤلفون: Michael W. Deininger, Stephanie G. Willis, Tibor Kovacsovics, Bill H. Chang, Thomas O'Hare, Heidi Erickson, Jeffrey W. Tyner, Jason Gotlib, Brian J. Druker, Marc M. Loriaux, Michael Heinrich

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 106(21)

مصطلحات موضوعية: Time Factors, medicine.medical_treatment, Targeted therapy, LYN, Cell Line, Tumor, medicine, Humans, Lemur tyrosine kinase 3, Alleles, Thrombopoietin receptor, Multidisciplinary, Janus kinase 2, Leukemia, biology, business.industry, Gene Expression Profiling, Janus Kinase 2, Biological Sciences, Gene expression profiling, Gene Expression Regulation, Neoplastic, Treatment Outcome, ROR1, Mutation, biology.protein, Cancer research, RNA Interference, Personalized medicine, business, Receptors, Thrombopoietin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4c5ca248630ef2ebee299ec7fbc29c
https://pubmed.ncbi.nlm.nih.gov/19433805

المؤلفون: Ross L. Levine, Christopher A. Eide, Stephanie G. Willis, Heidi Erickson, Brian J. Druker, Jeffrey W. Tyner, Michael W. Deininger, Michael Heinrich, D. Gary Gilliland, Norbert Gattermann, Marc M. Loriaux

المصدر: Blood. 113(8)

مصطلحات موضوعية: Neuroblastoma RAS viral oncogene homolog, Immunology, Bone Marrow Cells, Biology, medicine.disease_cause, Biochemistry, Cell Line, Proto-Oncogene Proteins p21(ras), Mice, medicine, Animals, Humans, Point Mutation, HRAS, Genetic Testing, Genetics, Mutation, Mice, Inbred BALB C, Myeloid Neoplasia, Point mutation, Myeloid leukemia, Leukemia, Myelomonocytic, Chronic, Cell Biology, Hematology, Fibroblasts, medicine.disease, Leukemia, Leukemia, Myeloid, Acute, Cell Transformation, Neoplastic, Cancer research, KRAS, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95cd19b51bee3fc7b4c9d6c9254c7466
https://pubmed.ncbi.nlm.nih.gov/19075190